Details for: HMOX2
Gene ID: 3163
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: HMOX2
Ensembl ID: ENSG00000103415
Description: heme oxygenase 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 14.56rCSI 32.52%PRS 36.94
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CSI 13.27rCSI 14.93%PRS 46.89
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CSI 11.82rCSI 22.77%PRS 61.58
-
CSI 11.11rCSI 7.41%PRS 59.9
-
CSI 9.43rCSI 11.31%PRS 30.59
-
CSI 9.21rCSI 14.72%PRS 34.63
-
CSI 8.2rCSI 26.6%PRS 36
-
CSI 8.04rCSI 6.11%PRS 41.12
-
CSI 7.75rCSI 11.69%PRS 32.73
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CSI 7.69rCSI 21.55%PRS 46.17
-
CSI 7.58rCSI 19.22%PRS 24.69
-
CSI 7.17rCSI 5.56%PRS 31.23
-
CSI 7.07rCSI 20.47%PRS 34.59
-
CSI 6.8rCSI 10.94%PRS 21.67
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CSI 6.61rCSI 6.15%PRS 31.67
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CSI 6.61rCSI 10.7%PRS 31.2
-
CSI 6.44rCSI 8.3%PRS 20.64
-
CSI 5.65rCSI 13.73%PRS 19.43
-
CSI 5.3rCSI 8.1%PRS 39.81
-
CSI 5.14rCSI 50.58%PRS 61.87
-
CSI 4.95rCSI 12.52%PRS 38.63
-
CSI 4.86rCSI 6.74%PRS 38.91
-
CSI 4.68rCSI 6.37%PRS 44
-
CSI 4.63rCSI 3.22%PRS 38.21
-
CSI 4.62rCSI 3.83%PRS 30.24
-
CSI 4.38rCSI 4.22%PRS 32.6
-
CSI 4.04rCSI 5.71%PRS 41.55
-
CSI 3.95rCSI 6.27%PRS 40.42
-
CSI 3.95rCSI 6.36%PRS 42.69
-
CSI 3.88rCSI 3.11%PRS 51.91
-
CSI 3.88rCSI 6.12%PRS 32.26
-
CSI 3.84rCSI 3.84%PRS 27.22
-
CSI 3.82rCSI 5.82%PRS 29.41
-
CSI 3.8rCSI 6.71%PRS 39.55
-
CSI 3.7rCSI 18.59%PRS 40.88
-
CSI 3.55rCSI 5.2%PRS 33.74
-
CSI 3.51rCSI 7.11%PRS 18.5
-
CSI 3.37rCSI 12.22%PRS 49.73
-
CSI 3.35rCSI 3.29%PRS 45.82
-
CSI 3.27rCSI 13.19%PRS 30.46
-
CSI 3.16rCSI 5.67%PRS 26.71
-
CSI 3.1rCSI 2.16%PRS 42.99
-
CSI 3.08rCSI 4.12%PRS 39.05
-
CSI 3.03rCSI 2.27%PRS 67.1
-
CSI 3.02rCSI 3.67%PRS 38.46
-
CSI 3.02rCSI 2.75%PRS 45.77
-
CSI 2.95rCSI 2.19%PRS 43.83
-
CSI 2.9rCSI 2.04%PRS 58.4
-
CSI 2.87rCSI 12.77%PRS 30.55
-
CSI 2.86rCSI 1.69%PRS 43.86
-
CSI 2.76rCSI 4.06%PRS 29.43
-
CSI 2.76rCSI 6.1%PRS 23.06
-
CSI 2.68rCSI 7.07%PRS 37.44
-
CSI 2.66rCSI 9.97%PRS 26.91
-
CSI 2.62rCSI 8.43%PRS 32.28
-
CSI 2.61rCSI 3.33%PRS 36.29
-
CSI 2.59rCSI 3.46%PRS 53.71
-
CSI 2.5rCSI 7.37%PRS 36.37
-
CSI 2.47rCSI 3.16%PRS 36.26
-
CSI 2.43rCSI 3.32%PRS 43.12
