Details for: PURG

Gene ID: 29942

Symbol: PURG

Ensembl ID: ENSG00000172733

Description: purine rich element binding protein G

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Purine-rich negative regulatory element binding
    (GO:0032422)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna binding
    (GO:0003723)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Synapse
    (GO:0045202)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 74.5587
    Cell Significance Index: -30.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.8096
    Cell Significance Index: -30.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6876
    Cell Significance Index: 338.5300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.4754
    Cell Significance Index: 35.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.4621
    Cell Significance Index: 89.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.3172
    Cell Significance Index: 49.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.3009
    Cell Significance Index: 57.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1185
    Cell Significance Index: 401.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0198
    Cell Significance Index: 22.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9404
    Cell Significance Index: 52.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9053
    Cell Significance Index: 60.8800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.5575
    Cell Significance Index: 6.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4887
    Cell Significance Index: 13.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3871
    Cell Significance Index: 267.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1920
    Cell Significance Index: 3.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1592
    Cell Significance Index: 8.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0424
    Cell Significance Index: 57.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0329
    Cell Significance Index: 50.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0101
    Cell Significance Index: 19.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0027
    Cell Significance Index: 4.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0177
    Cell Significance Index: -11.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0371
    Cell Significance Index: -16.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0389
    Cell Significance Index: -28.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0452
    Cell Significance Index: -33.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0551
    Cell Significance Index: -34.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0578
    Cell Significance Index: -32.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0606
    Cell Significance Index: -33.0800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0826
    Cell Significance Index: -3.5900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0855
    Cell Significance Index: -2.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0936
    Cell Significance Index: -26.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1275
    Cell Significance Index: -18.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1539
    Cell Significance Index: -32.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1614
    Cell Significance Index: -32.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1655
    Cell Significance Index: -29.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1773
    Cell Significance Index: -24.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1925
    Cell Significance Index: -24.6800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2205
    Cell Significance Index: -4.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2225
    Cell Significance Index: -38.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2392
    Cell Significance Index: -29.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2625
    Cell Significance Index: -30.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2698
    Cell Significance Index: -7.5400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2949
    Cell Significance Index: -3.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3011
    Cell Significance Index: -31.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3203
    Cell Significance Index: -36.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3397
    Cell Significance Index: -34.7000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3435
    Cell Significance Index: -7.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3587
    Cell Significance Index: -22.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3713
    Cell Significance Index: -12.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3824
    Cell Significance Index: -12.1800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4069
    Cell Significance Index: -8.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4249
    Cell Significance Index: -32.6100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4427
    Cell Significance Index: -5.5200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.4659
    Cell Significance Index: -6.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4672
    Cell Significance Index: -24.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5091
    Cell Significance Index: -11.0000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.5098
    Cell Significance Index: -5.3100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5113
    Cell Significance Index: -8.8400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5633
    Cell Significance Index: -7.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5642
    Cell Significance Index: -36.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5906
    Cell Significance Index: -26.7700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6066
    Cell Significance Index: -5.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6388
    Cell Significance Index: -22.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6683
    Cell Significance Index: -31.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7400
    Cell Significance Index: -18.4600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.7494
    Cell Significance Index: -7.1300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8215
    Cell Significance Index: -17.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8371
    Cell Significance Index: -29.0900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.8436
    Cell Significance Index: -10.9400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8718
    Cell Significance Index: -12.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8784
    Cell Significance Index: -22.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.8815
    Cell Significance Index: -45.7900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.9507
    Cell Significance Index: -10.8000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.9702
    Cell Significance Index: -10.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9951
    Cell Significance Index: -31.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.0106
    Cell Significance Index: -35.5100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.0710
    Cell Significance Index: -8.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0738
    Cell Significance Index: -30.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0757
    Cell Significance Index: -31.6900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.0774
    Cell Significance Index: -21.2100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.0794
    Cell Significance Index: -34.1400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.0804
    Cell Significance Index: -7.3200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.1038
    Cell Significance Index: -23.6000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -1.1051
    Cell Significance Index: -9.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.1169
    Cell Significance Index: -29.3700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.1473
    Cell Significance Index: -13.7200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.1595
    Cell Significance Index: -13.2700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.1835
    Cell Significance Index: -23.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1906
    Cell Significance Index: -19.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.1929
    Cell Significance Index: -34.3700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.1960
    Cell Significance Index: -29.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.2289
    Cell Significance Index: -32.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.2311
    Cell Significance Index: -32.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.2361
    Cell Significance Index: -33.0100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -1.2517
    Cell Significance Index: -9.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.2598
    Cell Significance Index: -26.3700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.2941
    Cell Significance Index: -32.9700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.3006
    Cell Significance Index: -17.3500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.3043
    Cell Significance Index: -26.5400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.3180
    Cell Significance Index: -32.9200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.3305
    Cell Significance Index: -16.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor Function:** PURG acts as a transcription factor, binding to specific DNA sequences and regulating gene expression. 2. **Purine-Rich Element Binding:** The protein binds to purine-rich elements, which are regulatory sequences found in the promoter regions of genes. 3. **Widespread Expression:** PURG is expressed in various cell types, including immune cells, neurons, and glial cells. 4. **Cell Type-Specific Expression:** The gene is significantly expressed in conventional dendritic cells, mesangial cells, and specific types of interneurons, suggesting cell-type-specific functions. **Pathways and Functions:** 1. **DNA-Binding Transcription Factor Activity:** PURG binds to specific DNA sequences, regulating gene expression by interacting with RNA polymerase II. 2. **RNA Polymerase II-Specific:** PURG interacts with RNA polymerase II, a key enzyme in the transcription process. 3. **Nucleus:** PURG is localized to the nucleus, where it regulates gene expression. 4. **Regulation of Transcription:** PURG regulates transcription by binding to specific DNA sequences, influencing the expression of target genes. 5. **RNA Binding:** PURG interacts with RNA molecules, modulating their stability and translation. 6. **Synapse-Related Functions:** PURG is expressed in neurons and interneurons, suggesting a role in synaptic function and plasticity. **Clinical Significance:** 1. **Immune System:** PURG may play a role in regulating immune responses, particularly in the context of dendritic cell function. 2. **Neurological Disorders:** Dysregulation of PURG expression may contribute to neurological disorders, such as Parkinson's disease, Alzheimer's disease, and schizophrenia. 3. **Cancer:** Alterations in PURG expression may influence cancer development and progression, particularly in the context of immune cell function. 4. **Neurodevelopmental Disorders:** PURG may be involved in the regulation of gene expression during neuronal development, influencing the development of neurodevelopmental disorders. In conclusion, PURG is a transcription factor gene with widespread expression in the immune system and neuronal cells. Its role in regulating gene expression, interacting with RNA polymerase II, and binding to purine-rich elements make it an important regulator of cellular processes. Further research is needed to fully elucidate the clinical significance of PURG and its potential role in various diseases.

