Details for: HMX1

Gene ID: 3166

Symbol: HMX1

Ensembl ID: ENSG00000215612

Description: H6 family homeobox 1

Associated with

  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 4.8473
    Cell Significance Index: 41.2000
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.8696
    Cell Significance Index: 31.6200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.8198
    Cell Significance Index: 35.6300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.3862
    Cell Significance Index: 46.6600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.9441
    Cell Significance Index: 27.3100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.2553
    Cell Significance Index: 15.5700
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.0714
    Cell Significance Index: 6.0900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.8728
    Cell Significance Index: 14.9200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.7205
    Cell Significance Index: 11.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3982
    Cell Significance Index: 9.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3528
    Cell Significance Index: 19.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2057
    Cell Significance Index: 10.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1777
    Cell Significance Index: 2.5500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1720
    Cell Significance Index: 2.0900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1507
    Cell Significance Index: 1.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1173
    Cell Significance Index: 74.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0946
    Cell Significance Index: 5.9600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0848
    Cell Significance Index: 0.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0830
    Cell Significance Index: 127.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0798
    Cell Significance Index: 108.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0766
    Cell Significance Index: 141.2200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0676
    Cell Significance Index: 0.9900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.0303
    Cell Significance Index: 0.3800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0195
    Cell Significance Index: 0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0065
    Cell Significance Index: 12.2600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0031
    Cell Significance Index: 0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0036
    Cell Significance Index: -2.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0076
    Cell Significance Index: -4.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0084
    Cell Significance Index: -3.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0120
    Cell Significance Index: -4.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0127
    Cell Significance Index: -2.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0139
    Cell Significance Index: -2.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0147
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0147
    Cell Significance Index: -2.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0161
    Cell Significance Index: -0.8100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0163
    Cell Significance Index: -0.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0220
    Cell Significance Index: -3.0200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0221
    Cell Significance Index: -0.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0230
    Cell Significance Index: -4.6200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0243
    Cell Significance Index: -0.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0309
    Cell Significance Index: -3.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0369
    Cell Significance Index: -4.2300
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: -0.0391
    Cell Significance Index: -0.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0440
    Cell Significance Index: -4.5800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0470
    Cell Significance Index: -1.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0523
    Cell Significance Index: -2.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0535
    Cell Significance Index: -3.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0560
    Cell Significance Index: -3.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0648
    Cell Significance Index: -4.3600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0656
    Cell Significance Index: -0.9000
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0679
    Cell Significance Index: -0.7300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0682
    Cell Significance Index: -0.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0767
    Cell Significance Index: -3.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0808
    Cell Significance Index: -2.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0884
    Cell Significance Index: -2.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0898
    Cell Significance Index: -3.9700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0994
    Cell Significance Index: -3.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1004
    Cell Significance Index: -2.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1056
    Cell Significance Index: -4.0000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.1101
    Cell Significance Index: -0.9700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1149
    Cell Significance Index: -1.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1194
    Cell Significance Index: -2.5000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1198
    Cell Significance Index: -1.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1270
    Cell Significance Index: -4.4500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1329
    Cell Significance Index: -1.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1411
    Cell Significance Index: -4.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1469
    Cell Significance Index: -4.6800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1516
    Cell Significance Index: -3.7000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1524
    Cell Significance Index: -4.3500
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.1567
    Cell Significance Index: -1.9700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1590
    Cell Significance Index: -3.9700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1620
    Cell Significance Index: -2.3300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1636
    Cell Significance Index: -2.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1685
    Cell Significance Index: -4.4300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1693
    Cell Significance Index: -4.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1741
    Cell Significance Index: -4.6500
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.1796
    Cell Significance Index: -2.0800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1796
    Cell Significance Index: -4.4800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1823
    Cell Significance Index: -3.7100
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.1834
    Cell Significance Index: -2.2800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1855
    Cell Significance Index: -1.9200
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1855
    Cell Significance Index: -1.6800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1889
    Cell Significance Index: -3.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1898
    Cell Significance Index: -4.1600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1911
    Cell Significance Index: -3.7300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1958
    Cell Significance Index: -3.9100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1976
    Cell Significance Index: -2.6000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2043
    Cell Significance Index: -2.2400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2074
    Cell Significance Index: -4.4800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2079
    Cell Significance Index: -4.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2134
    Cell Significance Index: -4.5300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2149
    Cell Significance Index: -2.8100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2160
    Cell Significance Index: -2.0900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2224
    Cell Significance Index: -2.4300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2241
    Cell Significance Index: -4.5000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2250
    Cell Significance Index: -2.8400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2253
    Cell Significance Index: -2.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2276
    Cell Significance Index: -3.9000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.2293
    Cell Significance Index: -3.7000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2301
    Cell Significance Index: -3.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HMX1 is a homeobox-containing transcription factor, which belongs to the H6 family of homeobox genes. It is characterized by its ability to bind to specific DNA sequences and regulate transcriptional activity. The HMX1 protein is a transcriptional repressor, meaning it inhibits the expression of target genes by interacting with RNA polymerase II and other transcriptional regulators. This repressive function is essential for maintaining cell-specific gene expression patterns and preventing excessive or aberrant transcription. **Pathways and Functions:** HMX1 is involved in various cellular processes, including: 1. **Chromatin remodeling:** HMX1 interacts with chromatin-associated proteins to regulate chromatin structure and transcriptional activity. 2. **RNA polymerase II-specific transcriptional regulation:** HMX1 binds to RNA polymerase II and other transcriptional regulators to inhibit transcriptional initiation and elongation. 3. **Negative regulation of DNA-templated transcription:** HMX1 represses transcription by interacting with transcriptional activators and co-activators, thereby preventing the expression of specific genes. 4. **Nucleus-specific regulation:** HMX1 is localized to the nucleus and regulates transcriptional activity in a cell-type-specific manner. **Clinical Significance:** The dysregulation of HMX1 has been implicated in various diseases, including: 1. **Cancer:** HMX1 is overexpressed in certain types of cancer, such as breast cancer and leukemia, where it promotes tumorigenesis and metastasis. 2. **Autoimmune diseases:** HMX1 has been linked to autoimmune disorders, such as multiple sclerosis, where it contributes to the dysregulation of the immune response. 3. **Neurological disorders:** HMX1 is expressed in the brain and regulates neuronal development and function. Dysregulation of HMX1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the HMX1 gene is a key regulator of transcriptional repression in various cell types. Its dysregulation has been implicated in several diseases, highlighting the importance of HMX1 in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms of HMX1 and its role in human disease.

