Gene GTF2H1 - ENSG00000110768 | NCBI Gene ID: 2965

Details for: GTF2H1

Gene ID: 2965

Symbol: GTF2H1

Ensembl ID: ENSG00000110768

Description: general transcription factor IIH subunit 1

Associated with

Disease
(R-HSA-1643685)
Dual incision in gg-ner
(R-HSA-5696400)
Dual incision in tc-ner
(R-HSA-6782135)
Epigenetic regulation of gene expression
(R-HSA-212165)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of incision complex in gg-ner
(R-HSA-5696395)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Hiv transcription initiation
(R-HSA-167161)
Infectious disease
(R-HSA-5663205)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of rna
(R-HSA-8953854)
Mrna capping
(R-HSA-72086)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleotide excision repair
(R-HSA-5696398)
Rna pol ii ctd phosphorylation and interaction with ce
(R-HSA-77075)
Rna pol ii ctd phosphorylation and interaction with ce during hiv infection
(R-HSA-167160)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Rna polymerase i transcription termination
(R-HSA-73863)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Chromatin binding
(GO:0003682)
Dna repair
(GO:0006281)
Hormone-mediated signaling pathway
(GO:0009755)
Nuclear thyroid hormone receptor binding
(GO:0046966)
Nucleoplasm
(GO:0005654)
Nucleotide-excision repair
(GO:0006289)
Positive regulation of dna-templated transcription
(GO:0045893)
Protein binding
(GO:0005515)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Transcription by rna polymerase i
(GO:0006360)
Transcription by rna polymerase ii
(GO:0006366)
Transcription factor tfiih core complex
(GO:0000439)
Transcription factor tfiih holo complex
(GO:0005675)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: germ cell (CL0000586)
Fold Change: 2
Marker Score: 3493.5
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.63
Marker Score: 1302
Cell Name: neuron (CL0000540)
Fold Change: 1.43
Marker Score: 5822
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 1.39
Marker Score: 497
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.34
Marker Score: 11547
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.34
Marker Score: 12761
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.33
Marker Score: 81592
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.32
Marker Score: 12416
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.29
Marker Score: 1994
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.16
Marker Score: 4497
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.16
Marker Score: 11985
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.15
Marker Score: 42476
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.13
Marker Score: 22518
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.07
Marker Score: 40506
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.05
Marker Score: 1109
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.04
Marker Score: 15612
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.02
Marker Score: 7816
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.02
Marker Score: 1459
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.01
Marker Score: 21627
Cell Name: proerythroblast (CL0000547)
Fold Change: 1
Marker Score: 678
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71675
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47897
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.99
Marker Score: 288
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30386
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.95
Marker Score: 554
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.95
Marker Score: 941
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.94
Marker Score: 1267
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2392
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.93
Marker Score: 3892
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.93
Marker Score: 324
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.92
Marker Score: 1018
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.92
Marker Score: 474
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.91
Marker Score: 431
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2692
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5292
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.87
Marker Score: 3610
Cell Name: basal cell (CL0000646)
Fold Change: 0.87
Marker Score: 1119
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.85
Marker Score: 1377
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 305
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.84
Marker Score: 409
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.84
Marker Score: 969
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.84
Marker Score: 1009
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.83
Marker Score: 4743
Cell Name: fat cell (CL0000136)
Fold Change: 0.82
Marker Score: 458
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.82
Marker Score: 882
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.8
Marker Score: 736
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.8
Marker Score: 321
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.78
Marker Score: 458
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.78
Marker Score: 326
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 588.5
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.77
Marker Score: 288
Cell Name: podocyte (CL0000653)
Fold Change: 0.77
Marker Score: 284
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.76
Marker Score: 520
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.76
Marker Score: 1117
Cell Name: astrocyte (CL0000127)
Fold Change: 0.76
Marker Score: 656
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.75
Marker Score: 940
Cell Name: male germ cell (CL0000015)
Fold Change: 0.74
Marker Score: 214
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.73
Marker Score: 438
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.73
Marker Score: 1605
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.73
Marker Score: 786
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.73
Marker Score: 1789.5
Cell Name: erythroblast (CL0000765)
Fold Change: 0.73
Marker Score: 454
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.73
Marker Score: 732
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.72
Marker Score: 873
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.71
Marker Score: 1371.5
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.71
Marker Score: 369
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.71
Marker Score: 2798
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.71
Marker Score: 2979.5
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.71
Marker Score: 3487
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.71
Marker Score: 1930
Cell Name: interneuron (CL0000099)
Fold Change: 0.71
Marker Score: 322
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.7
Marker Score: 286
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.7
Marker Score: 1223
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.7
Marker Score: 1587
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.69
Marker Score: 234.5
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.69
Marker Score: 338
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.69
Marker Score: 737
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.69
Marker Score: 831
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.69
Marker Score: 5930
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.69
Marker Score: 164
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.69
Marker Score: 206
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.69
Marker Score: 468
Cell Name: melanocyte (CL0000148)
Fold Change: 0.68
Marker Score: 277
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.68
Marker Score: 450
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.68
Marker Score: 1115.5
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 174
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.68
Marker Score: 12001
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.68
Marker Score: 23000
Cell Name: brush cell (CL0002204)
Fold Change: 0.67
Marker Score: 613
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.67
Marker Score: 710
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.67
Marker Score: 673
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.67
Marker Score: 232
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.67
Marker Score: 1814.5
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.67
Marker Score: 2293
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.67
Marker Score: 2580
Cell Name: Unknown (CL0002371)
Fold Change: 0.66
Marker Score: 706
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.66
Marker Score: 591
Cell Name: stromal cell (CL0000499)
Fold Change: 0.66
Marker Score: 775
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.66
Marker Score: 175
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.66
Marker Score: 1951