-
CSI 2.4rCSI 5.32%PRS 29.41
-
CSI 2.4rCSI 1.87%PRS 45.85
-
CSI 2.39rCSI 2.5%PRS 29.64
-
CSI 2.37rCSI 2.14%PRS 29.05
-
CSI 2.34rCSI 2.17%PRS 51.55
-
CSI 2.31rCSI 5.43%PRS 41.76
-
CSI 2.31rCSI 12.11%PRS 47.79
-
CSI 2.29rCSI 1.72%PRS 45.83
-
CSI 2.28rCSI 2.1%PRS 37.6
-
CSI 2.26rCSI 1.78%PRS 37.42
-
CSI 2.26rCSI 3.45%PRS 49.56
-
CSI 2.23rCSI 1.55%PRS 33.3
-
CSI 2.22rCSI 4.61%PRS 30.97
-
CSI 2.22rCSI 5.07%PRS 31.19
-
CSI 2.19rCSI 2.62%PRS 19.8
-
CSI 2.19rCSI 3.12%PRS 34.46
-
CSI 2.17rCSI 6.29%PRS 53.71
-
CSI 2.13rCSI 4.07%PRS 47.42
-
CSI 2.08rCSI 3.24%PRS 59.27
-
CSI 2.06rCSI 2.81%PRS 60.52
-
CSI 2.06rCSI 1.83%PRS 31.46
-
CSI 2.01rCSI 1.77%PRS 23.49
-
CSI 2rCSI 1.44%PRS 42.53
-
CSI 1.94rCSI 3.89%PRS 23.98
-
CSI 1.93rCSI 2.01%PRS 32.34
-
CSI 1.92rCSI 3.05%PRS 26.81
-
CSI 1.92rCSI 2.96%PRS 30.04
-
CSI 1.91rCSI 2.71%PRS 29.5
-
CSI 1.91rCSI 5.49%PRS 46.39
-
CSI 1.86rCSI 1.43%PRS 30.13
-
CSI 1.84rCSI 2.15%PRS 44.34
-
CSI 1.81rCSI 1.22%PRS 39.56
-
CSI 1.8rCSI 43.33%PRS 20.07
-
CSI 1.76rCSI 2.71%PRS 37.78
-
CSI 1.76rCSI 1.83%PRS 32.24
-
CSI 1.74rCSI 1.38%PRS 22.28
-
CSI 1.74rCSI 2.66%PRS 32.1
-
CSI 1.74rCSI 1.71%PRS 63.87
-
CSI 1.72rCSI 1.39%PRS 31.91
-
CSI 1.72rCSI 1.44%PRS 36.52
-
CSI 0.1rCSI 0.4%PRS 20.9%
-
CSI 0.2rCSI 3.9%PRS 64.8%
-
CSI 0.3rCSI 1.4%PRS 43.8%
-
CSI 0.3rCSI 2.1%PRS 29.1%
-
CSI 0.3rCSI 1.3%PRS 49.6%
-
CSI 0.3rCSI 1.7%PRS 42.9%
-
CSI 0.3rCSI 2.6%PRS 51.3%
-
CSI 0.4rCSI 3.2%PRS 20.9%
-
CSI 0.4rCSI 3.7%PRS 64.6%
-
CSI 0.4rCSI 1.9%PRS 41.6%
-
CSI 0.4rCSI 3.4%PRS 76.2%
-
CSI 0.6rCSI 0.9%PRS 24.7%
-
CSI 0.6rCSI 1.2%PRS 46.4%
-
CSI 0.6rCSI 2.0%PRS 48.4%
-
CSI 0.6rCSI 3.8%PRS 21.0%
-
CSI 0.7rCSI 2.1%PRS 40.6%
-
CSI 0.7rCSI 0.6%PRS 35.1%
-
CSI 0.7rCSI 0.8%PRS 33.3%
-
CSI 0.7rCSI 2.0%PRS 25.4%
-
CSI 0.8rCSI 4.8%PRS 25.9%
-
CSI 0.8rCSI 4.5%PRS 21.0%
-
CSI 0.8rCSI 2.3%PRS 29.7%
-
CSI 0.9rCSI 2.3%PRS 31.9%
-
CSI 0.9rCSI 1.7%PRS 40.0%
-
CSI 0.9rCSI 3.5%PRS 20.8%
-
CSI 1.0rCSI 1.7%PRS 19.3%
-
CSI 1.0rCSI 2.3%PRS 37.5%
-
CSI 1.0rCSI 1.9%PRS 49.1%
-
CSI 1.0rCSI 0.9%PRS 39.3%
-
CSI 1.0rCSI 3.5%PRS 46.1%
-
CSI 1.0rCSI 1.3%PRS 35.0%
-
CSI 1.0rCSI 1.5%PRS 33.8%
-
CSI 1.0rCSI 1.1%PRS 36.9%
-
CSI 1.0rCSI 2.0%PRS 32.9%
-
CSI 1.1rCSI 6.4%PRS 43.4%
-
CSI 1.1rCSI 2.4%PRS 35.4%
-
CSI 1.1rCSI 2.8%PRS 29.8%
-
CSI 1.1rCSI 1.2%PRS 47.7%
