Details for: GRIA2

Gene ID: 2891

Symbol: GRIA2

Ensembl ID: ENSG00000120251

Description: glutamate ionotropic receptor AMPA type subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.6540
    Cell Significance Index: -18.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 6.2531
    Cell Significance Index: 420.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 6.2353
    Cell Significance Index: 2236.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 5.7052
    Cell Significance Index: 162.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 5.5134
    Cell Significance Index: 338.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.4388
    Cell Significance Index: 196.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.4235
    Cell Significance Index: 167.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 3.8578
    Cell Significance Index: 92.5200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.7157
    Cell Significance Index: 28.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.5423
    Cell Significance Index: 710.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 3.2616
    Cell Significance Index: 2255.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0719
    Cell Significance Index: 56.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.6302
    Cell Significance Index: 10.8000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0257
    Cell Significance Index: 0.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0564
    Cell Significance Index: -106.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0698
    Cell Significance Index: -128.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0827
    Cell Significance Index: -127.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0949
    Cell Significance Index: -129.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1553
    Cell Significance Index: -115.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1679
    Cell Significance Index: -127.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1955
    Cell Significance Index: -124.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2086
    Cell Significance Index: -117.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.2094
    Cell Significance Index: -114.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2162
    Cell Significance Index: -135.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2733
    Cell Significance Index: -124.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3688
    Cell Significance Index: -106.1100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5915
    Cell Significance Index: -7.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.6082
    Cell Significance Index: -120.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6106
    Cell Significance Index: -128.6000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.6189
    Cell Significance Index: -7.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.6680
    Cell Significance Index: -120.4200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.6758
    Cell Significance Index: -6.4300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7779
    Cell Significance Index: -9.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.7835
    Cell Significance Index: -133.7900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8362
    Cell Significance Index: -18.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.8440
    Cell Significance Index: -115.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.8504
    Cell Significance Index: -123.6200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.8598
    Cell Significance Index: -11.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.9306
    Cell Significance Index: -120.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9599
    Cell Significance Index: -18.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.9623
    Cell Significance Index: -118.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0666
    Cell Significance Index: -34.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.0670
    Cell Significance Index: -124.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0735
    Cell Significance Index: -111.7800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0891
    Cell Significance Index: -23.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0964
    Cell Significance Index: -30.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.1366
    Cell Significance Index: -130.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -1.2393
    Cell Significance Index: -126.5900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.2408
    Cell Significance Index: -15.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.3989
    Cell Significance Index: -78.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4153
    Cell Significance Index: -45.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.4558
    Cell Significance Index: -13.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.5985
    Cell Significance Index: -122.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.6100
    Cell Significance Index: -119.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.6135
    Cell Significance Index: -127.7900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.7498
    Cell Significance Index: -35.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.8633
    Cell Significance Index: -117.4400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.9705
    Cell Significance Index: -24.4400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -2.2485
    Cell Significance Index: -48.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.2582
    Cell Significance Index: -79.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -2.3232
    Cell Significance Index: -121.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -2.4920
    Cell Significance Index: -117.1200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -2.6336
    Cell Significance Index: -37.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -2.6547
    Cell Significance Index: -120.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -2.7230
    Cell Significance Index: -67.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -2.8174
    Cell Significance Index: -131.3600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -2.8243
    Cell Significance Index: -35.6400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -2.8935
    Cell Significance Index: -50.0300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -3.1096
    Cell Significance Index: -64.9000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -3.1184
    Cell Significance Index: -37.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.2512
    Cell Significance Index: -119.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -3.4506
    Cell Significance Index: -121.2500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -3.5923
    Cell Significance Index: -42.9600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -3.6751
    Cell Significance Index: -51.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -3.7545
    Cell Significance Index: -120.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -3.7678
    Cell Significance Index: -130.9300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -3.7700
    Cell Significance Index: -80.5900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -3.7990
    Cell Significance Index: -50.6400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -3.8398
    Cell Significance Index: -93.0100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -3.8835
    Cell Significance Index: -32.0600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -3.9110
    Cell Significance Index: -40.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -3.9246
    Cell Significance Index: -100.8800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -3.9973
    Cell Significance Index: -78.6800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -4.0642
    Cell Significance Index: -62.8800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -4.0935
    Cell Significance Index: -129.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -4.1918
    Cell Significance Index: -120.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -4.2055
    Cell Significance Index: -121.1700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -4.2984
    Cell Significance Index: -85.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -4.4836
    Cell Significance Index: -132.0600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -4.5157
    Cell Significance Index: -91.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -4.5526
    Cell Significance Index: -121.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -4.6511
    Cell Significance Index: -124.4200
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -4.6839
    Cell Significance Index: -48.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -4.6956
    Cell Significance Index: -123.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -4.6971
    Cell Significance Index: -204.2400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -4.8026
    Cell Significance Index: -32.5400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -4.8066
    Cell Significance Index: -120.0500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -4.8336
    Cell Significance Index: -123.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -4.8653
    Cell Significance Index: -121.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -4.8672
    Cell Significance Index: -132.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The GRIA2 gene is a member of the glutamate receptor family and is primarily expressed in neuronal cells. The AMPA receptor subunit, encoded by GRIA2, is a ligand-gated ion channel that facilitates the influx of glutamate ions into the postsynaptic neuron. This receptor is composed of multiple subunits, including GRIA2, GRII2, and GRIN2A, which work together to regulate the receptor's activity. **Pathways and Functions:** GRIA2 is involved in various cellular processes, including: 1. **Excitatory neurotransmission**: GRIA2-mediated AMPA receptor activation regulates the release of neurotransmitters, such as glutamate, and modulates synaptic transmission. 2. **Synaptic plasticity**: The AMPA receptor complex, containing GRIA2, is essential for long-term potentiation (LTP) and long-term depression (LTD), two key mechanisms underlying learning and memory. 3. **Neuronal development**: GRIA2 is involved in the regulation of neuronal morphogenesis, axon growth, and dendritic spine formation. 4. **Gene expression**: GRIA2 interacts with other transcription factors to regulate the expression of genes involved in neuronal development and synaptic plasticity. **Clinical Significance:** GRIA2 has been implicated in various neurological disorders, including: 1. **Epilepsy**: Mutations in the GRIA2 gene have been associated with familial epilepsy, highlighting its critical role in regulating neuronal excitability. 2. **Autism Spectrum Disorder (ASD)**: Studies have shown that GRIA2 expression is altered in individuals with ASD, suggesting a link between AMPA receptor dysfunction and autism. 3. **Schizophrenia**: Research has implicated GRIA2 in the pathophysiology of schizophrenia, with altered AMPA receptor function contributing to cognitive and behavioral deficits. 4. **Stroke and traumatic brain injury**: GRIA2 has been shown to play a role in the regulation of excitotoxicity and neuroinflammation following stroke and traumatic brain injury. In conclusion, the GRIA2 gene plays a vital role in regulating excitatory neurotransmission, synaptic plasticity, and neuronal development. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of understanding the complex interactions between GRIA2 and other genes in maintaining neuronal function and health.

