Details for: ST8SIA5

Gene ID: 29906

Symbol: ST8SIA5

Ensembl ID: ENSG00000101638

Description: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.2493
    Cell Significance Index: 113.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 3.7840
    Cell Significance Index: 90.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.5921
    Cell Significance Index: 159.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.3789
    Cell Significance Index: 67.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.3017
    Cell Significance Index: 825.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1383
    Cell Significance Index: 428.9400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.7433
    Cell Significance Index: 23.2600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.4643
    Cell Significance Index: 18.9900
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.3866
    Cell Significance Index: 2.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3525
    Cell Significance Index: 15.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3379
    Cell Significance Index: 5.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2479
    Cell Significance Index: 19.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2374
    Cell Significance Index: 8.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1871
    Cell Significance Index: 35.6100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1722
    Cell Significance Index: 155.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0703
    Cell Significance Index: 6.9600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0324
    Cell Significance Index: 0.6400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0120
    Cell Significance Index: 0.2400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0052
    Cell Significance Index: 0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0030
    Cell Significance Index: -4.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0053
    Cell Significance Index: -8.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0055
    Cell Significance Index: -0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0065
    Cell Significance Index: -12.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0091
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0202
    Cell Significance Index: -3.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0218
    Cell Significance Index: -0.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0262
    Cell Significance Index: -16.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0290
    Cell Significance Index: -21.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0297
    Cell Significance Index: -21.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0310
    Cell Significance Index: -19.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0381
    Cell Significance Index: -21.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0395
    Cell Significance Index: -17.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0426
    Cell Significance Index: -23.2900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0573
    Cell Significance Index: -0.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0640
    Cell Significance Index: -12.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0684
    Cell Significance Index: -19.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0718
    Cell Significance Index: -10.4300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0759
    Cell Significance Index: -1.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0904
    Cell Significance Index: -9.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0949
    Cell Significance Index: -17.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1063
    Cell Significance Index: -7.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1076
    Cell Significance Index: -22.6700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1121
    Cell Significance Index: -1.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1177
    Cell Significance Index: -3.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1223
    Cell Significance Index: -13.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1277
    Cell Significance Index: -21.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1385
    Cell Significance Index: -7.7700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1433
    Cell Significance Index: -1.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1609
    Cell Significance Index: -19.7800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1650
    Cell Significance Index: -2.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1704
    Cell Significance Index: -23.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1719
    Cell Significance Index: -7.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1742
    Cell Significance Index: -20.5400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1744
    Cell Significance Index: -1.9000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1800
    Cell Significance Index: -2.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1815
    Cell Significance Index: -5.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1828
    Cell Significance Index: -5.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1856
    Cell Significance Index: -4.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1980
    Cell Significance Index: -22.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2020
    Cell Significance Index: -6.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2026
    Cell Significance Index: -23.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2032
    Cell Significance Index: -10.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2362
    Cell Significance Index: -16.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2424
    Cell Significance Index: -25.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2745
    Cell Significance Index: -21.7400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2922
    Cell Significance Index: -2.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3157
    Cell Significance Index: -20.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3248
    Cell Significance Index: -11.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3547
    Cell Significance Index: -7.6900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4073
    Cell Significance Index: -8.5000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4181
    Cell Significance Index: -5.0000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4267
    Cell Significance Index: -6.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4450
    Cell Significance Index: -20.7500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4455
    Cell Significance Index: -10.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4476
    Cell Significance Index: -23.2500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4478
    Cell Significance Index: -8.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4553
    Cell Significance Index: -21.4000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4788
    Cell Significance Index: -5.9700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5587
    Cell Significance Index: -7.0500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5610
    Cell Significance Index: -7.0800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.5638
    Cell Significance Index: -6.2200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5739
    Cell Significance Index: -8.0500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5825
    Cell Significance Index: -14.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5879
    Cell Significance Index: -15.4600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.6106
    Cell Significance Index: -5.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6176
    Cell Significance Index: -21.4600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6490
    Cell Significance Index: -14.2100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7180
    Cell Significance Index: -22.7100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.7296
    Cell Significance Index: -14.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7474
    Cell Significance Index: -22.0200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7527
    Cell Significance Index: -18.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7528
    Cell Significance Index: -19.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7551
    Cell Significance Index: -21.6500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7630
    Cell Significance Index: -5.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7687
    Cell Significance Index: -17.7600
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.7816
    Cell Significance Index: -6.1300
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.7840
    Cell Significance Index: -6.3300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.8096
    Cell Significance Index: -35.2100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.8372
    Cell Significance Index: -20.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** ST8SIA5 is an alpha-2,8-sialyltransferase enzyme that catalyzes the transfer of sialic acid residues to glycosphingolipids and glycoproteins. 2. **Subcellular Localization:** The enzyme is predominantly localized in the Golgi apparatus, where it regulates the biosynthesis of glycosphingolipids and glycoproteins. 3. **Cellular Expression:** ST8SIA5 is significantly expressed in GABAergic cortical interneurons, which are essential for regulating neural activity and synaptic transmission. 4. **Protein Interactions:** The enzyme interacts with various proteins, including SIA8E_HUMAN and F5H8D1_HUMAN, which are involved in glycosphingolipid and glycoprotein biosynthesis. **Pathways and Functions:** 1. **Glycosphingolipid Biosynthesis:** ST8SIA5 regulates the synthesis of glycosphingolipids, which are essential components of cell membranes and play a crucial role in maintaining cellular integrity and function. 2. **Glycoprotein Processing:** The enzyme is involved in the processing of glycoproteins, which are essential for regulating various cellular processes, including cell signaling and adhesion. 3. **N-Glycan Processing:** ST8SIA5 regulates the biosynthesis of N-glycans, which are essential components of glycoproteins and play a crucial role in regulating cellular function. 4. **Sialic Acid Metabolism:** The enzyme is involved in the metabolism of sialic acid, which is an essential component of glycosphingolipids and glycoproteins. **Clinical Significance:** 1. **Neurological Disorders:** The dysregulation of ST8SIA5 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 2. **Cognitive Impairment:** Alterations in ST8SIA5 expression and activity have been linked to cognitive impairment and memory loss in Alzheimer's disease. 3. **Motor Dysfunction:** The dysregulation of ST8SIA5 has also been implicated in motor dysfunction and Parkinson's disease. 4. **Therapeutic Target:** ST8SIA5 may serve as a therapeutic target for the treatment of neurological disorders, particularly those associated with glycosphingolipid and glycoprotein dysregulation. In conclusion, ST8SIA5 plays a crucial role in regulating the balance of glycosphingolipids and glycoproteins in the brain. The dysregulation of this enzyme has been implicated in various neurological disorders, highlighting its potential as a therapeutic target for the treatment of these diseases. Further research is needed to fully elucidate the role of ST8SIA5 in maintaining glycosphingolipid and glycoprotein balance and to explore its therapeutic potential.

