Details for: SLC27A6

Gene ID: 28965

Symbol: SLC27A6

Ensembl ID: ENSG00000113396

Description: solute carrier family 27 member 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.8177
    Cell Significance Index: -11.8800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.6924
    Cell Significance Index: 54.5000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.6632
    Cell Significance Index: 64.5100
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.6430
    Cell Significance Index: 29.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.4287
    Cell Significance Index: 64.8500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 2.1507
    Cell Significance Index: 8.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4981
    Cell Significance Index: 114.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4576
    Cell Significance Index: -3.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2981
    Cell Significance Index: 29.9900
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.0551
    Cell Significance Index: 4.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8669
    Cell Significance Index: 310.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6266
    Cell Significance Index: 17.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4389
    Cell Significance Index: 11.7600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.4044
    Cell Significance Index: 5.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3720
    Cell Significance Index: 73.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2369
    Cell Significance Index: 4.0600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1781
    Cell Significance Index: 2.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1323
    Cell Significance Index: 16.9600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1320
    Cell Significance Index: 0.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1258
    Cell Significance Index: 55.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0662
    Cell Significance Index: 1.4500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0635
    Cell Significance Index: 0.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0626
    Cell Significance Index: 3.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0449
    Cell Significance Index: 69.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0448
    Cell Significance Index: 20.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0401
    Cell Significance Index: 2.2500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0383
    Cell Significance Index: 0.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0210
    Cell Significance Index: 39.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0161
    Cell Significance Index: 10.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0112
    Cell Significance Index: 15.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0047
    Cell Significance Index: 8.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0002
    Cell Significance Index: -0.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0044
    Cell Significance Index: -3.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0060
    Cell Significance Index: -3.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0118
    Cell Significance Index: -1.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0159
    Cell Significance Index: -12.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0174
    Cell Significance Index: -12.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0197
    Cell Significance Index: -12.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0214
    Cell Significance Index: -3.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0229
    Cell Significance Index: -12.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0230
    Cell Significance Index: -6.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0267
    Cell Significance Index: -3.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0391
    Cell Significance Index: -0.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0411
    Cell Significance Index: -7.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0426
    Cell Significance Index: -2.8700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0450
    Cell Significance Index: -1.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0619
    Cell Significance Index: -4.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0642
    Cell Significance Index: -13.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0761
    Cell Significance Index: -8.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0778
    Cell Significance Index: -9.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0803
    Cell Significance Index: -10.3800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0915
    Cell Significance Index: -1.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1072
    Cell Significance Index: -2.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1078
    Cell Significance Index: -12.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1101
    Cell Significance Index: -11.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1104
    Cell Significance Index: -3.1500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1180
    Cell Significance Index: -2.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1507
    Cell Significance Index: -11.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1596
    Cell Significance Index: -7.0600
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.1629
    Cell Significance Index: -1.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1641
    Cell Significance Index: -10.3400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1645
    Cell Significance Index: -2.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1856
    Cell Significance Index: -7.0300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1924
    Cell Significance Index: -1.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2006
    Cell Significance Index: -9.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2020
    Cell Significance Index: -10.5200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2081
    Cell Significance Index: -1.4100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2106
    Cell Significance Index: -2.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2112
    Cell Significance Index: -5.4300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2120
    Cell Significance Index: -4.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2140
    Cell Significance Index: -2.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2186
    Cell Significance Index: -10.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2362
    Cell Significance Index: -12.4000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2435
    Cell Significance Index: -7.7000
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.2490
    Cell Significance Index: -2.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2542
    Cell Significance Index: -9.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2741
    Cell Significance Index: -3.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2817
    Cell Significance Index: -9.8700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2910
    Cell Significance Index: -3.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2926
    Cell Significance Index: -9.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2949
    Cell Significance Index: -3.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3240
    Cell Significance Index: -11.2600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3241
    Cell Significance Index: -4.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3273
    Cell Significance Index: -10.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3274
    Cell Significance Index: -5.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3502
    Cell Significance Index: -7.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3557
    Cell Significance Index: -7.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3609
    Cell Significance Index: -9.6600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3749
    Cell Significance Index: -5.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3780
    Cell Significance Index: -10.2900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3783
    Cell Significance Index: -15.5000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3836
    Cell Significance Index: -4.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3836
    Cell Significance Index: -11.3000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3840
    Cell Significance Index: -7.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3844
    Cell Significance Index: -11.0200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3943
    Cell Significance Index: -9.6200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3977
    Cell Significance Index: -3.7700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.4052
    Cell Significance Index: -2.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4064
    Cell Significance Index: -14.2800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4136
    Cell Significance Index: -10.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Protein:** SLC27A6 is a transmembrane protein that spans the plasma membrane, allowing for the transport of long-chain fatty acids across cell membranes. 2. **Fatty Acid Transport:** The gene's primary function is to facilitate the transport of long-chain fatty acids into cells, where they can be metabolized or stored. 3. **Expression in Lipid-Metabolizing Cells:** SLC27A6 is expressed in various cell types involved in lipid metabolism, including endothelial cells of the hepatic sinusoid, mature astrocytes, and cardiac endothelial cells. 4. **Association with Multiple Pathways:** The gene's involvement in fatty acid transport and metabolism is linked to multiple pathways, including arachidonate-coa ligase activity, long-chain fatty acid-coa ligase activity, and long-chain fatty acid transport. **Pathways and Functions:** 1. **Arachidonate-Coa Ligase Activity:** SLC27A6 is involved in the arachidonate-coa ligase activity, which is essential for the synthesis of prostaglandins from arachidonic acid. 2. **Long-Chain Fatty Acid-Coa Ligase Activity:** The gene's expression is also linked to the long-chain fatty acid-coa ligase activity, which is crucial for the synthesis of fatty acids from acetyl-CoA. 3. **Long-Chain Fatty Acid Transport:** SLC27A6 facilitates the transport of long-chain fatty acids into cells, where they can be metabolized or stored. 4. **Long-Chain Fatty Acid Metabolic Process:** The gene's involvement in fatty acid transport and metabolism is also linked to the long-chain fatty acid metabolic process, which involves the breakdown of fatty acids for energy production. **Clinical Significance:** 1. **Fatty Acid Metabolic Disorders:** Abnormalities in SLC27A6 expression or function may contribute to fatty acid metabolic disorders, such as fatty acid oxidation defects. 2. **Cardiovascular Disease:** The gene's involvement in fatty acid transport and metabolism may also contribute to the development of cardiovascular disease, particularly in the context of dyslipidemia. 3. **Neurological Disorders:** SLC27A6 expression in retinal cone cells and mature astrocytes suggests a potential role in neurological disorders, such as retinitis pigmentosa and neurodegenerative diseases. 4. **Cancer:** The gene's involvement in fatty acid transport and metabolism may also contribute to cancer development, particularly in the context of lipid metabolism and energy production. In conclusion, SLC27A6 plays a critical role in fatty acid transport and metabolism, and its dysregulation may contribute to various diseases, including fatty acid metabolic disorders, cardiovascular disease, and neurological disorders. Further research is needed to fully elucidate the gene's function and clinical significance.

