Details for: HPX

Gene ID: 3263

Symbol: HPX

Ensembl ID: ENSG00000110169

Description: hemopexin

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 4.45
    Marker Score: 14,565
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.39
    Marker Score: 18,207
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.24
    Marker Score: 14,387
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.2
    Marker Score: 9,486
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.99
    Marker Score: 2,137
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 1.52
    Marker Score: 472
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.11
    Marker Score: 809
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,056
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1
    Marker Score: 2,062
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.96
    Marker Score: 210
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.94
    Marker Score: 258
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,317
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.89
    Marker Score: 605
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.79
    Marker Score: 795
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3,237
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 499
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.63
    Marker Score: 236
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 372
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 446
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 126
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.46
    Marker Score: 1,768
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.45
    Marker Score: 190
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.42
    Marker Score: 791
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.39
    Marker Score: 1,096
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.37
    Marker Score: 282
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.34
    Marker Score: 692
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3
    Marker Score: 4,649
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.26
    Marker Score: 146
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.25
    Marker Score: 94
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.25
    Marker Score: 131
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.24
    Marker Score: 98
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.23
    Marker Score: 139
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.21
    Marker Score: 502
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.21
    Marker Score: 97
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 62
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.21
    Marker Score: 66
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.21
    Marker Score: 712
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.18
    Marker Score: 98
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.17
    Marker Score: 75
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 55
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.16
    Marker Score: 74
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.15
    Marker Score: 58
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.15
    Marker Score: 313
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.14
    Marker Score: 52
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.14
    Marker Score: 83
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.14
    Marker Score: 78
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.13
    Marker Score: 547
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.13
    Marker Score: 183
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.12
    Marker Score: 1,278
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.12
    Marker Score: 218
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.11
    Marker Score: 51
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 98
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.11
    Marker Score: 193
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 97
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.09
    Marker Score: 3,123
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.09
    Marker Score: 62
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.09
    Marker Score: 60
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.09
    Marker Score: 87
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.09
    Marker Score: 756
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 96
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.08
    Marker Score: 704
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.08
    Marker Score: 54
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.08
    Marker Score: 122
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.08
    Marker Score: 149
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.08
    Marker Score: 238

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Heme-binding protein**: HPX has a high affinity for heme, allowing it to bind and transport this iron-rich molecule. 2. **Scavenger receptor**: HPX acts as a scavenger receptor, binding to heme and facilitating its uptake and metabolism. 3. **Antioxidant function**: By binding to heme, HPX prevents its oxidative damage to tissues and cells, thereby maintaining cellular health. 4. **Immune regulatory function**: HPX is involved in regulating immune responses, including the production of immunoglobulins and the activation of immune cells. **Pathways and Functions:** 1. **Heme metabolic process**: HPX regulates the metabolism of heme, preventing its oxidative damage and facilitating its transport and utilization by cells. 2. **Intracellular iron ion homeostasis**: HPX helps maintain iron homeostasis within cells by regulating the uptake and metabolism of heme, which is a rich source of iron. 3. **Positive regulation of humoral immune response**: HPX promotes the production of immunoglobulins, which are essential for humoral immunity. 4. **Positive regulation of type II interferon-mediated signaling pathway**: HPX activates the type II interferon-mediated signaling pathway, which is involved in immune responses against viral infections. 5. **Positive regulation of tyrosine phosphorylation of Stat protein**: HPX regulates the activation of Stat protein, which is a key transcription factor in immune responses. **Clinical Significance:** 1. **Heme-related disorders**: HPX mutations have been associated with heme-related disorders, such as hemolytic anemia and hemochromatosis. 2. **Immune dysfunction**: Abnormalities in HPX expression or function may contribute to immune dysfunction, including impaired humoral immunity and increased susceptibility to infections. 3. **Cancer**: HPX has been implicated in cancer, as it may play a role in regulating iron homeostasis and promoting tumor growth. 4. **Inflammatory diseases**: HPX may also play a role in inflammatory diseases, such as atherosclerosis and rheumatoid arthritis, by regulating immune responses and promoting inflammation. In conclusion, HPX is a critical regulator of heme homeostasis and immune function, and its dysregulation may contribute to various diseases, including heme-related disorders, immune dysfunction, and inflammatory diseases. Further research is needed to fully elucidate the role of HPX in human health and disease.

