Details for: GRIA2

Gene ID: 2891

Symbol: GRIA2

Ensembl ID: ENSG00000120251

Description: glutamate ionotropic receptor AMPA type subunit 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 9.52
    Marker Score: 31,911
  • Cell Name: granule cell (CL0000120)
    Fold Change: 5.37
    Marker Score: 40,476
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 5.07
    Marker Score: 26,573
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 4.99
    Marker Score: 2,398
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.33
    Marker Score: 146,342
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.09
    Marker Score: 18,909
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.24
    Marker Score: 7,452
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 3.02
    Marker Score: 8,629
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.94
    Marker Score: 4,942
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.93
    Marker Score: 15,742
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.86
    Marker Score: 21,937
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.86
    Marker Score: 56,895
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.84
    Marker Score: 42,454
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.81
    Marker Score: 1,847
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.73
    Marker Score: 1,427
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.73
    Marker Score: 58,252
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.7
    Marker Score: 102,707
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.59
    Marker Score: 10,741
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.56
    Marker Score: 1,485
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.55
    Marker Score: 808
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.45
    Marker Score: 5,871
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.44
    Marker Score: 937
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.43
    Marker Score: 89,523
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.41
    Marker Score: 1,011
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.4
    Marker Score: 2,970
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.4
    Marker Score: 1,344
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.37
    Marker Score: 9,145
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.23
    Marker Score: 9,279
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20,634
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1,511
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127,882
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.03
    Marker Score: 8,277
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.01
    Marker Score: 20,776
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2
    Marker Score: 1,889
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.95
    Marker Score: 4,032
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.94
    Marker Score: 2,171
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,342
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,182
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.87
    Marker Score: 512
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.86
    Marker Score: 2,248
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.81
    Marker Score: 2,551
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.81
    Marker Score: 3,673
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.78
    Marker Score: 1,543
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.75
    Marker Score: 1,926
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.7
    Marker Score: 562
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.66
    Marker Score: 2,563
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.46
    Marker Score: 2,656
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.43
    Marker Score: 5,544
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.4
    Marker Score: 2,657
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.39
    Marker Score: 1,730
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 1.38
    Marker Score: 14,008
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.36
    Marker Score: 1,563
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.2
    Marker Score: 363
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.13
    Marker Score: 676
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.08
    Marker Score: 649
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.02
    Marker Score: 2,583
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.01
    Marker Score: 2,064
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,030
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.97
    Marker Score: 6,470
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,349
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.92
    Marker Score: 909
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9
    Marker Score: 444
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,285
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.84
    Marker Score: 343
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.81
    Marker Score: 468
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 501
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.74
    Marker Score: 722
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.71
    Marker Score: 257
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.69
    Marker Score: 366
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.65
    Marker Score: 10,233
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.65
    Marker Score: 623
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.62
    Marker Score: 195
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.61
    Marker Score: 194
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.59
    Marker Score: 278
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.57
    Marker Score: 161
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.57
    Marker Score: 190
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.55
    Marker Score: 951
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.55
    Marker Score: 264
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.54
    Marker Score: 217
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.52
    Marker Score: 493
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.51
    Marker Score: 489
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.51
    Marker Score: 564
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.5
    Marker Score: 187
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.5
    Marker Score: 174
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.48
    Marker Score: 450
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.45
    Marker Score: 580
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.44
    Marker Score: 493

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The GRIA2 gene is a member of the glutamate receptor family and is primarily expressed in neuronal cells. The AMPA receptor subunit, encoded by GRIA2, is a ligand-gated ion channel that facilitates the influx of glutamate ions into the postsynaptic neuron. This receptor is composed of multiple subunits, including GRIA2, GRII2, and GRIN2A, which work together to regulate the receptor's activity. **Pathways and Functions:** GRIA2 is involved in various cellular processes, including: 1. **Excitatory neurotransmission**: GRIA2-mediated AMPA receptor activation regulates the release of neurotransmitters, such as glutamate, and modulates synaptic transmission. 2. **Synaptic plasticity**: The AMPA receptor complex, containing GRIA2, is essential for long-term potentiation (LTP) and long-term depression (LTD), two key mechanisms underlying learning and memory. 3. **Neuronal development**: GRIA2 is involved in the regulation of neuronal morphogenesis, axon growth, and dendritic spine formation. 4. **Gene expression**: GRIA2 interacts with other transcription factors to regulate the expression of genes involved in neuronal development and synaptic plasticity. **Clinical Significance:** GRIA2 has been implicated in various neurological disorders, including: 1. **Epilepsy**: Mutations in the GRIA2 gene have been associated with familial epilepsy, highlighting its critical role in regulating neuronal excitability. 2. **Autism Spectrum Disorder (ASD)**: Studies have shown that GRIA2 expression is altered in individuals with ASD, suggesting a link between AMPA receptor dysfunction and autism. 3. **Schizophrenia**: Research has implicated GRIA2 in the pathophysiology of schizophrenia, with altered AMPA receptor function contributing to cognitive and behavioral deficits. 4. **Stroke and traumatic brain injury**: GRIA2 has been shown to play a role in the regulation of excitotoxicity and neuroinflammation following stroke and traumatic brain injury. In conclusion, the GRIA2 gene plays a vital role in regulating excitatory neurotransmission, synaptic plasticity, and neuronal development. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of understanding the complex interactions between GRIA2 and other genes in maintaining neuronal function and health.

