Details for: IGHV1 17

Gene ID: 28469

Symbol: IGHV1 17

Ensembl ID: ENSG00000254046

Description: immunoglobulin heavy variable 1-17 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.0346
    Cell Significance Index: 0.2300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0036
    Cell Significance Index: -0.2200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0051
    Cell Significance Index: -0.0600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0136
    Cell Significance Index: -0.1900
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0150
    Cell Significance Index: -0.1000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0158
    Cell Significance Index: -0.2000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0177
    Cell Significance Index: -0.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0184
    Cell Significance Index: -0.4700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0188
    Cell Significance Index: -0.2100
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0188
    Cell Significance Index: -0.1700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0195
    Cell Significance Index: -0.2100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0196
    Cell Significance Index: -0.5000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0224
    Cell Significance Index: -0.2700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0241
    Cell Significance Index: -0.2000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0250
    Cell Significance Index: -0.2700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0283
    Cell Significance Index: -0.4300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0290
    Cell Significance Index: -0.4700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0291
    Cell Significance Index: -0.3100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0294
    Cell Significance Index: -0.3000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0295
    Cell Significance Index: -0.2900
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0295
    Cell Significance Index: -0.3100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0296
    Cell Significance Index: -0.3000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0304
    Cell Significance Index: -0.3100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0309
    Cell Significance Index: -0.4200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0309
    Cell Significance Index: -0.3200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0312
    Cell Significance Index: -0.4100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0322
    Cell Significance Index: -0.6300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0323
    Cell Significance Index: -0.3400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0335
    Cell Significance Index: -0.4600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0337
    Cell Significance Index: -0.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0346
    Cell Significance Index: -0.6400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0352
    Cell Significance Index: -0.5000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0365
    Cell Significance Index: -0.3700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0368
    Cell Significance Index: -0.3200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0373
    Cell Significance Index: -0.3500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0385
    Cell Significance Index: -0.4300
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0389
    Cell Significance Index: -0.3600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.0393
    Cell Significance Index: -0.1100
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0394
    Cell Significance Index: -0.3600
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.0403
    Cell Significance Index: -0.3000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0407
    Cell Significance Index: -0.2800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0414
    Cell Significance Index: -0.4800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0420
    Cell Significance Index: -0.3400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0421
    Cell Significance Index: -0.5500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0432
    Cell Significance Index: -0.5100
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0438
    Cell Significance Index: -0.4200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0443
    Cell Significance Index: -0.4200
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0449
    Cell Significance Index: -0.3900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0451
    Cell Significance Index: -0.4500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0457
    Cell Significance Index: -0.5400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0461
    Cell Significance Index: -0.5300
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0463
    Cell Significance Index: -0.4100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0465
    Cell Significance Index: -0.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0479
    Cell Significance Index: -0.4600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0481
    Cell Significance Index: -0.5100
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.0481
    Cell Significance Index: -0.3400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0488
    Cell Significance Index: -0.5400
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0493
    Cell Significance Index: -0.4300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0497
    Cell Significance Index: -0.5500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0501
    Cell Significance Index: -0.5100
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0503
    Cell Significance Index: -0.4200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0513
    Cell Significance Index: -0.4100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0517
    Cell Significance Index: -0.6000
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0523
    Cell Significance Index: -0.4500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0528
    Cell Significance Index: -0.4900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0528
    Cell Significance Index: -0.4500
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0531
    Cell Significance Index: -0.5500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0535
    Cell Significance Index: -0.5000
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0539
    Cell Significance Index: -0.5100
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0548
    Cell Significance Index: -0.4400
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.0552
    Cell Significance Index: -0.2600
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0594
    Cell Significance Index: -0.5300
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0598
    Cell Significance Index: -0.5100
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0604
    Cell Significance Index: -0.5400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0618
    Cell Significance Index: -0.5500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0626
    Cell Significance Index: -0.5400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0640
    Cell Significance Index: -0.5600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0644
    Cell Significance Index: -0.6000
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0661
    Cell Significance Index: -0.6800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0708
    Cell Significance Index: -0.4700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0720
    Cell Significance Index: -0.5600
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0739
    Cell Significance Index: -0.5500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0766
    Cell Significance Index: -0.4100
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.0834
    Cell Significance Index: -0.6400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1100
    Cell Significance Index: -0.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV1 17 gene exhibits the following key characteristics: 1. **Pseudogenic nature**: IGHV1 17 is a non-functional variant of the immunoglobulin heavy chain gene family, lacking the typical exons and introns that encode the heavy chain variable region. 2. **Widespread expression**: IGHV1 17 is significantly expressed in various hematopoietic cells, including hematopoietic cells, double-negative thymocytes, CD8-positive, alpha-beta memory T cells, naive B cells, B cells, immature B cells, double-positive, alpha-beta thymocytes, plasmablasts, CD4-positive, alpha-beta T cells, and IgG plasma cells. 3. **Lack of somatic hypermutation**: Unlike functional immunoglobulin genes, IGHV1 17 does not undergo somatic hypermutation, a process that introduces mutations into the variable region during B cell activation. **Pathways and Functions:** Despite its pseudogenic nature, IGHV1 17 may still play a role in immune regulation through the following mechanisms: 1. **Regulation of B cell development**: IGHV1 17 expression in immature B cells may influence B cell development and maturation, potentially affecting the overall B cell repertoire. 2. **Influence on T cell development**: IGHV1 17 expression in thymocytes may also impact T cell development, particularly in alpha-beta T cells. 3. **Immune tolerance**: The presence of IGHV1 17 in hematopoietic cells may contribute to immune tolerance, as it could potentially interfere with the activation of immune responses. 4. **Epigenetic regulation**: IGHV1 17 expression may also be influenced by epigenetic mechanisms, such as DNA methylation or histone modification, which could impact its expression and function. **Clinical Significance:** The clinical significance of IGHV1 17 is multifaceted: 1. **Immunological disorders**: Abnormal expression of IGHV1 17 may contribute to immunological disorders, such as autoimmune diseases or cancer. 2. **Cancer immunotherapy**: IGHV1 17 expression in tumor cells may influence the efficacy of cancer immunotherapies, such as checkpoint inhibitors. 3. **Immunological surveillance**: IGHV1 17 expression in hematopoietic cells may serve as a marker for immune surveillance, helping to monitor the activity of the immune system. 4. **Gene therapy**: IGHV1 17 may also be a target for gene therapy, particularly in the treatment of immunodeficiency disorders. In conclusion, the IGHV1 17 gene is a complex and enigmatic molecule that continues to fascinate immunologists. Further research is needed to fully understand its functional significance and clinical implications, but it is clear that IGHV1 17 plays a unique role in immune regulation and may have significant implications for the treatment of immunological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.