Details for: HMOX2

Gene ID: 3163

Symbol: HMOX2

Ensembl ID: ENSG00000103415

Description: heme oxygenase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.14
    Marker Score: 3076
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.97
    Marker Score: 12611
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.84
    Marker Score: 18220
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.75
    Marker Score: 731
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.69
    Marker Score: 3440.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.65
    Marker Score: 14240
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.62
    Marker Score: 4741
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.53
    Marker Score: 2997
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.52
    Marker Score: 1469
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.52
    Marker Score: 1684
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.51
    Marker Score: 4770
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.49
    Marker Score: 33248
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.49
    Marker Score: 1865
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.46
    Marker Score: 1067
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.45
    Marker Score: 2590
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.44
    Marker Score: 847
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.44
    Marker Score: 414
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.43
    Marker Score: 16680
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.42
    Marker Score: 3212
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.41
    Marker Score: 5553
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.4
    Marker Score: 14477
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.4
    Marker Score: 1688
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.4
    Marker Score: 5990
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.37
    Marker Score: 6587
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.36
    Marker Score: 1811
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.34
    Marker Score: 34430
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.32
    Marker Score: 69940.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.29
    Marker Score: 3028
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.28
    Marker Score: 922
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.26
    Marker Score: 312
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.26
    Marker Score: 356
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.26
    Marker Score: 1849
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.25
    Marker Score: 1179
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.25
    Marker Score: 5386
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.22
    Marker Score: 7794
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.21
    Marker Score: 4965
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.21
    Marker Score: 887
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.21
    Marker Score: 1063
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.21
    Marker Score: 3386
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.21
    Marker Score: 1776
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.2
    Marker Score: 1004
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.2
    Marker Score: 1133
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2
    Marker Score: 1450
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.19
    Marker Score: 1013
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.18
    Marker Score: 1820
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.18
    Marker Score: 508
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.17
    Marker Score: 585
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.17
    Marker Score: 2006
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.14
    Marker Score: 1282
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.14
    Marker Score: 767
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.14
    Marker Score: 1067
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.14
    Marker Score: 1047
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.14
    Marker Score: 70018
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.11
    Marker Score: 612
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.1
    Marker Score: 1753
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.1
    Marker Score: 2686
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.1
    Marker Score: 1826
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.1
    Marker Score: 749
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.09
    Marker Score: 602
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.09
    Marker Score: 8535
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.08
    Marker Score: 364
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.08
    Marker Score: 258
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.07
    Marker Score: 450
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.07
    Marker Score: 10102
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.07
    Marker Score: 37165
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.07
    Marker Score: 799
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.06
    Marker Score: 330
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.06
    Marker Score: 4096
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.06
    Marker Score: 722
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.06
    Marker Score: 394
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.06
    Marker Score: 528
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.05
    Marker Score: 938
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.05
    Marker Score: 1135
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.05
    Marker Score: 1141
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.05
    Marker Score: 821.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.04
    Marker Score: 38322
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.03
    Marker Score: 3233
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.02
    Marker Score: 9694
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.02
    Marker Score: 8747
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1
    Marker Score: 894
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1
    Marker Score: 2442
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1
    Marker Score: 414
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1
    Marker Score: 574
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71581
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.99
    Marker Score: 386
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47803
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.99
    Marker Score: 995
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.99
    Marker Score: 6020
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.99
    Marker Score: 4016
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.99
    Marker Score: 252
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.98
    Marker Score: 2334
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30373
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.98
    Marker Score: 1574
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.97
    Marker Score: 1687
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.96
    Marker Score: 799
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.96
    Marker Score: 251.5
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.96
    Marker Score: 236
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.96
    Marker Score: 1059
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.95
    Marker Score: 1116
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.95
    Marker Score: 461

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Other Information

**Key characteristics:** * Gene ID: ENSG00000103415 * Ensembl ID: 202001124 * Protein: HMOX2_HUMAN (Heme oxygenase 2) * Protein length: 145 amino acids * Subcellular localization: Cytoplasm and nucleus **Pathways and functions:** * HMOX2 is involved in the regulation of inflammation and immune responses. * It is a key regulator of the innate immune system, where it is expressed in immune cells such as macrophages, dendritic cells, and neutrophils. * It is also expressed in epithelial cells of the gut and other tissues. * HMOX2 is involved in the production of reactive oxygen species (ROS), which are important for immune function. * It also regulates the expression of other genes involved in inflammation and immune responses. * HMOX2 is a potential therapeutic target for inflammatory diseases, such as rheumatoid arthritis and sepsis. **Clinical significance:** HMOX2 is a promising therapeutic target for inflammatory diseases, such as rheumatoid arthritis and sepsis. By blocking HMOX2, inflammation and damage to tissues can be reduced. This could lead to improved clinical outcomes and reduced disease severity.

