Details for: GSTA1

Gene ID: 2938

Symbol: GSTA1

Ensembl ID: ENSG00000243955

Description: glutathione S-transferase alpha 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 97.4788
    Cell Significance Index: 48.9600
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 32.7258
    Cell Significance Index: 248.1600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 28.8265
    Cell Significance Index: 431.9400
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 20.6442
    Cell Significance Index: 102.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.3518
    Cell Significance Index: -30.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 7.0846
    Cell Significance Index: 204.1200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 5.6999
    Cell Significance Index: 79.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.4734
    Cell Significance Index: 146.6600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 3.5437
    Cell Significance Index: 51.4500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.3551
    Cell Significance Index: 56.4300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 3.1885
    Cell Significance Index: 32.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.9213
    Cell Significance Index: 76.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.7163
    Cell Significance Index: 163.0700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.6081
    Cell Significance Index: 26.3100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.4809
    Cell Significance Index: 29.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9247
    Cell Significance Index: 209.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8415
    Cell Significance Index: 1662.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.6774
    Cell Significance Index: 41.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8504
    Cell Significance Index: 138.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.8215
    Cell Significance Index: 65.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7465
    Cell Significance Index: 148.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5651
    Cell Significance Index: 107.5400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3055
    Cell Significance Index: 7.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2836
    Cell Significance Index: 6.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2594
    Cell Significance Index: 17.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2342
    Cell Significance Index: 8.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1787
    Cell Significance Index: 131.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1599
    Cell Significance Index: 15.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1575
    Cell Significance Index: 26.9000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1328
    Cell Significance Index: 1.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0947
    Cell Significance Index: 0.9800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0620
    Cell Significance Index: 0.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0540
    Cell Significance Index: 1.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0419
    Cell Significance Index: 4.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0250
    Cell Significance Index: 4.5100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0246
    Cell Significance Index: 0.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0201
    Cell Significance Index: 0.9100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0184
    Cell Significance Index: 0.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0104
    Cell Significance Index: 5.6800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0062
    Cell Significance Index: 0.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0021
    Cell Significance Index: -0.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0042
    Cell Significance Index: -3.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0133
    Cell Significance Index: -25.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0134
    Cell Significance Index: -0.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0170
    Cell Significance Index: -31.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0192
    Cell Significance Index: -0.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0200
    Cell Significance Index: -1.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0205
    Cell Significance Index: -31.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0232
    Cell Significance Index: -31.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0285
    Cell Significance Index: -3.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0291
    Cell Significance Index: -0.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0297
    Cell Significance Index: -3.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0304
    Cell Significance Index: -13.4600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0321
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0334
    Cell Significance Index: -24.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0373
    Cell Significance Index: -0.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0390
    Cell Significance Index: -24.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0408
    Cell Significance Index: -25.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0441
    Cell Significance Index: -24.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0577
    Cell Significance Index: -26.1900
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0699
    Cell Significance Index: -0.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0842
    Cell Significance Index: -8.6100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0956
    Cell Significance Index: -1.4400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0983
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1232
    Cell Significance Index: -14.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1269
    Cell Significance Index: -25.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1344
    Cell Significance Index: -18.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1398
    Cell Significance Index: -29.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1398
    Cell Significance Index: -9.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1526
    Cell Significance Index: -1.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1698
    Cell Significance Index: -24.6800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1988
    Cell Significance Index: -1.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2047
    Cell Significance Index: -12.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2615
    Cell Significance Index: -7.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3099
    Cell Significance Index: -14.4500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3389
    Cell Significance Index: -4.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3420
    Cell Significance Index: -16.0800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3460
    Cell Significance Index: -3.6500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3472
    Cell Significance Index: -4.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3905
    Cell Significance Index: -26.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3929
    Cell Significance Index: -29.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3940
    Cell Significance Index: -24.8300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.4094
    Cell Significance Index: -4.0100
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.4159
    Cell Significance Index: -2.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4160
    Cell Significance Index: -9.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4666
    Cell Significance Index: -28.6800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.4744
    Cell Significance Index: -5.0400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4815
    Cell Significance Index: -7.9400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.5094
    Cell Significance Index: -3.1600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.5157
    Cell Significance Index: -2.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5192
    Cell Significance Index: -26.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5298
    Cell Significance Index: -29.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5366
    Cell Significance Index: -19.7000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.6381
    Cell Significance Index: -5.2800
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.6417
    Cell Significance Index: -4.4500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.6478
    Cell Significance Index: -8.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6524
    Cell Significance Index: -28.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6964
    Cell Significance Index: -11.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7168
    Cell Significance Index: -25.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GSTA1 is a 22-kDa protein that belongs to the alpha class of glutathione S-transferases. It is highly expressed in various tissues, including the exocrine pancreas, tracheobronchial tree, and colon, where it plays a critical role in protecting cells from oxidative damage. GSTA1 has a high affinity for glutathione and a low affinity for substrates, which makes it a versatile enzyme in various cellular processes. **Pathways and Functions** GSTA1 is involved in several cellular pathways, including: 1. **Glutathione conjugation**: GSTA1 catalyzes the conjugation of glutathione with electrophilic compounds, resulting in their detoxification and excretion. 2. **Oxidative stress response**: GSTA1 helps to protect cells from oxidative damage by detoxifying reactive oxygen species (ROS) and reducing oxidative stress. 3. **Detoxification of xenobiotics**: GSTA1 plays a role in the detoxification of environmental pollutants, such as pesticides and heavy metals. 4. **Antioxidant defense**: GSTA1 works in conjunction with other antioxidant enzymes to maintain cellular redox balance. **Clinical Significance** GSTA1 has been implicated in various diseases and disorders, including: 1. **Cancer**: GSTA1 has been found to be overexpressed in certain types of cancer, including lung, colon, and breast cancer, suggesting its potential role in tumorigenesis. 2. **Chronic obstructive pulmonary disease (COPD)**: GSTA1 has been shown to be decreased in patients with COPD, which may contribute to the development of oxidative stress and inflammation in the lungs. 3. **Neurodegenerative diseases**: GSTA1 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where oxidative stress and inflammation play a critical role in disease progression. In conclusion, GSTA1 is an essential enzyme in maintaining cellular homeostasis and preventing oxidative stress. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of GSTA1 in human health and disease. Further research is needed to fully understand the role of GSTA1 in human health and disease.

