Details for: GPR22

Gene ID: 2845

Symbol: GPR22

Ensembl ID: ENSG00000172209

Description: G protein-coupled receptor 22

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0736
    Cell Significance Index: 215.3600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.8081
    Cell Significance Index: 11.9300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.5934
    Cell Significance Index: 7.3600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.3606
    Cell Significance Index: 4.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3054
    Cell Significance Index: 6.5100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2971
    Cell Significance Index: 2.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2727
    Cell Significance Index: 97.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1681
    Cell Significance Index: 12.9000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.1508
    Cell Significance Index: 1.4400
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.1062
    Cell Significance Index: 1.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1045
    Cell Significance Index: 72.2900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0667
    Cell Significance Index: 1.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0179
    Cell Significance Index: 0.9000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0165
    Cell Significance Index: 0.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0141
    Cell Significance Index: 0.4600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.0016
    Cell Significance Index: 0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0026
    Cell Significance Index: -4.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0039
    Cell Significance Index: -7.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0043
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0112
    Cell Significance Index: -4.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0124
    Cell Significance Index: -7.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0139
    Cell Significance Index: -0.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0145
    Cell Significance Index: -0.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0146
    Cell Significance Index: -8.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0147
    Cell Significance Index: -6.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0152
    Cell Significance Index: -8.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0231
    Cell Significance Index: -6.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0255
    Cell Significance Index: -5.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0313
    Cell Significance Index: -4.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0337
    Cell Significance Index: -6.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0377
    Cell Significance Index: -1.2000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0386
    Cell Significance Index: -1.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0391
    Cell Significance Index: -1.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0406
    Cell Significance Index: -6.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0464
    Cell Significance Index: -9.7700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0478
    Cell Significance Index: -0.9600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0528
    Cell Significance Index: -1.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0530
    Cell Significance Index: -7.7100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0532
    Cell Significance Index: -1.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0533
    Cell Significance Index: -6.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0588
    Cell Significance Index: -3.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0597
    Cell Significance Index: -7.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0651
    Cell Significance Index: -2.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0652
    Cell Significance Index: -7.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0739
    Cell Significance Index: -3.8400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0762
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0770
    Cell Significance Index: -8.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0788
    Cell Significance Index: -2.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0790
    Cell Significance Index: -3.5800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0800
    Cell Significance Index: -1.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0844
    Cell Significance Index: -8.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0849
    Cell Significance Index: -8.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0877
    Cell Significance Index: -2.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0882
    Cell Significance Index: -4.1100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0907
    Cell Significance Index: -0.8600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0930
    Cell Significance Index: -1.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1009
    Cell Significance Index: -5.6600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1037
    Cell Significance Index: -1.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1054
    Cell Significance Index: -6.6400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1062
    Cell Significance Index: -1.8200
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.1119
    Cell Significance Index: -0.8700
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.1192
    Cell Significance Index: -1.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1198
    Cell Significance Index: -1.7200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1331
    Cell Significance Index: -2.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1380
    Cell Significance Index: -8.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1386
    Cell Significance Index: -7.2200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1413
    Cell Significance Index: -1.6900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.1416
    Cell Significance Index: -1.4800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1560
    Cell Significance Index: -1.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1660
    Cell Significance Index: -7.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1760
    Cell Significance Index: -5.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1944
    Cell Significance Index: -6.8300
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: -0.1954
    Cell Significance Index: -0.5600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1957
    Cell Significance Index: -6.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1975
    Cell Significance Index: -7.2500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1989
    Cell Significance Index: -2.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2001
    Cell Significance Index: -6.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2063
    Cell Significance Index: -4.4700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2189
    Cell Significance Index: -2.7300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2289
    Cell Significance Index: -3.4500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2329
    Cell Significance Index: -3.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2381
    Cell Significance Index: -4.9400
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.2384
    Cell Significance Index: -2.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2403
    Cell Significance Index: -6.5400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2412
    Cell Significance Index: -4.8100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2429
    Cell Significance Index: -4.2000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2448
    Cell Significance Index: -3.0900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2536
    Cell Significance Index: -3.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2558
    Cell Significance Index: -3.4900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2649
    Cell Significance Index: -5.3900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2663
    Cell Significance Index: -3.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2692
    Cell Significance Index: -7.9300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2745
    Cell Significance Index: -6.8500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2771
    Cell Significance Index: -6.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2820
    Cell Significance Index: -6.5200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2896
    Cell Significance Index: -3.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2916
    Cell Significance Index: -7.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR22 is a GPCR, characterized by its seven transmembrane helices and a characteristic sequence of amino acids. Its expression is widespread, with significant levels found in blood vessel endothelial cells, colon goblet cells, and various types of neurons. Notably, GPR22 is also expressed in immune cells, such as granulocyte monocyte progenitor cells and intestinal crypt stem cells, suggesting its potential role in immune regulation. **Pathways and Functions:** GPR22's signaling pathways are multifaceted, involving the activation of G-proteins, which in turn modulate various downstream effectors. The receptor's primary ligand is unknown, but it is thought to interact with peptides and other small molecules. GPR22's signaling pathways are also intersecting with other cellular processes, such as cell migration, proliferation, and differentiation. One of the most intriguing aspects of GPR22 is its involvement in the regulation of cellular responses to hormone stimuli. The receptor's ability to modulate G-protein signaling pathways suggests that it may play a role in the regulation of hormone-dependent cellular processes, such as those involved in the reproductive and endocrine systems. **Clinical Significance:** Despite its relatively low expression levels, GPR22's involvement in various cellular processes makes it a potential candidate for therapeutic interventions. For example, its role in regulating immune responses and cellular migration suggests that it may be involved in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. Furthermore, GPR22's involvement in hormone-dependent cellular processes raises the possibility of its role in reproductive disorders, such as endometriosis and infertility. Additionally, its expression in neurons suggests that it may play a role in neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, GPR22 is a multifaceted receptor with a wide range of potential functions. Its involvement in various cellular processes, including immune regulation, cellular migration, and hormone-dependent cellular processes, makes it a promising candidate for therapeutic interventions. Further research is needed to fully elucidate the role of GPR22 in human disease. **Future Directions:** 1. **Identification of ligands:** The identification of GPR22's primary ligand(s) is crucial for understanding its signaling pathways and functions. 2. **Functional characterization:** Further studies are needed to elucidate the receptor's role in various cellular processes, including immune regulation, cellular migration, and hormone-dependent cellular processes. 3. **Therapeutic applications:** The potential therapeutic applications of GPR22, including its role in autoimmune diseases, reproductive disorders, and neurological disorders, warrant further investigation. By continuing to explore the mysteries of GPR22, we may uncover new avenues for therapeutic intervention and shed light on the complex interplay between this receptor and various cellular processes.

