Details for: RBM15B

Gene ID: 29890

Symbol: RBM15B

Ensembl ID: ENSG00000259956

Description: RNA binding motif protein 15B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 36.9607
    Cell Significance Index: -17.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 33.5352
    Cell Significance Index: -17.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.1369
    Cell Significance Index: -16.4400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 3.0149
    Cell Significance Index: 31.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.0378
    Cell Significance Index: -4.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0073
    Cell Significance Index: 326.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6379
    Cell Significance Index: 98.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4517
    Cell Significance Index: 157.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3386
    Cell Significance Index: 36.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8670
    Cell Significance Index: 45.0400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8667
    Cell Significance Index: 11.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7963
    Cell Significance Index: 21.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7622
    Cell Significance Index: 52.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5616
    Cell Significance Index: 69.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5163
    Cell Significance Index: 281.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4990
    Cell Significance Index: 32.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4427
    Cell Significance Index: 60.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4401
    Cell Significance Index: 32.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4187
    Cell Significance Index: 11.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4015
    Cell Significance Index: 72.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3897
    Cell Significance Index: 50.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3682
    Cell Significance Index: 16.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.3308
    Cell Significance Index: 33.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3237
    Cell Significance Index: 143.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3208
    Cell Significance Index: 6.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3124
    Cell Significance Index: 6.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3070
    Cell Significance Index: 21.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2866
    Cell Significance Index: 9.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2825
    Cell Significance Index: 8.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2735
    Cell Significance Index: 17.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2734
    Cell Significance Index: 246.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2732
    Cell Significance Index: 12.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2621
    Cell Significance Index: 25.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2392
    Cell Significance Index: 11.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1952
    Cell Significance Index: 37.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1908
    Cell Significance Index: 4.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1858
    Cell Significance Index: 36.8800
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.1493
    Cell Significance Index: 1.1600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1444
    Cell Significance Index: 1.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1292
    Cell Significance Index: 25.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0694
    Cell Significance Index: 24.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0690
    Cell Significance Index: 8.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0454
    Cell Significance Index: 5.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0356
    Cell Significance Index: 1.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0196
    Cell Significance Index: 1.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0108
    Cell Significance Index: 0.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0033
    Cell Significance Index: -2.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0043
    Cell Significance Index: -8.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0047
    Cell Significance Index: -3.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0068
    Cell Significance Index: -1.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0115
    Cell Significance Index: -21.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0135
    Cell Significance Index: -20.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0156
    Cell Significance Index: -21.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0184
    Cell Significance Index: -0.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0203
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0204
    Cell Significance Index: -15.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0216
    Cell Significance Index: -13.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0243
    Cell Significance Index: -13.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0244
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0276
    Cell Significance Index: -17.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0333
    Cell Significance Index: -15.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0400
    Cell Significance Index: -2.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0548
    Cell Significance Index: -0.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0585
    Cell Significance Index: -16.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0594
    Cell Significance Index: -1.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0635
    Cell Significance Index: -2.2300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0681
    Cell Significance Index: -1.0200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0764
    Cell Significance Index: -1.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0783
    Cell Significance Index: -16.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0829
    Cell Significance Index: -4.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0938
    Cell Significance Index: -13.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1120
    Cell Significance Index: -13.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1386
    Cell Significance Index: -4.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1530
    Cell Significance Index: -10.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1566
    Cell Significance Index: -16.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1642
    Cell Significance Index: -2.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1691
    Cell Significance Index: -4.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1696
    Cell Significance Index: -13.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1709
    Cell Significance Index: -2.8600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1884
    Cell Significance Index: -2.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1929
    Cell Significance Index: -14.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2342
    Cell Significance Index: -14.3600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2494
    Cell Significance Index: -1.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2573
    Cell Significance Index: -4.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3448
    Cell Significance Index: -15.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3588
    Cell Significance Index: -13.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3646
    Cell Significance Index: -10.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3866
    Cell Significance Index: -8.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4011
    Cell Significance Index: -15.1900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4040
    Cell Significance Index: -11.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4170
    Cell Significance Index: -14.6100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4200
    Cell Significance Index: -2.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4319
    Cell Significance Index: -14.1400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4431
    Cell Significance Index: -6.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4447
    Cell Significance Index: -11.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4584
    Cell Significance Index: -14.6000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4644
    Cell Significance Index: -11.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4685
    Cell Significance Index: -11.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4762
    Cell Significance Index: -8.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4846
    Cell Significance Index: -10.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RBM15B is a member of the RNA binding motif protein family, which is characterized by its ability to bind to specific RNA sequences, thereby regulating RNA processing, export, and splicing. The gene's expression profile suggests a high degree of specificity, with significant expression in cells involved in differentiation and development. Notably, RBM15B is also implicated in dosage compensation, a process that ensures equal expression of genes between males and females, which is critical in the development of sex-specific traits. **Pathways and Functions:** RBM15B is involved in various cellular processes, including: 1. **Dosage compensation**: RBM15B contributes to the inactivation of X-linked genes in males, ensuring equal expression between males and females. 2. **RNA binding**: RBM15B interacts with specific RNA sequences, regulating RNA processing, export, and splicing. 3. **RNA methylation**: RBM15B is involved in the methylation of RNA, specifically the N6-methyladenosine (m6A) modification, which plays a crucial role in RNA regulation. 4. **Splicing regulation**: RBM15B interacts with the spliceosome, a complex that catalyzes the removal of introns and the joining of exons during RNA splicing. 5. **Nuclear envelope and nuclear speck formation**: RBM15B is involved in the regulation of nuclear envelope dynamics and the formation of nuclear specks, which are involved in various cellular processes, including transcriptional regulation. **Clinical Significance:** RBM15B's role in dosage compensation and RNA regulation has significant implications for our understanding of disease pathogenesis. Alterations in RBM15B expression or function have been implicated in various diseases, including: 1. **X-linked disorders**: Mutations in RBM15B have been associated with X-linked disorders, such as X-linked mental retardation and X-linked immunodeficiency. 2. **Cancer**: RBM15B's involvement in RNA methylation and splicing regulation has led to its investigation as a potential oncogene or tumor suppressor. 3. **Neurological disorders**: RBM15B's expression in GABAergic interneurons has led to its investigation as a potential contributor to neurological disorders, such as epilepsy and schizophrenia. In conclusion, RBM15B is a complex gene that plays a critical role in RNA regulation and cellular differentiation. Further research is necessary to fully elucidate the gene's function and its implications for human disease.

