Details for: GPR22

Gene ID: 2845

Symbol: GPR22

Ensembl ID: ENSG00000172209

Description: G protein-coupled receptor 22

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.36
    Marker Score: 2371.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169494
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.43
    Marker Score: 1609
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 872
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.24
    Marker Score: 1917
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.15
    Marker Score: 685
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.05
    Marker Score: 1472
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.04
    Marker Score: 38330
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.02
    Marker Score: 336
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.02
    Marker Score: 2073
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.01
    Marker Score: 61815
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.94
    Marker Score: 8051
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.92
    Marker Score: 423
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.88
    Marker Score: 671.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3252.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.7
    Marker Score: 331
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.65
    Marker Score: 12865
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.64
    Marker Score: 6086
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 477
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.57
    Marker Score: 21730
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.55
    Marker Score: 2138
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.55
    Marker Score: 3642
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.54
    Marker Score: 4135
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.53
    Marker Score: 5026
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.51
    Marker Score: 173
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.51
    Marker Score: 246
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.5
    Marker Score: 7482
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.49
    Marker Score: 10983
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.47
    Marker Score: 783
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.43
    Marker Score: 4463
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.43
    Marker Score: 1531
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.41
    Marker Score: 1173
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.4
    Marker Score: 133
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.33
    Marker Score: 219
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.32
    Marker Score: 4270
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.32
    Marker Score: 1306
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 317
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.3
    Marker Score: 1246
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.3
    Marker Score: 1229
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.23
    Marker Score: 367
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.21
    Marker Score: 88
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.2
    Marker Score: 139
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.2
    Marker Score: 254
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.17
    Marker Score: 91
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.16
    Marker Score: 142
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.16
    Marker Score: 73
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.16
    Marker Score: 177
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.16
    Marker Score: 78
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.15
    Marker Score: 1561
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.15
    Marker Score: 61
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.14
    Marker Score: 38
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.13
    Marker Score: 165
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.13
    Marker Score: 52
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.12
    Marker Score: 331
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.11
    Marker Score: 220
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.11
    Marker Score: 521
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.11
    Marker Score: 59
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.11
    Marker Score: 62
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.1
    Marker Score: 41
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.1
    Marker Score: 284
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.1
    Marker Score: 75
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.1
    Marker Score: 39
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.09
    Marker Score: 135
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.09
    Marker Score: 36
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.09
    Marker Score: 18
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.09
    Marker Score: 51
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.08
    Marker Score: 174
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.08
    Marker Score: 78.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 89
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.08
    Marker Score: 186
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.08
    Marker Score: 100

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Other Information

**Key characteristics:** * GPR22 is a single-pass transmembrane protein with a predicted molecular weight of approximately 130 kDa. * It is a member of the GPCR superfamily, which are characterized by seven transmembrane domains and a conserved cysteine-rich intracellular domain. * It is expressed in high levels in blood vessel endothelial cells, colon goblet cells, mural cells, peripheral nervous system neurons, and certain immune cells. * It is a key regulator of vascular permeability and inflammation. **Pathways and functions:** * GPR22 is a key regulator of cell projection organization. It is expressed in endothelial cells of blood vessels and is involved in the regulation of vascular permeability. * It is also expressed in goblet cells in the colon, where it is involved in the regulation of mucus production. * It is expressed in mural cells in blood vessels and is involved in the regulation of blood flow. * It is also expressed in neurons of the peripheral nervous system, where it is involved in the regulation of sensory perception and motor function. * It is expressed in immune cells, where it is involved in the regulation of inflammation and immune responses. **Clinical significance:** * Mutations in GPR22 have been linked to several human diseases, including hypertension, heart failure, and cancer. * In hypertension, mutations in GPR22 are associated with the development of abnormal blood vessel remodeling and increased vascular permeability. * In heart failure, mutations in GPR22 are associated with the development of heart failure-associated endothelial cell dysfunction. * In cancer, mutations in GPR22 are associated with the development of tumor growth and metastasis. **Conclusion:** GPR22 is a key regulator of cell projection organization, cellular response to hormone stimuli, and the regulation of various cellular processes. Mutations in GPR22 have been linked to several human diseases, highlighting its importance in human health.