Genular Protein ID: 2082835424

Symbol: HMX1_HUMAN

Name: Homeobox protein HMX1

UniProtKB Accession Codes:

Q9NP08

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1360670

Title: Identification and genetic mapping of a homeobox gene to the 4p16.1 region of human chromosome 4.

PubMed ID: 1360670

DOI: 10.1073/pnas.89.23.11579

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 10206974

Title: Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site.

PubMed ID: 10206974

DOI: 10.1074/jbc.274.17.11635

PubMed ID: 18423520

Title: Mutation in the human homeobox gene NKX5-3 causes an oculo-auricular syndrome.

PubMed ID: 18423520

DOI: 10.1016/j.ajhg.2008.03.007

Sequence Information:

  • Length: 348
  • Mass: 36155
  • Checksum: 7B2AE7662699B15A
  • Sequence:
    • MPDELTEPGR ATPARASSFL IENLLAAEAK GAGRATQGDG SREDEEEDDD DPEDEDAEQA 
RRRRLQRRRQ LLAGTGPGGE ARARALLGPG ALGLGPRPPP GPGPPFALGC GGAARWYPRA 
HGGYGGGLSP DTSDRDSPET GEEMGRAEGA WPRGPGPGAV QREAAELAAR GPAAGTEEAS 
ELAEVPAAAG ETRGGVGVGG GRKKKTRTVF SRSQVFQLES TFDLKRYLSS AERAGLAASL 
QLTETQVKIW FQNRRNKWKR QLAAELEAAS LSPPGAQRLV RVPVLYHESP PAAAAAGPPA 
TLPFPLAPAA PAPPPPLLGF SGALAYPLAA FPAAASVPFL RAQMPGLV

Genular Protein ID: 933340411

Symbol: F1T0J4_HUMAN

Name: N/A

UniProtKB Accession Codes:

F1T0J4 F8W1B1

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 GO 1 GeneTree 1 HGNC 1 HOGENOM 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

Sequence Information:

  • Length: 190
  • Mass: 20011
  • Checksum: 99315075D5F560DC
  • Sequence:
    • MPDELTEPGR ATPARASSFL IENLLAAEAK GAGRATQGDG SREDEEEDDD DPEDEDAEQA 
RRRRLQRRRQ LLAGTGPGGE ARARALLGPG ALGLGPRPPP GPGPPFALGC GGAARWYPRA 
HGGYGGGLSP DSTQKITPQP VQCGEGQVTR ADKYKVNRSD SGSLWMAEEA AGTGWCSHNT 
VEPLSAWTPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.