Genular Protein ID: 487563818

Symbol: GSTA1_HUMAN

Name: GST HA subunit 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3800996

Title: Human liver glutathione S-transferases: complete primary sequence of an Ha subunit cDNA.

PubMed ID: 3800996

DOI: 10.1016/s0006-291x(86)80358-8

PubMed ID: 3036131

Title: The basic glutathione S-transferases from human livers are products of separate genes.

PubMed ID: 3036131

DOI: 10.1016/0006-291x(87)91345-3

PubMed ID: 3678589

Title: Nucleotide sequence of the human liver glutathione S-transferase subunit 1 cDNA.

PubMed ID: 3678589

DOI: 10.1042/bst0150734

PubMed ID: 3031680

Title: Isolation of a cDNA clone and localization of human glutathione S-transferase 2 genes to chromosome band 6p12.

PubMed ID: 3031680

DOI: 10.1073/pnas.84.8.2377

PubMed ID: 1731620

Title: Isolation and characterization of a human glutathione S-transferase Ha1 subunit gene.

PubMed ID: 1731620

DOI: 10.1016/0003-9861(92)90035-u

PubMed ID: 1330133

Title: Heterologous expression of recombinant human glutathione transferase A1-1 from a hepatoma cell line.

PubMed ID: 1330133

DOI: 10.1016/1046-5928(92)90060-a

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3138230

Title: Human glutathione S-transferases. The Ha multigene family encodes products of different but overlapping substrate specificities.

PubMed ID: 3138230

DOI: 10.1016/s0021-9258(18)37626-9

PubMed ID: 8431482

Title: Characterization of two novel subunits of the alpha-class glutathione S-transferases of human liver.