Genular Protein ID: 1657512220

Symbol: SIA8E_HUMAN

Name: Sialyltransferase 8E

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9199191

Title: Molecular cloning and expression of human alpha2,8-sialyltransferase (hST8Sia V).

PubMed ID: 9199191

DOI: 10.1006/bbrc.1997.6725

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 376
  • Mass: 43895
  • Checksum: 15B57F3E06080236
  • Sequence:
  • MRYADPSANR DLLGSRTLLF IFICAFALVT LLQQILYGRN YIKRYFEFYE GPFEYNSTRC 
    LELRHEILEV KVLSMVKQSE LFDRWKSLQM CKWAMNISEA NQFKSTLSRC CNAPAFLFTT 
    QKNTPLGTKL KYEVDTSGIY HINQEIFRMF PKDMPYYRSQ FKKCAVVGNG GILKNSRCGR 
    EINSADFVFR CNLPPISEKY TMDVGVKTDV VTVNPSIITE RFHKLEKWRR PFYRVLQVYE 
    NASVLLPAFY NTRNTDVSIR VKYVLDDFES PQAVYYFHPQ YLVNVSRYWL SLGVRAKRIS 
    TGLILVTAAL ELCEEVHLFG FWAFPMNPSG LYITHHYYDN VKPRPGFHAM PSEIFNFLHL 
    HSRGILRVHT GTCSCC

Genular Protein ID: 1516976462

Symbol: F5H8D1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 345
  • Mass: 40069
  • Checksum: 11A660008B03A899
  • Sequence:
  • MRYADPSANR DLLGSRTLLF IFICAFALVT LLQQILYGRN YIKRVKQSEL FDRWKSLQMC 
    KWAMNISEAN QFKSTLSRCC NAPAFLFTTQ KNTPLGTKLK YEVDTSGIYH INQEIFRMFP 
    KDMPYYRSQF KKCAVVGNGG ILKNSRCGRE INSADFVFRC NLPPISEKYT MDVGVKTDVV 
    TVNPSIITER FHKLEKWRRP FYRVLQVYEN ASVLLPAFYN TRNTDVSIRV KYVLDDFESP 
    QAVYYFHPQY LVNVSRYWLS LGVRAKRIST GLILVTAALE LCEEVHLFGF WAFPMNPSGL 
    YITHHYYDNV KPRPGFHAMP SEIFNFLHLH SRGILRVHTG TCSCC

Genular Protein ID: 2463481657

Symbol: B7Z5F7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 345
  • Mass: 40053
  • Checksum: 11BD0C0BA713E899
  • Sequence:
  • MRYADPSANR DLLGSRTLLF IFICAFALVT LLQQILYGRN YIKRVKQSEL FDRWKSLQMC 
    KWAMNISEAN QFKSTLSRCC NAPAFLFTTQ KNTPLGTKLK YEVDTSGIYH INQEIFRMFP 
    KDMPYYRSQF KKCAVVGNGG ILKNSRCGRE INSADFVFRC NLPPISEKYT MDVGVKTDVV 
    TVNPSIITER FHKLEKWRRP FYRVLQVYEN ASVPLPAFYN TRNTDVSIRV KYVLDDFESP 
    QAVYYFHPQY LVNVSRYWLS LGVRAKRIST GLILVTAALE LCEEVHLFGF WAFPMNPSGL 
    YITHHYYDNV KPRPGFHAMP SEIFNFLHLH SRGILRVHTG TCSCC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.