Genular Protein ID: 1911046325

Symbol: PURG_HUMAN

Name: Purine-rich element-binding protein gamma

UniProtKB Accession Codes:

Q9UJV8 Q8TE64

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12034829

Title: Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation.

PubMed ID: 12034829

DOI: 10.1093/nar/30.11.2417

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 347
  • Mass: 39556
  • Checksum: 6134333196DAAFC3
  • Sequence:
    • MERARRRGGG GGRGRGGKNV GGSGLSKSRL YPQAQHSHYP HYAASATPNQ AGGAAEIQEL 
ASKRVDIQKK RFYLDVKQSS RGRFLKIAEV WIGRGRQDNI RKSKLTLSLS VAAELKDCLG 
DFIEHYAHLG LKGHRQEHGH SKEQGSRRRQ KHSAPSPPVS VGSEEHPHSV LKTDYIERDN 
RKYYLDLKEN QRGRFLRIRQ TMMRGTGMIG YFGHSLGQEQ TIVLPAQGMI EFRDALVQLI 
EDYGEGDIEE RRGGDDDPLE LPEGTSFRVD NKRFYFDVGS NKYGIFLKVS EVRPPYRNTI 
TVPFKAWTRF GENFIKYEEE MRKICNSHKE KRMDGRKASG EEQECLD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.