Details for: IGHV1 14

Gene ID: 28470

Symbol: IGHV1 14

Ensembl ID: ENSG00000253709

Description: immunoglobulin heavy variable 1-14 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0842
    Cell Significance Index: 0.8600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0026
    Cell Significance Index: -0.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0042
    Cell Significance Index: -0.5800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0096
    Cell Significance Index: -0.1300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0130
    Cell Significance Index: -0.1700
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.0311
    Cell Significance Index: -0.2200
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.0321
    Cell Significance Index: -0.3400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0323
    Cell Significance Index: -0.2800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0394
    Cell Significance Index: -0.5100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0421
    Cell Significance Index: -0.4700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0435
    Cell Significance Index: -0.6600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0442
    Cell Significance Index: -0.4800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0461
    Cell Significance Index: -1.1800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0463
    Cell Significance Index: -0.4700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0479
    Cell Significance Index: -0.6300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0522
    Cell Significance Index: -1.0200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0576
    Cell Significance Index: -0.7400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0590
    Cell Significance Index: -0.6700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0591
    Cell Significance Index: -0.3900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0592
    Cell Significance Index: -0.7000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0599
    Cell Significance Index: -0.6700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0608
    Cell Significance Index: -0.6400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0630
    Cell Significance Index: -0.6700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0650
    Cell Significance Index: -0.6600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0652
    Cell Significance Index: -0.7100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0659
    Cell Significance Index: -0.8600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0670
    Cell Significance Index: -0.7200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0673
    Cell Significance Index: -0.9600
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0676
    Cell Significance Index: -0.4500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0694
    Cell Significance Index: -0.8200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0699
    Cell Significance Index: -0.8500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0700
    Cell Significance Index: -0.8900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0702
    Cell Significance Index: -0.5600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0709
    Cell Significance Index: -0.8500
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0712
    Cell Significance Index: -0.7600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0716
    Cell Significance Index: -0.8500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0730
    Cell Significance Index: -0.7700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0732
    Cell Significance Index: -0.9600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0740
    Cell Significance Index: -0.9100
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.0748
    Cell Significance Index: -0.4000
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0763
    Cell Significance Index: -0.6500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0768
    Cell Significance Index: -0.9100
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0772
    Cell Significance Index: -0.6700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0774
    Cell Significance Index: -0.6500
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.0781
    Cell Significance Index: -0.3900
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0784
    Cell Significance Index: -0.7000
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0803
    Cell Significance Index: -0.7600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0807
    Cell Significance Index: -0.8200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0807
    Cell Significance Index: -0.8700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0808
    Cell Significance Index: -0.9400
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0813
    Cell Significance Index: -0.7800
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0826
    Cell Significance Index: -0.7200
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0842
    Cell Significance Index: -0.7700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0849
    Cell Significance Index: -0.9400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0851
    Cell Significance Index: -1.0100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0860
    Cell Significance Index: -0.9900
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.0861
    Cell Significance Index: -0.6300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0872
    Cell Significance Index: -0.8900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0886
    Cell Significance Index: -1.0200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0889
    Cell Significance Index: -1.0500
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0899
    Cell Significance Index: -0.8800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0907
    Cell Significance Index: -0.9200
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0914
    Cell Significance Index: -1.0500
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0933
    Cell Significance Index: -0.7500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0937
    Cell Significance Index: -0.8800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0937
    Cell Significance Index: -0.8700
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1014
    Cell Significance Index: -0.6600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1016
    Cell Significance Index: -0.9500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1021
    Cell Significance Index: -1.1300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1039
    Cell Significance Index: -0.8900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1053
    Cell Significance Index: -0.9800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1078
    Cell Significance Index: -0.9600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1089
    Cell Significance Index: -0.9400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1097
    Cell Significance Index: -1.0400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1132
    Cell Significance Index: -1.1300
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1157
    Cell Significance Index: -1.0700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1175
    Cell Significance Index: -1.0500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1238
    Cell Significance Index: -0.9000
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1244
    Cell Significance Index: -1.1100
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.1278
    Cell Significance Index: -0.6000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1281
    Cell Significance Index: -1.1200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1289
    Cell Significance Index: -0.6900
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.1328
    Cell Significance Index: -1.0200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1414
    Cell Significance Index: -1.1000
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.1879
    Cell Significance Index: -0.9400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2219
    Cell Significance Index: -1.2100
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: -0.2727
    Cell Significance Index: -1.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** The IGHV1-14 gene is located on chromosome 14q32.33 and is significantly expressed in various B cell subsets, including B-2 B cells, precursor B cells, and plasmablasts. 2. **Pseudogene Status:** The IGHV1-14 gene is a pseudogene, meaning it does not encode a functional protein but instead serves as a template for the generation of antibody diversity. 3. **Cellular Specificity:** The expression of IGHV1-14 is restricted to specific B cell subsets, suggesting a specialized role in the development and function of these cells. **Pathways and Functions:** 1. **V(D)J Recombination:** The IGHV1-14 gene is involved in the V(D)J recombination process, which is responsible for generating antibody diversity. This process involves the random rearrangement of gene segments, resulting in the creation of unique antibody variable regions. 2. **Antibody Production:** The IGHV1-14 gene contributes to the generation of antibody variable regions, which are essential for the production of antibodies that recognize and bind to specific antigens. 3. **Immune Response:** The IGHV1-14 gene plays a critical role in the immune response, particularly in the recognition and elimination of pathogens. The unique antibody variable regions generated by this gene enable the immune system to recognize and respond to a wide range of pathogens. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations or deletions in the IGHV1-14 gene can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). This condition is characterized by a lack of antibody production, making individuals susceptible to recurrent infections. 2. **Cancer:** Aberrant expression of IGHV1-14 has been implicated in certain types of cancer, including follicular lymphoma. This suggests that the IGHV1-14 gene may play a role in the development of these cancers. 3. **Autoimmune Diseases:** The IGHV1-14 gene has been associated with certain autoimmune diseases, such as lupus and rheumatoid arthritis. This suggests that the gene may contribute to the development of these diseases by promoting the production of autoantibodies. In conclusion, the immunoglobulin heavy variable 1-14 (IGHV1-14) gene is a critical component of the immune system, playing a key role in the generation of antibody diversity and the recognition and elimination of pathogens. Its clinical significance extends to immunodeficiency disorders, cancer, and autoimmune diseases, highlighting the importance of this gene in maintaining immune homeostasis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.