Details for: TRBJ2 2

Gene ID: 28628

Symbol: TRBJ2 2

Ensembl ID: ENSG00000211765

Description: T cell receptor beta joining 2-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4922
    Cell Significance Index: 36.1500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4110
    Cell Significance Index: 5.9900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3951
    Cell Significance Index: 5.1900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2584
    Cell Significance Index: 4.1900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0650
    Cell Significance Index: 0.8200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0596
    Cell Significance Index: 0.3300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0098
    Cell Significance Index: 0.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0040
    Cell Significance Index: -0.8100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0066
    Cell Significance Index: -0.1300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0114
    Cell Significance Index: -0.1400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0186
    Cell Significance Index: -0.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0211
    Cell Significance Index: -0.3900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0274
    Cell Significance Index: -0.2300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0284
    Cell Significance Index: -0.2500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0287
    Cell Significance Index: -0.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0289
    Cell Significance Index: -0.6100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0297
    Cell Significance Index: -0.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0323
    Cell Significance Index: -0.3100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0324
    Cell Significance Index: -0.4300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0336
    Cell Significance Index: -0.3900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0341
    Cell Significance Index: -0.2800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0348
    Cell Significance Index: -0.3300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0349
    Cell Significance Index: -0.4600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0355
    Cell Significance Index: -0.4200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0356
    Cell Significance Index: -0.4100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0357
    Cell Significance Index: -0.3800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0357
    Cell Significance Index: -0.4700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0364
    Cell Significance Index: -0.4300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0364
    Cell Significance Index: -0.7200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0365
    Cell Significance Index: -0.3700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0374
    Cell Significance Index: -0.4300
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0374
    Cell Significance Index: -0.3400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0376
    Cell Significance Index: -0.4200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0379
    Cell Significance Index: -0.3200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0380
    Cell Significance Index: -0.3800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0387
    Cell Significance Index: -0.4100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0394
    Cell Significance Index: -0.4000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0395
    Cell Significance Index: -0.4700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0397
    Cell Significance Index: -0.4400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0399
    Cell Significance Index: -0.4200
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0399
    Cell Significance Index: -0.4100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0410
    Cell Significance Index: -0.5300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0417
    Cell Significance Index: -0.3900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0421
    Cell Significance Index: -0.4100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0421
    Cell Significance Index: -0.4200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0423
    Cell Significance Index: -0.3700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0437
    Cell Significance Index: -0.3900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0444
    Cell Significance Index: -0.4200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0453
    Cell Significance Index: -0.4200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0463
    Cell Significance Index: -0.6100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0468
    Cell Significance Index: -0.5800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0472
    Cell Significance Index: -0.4200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0476
    Cell Significance Index: -0.4400
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0479
    Cell Significance Index: -0.4000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0483
    Cell Significance Index: -0.4500
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0485
    Cell Significance Index: -0.3900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0488
    Cell Significance Index: -0.3800
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0498
    Cell Significance Index: -0.4600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0519
    Cell Significance Index: -0.4200
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.0531
    Cell Significance Index: -0.4300
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0552
    Cell Significance Index: -0.4500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0563
    Cell Significance Index: -0.4500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0569
    Cell Significance Index: -0.6000
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0580
    Cell Significance Index: -0.5000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0588
    Cell Significance Index: -0.5400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0591
    Cell Significance Index: -0.4400
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0596
    Cell Significance Index: -0.4100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0597
    Cell Significance Index: -0.6100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0612
    Cell Significance Index: -0.7200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0682
    Cell Significance Index: -0.6400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0724
    Cell Significance Index: -0.8800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0751
    Cell Significance Index: -0.8200
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0753
    Cell Significance Index: -0.7400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0772
    Cell Significance Index: -0.6800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0840
    Cell Significance Index: -0.4500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0883
    Cell Significance Index: -0.9000
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0984
    Cell Significance Index: -0.3000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0997
    Cell Significance Index: -0.7600
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.2981
    Cell Significance Index: -0.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** The TRBJ2 gene is located on chromosome 7 and encodes a protein that is part of the T cell receptor (TCR) complex. The TCR complex is a heterodimer composed of an alpha chain and a beta chain, with the TRBJ2 gene contributing to the beta chain. 2. **Expression Pattern:** TRBJ2 is expressed in various cell types, including goblet cells, neoplastic cells, and intestinal epithelial cells. This widespread expression suggests a critical role in maintaining immune homeostasis and tissue development. 3. **Cellular Localization:** The TRBJ2 protein is likely localized to the surface of T cells, where it interacts with other components of the TCR complex to facilitate T cell activation and recognition of antigens. **Pathways and Functions:** 1. **Adaptive Immune Response:** The TRBJ2 gene plays a crucial role in the adaptive immune response, which involves the activation of T cells in response to specific antigens. The TCR complex, including the TRBJ2 gene, recognizes and binds to peptide-MHC complexes, leading to T cell activation and proliferation. 2. **T Cell Receptor Complex:** The TRBJ2 gene is part of the TCR complex, which is essential for T cell recognition and activation. The TCR complex is composed of an alpha chain, a beta chain, and gamma, delta, and epsilon chains, with the TRBJ2 gene contributing to the beta chain. 3. **Immune Homeostasis:** The TRBJ2 gene is likely involved in maintaining immune homeostasis, particularly in the gut-associated lymphoid tissue (GALT). The expression of TRBJ2 in goblet cells and intestinal epithelial cells suggests a role in regulating the immune response in the gut. **Clinical Significance:** The TRBJ2 gene has significant clinical implications in various diseases, including: 1. **Autoimmune Diseases:** Alterations in the TRBJ2 gene have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. Understanding the role of TRBJ2 in autoimmune diseases may lead to the development of novel therapeutic strategies. 2. **Cancer:** The expression of TRBJ2 in neoplastic cells suggests a potential role in cancer development and progression. Further studies are needed to elucidate the relationship between TRBJ2 and cancer. 3. **Inflammatory Bowel Disease (IBD):** The expression of TRBJ2 in goblet cells and intestinal epithelial cells highlights its potential role in maintaining immune homeostasis in the gut. Alterations in TRBJ2 expression may contribute to the development of IBD, such as Crohn's disease and ulcerative colitis. In conclusion, the TRBJ2 gene plays a critical role in the adaptive immune response and is involved in maintaining immune homeostasis in various tissues. Further studies are needed to fully elucidate the functions and clinical significance of TRBJ2, with potential implications for the development of novel therapeutic strategies for autoimmune diseases, cancer, and inflammatory bowel disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.