Genular Protein ID: 3326337149

Symbol: GRIA2_HUMAN

Name: AMPA-selective glutamate receptor 2

UniProtKB Accession Codes:

P42262 A8MT92 I6L997 Q96FP6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 42 DrugCentral 1 EMBL 5 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 15 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 5 RefSeq 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8003671

Title: Primary structure and functional expression of the AMPA/kainate receptor subunit 2 from human brain.

PubMed ID: 8003671

DOI: 10.1097/00001756-199401120-00018

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7523595

Title: RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue.

PubMed ID: 7523595

DOI: 10.1046/j.1471-4159.1994.63051596.x

PubMed ID: 14687553

Title: Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors.

PubMed ID: 14687553

DOI: 10.1016/s0896-6273(03)00722-0

PubMed ID: 15247289

Title: The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.

PubMed ID: 15247289

DOI: 10.1074/jbc.m404499200

PubMed ID: 23129617

Title: Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission.

PubMed ID: 23129617

DOI: 10.1073/pnas.1217477109

PubMed ID: 23739980

Title: A eukaryotic specific transmembrane segment is required for tetramerization in AMPA receptors.

PubMed ID: 23739980

DOI: 10.1523/jneurosci.2626-12.2013

PubMed ID: 19651138

Title: Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors.

PubMed ID: 19651138

DOI: 10.1016/j.jmb.2009.07.082

PubMed ID: 20614889

Title: Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator.

PubMed ID: 20614889

DOI: 10.1021/jm1005429

PubMed ID: 21531559

Title: Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity.

PubMed ID: 21531559

DOI: 10.1016/j.bmcl.2011.04.017

PubMed ID: 31300657

Title: AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders.

PubMed ID: 31300657

DOI: 10.1038/s41467-019-10910-w

Sequence Information:

  • Length: 883
  • Mass: 98821
  • Checksum: 6DAB96C76D1D8448
  • Sequence:
    • MQKIMHISVL LSPVLWGLIF GVSSNSIQIG GLFPRGADQE YSAFRVGMVQ FSTSEFRLTP 
HIDNLEVANS FAVTNAFCSQ FSRGVYAIFG FYDKKSVNTI TSFCGTLHVS FITPSFPTDG 
THPFVIQMRP DLKGALLSLI EYYQWDKFAY LYDSDRGLST LQAVLDSAAE KKWQVTAINV 
GNINNDKKDE MYRSLFQDLE LKKERRVILD CERDKVNDIV DQVITIGKHV KGYHYIIANL 
GFTDGDLLKI QFGGANVSGF QIVDYDDSLV SKFIERWSTL EEKEYPGAHT TTIKYTSALT 
YDAVQVMTEA FRNLRKQRIE ISRRGNAGDC LANPAVPWGQ GVEIERALKQ VQVEGLSGNI 
KFDQNGKRIN YTINIMELKT NGPRKIGYWS EVDKMVVTLT ELPSGNDTSG LENKTVVVTT 
ILESPYVMMK KNHEMLEGNE RYEGYCVDLA AEIAKHCGFK YKLTIVGDGK YGARDADTKI 
WNGMVGELVY GKADIAIAPL TITLVREEVI DFSKPFMSLG ISIMIKKPQK SKPGVFSFLD 
PLAYEIWMCI VFAYIGVSVV LFLVSRFSPY EWHTEEFEDG RETQSSESTN EFGIFNSLWF 
SLGAFMQQGC DISPRSLSGR IVGGVWWFFT LIIISSYTAN LAAFLTVERM VSPIESAEDL 
SKQTEIAYGT LDSGSTKEFF RRSKIAVFDK MWTYMRSAEP SVFVRTTAEG VARVRKSKGK 
YAYLLESTMN EYIEQRKPCD TMKVGGNLDS KGYGIATPKG SSLRNAVNLA VLKLNEQGLL 
DKLKNKWWYD KGECGSGGGD SKEKTSALSL SNVAGVFYIL VGGLGLAMLV ALIEFCYKSR 
AEAKRMKVAK NAQNINPSSS QNSQNFATYK EGYNVYGIES VKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.