Details for: PRICKLE4

Gene ID: 29964

Symbol: PRICKLE4

Ensembl ID: ENSG00000278224

Description: prickle planar cell polarity protein 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.6458
    Cell Significance Index: -1.7300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2865
    Cell Significance Index: 4.1200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.2575
    Cell Significance Index: 3.2500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1509
    Cell Significance Index: 3.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1276
    Cell Significance Index: 7.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1115
    Cell Significance Index: 2.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0812
    Cell Significance Index: 2.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0626
    Cell Significance Index: 11.9200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0609
    Cell Significance Index: 0.7200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0522
    Cell Significance Index: 0.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0423
    Cell Significance Index: 4.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0415
    Cell Significance Index: 7.4800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0365
    Cell Significance Index: 0.5500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0306
    Cell Significance Index: 0.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0298
    Cell Significance Index: 2.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0174
    Cell Significance Index: 3.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0131
    Cell Significance Index: 1.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0129
    Cell Significance Index: 1.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0082
    Cell Significance Index: 0.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0078
    Cell Significance Index: 0.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0051
    Cell Significance Index: 0.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0031
    Cell Significance Index: 0.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0011
    Cell Significance Index: 0.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0038
    Cell Significance Index: -2.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0041
    Cell Significance Index: -0.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0044
    Cell Significance Index: -0.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0050
    Cell Significance Index: -2.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0050
    Cell Significance Index: -0.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0066
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0069
    Cell Significance Index: -0.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0081
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0090
    Cell Significance Index: -1.5300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0098
    Cell Significance Index: -0.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0104
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0104
    Cell Significance Index: -2.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0142
    Cell Significance Index: -1.6600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0147
    Cell Significance Index: -0.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0165
    Cell Significance Index: -2.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0169
    Cell Significance Index: -0.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0170
    Cell Significance Index: -0.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0243
    Cell Significance Index: -1.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0292
    Cell Significance Index: -1.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0294
    Cell Significance Index: -3.7700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0318
    Cell Significance Index: -0.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0330
    Cell Significance Index: -0.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0353
    Cell Significance Index: -1.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0396
    Cell Significance Index: -2.2200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0404
    Cell Significance Index: -1.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0411
    Cell Significance Index: -1.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0455
    Cell Significance Index: -1.4500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0462
    Cell Significance Index: -0.9400
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0502
    Cell Significance Index: -0.5100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0504
    Cell Significance Index: -0.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0513
    Cell Significance Index: -1.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0530
    Cell Significance Index: -1.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0549
    Cell Significance Index: -1.5800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0554
    Cell Significance Index: -0.7100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0598
    Cell Significance Index: -0.8300
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.0605
    Cell Significance Index: -0.6400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0607
    Cell Significance Index: -2.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0655
    Cell Significance Index: -1.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0660
    Cell Significance Index: -1.6500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0680
    Cell Significance Index: -1.4700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0693
    Cell Significance Index: -1.0100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0710
    Cell Significance Index: -1.0200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0723
    Cell Significance Index: -1.5500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0752
    Cell Significance Index: -1.2900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0758
    Cell Significance Index: -1.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0768
    Cell Significance Index: -3.8800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0781
    Cell Significance Index: -1.2700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0781
    Cell Significance Index: -1.0100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0785
    Cell Significance Index: -1.5800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0793
    Cell Significance Index: -1.5500
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0805
    Cell Significance Index: -0.8300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0813
    Cell Significance Index: -1.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0820
    Cell Significance Index: -2.1600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0834
    Cell Significance Index: -1.7400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0865
    Cell Significance Index: -1.7100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0918
    Cell Significance Index: -1.4200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0922
    Cell Significance Index: -2.3000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0947
    Cell Significance Index: -1.2000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0970
    Cell Significance Index: -1.9100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0986
    Cell Significance Index: -1.1200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1058
    Cell Significance Index: -2.1100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1137
    Cell Significance Index: -1.4200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1146
    Cell Significance Index: -1.9300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1165
    Cell Significance Index: -1.9600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1169
    Cell Significance Index: -2.9200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1176
    Cell Significance Index: -1.7600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1179
    Cell Significance Index: -1.5900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1183
    Cell Significance Index: -1.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1186
    Cell Significance Index: -1.1400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1198
    Cell Significance Index: -1.7400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1208
    Cell Significance Index: -1.5800
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.1236
    Cell Significance Index: -0.7300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1244
    Cell Significance Index: -2.3000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1258
    Cell Significance Index: -1.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Polarity:** PRICKLE4 is a key regulator of planar cell polarity (PCP), which is essential for maintaining the correct orientation of cells within tissues. PCP influences various cellular processes, including cell migration, differentiation, and signaling. 2. **Actin Cytoskeleton Organization:** PRICKLE4 interacts with actin-binding proteins to regulate the organization and dynamics of the actin cytoskeleton, which is crucial for maintaining cellular shape, motility, and signaling. 3. **Muscle Structure Development:** PRICKLE4 is involved in the development and organization of muscle structures, including the z-disk and stress fibers, which are essential for muscle contraction and relaxation. 4. **Cell-Cell Adhesion:** PRICKLE4 regulates adherens junctions, which are crucial for maintaining cell-cell adhesion and tissue integrity. **Pathways and Functions:** 1. **Actin Binding:** PRICKLE4 interacts with actin-binding proteins to regulate the organization and dynamics of the actin cytoskeleton. 2. **Adherens Junction:** PRICKLE4 regulates adherens junctions, which are essential for maintaining cell-cell adhesion and tissue integrity. 3. **Muscle Structure Development:** PRICKLE4 is involved in the development and organization of muscle structures, including the z-disk and stress fibers. 4. **Heart Development:** PRICKLE4 plays a role in heart development, particularly in the organization of cardiac muscle myoblasts. 5. **Biological Process:** PRICKLE4 is involved in various biological processes, including cell migration, differentiation, and signaling. **Clinical Significance:** Dysregulation of PRICKLE4 has been implicated in various diseases, including: 1. **Muscular Dystrophy:** Mutations in PRICKLE4 have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cardiovascular Disease:** PRICKLE4 has been implicated in the development of cardiovascular disease, particularly in the context of cardiac muscle myoblasts. 3. **Cancer:** PRICKLE4 has been shown to be involved in the regulation of cell-cell adhesion and tissue integrity, which can impact cancer progression and metastasis. In conclusion, PRICKLE4 is a critical gene that plays a pivotal role in maintaining cellular polarity, regulating the actin cytoskeleton, and influencing muscle structure development. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the function and clinical significance of this gene.

