Details for: IGHV3 32

Gene ID: 28435

Symbol: IGHV3 32

Ensembl ID: ENSG00000270474

Description: immunoglobulin heavy variable 3-32 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.6785
    Cell Significance Index: 8.0600
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.4028
    Cell Significance Index: 4.0900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.3589
    Cell Significance Index: 4.5400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.3030
    Cell Significance Index: 3.8400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.1069
    Cell Significance Index: 1.2900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0952
    Cell Significance Index: 1.1600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0788
    Cell Significance Index: 0.8500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.0617
    Cell Significance Index: 0.6000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0129
    Cell Significance Index: 0.3300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.0046
    Cell Significance Index: 0.0500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0099
    Cell Significance Index: -0.6400
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0099
    Cell Significance Index: -0.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0165
    Cell Significance Index: -0.7700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0187
    Cell Significance Index: -0.2700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0347
    Cell Significance Index: -0.3600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0358
    Cell Significance Index: -0.4600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0372
    Cell Significance Index: -0.4400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0381
    Cell Significance Index: -0.3900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0400
    Cell Significance Index: -1.0200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0453
    Cell Significance Index: -0.5100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0466
    Cell Significance Index: -0.7900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0508
    Cell Significance Index: -0.6000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0526
    Cell Significance Index: -0.6800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0597
    Cell Significance Index: -1.0200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0647
    Cell Significance Index: -0.8800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0668
    Cell Significance Index: -0.9800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0686
    Cell Significance Index: -0.7000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0696
    Cell Significance Index: -1.0100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0716
    Cell Significance Index: -0.8000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0737
    Cell Significance Index: -0.9100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0762
    Cell Significance Index: -1.0000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0763
    Cell Significance Index: -0.8200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0774
    Cell Significance Index: -1.0100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0779
    Cell Significance Index: -0.7900
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0799
    Cell Significance Index: -0.7300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0802
    Cell Significance Index: -0.9300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0818
    Cell Significance Index: -0.8700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0832
    Cell Significance Index: -0.9100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0855
    Cell Significance Index: -1.0100
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0855
    Cell Significance Index: -0.4600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0857
    Cell Significance Index: -0.9700
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0861
    Cell Significance Index: -0.8200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0871
    Cell Significance Index: -0.8800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0875
    Cell Significance Index: -1.0300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0886
    Cell Significance Index: -1.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0905
    Cell Significance Index: -0.8700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0907
    Cell Significance Index: -0.8600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0912
    Cell Significance Index: -0.9600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0913
    Cell Significance Index: -1.0200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0916
    Cell Significance Index: -0.7800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0921
    Cell Significance Index: -1.0200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0923
    Cell Significance Index: -0.9300
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0936
    Cell Significance Index: -0.9500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0956
    Cell Significance Index: -1.1300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0975
    Cell Significance Index: -0.8800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0990
    Cell Significance Index: -1.0500
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1000
    Cell Significance Index: -0.9000
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1011
    Cell Significance Index: -0.9700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1012
    Cell Significance Index: -1.0100
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1019
    Cell Significance Index: -1.0600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1032
    Cell Significance Index: -0.9700
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1052
    Cell Significance Index: -1.0900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1058
    Cell Significance Index: -0.9300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1065
    Cell Significance Index: -1.0000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1095
    Cell Significance Index: -1.1100
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1097
    Cell Significance Index: -1.0200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1099
    Cell Significance Index: -1.0200
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.1106
    Cell Significance Index: -1.0200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1113
    Cell Significance Index: -0.9600
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1115
    Cell Significance Index: -0.9500
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.1128
    Cell Significance Index: -1.0100
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1140
    Cell Significance Index: -1.0100
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1170
    Cell Significance Index: -1.2500
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1186
    Cell Significance Index: -1.0200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1209
    Cell Significance Index: -1.0200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1221
    Cell Significance Index: -0.9500
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.1243
    Cell Significance Index: -1.0200
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1359
    Cell Significance Index: -0.9100
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.1402
    Cell Significance Index: -1.0700
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1609
    Cell Significance Index: -1.0500
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.1899
    Cell Significance Index: -0.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding nature**: IGHV3-32 does not encode a functional protein, unlike its functional counterparts, which encode the heavy chain of antibodies. 2. **Pseudogenization**: The IGHV3-32 pseudogene has undergone significant mutations, resulting in a non-functional allele that cannot be recombined with functional alleles. 3. **Expression in immune cells**: IGHV3-32 is expressed in a wide range of immune cells, including double-negative thymocytes, thymocytes, double-positive thymocytes, alpha-beta thymocytes, early lymphoid progenitors, precursor B cells, pro-B cells, fraction A pre-pro B cells, medullary thymic epithelial cells, pro-T cells, and type I NK T cells. 4. **Unique sequence**: The IGHV3-32 pseudogene has a distinct sequence that differs from its functional counterparts, suggesting a possible role in regulating gene expression or cell development. **Pathways and Functions:** 1. **Immunoglobulin gene regulation**: IGHV3-32 may play a role in regulating the expression of immunoglobulin genes, particularly in early lymphoid progenitors and precursor B cells. 2. **Thymocyte development**: The expression of IGHV3-32 in thymocytes suggests a role in thymocyte development and selection, possibly influencing the selection of alpha-beta T cells over gamma delta T cells. 3. **NK T cell development**: IGHV3-32 is also expressed in type I NK T cells, indicating a possible role in the development and maturation of these cells. 4. **Epigenetic regulation**: The pseudogene may influence epigenetic regulation of gene expression, particularly in the context of immune cell development and differentiation. **Clinical Significance:** 1. **Immunodeficiency**: Alterations in IGHV3-32 expression or function may contribute to immunodeficiency disorders, such as thymic dysplasia or immunoglobulin deficiencies. 2. **Cancer**: Aberrant expression of IGHV3-32 has been linked to certain types of cancer, including T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoma. 3. **Autoimmunity**: The pseudogene's expression in precursor B cells and pro-B cells suggests a potential role in the development of autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis. 4. **Immunological monitoring**: IGHV3-32 can serve as a valuable marker for monitoring immune cell populations and tracking immune responses in clinical settings. In conclusion, the IGHV3-32 pseudogene is a unique and complex gene that plays a significant role in the development and maturation of immune cells. Further research is needed to fully understand its functions and clinical significance, but its expression in various immune cell lineages highlights its importance in immunology and immunotherapy.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.