Genular Protein ID: 3326337149

Symbol: GRIA2_HUMAN

Name: AMPA-selective glutamate receptor 2

UniProtKB Accession Codes:

P42262 A8MT92 I6L997 Q96FP6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 42 DrugCentral 1 EMBL 5 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 5 RefSeq 5 Rhea 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8003671

Title: Primary structure and functional expression of the AMPA/kainate receptor subunit 2 from human brain.

PubMed ID: 8003671

DOI: 10.1097/00001756-199401120-00018

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7523595

Title: RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue.

PubMed ID: 7523595

DOI: 10.1046/j.1471-4159.1994.63051596.x

PubMed ID: 14687553

Title: Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors.

PubMed ID: 14687553

DOI: 10.1016/s0896-6273(03)00722-0

PubMed ID: 15247289

Title: The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.

PubMed ID: 15247289

DOI: 10.1074/jbc.m404499200

PubMed ID: 23129617

Title: Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission.

PubMed ID: 23129617

DOI: 10.1073/pnas.1217477109

PubMed ID: 23739980

Title: A eukaryotic specific transmembrane segment is required for tetramerization in AMPA receptors.

PubMed ID: 23739980

DOI: 10.1523/jneurosci.2626-12.2013

PubMed ID: 19651138

Title: Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors.

PubMed ID: 19651138

DOI: 10.1016/j.jmb.2009.07.082

PubMed ID: 20614889

Title: Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator.

PubMed ID: 20614889

DOI: 10.1021/jm1005429

PubMed ID: 21531559

Title: Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity.

PubMed ID: 21531559

DOI: 10.1016/j.bmcl.2011.04.017

PubMed ID: 31300657

Title: AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders.

PubMed ID: 31300657

DOI: 10.1038/s41467-019-10910-w

Sequence Information:

  • Length: 883
  • Mass: 98821
  • Checksum: 6DAB96C76D1D8448
  • Sequence:
    • MQKIMHISVL LSPVLWGLIF GVSSNSIQIG GLFPRGADQE YSAFRVGMVQ FSTSEFRLTP 
HIDNLEVANS FAVTNAFCSQ FSRGVYAIFG FYDKKSVNTI TSFCGTLHVS FITPSFPTDG 
THPFVIQMRP DLKGALLSLI EYYQWDKFAY LYDSDRGLST LQAVLDSAAE KKWQVTAINV 
GNINNDKKDE MYRSLFQDLE LKKERRVILD CERDKVNDIV DQVITIGKHV KGYHYIIANL 
GFTDGDLLKI QFGGANVSGF QIVDYDDSLV SKFIERWSTL EEKEYPGAHT TTIKYTSALT 
YDAVQVMTEA FRNLRKQRIE ISRRGNAGDC LANPAVPWGQ GVEIERALKQ VQVEGLSGNI 
KFDQNGKRIN YTINIMELKT NGPRKIGYWS EVDKMVVTLT ELPSGNDTSG LENKTVVVTT 
ILESPYVMMK KNHEMLEGNE RYEGYCVDLA AEIAKHCGFK YKLTIVGDGK YGARDADTKI 
WNGMVGELVY GKADIAIAPL TITLVREEVI DFSKPFMSLG ISIMIKKPQK SKPGVFSFLD 
PLAYEIWMCI VFAYIGVSVV LFLVSRFSPY EWHTEEFEDG RETQSSESTN EFGIFNSLWF 
SLGAFMQQGC DISPRSLSGR IVGGVWWFFT LIIISSYTAN LAAFLTVERM VSPIESAEDL 
SKQTEIAYGT LDSGSTKEFF RRSKIAVFDK MWTYMRSAEP SVFVRTTAEG VARVRKSKGK 
YAYLLESTMN EYIEQRKPCD TMKVGGNLDS KGYGIATPKG SSLRNAVNLA VLKLNEQGLL 
DKLKNKWWYD KGECGSGGGD SKEKTSALSL SNVAGVFYIL VGGLGLAMLV ALIEFCYKSR 
AEAKRMKVAK NAQNINPSSS QNSQNFATYK EGYNVYGIES VKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.