Details for: HPX

Gene ID: 3263

Symbol: HPX

Ensembl ID: ENSG00000110169

Description: hemopexin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 45.5126
    Cell Significance Index: 120.0600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 18.8646
    Cell Significance Index: 317.2900
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 6.1428
    Cell Significance Index: 3.0900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 6.0054
    Cell Significance Index: 101.1600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.0417
    Cell Significance Index: 30.1400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.2187
    Cell Significance Index: 7.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2163
    Cell Significance Index: 241.3700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.2112
    Cell Significance Index: 6.9800
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.0739
    Cell Significance Index: 10.6000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.0452
    Cell Significance Index: 2.8000
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.8451
    Cell Significance Index: 2.9400
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.6150
    Cell Significance Index: 4.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4550
    Cell Significance Index: 33.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2448
    Cell Significance Index: 5.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.1685
    Cell Significance Index: 10.3300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1483
    Cell Significance Index: 1.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1308
    Cell Significance Index: 24.8900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1193
    Cell Significance Index: 1.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0868
    Cell Significance Index: 1.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0723
    Cell Significance Index: 2.5400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0689
    Cell Significance Index: 0.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0601
    Cell Significance Index: 1.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0508
    Cell Significance Index: 1.3600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0331
    Cell Significance Index: 0.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0278
    Cell Significance Index: 0.8000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.0277
    Cell Significance Index: 0.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0264
    Cell Significance Index: 5.2900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.0239
    Cell Significance Index: 0.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0216
    Cell Significance Index: 19.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0158
    Cell Significance Index: 5.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0153
    Cell Significance Index: 0.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0128
    Cell Significance Index: 0.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0108
    Cell Significance Index: 1.1800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.0107
    Cell Significance Index: 0.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0104
    Cell Significance Index: 0.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0102
    Cell Significance Index: 1.6700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0097
    Cell Significance Index: 0.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0081
    Cell Significance Index: 0.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0080
    Cell Significance Index: 1.4500
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.0076
    Cell Significance Index: 0.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0074
    Cell Significance Index: 0.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0072
    Cell Significance Index: 0.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0071
    Cell Significance Index: 0.8700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0050
    Cell Significance Index: 0.0600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0049
    Cell Significance Index: 0.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0040
    Cell Significance Index: 0.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0039
    Cell Significance Index: 0.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0039
    Cell Significance Index: 0.5000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0022
    Cell Significance Index: 0.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0009
    Cell Significance Index: 0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0024
    Cell Significance Index: -1.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0025
    Cell Significance Index: -1.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0026
    Cell Significance Index: -1.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0028
    Cell Significance Index: -1.5800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0028
    Cell Significance Index: -0.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0031
    Cell Significance Index: -2.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0032
    Cell Significance Index: -0.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0034
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0035
    Cell Significance Index: -0.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0036
    Cell Significance Index: -0.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0038
    Cell Significance Index: -0.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0040
    Cell Significance Index: -0.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0043
    Cell Significance Index: -1.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0063
    Cell Significance Index: -0.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0072
    Cell Significance Index: -0.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0074
    Cell Significance Index: -0.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0078
    Cell Significance Index: -0.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0078
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0091
    Cell Significance Index: -1.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0111
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0117
    Cell Significance Index: -1.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0149
    Cell Significance Index: -0.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0167
    Cell Significance Index: -1.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0169
    Cell Significance Index: -0.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0174
    Cell Significance Index: -1.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0176
    Cell Significance Index: -0.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0178
    Cell Significance Index: -0.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0183
    Cell Significance Index: -1.9100
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0205
    Cell Significance Index: -0.2200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0208
    Cell Significance Index: -0.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0222
    Cell Significance Index: -0.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0225
    Cell Significance Index: -1.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0236
    Cell Significance Index: -1.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0239
    Cell Significance Index: -1.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0257
    Cell Significance Index: -1.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0301
    Cell Significance Index: -0.4100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0332
    Cell Significance Index: -0.5000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0347
    Cell Significance Index: -0.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0358
    Cell Significance Index: -0.9200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0367
    Cell Significance Index: -0.3800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0367
    Cell Significance Index: -1.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0374
    Cell Significance Index: -1.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0378
    Cell Significance Index: -2.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0383
    Cell Significance Index: -1.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Heme-binding protein**: HPX has a high affinity for heme, allowing it to bind and transport this iron-rich molecule. 2. **Scavenger receptor**: HPX acts as a scavenger receptor, binding to heme and facilitating its uptake and metabolism. 3. **Antioxidant function**: By binding to heme, HPX prevents its oxidative damage to tissues and cells, thereby maintaining cellular health. 4. **Immune regulatory function**: HPX is involved in regulating immune responses, including the production of immunoglobulins and the activation of immune cells. **Pathways and Functions:** 1. **Heme metabolic process**: HPX regulates the metabolism of heme, preventing its oxidative damage and facilitating its transport and utilization by cells. 2. **Intracellular iron ion homeostasis**: HPX helps maintain iron homeostasis within cells by regulating the uptake and metabolism of heme, which is a rich source of iron. 3. **Positive regulation of humoral immune response**: HPX promotes the production of immunoglobulins, which are essential for humoral immunity. 4. **Positive regulation of type II interferon-mediated signaling pathway**: HPX activates the type II interferon-mediated signaling pathway, which is involved in immune responses against viral infections. 5. **Positive regulation of tyrosine phosphorylation of Stat protein**: HPX regulates the activation of Stat protein, which is a key transcription factor in immune responses. **Clinical Significance:** 1. **Heme-related disorders**: HPX mutations have been associated with heme-related disorders, such as hemolytic anemia and hemochromatosis. 2. **Immune dysfunction**: Abnormalities in HPX expression or function may contribute to immune dysfunction, including impaired humoral immunity and increased susceptibility to infections. 3. **Cancer**: HPX has been implicated in cancer, as it may play a role in regulating iron homeostasis and promoting tumor growth. 4. **Inflammatory diseases**: HPX may also play a role in inflammatory diseases, such as atherosclerosis and rheumatoid arthritis, by regulating immune responses and promoting inflammation. In conclusion, HPX is a critical regulator of heme homeostasis and immune function, and its dysregulation may contribute to various diseases, including heme-related disorders, immune dysfunction, and inflammatory diseases. Further research is needed to fully elucidate the role of HPX in human health and disease.