Genular Protein ID: 2389270517

Symbol: GPR22_HUMAN

Name: G-protein coupled receptor 22

UniProtKB Accession Codes:

Q99680 A4D0R8 O14554

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9073069

Title: Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes.

PubMed ID: 9073069

DOI: 10.1016/s0378-1119(96)00722-6

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 18539757

Title: Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor.

PubMed ID: 18539757

DOI: 10.1152/ajpheart.00368.2008

Sequence Information:

  • Length: 433
  • Mass: 49265
  • Checksum: 2D4DC8AC567C4DC1
  • Sequence:
    • MCFSPILEIN MQSESNITVR DDIDDINTNM YQPLSYPLSF QVSLTGFLML EIVLGLGSNL 
TVLVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI VILLLSLESN TALICCFHEA 
CVSFASVSTA INVFAITLDR YDISVKPANR ILTMGRAVML MISIWIFSFF SFLIPFIEVN 
FFSLQSGNTW ENKTLLCVST NEYYTELGMY YHLLVQIPIF FFTVVVMLIT YTKILQALNI 
RIGTRFSTGQ KKKARKKKTI SLTTQHEATD MSQSSGGRNV VFGVRTSVSV IIALRRAVKR 
HRERRERQKR VFRMSLLIIS TFLLCWTPIS VLNTTILCLG PSDLLVKLRL CFLVMAYGTT 
IFHPLLYAFT RQKFQKVLKS KMKKRVVSIV EADPLPNNAV IHNSWIDPKR NKKITFEDSE 
IREKCLVPQV VTD

Genular Protein ID: 713417918

Symbol: Q3KNS9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q3KNS9

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 433
  • Mass: 49223
  • Checksum: 2B91B1D524B53671
  • Sequence:
    • MCFSPILEIN MQSESNITVR DDIDDINTNM YQPLSYPLSF QVSLTGFLML EIGLGLGSNL 
TVLVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI VILLLSLESN TALICCFHEA 
CVSFASVSTA INVFAITLDR YDISVKPANR ILTMGRAVML MISIWIFSFF SFLIPFIEVN 
FFSLQSGNTW ENKTLLCVST NEYYTELGMY YHLLVQIPIF FFTVVVMLIT YTKILQALNI 
RIGTRFSTGQ KKKARKKKTI SLTTQHEATD MSQSSGGRNV VFGVRTSVSV IIALRRAVKR 
HRERRERQKR VFRMSLLIIS TFLLCWTPIS VLNTTILCLG PSDLLVKLRL CFLVMAYGTT 
IFHPLLYAFT RQKFQKVLKS KMKKRVVSIV EADPLPNNAV IHNSWIDPKR NKKITFEDSE 
IREKCLVPQV VTD

Genular Protein ID: 2521200633

Symbol: B3KV13_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KV13

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 433
  • Mass: 49279
  • Checksum: 0E47FBAE790596A9
  • Sequence:
    • MCFSPILEIN MQSESNITVR DDIDDINTNM YQPLSYPLSF QVSLTGFLML EIVLGLGSNL 
TILVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI VILLLSLESN TALICCFHEA 
CVSFASVSTA INVFAITLDR YDISVKPANR ILTMGRAVML MISIWIFSFF SFLIPFIEVN 
FFSLQSGNTW ENKTLLCVST NEYYTELGMY YHLLVQIPIF FFTVVVMLIT YTKILQALNI 
RIGTRFSTGQ KKKARKKKTI SLTTQHEATD MSQSSGGRNV VFGVRTSVSV IIALRRAVKR 
HRERRERQKR VFRMSLLIIS TFLLCWTPIS VLNTTILCLG PSDLLVKLRL CFLVMAYGTT 
IFHPLLYAFT RQKFQKVLKS KMKKRVVSIV EADPLPNNAV IHNSWIDPKR NKKITFEDSE 
IREKCLVPQV VTD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.