Details for: GRIA2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.6540
Cell Significance Index: -18.9400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 6.2531
Cell Significance Index: 420.4600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 6.2353
Cell Significance Index: 2236.5000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 5.7052
Cell Significance Index: 162.8100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 5.5134
Cell Significance Index: 338.8800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 4.4388
Cell Significance Index: 196.3400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 4.4235
Cell Significance Index: 167.5100 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 3.8578
Cell Significance Index: 92.5200 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 3.7157
Cell Significance Index: 28.6400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.5423
Cell Significance Index: 710.5800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 3.2616
Cell Significance Index: 2255.8100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.0719
Cell Significance Index: 56.2800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.6302
Cell Significance Index: 10.8000 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.0257
Cell Significance Index: 0.2800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0564
Cell Significance Index: -106.2500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0698
Cell Significance Index: -128.7500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0827
Cell Significance Index: -127.2400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0949
Cell Significance Index: -129.0400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1553
Cell Significance Index: -115.0200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1679
Cell Significance Index: -127.0500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1955
Cell Significance Index: -124.1800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2086
Cell Significance Index: -117.6300 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.2094
Cell Significance Index: -114.3900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.2162
Cell Significance Index: -135.0300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2733
Cell Significance Index: -124.0300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3688
Cell Significance Index: -106.1100 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.5915
Cell Significance Index: -7.8900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.6082
Cell Significance Index: -120.7000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.6106
Cell Significance Index: -128.6000 - Cell Name: neural cell (CL0002319)
Fold Change: -0.6189
Cell Significance Index: -7.2200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.6680
Cell Significance Index: -120.4200 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.6758
Cell Significance Index: -6.4300 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.7779
Cell Significance Index: -9.7000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.7835
Cell Significance Index: -133.7900 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.8362
Cell Significance Index: -18.3100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.8440
Cell Significance Index: -115.9000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.8504
Cell Significance Index: -123.6200 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.8598
Cell Significance Index: -11.1500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.9306
Cell Significance Index: -120.2300 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.9599
Cell Significance Index: -18.9800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.9623
Cell Significance Index: -118.3200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.0666
Cell Significance Index: -34.9200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -1.0670
Cell Significance Index: -124.3500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.0735
Cell Significance Index: -111.7800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.0891
Cell Significance Index: -23.1200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.0964
Cell Significance Index: -30.6400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.1366
Cell Significance Index: -130.2200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -1.2393
Cell Significance Index: -126.5900 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -1.2408
Cell Significance Index: -15.6600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.3989
Cell Significance Index: -78.5000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.4153
Cell Significance Index: -45.0800 - Cell Name: neuron (CL0000540)
Fold Change: -1.4558
Cell Significance Index: -13.8000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.5985
Cell Significance Index: -122.6700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -1.6100
Cell Significance Index: -119.9900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.6135
Cell Significance Index: -127.7900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.7498
Cell Significance Index: -35.1300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.8633
Cell Significance Index: -117.4400 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -1.9705
Cell Significance Index: -24.4400 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -2.2485
Cell Significance Index: -48.5800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -2.2582
Cell Significance Index: -79.1100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -2.3232
Cell Significance Index: -121.0100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -2.4920
Cell Significance Index: -117.1200 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -2.6336
Cell Significance Index: -37.7200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -2.6547
Cell Significance Index: -120.3300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -2.7230
Cell Significance Index: -67.9300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -2.8174
Cell Significance Index: -131.3600 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -2.8243
Cell Significance Index: -35.6400 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -2.8935
Cell Significance Index: -50.0300 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -3.1096
Cell Significance Index: -64.9000 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -3.1184
Cell Significance Index: -37.8000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -3.2512
Cell Significance Index: -119.3500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -3.4506
Cell Significance Index: -121.2500 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -3.5923
Cell Significance Index: -42.9600 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -3.6751
Cell Significance Index: -51.3900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -3.7545
Cell Significance Index: -120.2500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -3.7678
Cell Significance Index: -130.9300 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -3.7700
Cell Significance Index: -80.5900 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -3.7990
Cell Significance Index: -50.6400 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -3.8398
Cell Significance Index: -93.0100 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -3.8835
Cell Significance Index: -32.0600 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -3.9110
Cell Significance Index: -40.7400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -3.9246
Cell Significance Index: -100.8800 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -3.9973
Cell Significance Index: -78.6800 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -4.0642
Cell Significance Index: -62.8800 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -4.0935
Cell Significance Index: -129.4700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -4.1918
Cell Significance Index: -120.1600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -4.2055
Cell Significance Index: -121.1700 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -4.2984
Cell Significance Index: -85.7200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -4.4836
Cell Significance Index: -132.0600 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -4.5157
Cell Significance Index: -91.8900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -4.5526
Cell Significance Index: -121.5600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -4.6511
Cell Significance Index: -124.4200 - Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
Fold Change: -4.6839
Cell Significance Index: -48.1600 - Cell Name: granulosa cell (CL0000501)
Fold Change: -4.6956
Cell Significance Index: -123.4700 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -4.6971
Cell Significance Index: -204.2400 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -4.8026
Cell Significance Index: -32.5400 - Cell Name: keratinocyte (CL0000312)
Fold Change: -4.8066
Cell Significance Index: -120.0500 - Cell Name: erythrocyte (CL0000232)
Fold Change: -4.8336
Cell Significance Index: -123.1500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -4.8653
Cell Significance Index: -121.6200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -4.8672
Cell Significance Index: -132.4800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3326337149
Symbol: GRIA2_HUMAN
Name: AMPA-selective glutamate receptor 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8003671
Title: Primary structure and functional expression of the AMPA/kainate receptor subunit 2 from human brain.