Genular Protein ID: 4122186282

Symbol: RB15B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8NDT2 A4QPG7 Q6QE19 Q9BV96

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16129689

Title: Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export.

PubMed ID: 16129689

DOI: 10.1074/jbc.m501725200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19586903

Title: The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.

PubMed ID: 19586903

DOI: 10.1074/jbc.m109.040113

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21044963

Title: The RNA binding motif protein 15B (RBM15B/OTT3) is a functional competitor of serine-arginine (SR) proteins and antagonizes the positive effect of the CDK11p110-cyclin L2alpha complex on splicing.

PubMed ID: 21044963

DOI: 10.1074/jbc.m110.192518

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 27602518

Title: m(6)A RNA methylation promotes XIST-mediated transcriptional repression.

PubMed ID: 27602518

DOI: 10.1038/nature19342

Sequence Information:

  • Length: 890
  • Mass: 97205
  • Checksum: 276C94252F036C83
  • Sequence:
    • MKRQSERDSS PSGRGSSSSA KRPREREREA EAGGRRAAHK ASGGAKHPVP ARARDKPRGS 
GSGGGGHRDG RGTGDANHRA SSGRSSGSGA GGGGRGGKAS GDPGASGMSP RASPLPPPPP 
PPGAEPACPG SSAAAPEYKT LLISSLSPAL PAEHLEDRLF HQFKRFGEIS LRLSHTPELG 
RVAYVNFRHP QDAREARQHA LARQLLLYDR PLKVEPVYLR GGGGSSRRSS SSSAAASTPP 
PGPPAPADPL GYLPLHGGYQ YKQRSLSPVA APPLREPRAR HAAAAFALDA AAAAAVGLSR 
ERALDYYGLY DDRGRPYGYP AVCEEDLMPE DDQRATRNLF IGNLDHSVSE VELRRAFEKY 
GIIEEVVIKR PARGQGGAYA FLKFQNLDMA HRAKVAMSGR VIGRNPIKIG YGKANPTTRL 
WVGGLGPNTS LAALAREFDR FGSIRTIDHV KGDSFAYIQY ESLDAAQAAC AKMRGFPLGG 
PDRRLRVDFA KAEETRYPQQ YQPSPLPVHY ELLTDGYTRH RNLDADLVRD RTPPHLLYSD 
RDRTFLEGDW TSPSKSSDRR NSLEGYSRSV RSRSGERWGA DGDRGLPKPW EERRKRRSLS 
SDRGRTTHSP YEERSRTKGS GQQSERGSDR TPERSRKENH SSEGTKESSS NSLSNSRHGA 
EERGHHHHHH EAADSSHGKK ARDSERNHRT TEAEPKPLEE PKHETKKLKN LSEYAQTLQL 
GWNGLLVLKN SCFPTSMHIL EGDQGVISSL LKDHTSGSKL TQLKIAQRLR LDQPKLDEVT 
RRIKQGSPNG YAVLLATQAT PSGLGTEGMP TVEPGLQRRL LRNLVSYLKQ KQAAGVISLP 
VGGSKGRDGT GMLYAFPPCD FSQQYLQSAL RTLGKLEEEH MVIVIVRDTA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.