Details for: ST8SIA5

Gene ID: 29906

Symbol: ST8SIA5

Ensembl ID: ENSG00000101638

Description: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.36
    Marker Score: 89,454
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.18
    Marker Score: 80,528
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.13
    Marker Score: 8,829
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.1
    Marker Score: 19,708
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.09
    Marker Score: 8,079
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.97
    Marker Score: 29,433
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.91
    Marker Score: 117,467
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.9
    Marker Score: 37,788
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.82
    Marker Score: 32,241
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.78
    Marker Score: 16,885
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.77
    Marker Score: 15,166
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.72
    Marker Score: 2,886
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.64
    Marker Score: 2,524
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,171
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.58
    Marker Score: 1,571
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,100
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.4
    Marker Score: 445
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.37
    Marker Score: 14,161
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.36
    Marker Score: 5,670
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.33
    Marker Score: 776
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.22
    Marker Score: 4,722
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.19
    Marker Score: 2,465
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.18
    Marker Score: 4,809
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.16
    Marker Score: 737
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.15
    Marker Score: 17,997
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,813
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7,548
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.1
    Marker Score: 2,079
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 504
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,043
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,352
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.93
    Marker Score: 7,136
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.91
    Marker Score: 4,903
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,288
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.87
    Marker Score: 459
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.74
    Marker Score: 1,506
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.72
    Marker Score: 302
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.68
    Marker Score: 624
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.57
    Marker Score: 2,024
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.55
    Marker Score: 3,266
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.54
    Marker Score: 1,360
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.53
    Marker Score: 144
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.52
    Marker Score: 645
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 209
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.48
    Marker Score: 208
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 279
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.46
    Marker Score: 10,305
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.45
    Marker Score: 204
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.44
    Marker Score: 701
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.44
    Marker Score: 1,001
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.42
    Marker Score: 450
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.39
    Marker Score: 416
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.38
    Marker Score: 212
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.37
    Marker Score: 1,731
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.34
    Marker Score: 825
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.34
    Marker Score: 478
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.33
    Marker Score: 335
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.33
    Marker Score: 106
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.33
    Marker Score: 133
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.33
    Marker Score: 930
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.32
    Marker Score: 922
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.31
    Marker Score: 573
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.31
    Marker Score: 183
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 145
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.3
    Marker Score: 176
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.3
    Marker Score: 332
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.3
    Marker Score: 3,056
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.3
    Marker Score: 6,307
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.29
    Marker Score: 252
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.29
    Marker Score: 191
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.29
    Marker Score: 586
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.28
    Marker Score: 670
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.28
    Marker Score: 88
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.26
    Marker Score: 175
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.26
    Marker Score: 252
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.26
    Marker Score: 299
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.26
    Marker Score: 151
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.25
    Marker Score: 412
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.24
    Marker Score: 305
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.24
    Marker Score: 108
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.24
    Marker Score: 336

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** ST8SIA5 is an alpha-2,8-sialyltransferase enzyme that catalyzes the transfer of sialic acid residues to glycosphingolipids and glycoproteins. 2. **Subcellular Localization:** The enzyme is predominantly localized in the Golgi apparatus, where it regulates the biosynthesis of glycosphingolipids and glycoproteins. 3. **Cellular Expression:** ST8SIA5 is significantly expressed in GABAergic cortical interneurons, which are essential for regulating neural activity and synaptic transmission. 4. **Protein Interactions:** The enzyme interacts with various proteins, including SIA8E_HUMAN and F5H8D1_HUMAN, which are involved in glycosphingolipid and glycoprotein biosynthesis. **Pathways and Functions:** 1. **Glycosphingolipid Biosynthesis:** ST8SIA5 regulates the synthesis of glycosphingolipids, which are essential components of cell membranes and play a crucial role in maintaining cellular integrity and function. 2. **Glycoprotein Processing:** The enzyme is involved in the processing of glycoproteins, which are essential for regulating various cellular processes, including cell signaling and adhesion. 3. **N-Glycan Processing:** ST8SIA5 regulates the biosynthesis of N-glycans, which are essential components of glycoproteins and play a crucial role in regulating cellular function. 4. **Sialic Acid Metabolism:** The enzyme is involved in the metabolism of sialic acid, which is an essential component of glycosphingolipids and glycoproteins. **Clinical Significance:** 1. **Neurological Disorders:** The dysregulation of ST8SIA5 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 2. **Cognitive Impairment:** Alterations in ST8SIA5 expression and activity have been linked to cognitive impairment and memory loss in Alzheimer's disease. 3. **Motor Dysfunction:** The dysregulation of ST8SIA5 has also been implicated in motor dysfunction and Parkinson's disease. 4. **Therapeutic Target:** ST8SIA5 may serve as a therapeutic target for the treatment of neurological disorders, particularly those associated with glycosphingolipid and glycoprotein dysregulation. In conclusion, ST8SIA5 plays a crucial role in regulating the balance of glycosphingolipids and glycoproteins in the brain. The dysregulation of this enzyme has been implicated in various neurological disorders, highlighting its potential as a therapeutic target for the treatment of these diseases. Further research is needed to fully elucidate the role of ST8SIA5 in maintaining glycosphingolipid and glycoprotein balance and to explore its therapeutic potential.

