Details for: WDR91

Gene ID: 29062

Symbol: WDR91

Ensembl ID: ENSG00000105875

Description: WD repeat domain 91

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 74.9621
    Cell Significance Index: -11.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.8768
    Cell Significance Index: -11.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.1382
    Cell Significance Index: -12.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.7408
    Cell Significance Index: -12.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2235
    Cell Significance Index: -12.7200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.1749
    Cell Significance Index: -4.7600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.6966
    Cell Significance Index: 13.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8695
    Cell Significance Index: 24.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5479
    Cell Significance Index: 14.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5212
    Cell Significance Index: 51.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4727
    Cell Significance Index: 426.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4700
    Cell Significance Index: 10.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3497
    Cell Significance Index: 70.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3293
    Cell Significance Index: 53.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3215
    Cell Significance Index: 63.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2936
    Cell Significance Index: 31.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2119
    Cell Significance Index: 8.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1982
    Cell Significance Index: 137.0700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1954
    Cell Significance Index: 11.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1949
    Cell Significance Index: 8.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1874
    Cell Significance Index: 4.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1726
    Cell Significance Index: 61.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1433
    Cell Significance Index: 3.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1296
    Cell Significance Index: 8.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1265
    Cell Significance Index: 69.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1109
    Cell Significance Index: 21.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1055
    Cell Significance Index: 19.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1014
    Cell Significance Index: 44.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0818
    Cell Significance Index: 111.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0786
    Cell Significance Index: 10.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0659
    Cell Significance Index: 1.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0574
    Cell Significance Index: 6.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0501
    Cell Significance Index: 6.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0441
    Cell Significance Index: 5.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0356
    Cell Significance Index: 0.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0304
    Cell Significance Index: 3.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0196
    Cell Significance Index: 0.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0165
    Cell Significance Index: 31.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0113
    Cell Significance Index: 17.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0109
    Cell Significance Index: 7.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0104
    Cell Significance Index: 0.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0084
    Cell Significance Index: 0.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0077
    Cell Significance Index: 4.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0068
    Cell Significance Index: 1.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0068
    Cell Significance Index: 12.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0064
    Cell Significance Index: 0.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0044
    Cell Significance Index: 0.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0031
    Cell Significance Index: 0.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0026
    Cell Significance Index: 0.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0033
    Cell Significance Index: -0.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0049
    Cell Significance Index: -2.2100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0063
    Cell Significance Index: -0.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0072
    Cell Significance Index: -0.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0116
    Cell Significance Index: -1.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0129
    Cell Significance Index: -9.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0155
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0169
    Cell Significance Index: -12.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0174
    Cell Significance Index: -1.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0178
    Cell Significance Index: -1.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0208
    Cell Significance Index: -11.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0230
    Cell Significance Index: -14.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0326
    Cell Significance Index: -9.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0375
    Cell Significance Index: -4.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0422
    Cell Significance Index: -2.5900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0609
    Cell Significance Index: -0.8600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0613
    Cell Significance Index: -0.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0632
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0672
    Cell Significance Index: -14.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0735
    Cell Significance Index: -4.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0879
    Cell Significance Index: -4.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1073
    Cell Significance Index: -11.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1104
    Cell Significance Index: -8.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1144
    Cell Significance Index: -3.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1173
    Cell Significance Index: -2.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1176
    Cell Significance Index: -7.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1215
    Cell Significance Index: -2.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1226
    Cell Significance Index: -3.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1258
    Cell Significance Index: -2.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1296
    Cell Significance Index: -9.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1503
    Cell Significance Index: -7.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1512
    Cell Significance Index: -2.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1520
    Cell Significance Index: -7.6800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1522
    Cell Significance Index: -2.9700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1552
    Cell Significance Index: -2.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1610
    Cell Significance Index: -3.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1689
    Cell Significance Index: -8.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1790
    Cell Significance Index: -4.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1833
    Cell Significance Index: -6.0000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2030
    Cell Significance Index: -4.3400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2032
    Cell Significance Index: -2.8500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2082
    Cell Significance Index: -4.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2099
    Cell Significance Index: -5.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2107
    Cell Significance Index: -6.7500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2119
    Cell Significance Index: -4.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2147
    Cell Significance Index: -7.5200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2149
    Cell Significance Index: -3.0800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2158
    Cell Significance Index: -1.6500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2170
    Cell Significance Index: -4.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2243
    Cell Significance Index: -3.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2251
    Cell Significance Index: -7.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** WDR91 is a protein with a WD repeat domain, a structural motif known for its involvement in protein-protein interactions. The WD repeat domain is characterized by a conserved sequence of 40-50 amino acids, which forms a beta-sheet structure. This domain is essential for WDR91's ability to interact with other proteins, influencing its function in various cellular processes. WDR91 is primarily localized to the cytosol and is involved in several signaling pathways, including the Cdc42 and Rho GTPase cycles. **Pathways and Functions:** WDR91's involvement in multiple signaling pathways underscores its multifaceted role in cellular regulation. Some of the key pathways and functions associated with WDR91 include: 1. **Cdc42 GTPase Cycle:** WDR91 interacts with Cdc42, a small GTPase involved in cell migration, adhesion, and polarity. This interaction regulates Cdc42's activity, modulating the cytoskeleton and cell shape. 2. **Rho GTPase Cycle:** WDR91 also interacts with Rho GTPases, influencing their activity and, subsequently, cell migration, contraction, and cytoskeleton organization. 3. **Endosomal Transport:** WDR91 is involved in the regulation of endosomal transport, including the early endosome to late endosome transport and the endosome membrane. This function is crucial for the proper sorting and degradation of proteins and lipids. 4. **Phosphatidylinositol 3-kinase (PI3K) Signaling:** WDR91 inhibits PI3K activity, modulating the PI3K signaling pathway, which is involved in cell proliferation, survival, and metabolism. **Clinical Significance:** WDR91's involvement in various signaling pathways and cellular processes has significant implications for human health and disease. Aberrant WDR91 expression or function has been implicated in several diseases, including: 1. **Cancer:** WDR91's role in regulating cell proliferation, migration, and survival makes it a potential target for cancer therapy. 2. **Neurological Disorders:** WDR91's involvement in the Cdc42 and Rho GTPase cycles suggests its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Immune System:** WDR91's interaction with innate lymphoid cells and other immune cells highlights its importance in immune system function and regulation. In conclusion, WDR91 is a multifaceted protein with a critical role in various cellular processes, including signaling pathways and endosomal transport. Its involvement in disease has significant implications for human health and disease, highlighting the need for further research into WDR91's functions and potential therapeutic applications.