Hover over a box to see details here...

**Key characteristics** * GTF2H1 is a large protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including germ cells, neurons, and endothelial cells. * It is a key regulator of gene expression in these cells. * It is involved in the regulation of a wide range of genes, including those involved in development, differentiation, and apoptosis. **Pathways and functions** * GTF2H1 is involved in a variety of cellular processes, including development, differentiation, and apoptosis. * It is essential for the development of the germ layer of the embryo. * It is involved in the regulation of the nervous system. * It is involved in the regulation of a wide range of genes, including those involved in development, differentiation, and apoptosis. **Clinical significance** GTF2H1 is a promising target for the treatment of a variety of diseases. For example, it is a target for the treatment of cancer, where it is expressed in high levels in tumors. Inhibition of GTF2H1 has been shown to inhibit tumor growth and metastasis. **Additional information** * GTF2H1 is a highly conserved gene, with a similar gene found in other mammals. * It is a member of the ETS family of transcription factors, which are involved in the regulation of gene expression in eukaryotes. * It is a highly effective target for the treatment of cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

General transcription factor IIH subunit 1

Genular Protein ID: 3897392737

Symbol: TF2H1_HUMAN

Name: General transcription factor IIH subunit 1

UniProtKB Accession Codes:

P32780 B3KXE0 D3DQY2 Q6I9Y7 Q9H5K5 Q9NQD9

Database IDs:

Citations:

PubMed ID: 1529339

Title: Cloning of the 62-kilodalton component of basic transcription factor BTF2.

PubMed ID: 1529339

DOI: 10.1126/science.1529339

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 10882074

Title: The FBP interacting repressor targets TFIIH to inhibit activated transcription.

PubMed ID: 10882074

DOI: 10.1016/s1097-2765(00)80428-1

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25918396

Title: A OmegaXaV motif in the Rift Valley fever virus NSs protein is essential for degrading p62, forming nuclear filaments and virulence.

PubMed ID: 25918396

DOI: 10.1073/pnas.1503688112

Sequence Information:

Length: 548
Mass: 62032
Checksum: 8F0FCEBBB1FC9C1D
Sequence:

MATSSEEVLL IVKKVRQKKQ DGALYLMAER IAWAPEGKDR FTISHMYADI KCQKISPEGK 
AKIQLQLVLH AGDTTNFHFS NESTAVKERD AVKDLLQQLL PKFKRKANKE LEEKNRMLQE 
DPVLFQLYKD LVVSQVISAE EFWANRLNVN ATDSSSTSNH KQDVGISAAF LADVRPQTDG 
CNGLRYNLTS DIIESIFRTY PAVKMKYAEN VPHNMTEKEF WTRFFQSHYF HRDRLNTGSK 
DLFAECAKID EKGLKTMVSL GVKNPLLDLT ALEDKPLDEG YGISSVPSAS NSKSIKENSN 
AAIIKRFNHH SAMVLAAGLR KQEAQNEQTS EPSNMDGNSG DADCFQPAVK RAKLQESIEY 
EDLGKNNSVK TIALNLKKSD RYYHGPTPIQ SLQYATSQDI INSFQSIRQE MEAYTPKLTQ 
VLSSSAASST ITALSPGGAL MQGGTQQAIN QMVPNDIQSE LKHLYVAVGE LLRHFWSCFP 
VNTPFLEEKV VKMKSNLERF QVTKLCPFQE KIRRQYLSTN LVSHIEEMLQ TAYNKLHTWQ 
SRRLMKKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GTF2H1

Associated with

Cells (max top 100)

Other Information

Cloning of the 62-kilodalton component of basic transcription factor BTF2. PubMed ID: 1529339

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. PubMed ID: 9852112

The FBP interacting repressor targets TFIIH to inhibit activated transcription. PubMed ID: 10882074

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A OmegaXaV motif in the Rift Valley fever virus NSs protein is essential for degrading p62, forming nuclear filaments and virulence. PubMed ID: 25918396