PubMed ID: 8003671
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7523595
Title: RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue.
PubMed ID: 7523595
PubMed ID: 14687553
Title: Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors.
PubMed ID: 14687553
PubMed ID: 15247289
Title: The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.
PubMed ID: 15247289
PubMed ID: 23129617
Title: Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission.
PubMed ID: 23129617
PubMed ID: 23739980
Title: A eukaryotic specific transmembrane segment is required for tetramerization in AMPA receptors.
PubMed ID: 23739980
PubMed ID: 19651138
Title: Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors.
PubMed ID: 19651138
PubMed ID: 20614889
Title: Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator.
PubMed ID: 20614889
DOI: 10.1021/jm1005429
PubMed ID: 21531559
Title: Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity.
PubMed ID: 21531559
PubMed ID: 31300657
Title: AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders.
PubMed ID: 31300657
Sequence Information:
- Length: 883
- Mass: 98821
- Checksum: 6DAB96C76D1D8448
- Sequence:
MQKIMHISVL LSPVLWGLIF GVSSNSIQIG GLFPRGADQE YSAFRVGMVQ FSTSEFRLTP HIDNLEVANS FAVTNAFCSQ FSRGVYAIFG FYDKKSVNTI TSFCGTLHVS FITPSFPTDG THPFVIQMRP DLKGALLSLI EYYQWDKFAY LYDSDRGLST LQAVLDSAAE KKWQVTAINV GNINNDKKDE MYRSLFQDLE LKKERRVILD CERDKVNDIV DQVITIGKHV KGYHYIIANL GFTDGDLLKI QFGGANVSGF QIVDYDDSLV SKFIERWSTL EEKEYPGAHT TTIKYTSALT YDAVQVMTEA FRNLRKQRIE ISRRGNAGDC LANPAVPWGQ GVEIERALKQ VQVEGLSGNI KFDQNGKRIN YTINIMELKT NGPRKIGYWS EVDKMVVTLT ELPSGNDTSG LENKTVVVTT ILESPYVMMK KNHEMLEGNE RYEGYCVDLA AEIAKHCGFK YKLTIVGDGK YGARDADTKI WNGMVGELVY GKADIAIAPL TITLVREEVI DFSKPFMSLG ISIMIKKPQK SKPGVFSFLD PLAYEIWMCI VFAYIGVSVV LFLVSRFSPY EWHTEEFEDG RETQSSESTN EFGIFNSLWF SLGAFMQQGC DISPRSLSGR IVGGVWWFFT LIIISSYTAN LAAFLTVERM VSPIESAEDL SKQTEIAYGT LDSGSTKEFF RRSKIAVFDK MWTYMRSAEP SVFVRTTAEG VARVRKSKGK YAYLLESTMN EYIEQRKPCD TMKVGGNLDS KGYGIATPKG SSLRNAVNLA VLKLNEQGLL DKLKNKWWYD KGECGSGGGD SKEKTSALSL SNVAGVFYIL VGGLGLAMLV ALIEFCYKSR AEAKRMKVAK NAQNINPSSS QNSQNFATYK EGYNVYGIES VKI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.