Genular Protein ID: 181133486

Symbol: HMOX2_HUMAN

Name: Heme oxygenase 2

UniProtKB Accession Codes:

P30519 A8MT35 D3DUD5 I3L430 O60605

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 10 EPD 1 Ensembl 18 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 7 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 11 Rhea 4 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7890772

Title: Heme oxygenase-2. Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2.

PubMed ID: 7890772

DOI: 10.1074/jbc.270.11.6345

PubMed ID: 1575508

Title: Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal.

PubMed ID: 1575508

DOI: 10.1016/0003-9861(92)90481-b

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 17965015

Title: Comparison of apo- and heme-bound crystal structures of a truncated human heme oxygenase-2.

PubMed ID: 17965015

DOI: 10.1074/jbc.m707396200

Sequence Information:

  • Length: 316
  • Mass: 36033
  • Checksum: BF4B6A341F1A81AC
  • Sequence:
    • MSAEVETSEG VDESEKKNSG ALEKENQMRM ADLSELLKEG TKEAHDRAEN TQFVKDFLKG 
NIKKELFKLA TTALYFTYSA LEEEMERNKD HPAFAPLYFP MELHRKEALT KDMEYFFGEN 
WEEQVQCPKA AQKYVERIHY IGQNEPELLV AHAYTRYMGD LSGGQVLKKV AQRALKLPST 
GEGTQFYLFE NVDNAQQFKQ LYRARMNALD LNMKTKERIV EEANKAFEYN MQIFNELDQA 
GSTLARETLE DGFPVHDGKG DMRKCPFYAA EQDKGALEGS SCPFRTAMAV LRKPSLQFIL 
AAGVALAAGL LAWYYM

Genular Protein ID: 185400223

Symbol: B3KSE0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KSE0

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 14 DNASU 1 EC 1 EMBL 2 GO 4 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 3 SAM 2 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 316
  • Mass: 35961
  • Checksum: 99896A34B53881AD
  • Sequence:
    • MSAEVETSEG VDESEKKNSG ALEKENQMRM ADLSELLKEG TKEAHDRAGN TQFVKDFLKG 
NIKKELFKLA TTALYFTYSA LEEEMERNKD HPAFAPLYFP MELHRKEALT KDMEYFFGEN 
WEEQVQCPKA AQKYVERIHY IGQNEPELLV AHAYTRYMGD LSGGQVLKKV AQRALKLPST 
GEGTQFYLFE NVDNAQQFKQ LYRARMNALD LNMKTKERIV EEANKAFEYN MQIFNELDQA 
GSTLARETLE DGFPVHDGKG DMRKCPFYAA EQDKGALEGS SCPFRTAMAV LRKPSLQFIL 
AAGVALAAGL LAWYYM

Genular Protein ID: 2425497970

Symbol: A0A087WT44_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WT44

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 3 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 Proteomes 2 RefSeq 2 SAM 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 370
  • Mass: 41669
  • Checksum: A2E0B8443B79108C
  • Sequence:
    • MESRSVAQAG VQWISLAHCS LHLLGSRDSP ASASCVAGIT GPEEREQQEP HPAAMSAEVE 
TSEGVDESEK KNSGALEKEN QMRMADLSEL LKEGTKEAHD RAENTQFVKD FLKGNIKKEL 
FKLATTALYF TYSALEEEME RNKDHPAFAP LYFPMELHRK EALTKDMEYF FGENWEEQVQ 
CPKAAQKYVE RIHYIGQNEP ELLVAHAYTR YMGDLSGGQV LKKVAQRALK LPSTGEGTQF 
YLFENVDNAQ QFKQLYRARM NALDLNMKTK ERIVEEANKA FEYNMQIFNE LDQAGSTLAR 
ETLEDGFPVH DGKGDMRKCP FYAAEQDKGA LEGSSCPFRT AMAVLRKPSL QFILAAGVAL 
AAGLLAWYYM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.