Details for: GPR42

Gene ID: 2866

Symbol: GPR42

Ensembl ID: ENSG00000126251

Description: G protein-coupled receptor 42

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 9.57
    Marker Score: 97013
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 5.42
    Marker Score: 3002
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 3.56
    Marker Score: 4405
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.93
    Marker Score: 4042
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.81
    Marker Score: 1594.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.44
    Marker Score: 1284
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2001
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.97
    Marker Score: 1985
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1174
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4825
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 506
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71838
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48063
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.89
    Marker Score: 370.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 499
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.54
    Marker Score: 414
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.51
    Marker Score: 191
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.32
    Marker Score: 356
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.25
    Marker Score: 249.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.18
    Marker Score: 180
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.17
    Marker Score: 69
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.15
    Marker Score: 138
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.15
    Marker Score: 373
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.12
    Marker Score: 77
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.11
    Marker Score: 107
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.1
    Marker Score: 126
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1
    Marker Score: 55
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.1
    Marker Score: 239
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.07
    Marker Score: 123
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 67
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 74
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 135
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.05
    Marker Score: 71
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.04
    Marker Score: 139
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.04
    Marker Score: 102
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.04
    Marker Score: 109
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.03
    Marker Score: 142
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.03
    Marker Score: 36
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.03
    Marker Score: 40
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.03
    Marker Score: 64.5
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.03
    Marker Score: 42
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.02
    Marker Score: 51
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.02
    Marker Score: 13

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Other Information

**Key characteristics:** - G protein-coupled receptor 42 (GPR42) is a transmembrane protein that is expressed in various cell types. - It is a member of the GPCR superfamily, which is a large family of cell surface receptors that are coupled to G proteins. - GPR42 is a ligand-gated channel that is activated by a variety of ligands, including cytokines, chemokines, and growth factors. - Upon activation, GPR42 opens a chloride channel in the plasma membrane, which leads to changes in intracellular signaling pathways. **Pathways and functions:** - GPR42 is involved in the regulation of inflammation and immune responses. - It is expressed in immune cells, such as macrophages and dendritic cells, and is important for the activation of these cells. - GPR42 is also expressed in endothelial cells, where it plays a role in regulating blood flow and inflammation. - It is involved in the regulation of cell migration and differentiation, as well as the production of cytokines and chemokines. **Clinical significance:** - Mutations in GPR42 have been linked to a number of human diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. - Targeting GPR42 signaling has been investigated as a therapeutic strategy for these diseases. - Pharmacological agents that block GPR42 have been shown to be effective in reducing inflammation and disease activity in animal models of arthritis and asthma. **Conclusion:** GPR42 is a key regulator of inflammation and immune responses. Its expression and function are important for maintaining homeostasis and preventing disease.

Genular Protein ID: 1847029205

Symbol: GPR42_HUMAN

Name: G-protein coupled receptor 42

UniProtKB Accession Codes:

O15529

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9344866

Title: A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.

PubMed ID: 9344866

DOI: 10.1006/bbrc.1997.7513

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 12496283

Title: The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.

PubMed ID: 12496283

DOI: 10.1074/jbc.m211609200

PubMed ID: 19630535

Title: Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.

PubMed ID: 19630535

DOI: 10.1089/dna.2009.0916

Sequence Information:

  • Length: 346
  • Mass: 38665
  • Checksum: 802BC2F010A3CB58
  • Sequence:
    • MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLRCRPVAV DVLLLNLTAS 
DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY LTALFLAAVS IERFLSVAHP 
LWYKTRPRLG QAGLVSVACW LLASAHCSVV YVIEFSGDIS HSQGTNGTCY LEFRKDQLAI 
LLPVRLEMAV VLFVVPLIIT SYCYSRLVWI LGRGGSHRRQ RRVAGLVAAT LLNFLVCFGP 
YNVSHVVGYI CGESPVWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ 
WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAEN

Genular Protein ID: 2032535740

Symbol: A0A0K0PUY3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0K0PUY3

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 Pfam 1 PhylomeDB 1 RefSeq 1 RuleBase 1 SAM 2 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 346
  • Mass: 38695
  • Checksum: 03F6742DA4B798D0
  • Sequence:
    • MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLRCRPVAV DVLLLNLTAS 
DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY LTALFLAAVS IERFLSVAHP 
LWYKTRPRLG QAGLVSVACW LLASAHCSVV YVIEFSGDIS HSQGTNGTCY LEFWKDQLAI 
LLPVRLEMAV VLFVVPLIIT SYCYSRLVWI LGRGGSHRRQ RRVAGLVAAT LLNFLVCFGP 
YNVSHVVGYI CGESPVWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ 
WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.