-
CSI 1.1rCSI 1.6%PRS 25.2%
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CSI 1.2rCSI 1.3%PRS 23.9%
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CSI 1.2rCSI 1.6%PRS 27.4%
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CSI 1.2rCSI 1.5%PRS 40.0%
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CSI 1.2rCSI 0.9%PRS 34.1%
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CSI 1.2rCSI 2.1%PRS 30.0%
-
CSI 1.2rCSI 2.1%PRS 47.5%
-
CSI 1.3rCSI 1.7%PRS 34.4%
-
CSI 1.3rCSI 2.1%PRS 36.5%
-
CSI 1.3rCSI 3.4%PRS 54.7%
-
CSI 1.3rCSI 2.5%PRS 23.9%
-
CSI 1.3rCSI 1.7%PRS 18.8%
-
CSI 1.4rCSI 1.7%PRS 30.3%
-
CSI 1.4rCSI 1.7%PRS 33.9%
-
CSI 1.4rCSI 2.2%PRS 24.9%
-
CSI 1.4rCSI 3.6%PRS 42.3%
-
CSI 1.4rCSI 3.2%PRS 52.3%
-
CSI 1.4rCSI 3.3%PRS 49.2%
-
CSI 1.4rCSI 2.1%PRS 47.7%
-
CSI 1.4rCSI 3.1%PRS 20.5%
-
CSI 1.4rCSI 0.9%PRS 36.1%
-
CSI 1.4rCSI 5.1%PRS 19.0%
-
CSI 1.4rCSI 1.4%PRS 32.9%
-
CSI 1.4rCSI 3.6%PRS 30.1%
-
CSI 1.4rCSI 3.6%PRS 29.9%
-
CSI 1.5rCSI 1.6%PRS 29.6%
-
CSI 1.5rCSI 7.9%PRS 71.9%
-
CSI 1.5rCSI 2.2%PRS 41.0%
-
CSI 1.5rCSI 1.8%PRS 50.6%
-
CSI 1.5rCSI 2.6%PRS 52.9%
-
CSI 1.5rCSI 3.6%PRS 59.7%
-
CSI 1.5rCSI 2.9%PRS 67.8%
-
CSI 1.5rCSI 6.3%PRS 31.6%
-
CSI 1.5rCSI 2.1%PRS 52.8%
-
CSI 1.6rCSI 2.2%PRS 45.4%
-
CSI 1.6rCSI 1.5%PRS 24.3%
-
CSI 1.6rCSI 1.2%PRS 52.1%
-
CSI 1.6rCSI 3.6%PRS 26.1%
-
CSI 1.6rCSI 2.0%PRS 28.3%
-
CSI 1.6rCSI 1.5%PRS 32.8%
-
CSI 1.6rCSI 6.2%PRS 41.1%
-
CSI 1.6rCSI 1.4%PRS 36.0%
-
CSI 1.6rCSI 2.2%PRS 35.5%
-
CSI 1.6rCSI 38.7%PRS 19.3%
-
CSI 1.6rCSI 2.3%PRS 39.7%
-
CSI 1.7rCSI 3.8%PRS 27.2%
-
CSI 1.7rCSI 3.5%PRS 41.3%
-
CSI 1.7rCSI 1.3%PRS 42.5%
-
CSI 1.7rCSI 1.7%PRS 43.5%
-
CSI 1.7rCSI 1.8%PRS 33.6%
-
CSI 1.7rCSI 1.4%PRS 36.5%
-
CSI 1.7rCSI 1.4%PRS 31.9%
-
CSI 1.7rCSI 1.7%PRS 63.9%
-
CSI 1.7rCSI 2.7%PRS 32.1%
-
CSI 1.7rCSI 1.4%PRS 22.3%
-
CSI 1.8rCSI 1.8%PRS 32.2%
-
CSI 1.8rCSI 2.7%PRS 37.8%
-
CSI 1.8rCSI 43.3%PRS 20.1%
-
CSI 1.8rCSI 1.2%PRS 39.6%
-
CSI 1.8rCSI 2.2%PRS 44.3%
-
CSI 1.9rCSI 1.4%PRS 30.1%
-
CSI 1.9rCSI 5.5%PRS 46.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 181133486
Symbol: HMOX2_HUMAN
Name: Heme oxygenase 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7890772
Title: Heme oxygenase-2. Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2.