Genular Protein ID: 3525636044

Symbol: WDR91_HUMAN

Name: N/A

UniProtKB Accession Codes:

A4D1P6 A6NK54 C9JMI4 Q6FI65 Q6MZQ1 Q6P4I1 Q96AE5 Q96G63 Q9H062 Q9H9B6 Q9NVG7 Q9NZY6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26783301

Title: Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.

PubMed ID: 26783301

DOI: 10.1083/jcb.201506081

PubMed ID: 27126989

Title: A genetic screen identifies a critical role for the WDR81-WDR91 complex in the trafficking and degradation of tetherin.

PubMed ID: 27126989

DOI: 10.1111/tra.12409

PubMed ID: 28404643

Title: The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy.

PubMed ID: 28404643

DOI: 10.1083/jcb.201608039

Sequence Information:

  • Length: 747
  • Mass: 83344
  • Checksum: A93CF7F02D12629A
  • Sequence:
    • MAEAVERTDE LVREYLLFRG FTHTLRQLDA EIKADKEKGF RVDKIVDQLQ QLMQVYDLAA 
LRDYWSYLER RLFSRLEDIY RPTIHKLKTS LFRFYLVYTI QTNRNDKAQE FFAKQATELQ 
NQAEWKDWFV LPFLPSPDTN PTFATYFSRQ WADTFIVSLH NFLSVLFQCM PVPVILNFDA 
ECQRTNQVQE ENEVLRQKLF ALQAEIHRLK KEEQQPEEEE ALVQHKLPPY VSNMDRLGDS 
ELAMVCSQRN ASLSQSPRVG FLSSLLPQSK KSPSRLSPAQ GPPQPQSSAK KESFGGQGTK 
GKDPTSGAKD GKSLLSGLAT GESGWSQHRQ RRLQDHGKER KELFSTTTSQ CAEKKPEASG 
PEAEPCPELH TEPVEPLTRA SSAGPEGGGV RPEQPFIVLG QEEYGEHHSS IMHCRVDCSG 
RRVASLDVDG VIKVWSFNPI MQTKASSISK SPLLSLEWAT KRDRLLLLGS GVGTVRLYDT 
EAKKNLCEIN INDNMPRILS LACSPNGASF VCSAAAPSLT SQVDFSAPDI GSKGMNQVPG 
RLLLWDTKTM KQQLQFSLDP EPIAINCTAF NHNGNLLVTG AADGVIRLFD MQQHECAMSW 
RAHYGEVYSV EFSYDENTVY SIGEDGKFIQ WNIHKSGLKV SEYSLPSDAT GPFVLSGYSG 
YKQVQVPRGR LFAFDSEGNY MLTCSATGGV IYKLGGDEKV LESCLSLGGH RAPVVTVDWS 
TAMDCGTCLT ASMDGKIKLT TLLAHKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.