Genular Protein ID: 1910631548

Symbol: HEMO_HUMAN

Name: Hemopexin

UniProtKB Accession Codes:

P02790 B2R957

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 CarbonylDB 1 ChEBI 8 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 3 EMBL 9 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2842511

Title: Structure of the human hemopexin gene and evidence for intron-mediated evolution.

PubMed ID: 2842511

DOI: 10.1007/bf02138368

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 3220477

Title: The hemopexin gene maps to the same location as the beta-globin gene cluster on human chromosome 11.

PubMed ID: 3220477

DOI: 10.1016/0888-7543(88)90158-9

PubMed ID: 2989777

Title: The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology.

PubMed ID: 2989777

DOI: 10.1093/nar/13.11.3841

PubMed ID: 3855550

Title: Complete amino acid sequence of human hemopexin, the heme-binding protein of serum.

PubMed ID: 3855550

DOI: 10.1073/pnas.82.1.73

PubMed ID: 6510521

Title: Amino acid sequence of the N-terminal region of human hemopexin.

PubMed ID: 6510521

DOI: 10.1016/0014-5793(84)80603-1

PubMed ID: 6371807

Title: Structure of human hemopexin: O-glycosyl and N-glycosyl sites and unusual clustering of tryptophan residues.

PubMed ID: 6371807

DOI: 10.1073/pnas.81.7.2021

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 18211098

Title: The ORF3 protein of hepatitis E virus interacts with hemopexin by means of its 26 amino acid N-terminal hydrophobic domain II.

PubMed ID: 18211098

DOI: 10.1021/bi7016552

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 20610401

Title: Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin.

PubMed ID: 20610401

DOI: 10.1074/jbc.m110.119131

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 462
  • Mass: 51676
  • Checksum: 054B44D0603763B8
  • Sequence:
    • MARVLGAPVA LGLWSLCWSL AIATPLPPTS AHGNVAEGET KPDPDVTERC SDGWSFDATT 
LDDNGTMLFF KGEFVWKSHK WDRELISERW KNFPSPVDAA FRQGHNSVFL IKGDKVWVYP 
PEKKEKGYPK LLQDEFPGIP SPLDAAVECH RGECQAEGVL FFQGDREWFW DLATGTMKER 
SWPAVGNCSS ALRWLGRYYC FQGNQFLRFD PVRGEVPPRY PRDVRDYFMP CPGRGHGHRN 
GTGHGNSTHH GPEYMRCSPH LVLSALTSDN HGATYAFSGT HYWRLDTSRD GWHSWPIAHQ 
WPQGPSAVDA AFSWEEKLYL VQGTQVYVFL TKGGYTLVSG YPKRLEKEVG TPHGIILDSV 
DAAFICPGSS RLHIMAGRRL WWLDLKSGAQ ATWTELPWPH EKVDGALCME KSLGPNSCSA 
NGPGLYLIHG PNLYCYSDVE KLNAAKALPQ PQNVTSLLGC TH

Genular Protein ID: 3921507316

Symbol: Q9BS19_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BS19

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 Gene3D 1 GenomeRNAi 1 HOGENOM 1 InterPro 4 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 254
  • Mass: 28630
  • Checksum: C935C273FF6B21BA
  • Sequence:
    • MARVLGAPVA LGLWSLCWSL AIATPLPPTS AHGNVAEGET KPDPDVTERC SDGWSFDATT 
LDDNGTMLFF KGEFVWKSHK WDRELISERW KNFPSPVDAA FRQGHNSVFL IKGDKVWVYP 
PEKKEKGYPK LLQDEFPGIP SPLDAAVECH RGECQAEGVL FFQGDREWFW DLATGTMKER 
SWPAVGNCSS ALRWLGRYYC FQGNQFLRFD PVRGEVPPRY PRDVRDYFMP CPGRGHGHRN 
GTGHGNSICA VAHI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.