Genular Protein ID: 1657512220

Symbol: SIA8E_HUMAN

Name: Sialyltransferase 8E

UniProtKB Accession Codes:

O15466 B7Z1K9 Q6IAW7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CTD 1 ChEBI 25 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 Rhea 10 SMR 1 STRING 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9199191

Title: Molecular cloning and expression of human alpha2,8-sialyltransferase (hST8Sia V).

PubMed ID: 9199191

DOI: 10.1006/bbrc.1997.6725

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 376
  • Mass: 43895
  • Checksum: 15B57F3E06080236
  • Sequence:
    • MRYADPSANR DLLGSRTLLF IFICAFALVT LLQQILYGRN YIKRYFEFYE GPFEYNSTRC 
LELRHEILEV KVLSMVKQSE LFDRWKSLQM CKWAMNISEA NQFKSTLSRC CNAPAFLFTT 
QKNTPLGTKL KYEVDTSGIY HINQEIFRMF PKDMPYYRSQ FKKCAVVGNG GILKNSRCGR 
EINSADFVFR CNLPPISEKY TMDVGVKTDV VTVNPSIITE RFHKLEKWRR PFYRVLQVYE 
NASVLLPAFY NTRNTDVSIR VKYVLDDFES PQAVYYFHPQ YLVNVSRYWL SLGVRAKRIS 
TGLILVTAAL ELCEEVHLFG FWAFPMNPSG LYITHHYYDN VKPRPGFHAM PSEIFNFLHL 
HSRGILRVHT GTCSCC

Genular Protein ID: 1516976462

Symbol: F5H8D1_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H8D1

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 345
  • Mass: 40069
  • Checksum: 11A660008B03A899
  • Sequence:
    • MRYADPSANR DLLGSRTLLF IFICAFALVT LLQQILYGRN YIKRVKQSEL FDRWKSLQMC 
KWAMNISEAN QFKSTLSRCC NAPAFLFTTQ KNTPLGTKLK YEVDTSGIYH INQEIFRMFP 
KDMPYYRSQF KKCAVVGNGG ILKNSRCGRE INSADFVFRC NLPPISEKYT MDVGVKTDVV 
TVNPSIITER FHKLEKWRRP FYRVLQVYEN ASVLLPAFYN TRNTDVSIRV KYVLDDFESP 
QAVYYFHPQY LVNVSRYWLS LGVRAKRIST GLILVTAALE LCEEVHLFGF WAFPMNPSGL 
YITHHYYDNV KPRPGFHAMP SEIFNFLHLH SRGILRVHTG TCSCC

Genular Protein ID: 2463481657

Symbol: B7Z5F7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z5F7

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 345
  • Mass: 40053
  • Checksum: 11BD0C0BA713E899
  • Sequence:
    • MRYADPSANR DLLGSRTLLF IFICAFALVT LLQQILYGRN YIKRVKQSEL FDRWKSLQMC 
KWAMNISEAN QFKSTLSRCC NAPAFLFTTQ KNTPLGTKLK YEVDTSGIYH INQEIFRMFP 
KDMPYYRSQF KKCAVVGNGG ILKNSRCGRE INSADFVFRC NLPPISEKYT MDVGVKTDVV 
TVNPSIITER FHKLEKWRRP FYRVLQVYEN ASVPLPAFYN TRNTDVSIRV KYVLDDFESP 
QAVYYFHPQY LVNVSRYWLS LGVRAKRIST GLILVTAALE LCEEVHLFGF WAFPMNPSGL 
YITHHYYDNV KPRPGFHAMP SEIFNFLHLH SRGILRVHTG TCSCC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.