Genular Protein ID: 1628461357

Symbol: PRIC4_HUMAN

Name: Prickle-like protein 4

UniProtKB Accession Codes:

Q2TBC4 A2A3M0 A6PVU1 B3KQ15 Q5T3D4 Q9NSV1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 4 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15702247

Title: Characterization of OEBT, a LIM protein.

PubMed ID: 15702247

Sequence Information:

  • Length: 344
  • Mass: 37551
  • Checksum: BB23045A87A4135F
  • Sequence:
    • MSPQGPAVLS LGSLCLDTNQ APNWTGLQTL LQQLPPQDID ERYCLALGEE ERAELQLFCA 
RRKQEALGQG VARLVLPKLE GHTCEKCREL LKPGEYGVFA ARAGEQRCWH QPCFACQACG 
QALINLIYFY HDGQLYCGRH HAELLRPRCP ACDQLIFSWR CTEAEGQRWH ENHFCCQDCA 
GPLGGGRYAL PGGSPCCPSC FENRYSDAGS SWAGALEGQA FLGETGLDRT EGRDQTSVNS 
ATLSRTLLAA AGGSSLQTQR GLPGSSPQQE NRPGDKAEAP KGQEQCRLET IRDPKDTPFS 
TCSSSSDSEP EGFFLGERLP QSWKTPGSLQ AEDSNASKTH CTMC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.