Genular Protein ID: 2389270517

Symbol: GPR22_HUMAN

Name: G-protein coupled receptor 22

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9073069

Title: Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes.

PubMed ID: 9073069

DOI: 10.1016/s0378-1119(96)00722-6

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 18539757

Title: Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor.

PubMed ID: 18539757

DOI: 10.1152/ajpheart.00368.2008

Sequence Information:

  • Length: 433
  • Mass: 49265
  • Checksum: 2D4DC8AC567C4DC1
  • Sequence:
  • MCFSPILEIN MQSESNITVR DDIDDINTNM YQPLSYPLSF QVSLTGFLML EIVLGLGSNL 
    TVLVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI VILLLSLESN TALICCFHEA 
    CVSFASVSTA INVFAITLDR YDISVKPANR ILTMGRAVML MISIWIFSFF SFLIPFIEVN 
    FFSLQSGNTW ENKTLLCVST NEYYTELGMY YHLLVQIPIF FFTVVVMLIT YTKILQALNI 
    RIGTRFSTGQ KKKARKKKTI SLTTQHEATD MSQSSGGRNV VFGVRTSVSV IIALRRAVKR 
    HRERRERQKR VFRMSLLIIS TFLLCWTPIS VLNTTILCLG PSDLLVKLRL CFLVMAYGTT 
    IFHPLLYAFT RQKFQKVLKS KMKKRVVSIV EADPLPNNAV IHNSWIDPKR NKKITFEDSE 
    IREKCLVPQV VTD

Genular Protein ID: 2521200633

Symbol: B3KV13_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 433
  • Mass: 49279
  • Checksum: 0E47FBAE790596A9
  • Sequence:
  • MCFSPILEIN MQSESNITVR DDIDDINTNM YQPLSYPLSF QVSLTGFLML EIVLGLGSNL 
    TILVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI VILLLSLESN TALICCFHEA 
    CVSFASVSTA INVFAITLDR YDISVKPANR ILTMGRAVML MISIWIFSFF SFLIPFIEVN 
    FFSLQSGNTW ENKTLLCVST NEYYTELGMY YHLLVQIPIF FFTVVVMLIT YTKILQALNI 
    RIGTRFSTGQ KKKARKKKTI SLTTQHEATD MSQSSGGRNV VFGVRTSVSV IIALRRAVKR 
    HRERRERQKR VFRMSLLIIS TFLLCWTPIS VLNTTILCLG PSDLLVKLRL CFLVMAYGTT 
    IFHPLLYAFT RQKFQKVLKS KMKKRVVSIV EADPLPNNAV IHNSWIDPKR NKKITFEDSE 
    IREKCLVPQV VTD

Genular Protein ID: 713417918

Symbol: Q3KNS9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 433
  • Mass: 49223
  • Checksum: 2B91B1D524B53671
  • Sequence:
  • MCFSPILEIN MQSESNITVR DDIDDINTNM YQPLSYPLSF QVSLTGFLML EIGLGLGSNL 
    TVLVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI VILLLSLESN TALICCFHEA 
    CVSFASVSTA INVFAITLDR YDISVKPANR ILTMGRAVML MISIWIFSFF SFLIPFIEVN 
    FFSLQSGNTW ENKTLLCVST NEYYTELGMY YHLLVQIPIF FFTVVVMLIT YTKILQALNI 
    RIGTRFSTGQ KKKARKKKTI SLTTQHEATD MSQSSGGRNV VFGVRTSVSV IIALRRAVKR 
    HRERRERQKR VFRMSLLIIS TFLLCWTPIS VLNTTILCLG PSDLLVKLRL CFLVMAYGTT 
    IFHPLLYAFT RQKFQKVLKS KMKKRVVSIV EADPLPNNAV IHNSWIDPKR NKKITFEDSE 
    IREKCLVPQV VTD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.