Genular Protein ID: 1910631548

Symbol: HEMO_HUMAN

Name: Hemopexin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2842511

Title: Structure of the human hemopexin gene and evidence for intron-mediated evolution.

PubMed ID: 2842511

DOI: 10.1007/bf02138368

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 3220477

Title: The hemopexin gene maps to the same location as the beta-globin gene cluster on human chromosome 11.

PubMed ID: 3220477

DOI: 10.1016/0888-7543(88)90158-9

PubMed ID: 2989777

Title: The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology.

PubMed ID: 2989777

DOI: 10.1093/nar/13.11.3841

PubMed ID: 3855550

Title: Complete amino acid sequence of human hemopexin, the heme-binding protein of serum.

PubMed ID: 3855550

DOI: 10.1073/pnas.82.1.73

PubMed ID: 6510521

Title: Amino acid sequence of the N-terminal region of human hemopexin.

PubMed ID: 6510521

DOI: 10.1016/0014-5793(84)80603-1

PubMed ID: 6371807

Title: Structure of human hemopexin: O-glycosyl and N-glycosyl sites and unusual clustering of tryptophan residues.

PubMed ID: 6371807

DOI: 10.1073/pnas.81.7.2021

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 18211098

Title: The ORF3 protein of hepatitis E virus interacts with hemopexin by means of its 26 amino acid N-terminal hydrophobic domain II.

PubMed ID: 18211098

DOI: 10.1021/bi7016552

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 20610401

Title: Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin.

PubMed ID: 20610401

DOI: 10.1074/jbc.m110.119131

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 462
  • Mass: 51676
  • Checksum: 054B44D0603763B8
  • Sequence:
  • MARVLGAPVA LGLWSLCWSL AIATPLPPTS AHGNVAEGET KPDPDVTERC SDGWSFDATT 
    LDDNGTMLFF KGEFVWKSHK WDRELISERW KNFPSPVDAA FRQGHNSVFL IKGDKVWVYP 
    PEKKEKGYPK LLQDEFPGIP SPLDAAVECH RGECQAEGVL FFQGDREWFW DLATGTMKER 
    SWPAVGNCSS ALRWLGRYYC FQGNQFLRFD PVRGEVPPRY PRDVRDYFMP CPGRGHGHRN 
    GTGHGNSTHH GPEYMRCSPH LVLSALTSDN HGATYAFSGT HYWRLDTSRD GWHSWPIAHQ 
    WPQGPSAVDA AFSWEEKLYL VQGTQVYVFL TKGGYTLVSG YPKRLEKEVG TPHGIILDSV 
    DAAFICPGSS RLHIMAGRRL WWLDLKSGAQ ATWTELPWPH EKVDGALCME KSLGPNSCSA 
    NGPGLYLIHG PNLYCYSDVE KLNAAKALPQ PQNVTSLLGC TH

Genular Protein ID: 3921507316

Symbol: Q9BS19_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 254
  • Mass: 28630
  • Checksum: C935C273FF6B21BA
  • Sequence:
  • MARVLGAPVA LGLWSLCWSL AIATPLPPTS AHGNVAEGET KPDPDVTERC SDGWSFDATT 
    LDDNGTMLFF KGEFVWKSHK WDRELISERW KNFPSPVDAA FRQGHNSVFL IKGDKVWVYP 
    PEKKEKGYPK LLQDEFPGIP SPLDAAVECH RGECQAEGVL FFQGDREWFW DLATGTMKER 
    SWPAVGNCSS ALRWLGRYYC FQGNQFLRFD PVRGEVPPRY PRDVRDYFMP CPGRGHGHRN 
    GTGHGNSICA VAHI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.