Genular Protein ID: 4025045433

Symbol: S27A6_HUMAN

Name: Long-chain fatty acid transport protein 6

UniProtKB Accession Codes:

Q9Y2P4 Q6IAM5 Q7Z6E6 Q86YF6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 35 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 14 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12556534

Title: Characterization of a heart-specific fatty acid transport protein.

PubMed ID: 12556534

DOI: 10.1074/jbc.m211412200

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 619
  • Mass: 70112
  • Checksum: 20264CE3FBB44FF5
  • Sequence:
    • MLLSWLTVLG AGMVVLHFLQ KLLFPYFWDD FWFVLKVVLI IIRLKKYEKR GELVTVLDKF 
LSHAKRQPRK PFIIYEGDIY TYQDVDKRSS RVAHVFLNHS SLKKGDTVAL LMSNEPDFVH 
VWFGLAKLGC VVAFLNTNIR SNSLLNCIRA CGPRALVVGA DLLGTVEEIL PSLSENISVW 
GMKDSVPQGV ISLKEKLSTS PDEPVPRSHH VVSLLKSTCL YIFTSGTTGL PKAAVISQLQ 
VLRGSAVLWA FGCTAHDIVY ITLPLYHSSA AILGISGCVE LGATCVLKKK FSASQFWSDC 
KKYDVTVFQY IGELCRYLCK QSKREGEKDH KVRLAIGNGI RSDVWREFLD RFGNIKVCEL 
YAATESSISF MNYTGRIGAI GRTNLFYKLL STFDLIKYDF QKDEPMRNEQ GWCIHVKKGE 
PGLLISRVNA KNPFFGYAGP YKHTKDKLLC DVFKKGDVYL NTGDLIVQDQ DNFLYFWDRT 
GDTFRWKGEN VATTEVADVI GMLDFIQEAN VYGVAISGYE GRAGMASIIL KPNTSLDLEK 
VYEQVVTFLP AYACPRFLRI QEKMEATGTF KLLKHQLVED GFNPLKISEP LYFMDNLKKS 
YVLLTRELYD QIMLGEIKL

Genular Protein ID: 868338506

Symbol: B2R8P6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R8P6

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 18 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 3 Gene3D 2 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 4 RefSeq 1 Rhea 6 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 619
  • Mass: 70082
  • Checksum: 89FC98D2956E27C2
  • Sequence:
    • MLLSWLTVLG AGMVVLHFVQ KLLFPYFWDD FWFVLKVVLI IIRLKKYEKR GELVTVLDKF 
LSHAKRQPRK PFIIYEGDIY TYQDVDKRSS RVAHVFLNHS SLKKGDTVAL LMSNEPDFVH 
VWFGLAKLGC VVAFLNTNIR SNSLLNCIRA CGPRALVVGA DLLGTVEEIL PSLSENISVW 
GMKDSVPQGV ISLKEKLSTS PDEPVPRSHH VVSLLKSTCP YIFTSGTTGL PKAAVISQLQ 
VLRGSAVLWA FGCTAHDIVY ITLPLYHSSA AILGISGCVE LGATCVLKKK FSASQFWSDC 
KKYDVTVFQY IGELCRYLCK QSKREGEKDH KVRLAIGNGI RSDVWREFLD RFGNIKVCEL 
YAATESSISF MNYTGRIGAI GRTNLFYKLL STFDLIKYDF QKDEPMRNEQ GWCIHVKKGE 
PGLLISRVNA KNPFFGYAGP YKHTKDKLLC DVFKKGDVYL NTGDLIVQDQ DNFLYFWDRT 
GDTFRWKGEN VATTEVADVI GMLDFIQEAN VYGVAISGYE GRAGMASIIL KPNTSLDLEK 
VYEQVVTFLP AYACPRFLRI QEKMEATGTF KLLKHQLVED GFNPLKISEP LYFMDNLKKS 
YVLLTRELYD QIMLGEIKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.