PubMed ID: 7890772
PubMed ID: 1575508
Title: Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal.
PubMed ID: 1575508
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 38056462
Title: An enzyme that selectively S-nitrosylates proteins to regulate insulin signaling.
PubMed ID: 38056462
PubMed ID: 17965015
Title: Comparison of apo- and heme-bound crystal structures of a truncated human heme oxygenase-2.
PubMed ID: 17965015
Sequence Information:
- Length: 316
- Mass: 36033
- Checksum: BF4B6A341F1A81AC
- Sequence:
MSAEVETSEG VDESEKKNSG ALEKENQMRM ADLSELLKEG TKEAHDRAEN TQFVKDFLKG NIKKELFKLA TTALYFTYSA LEEEMERNKD HPAFAPLYFP MELHRKEALT KDMEYFFGEN WEEQVQCPKA AQKYVERIHY IGQNEPELLV AHAYTRYMGD LSGGQVLKKV AQRALKLPST GEGTQFYLFE NVDNAQQFKQ LYRARMNALD LNMKTKERIV EEANKAFEYN MQIFNELDQA GSTLARETLE DGFPVHDGKG DMRKCPFYAA EQDKGALEGS SCPFRTAMAV LRKPSLQFIL AAGVALAAGL LAWYYM
Genular Protein ID: 185400223
Symbol: B3KSE0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 316
- Mass: 35961
- Checksum: 99896A34B53881AD
- Sequence:
MSAEVETSEG VDESEKKNSG ALEKENQMRM ADLSELLKEG TKEAHDRAGN TQFVKDFLKG NIKKELFKLA TTALYFTYSA LEEEMERNKD HPAFAPLYFP MELHRKEALT KDMEYFFGEN WEEQVQCPKA AQKYVERIHY IGQNEPELLV AHAYTRYMGD LSGGQVLKKV AQRALKLPST GEGTQFYLFE NVDNAQQFKQ LYRARMNALD LNMKTKERIV EEANKAFEYN MQIFNELDQA GSTLARETLE DGFPVHDGKG DMRKCPFYAA EQDKGALEGS SCPFRTAMAV LRKPSLQFIL AAGVALAAGL LAWYYM
Genular Protein ID: 2425497970
Symbol: A0A087WT44_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 370
- Mass: 41669
- Checksum: A2E0B8443B79108C
- Sequence:
MESRSVAQAG VQWISLAHCS LHLLGSRDSP ASASCVAGIT GPEEREQQEP HPAAMSAEVE TSEGVDESEK KNSGALEKEN QMRMADLSEL LKEGTKEAHD RAENTQFVKD FLKGNIKKEL FKLATTALYF TYSALEEEME RNKDHPAFAP LYFPMELHRK EALTKDMEYF FGENWEEQVQ CPKAAQKYVE RIHYIGQNEP ELLVAHAYTR YMGDLSGGQV LKKVAQRALK LPSTGEGTQF YLFENVDNAQ QFKQLYRARM NALDLNMKTK ERIVEEANKA FEYNMQIFNE LDQAGSTLAR ETLEDGFPVH DGKGDMRKCP FYAAEQDKGA LEGSSCPFRT AMAVLRKPSL QFILAAGVAL AAGLLAWYYM