Details for: TRBJ2 2

Gene ID: 28628

Symbol: TRBJ2 2

Ensembl ID: ENSG00000211765

Description: T cell receptor beta joining 2-2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,813
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,578
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,656
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,729
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,405
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,346
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 740
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.71
    Marker Score: 676
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.24
    Marker Score: 408
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.18
    Marker Score: 343
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.16
    Marker Score: 211
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.15
    Marker Score: 237
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.09
    Marker Score: 70
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.08
    Marker Score: 68
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.06
    Marker Score: 106
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.04
    Marker Score: 95
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.03
    Marker Score: 37
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.03
    Marker Score: 96
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.03
    Marker Score: 1,538
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.03
    Marker Score: 82
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.03
    Marker Score: 46
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.01
    Marker Score: 30
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0
    Marker Score: 11
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0
    Marker Score: 11
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 21

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** The TRBJ2 gene is located on chromosome 7 and encodes a protein that is part of the T cell receptor (TCR) complex. The TCR complex is a heterodimer composed of an alpha chain and a beta chain, with the TRBJ2 gene contributing to the beta chain. 2. **Expression Pattern:** TRBJ2 is expressed in various cell types, including goblet cells, neoplastic cells, and intestinal epithelial cells. This widespread expression suggests a critical role in maintaining immune homeostasis and tissue development. 3. **Cellular Localization:** The TRBJ2 protein is likely localized to the surface of T cells, where it interacts with other components of the TCR complex to facilitate T cell activation and recognition of antigens. **Pathways and Functions:** 1. **Adaptive Immune Response:** The TRBJ2 gene plays a crucial role in the adaptive immune response, which involves the activation of T cells in response to specific antigens. The TCR complex, including the TRBJ2 gene, recognizes and binds to peptide-MHC complexes, leading to T cell activation and proliferation. 2. **T Cell Receptor Complex:** The TRBJ2 gene is part of the TCR complex, which is essential for T cell recognition and activation. The TCR complex is composed of an alpha chain, a beta chain, and gamma, delta, and epsilon chains, with the TRBJ2 gene contributing to the beta chain. 3. **Immune Homeostasis:** The TRBJ2 gene is likely involved in maintaining immune homeostasis, particularly in the gut-associated lymphoid tissue (GALT). The expression of TRBJ2 in goblet cells and intestinal epithelial cells suggests a role in regulating the immune response in the gut. **Clinical Significance:** The TRBJ2 gene has significant clinical implications in various diseases, including: 1. **Autoimmune Diseases:** Alterations in the TRBJ2 gene have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. Understanding the role of TRBJ2 in autoimmune diseases may lead to the development of novel therapeutic strategies. 2. **Cancer:** The expression of TRBJ2 in neoplastic cells suggests a potential role in cancer development and progression. Further studies are needed to elucidate the relationship between TRBJ2 and cancer. 3. **Inflammatory Bowel Disease (IBD):** The expression of TRBJ2 in goblet cells and intestinal epithelial cells highlights its potential role in maintaining immune homeostasis in the gut. Alterations in TRBJ2 expression may contribute to the development of IBD, such as Crohn's disease and ulcerative colitis. In conclusion, the TRBJ2 gene plays a critical role in the adaptive immune response and is involved in maintaining immune homeostasis in various tissues. Further studies are needed to fully elucidate the functions and clinical significance of TRBJ2, with potential implications for the development of novel therapeutic strategies for autoimmune diseases, cancer, and inflammatory bowel disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.