PubMed ID: 8431482

DOI: 10.1016/0167-4838(93)90234-i

PubMed ID: 2604726

Title: Evidence that glutathione S-transferases B1B1 and B2B2 are the products of separate genes and that their expression in human liver is subject to inter-individual variation. Molecular relationships between the B1 and B2 subunits and other alpha class glutathione S-transferases.

PubMed ID: 2604726

DOI: 10.1042/bj2640437

PubMed ID: 2018473

Title: The contribution of the C-terminal sequence to the catalytic activity of GST2, a human alpha-class glutathione transferase.

PubMed ID: 2018473

DOI: 10.1042/bj2750171

PubMed ID: 9084911

Title: Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1.

PubMed ID: 9084911

DOI: 10.1021/tx9601770

PubMed ID: 11152686

Title: The role of glutathione in the isomerization of delta 5-androstene-3,17-dione catalyzed by human glutathione transferase A1-1.

PubMed ID: 11152686

DOI: 10.1074/jbc.m009146200

PubMed ID: 16624487

Title: Metabolism of oxidized linoleic acid by glutathione transferases: peroxidase activity toward 13-hydroperoxyoctadecadienoic acid.

PubMed ID: 16624487

DOI: 10.1016/j.bbagen.2006.02.020

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8331657

Title: Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes.

PubMed ID: 8331657

DOI: 10.1006/jmbi.1993.1376

PubMed ID: 8591048

Title: Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.

PubMed ID: 8591048

DOI: 10.1016/s0969-2126(01)00206-4

PubMed ID: 12211029

Title: 1.3-A resolution structure of human glutathione S-transferase with S-hexyl glutathione bound reveals possible extended ligandin binding site.

PubMed ID: 12211029

DOI: 10.1002/prot.10162

PubMed ID: 15333749

Title: Incorporation of a single His residue by rational design enables thiol-ester hydrolysis by human glutathione transferase A1-1.

PubMed ID: 15333749

DOI: 10.1073/pnas.0403045101

PubMed ID: 15893769

Title: Tertiary interactions stabilise the C-terminal region of human glutathione transferase A1-1: a crystallographic and calorimetric study.

PubMed ID: 15893769

DOI: 10.1016/j.jmb.2005.04.025

PubMed ID: 16421451

Title: New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix.

PubMed ID: 16421451

DOI: 10.1107/s0907444905039296

PubMed ID: 19618965

Title: Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals.

PubMed ID: 19618965

DOI: 10.1021/bi900895b

PubMed ID: 20606271

Title: The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function.

PubMed ID: 20606271

DOI: 10.1107/s1744309110019135

Sequence Information:

  • Length: 222
  • Mass: 25631
  • Checksum: C8B6786DCD761350
  • Sequence:
  • MAEKPKLHYF NARGRMESTR WLLAAAGVEF EEKFIKSAED LDKLRNDGYL MFQQVPMVEI 
    DGMKLVQTRA ILNYIASKYN LYGKDIKERA LIDMYIEGIA DLGEMILLLP VCPPEEKDAK 
    LALIKEKIKN RYFPAFEKVL KSHGQDYLVG NKLSRADIHL VELLYYVEEL DSSLISSFPL 
    LKALKTRISN LPTVKKFLQP GSPRKPPMDE KSLEEARKIF RF

Genular Protein ID: 1303165266

Symbol: B7Z1F9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 225
  • Mass: 25648
  • Checksum: 10E7597C948D5DF2
  • Sequence:
  • MAEKPKLHYF NARGRMESTR WLLAAAGVEF EEKFIKSAED LDKLRNDGYL MFQQVPMVEI 
    DGMKLVQTRA ILNYIASKYN LYGKDIKERA LIDMYIEGIA DLGEMILLLP VCPPEEKDAK 
    LALIKEKIKN RYFPAFEKVL KSHGQDYLVG NKLSRADIHL VELLYYVEEL DSSLISSFPL 
    LKVTHFTAQR GSPTSPILGS CIWALRLTKF CPSLLQAFSA PRSPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.