Details for: HTR1D

Gene ID: 3352

Symbol: HTR1D

Ensembl ID: ENSG00000179546

Description: 5-hydroxytryptamine receptor 1D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1630
    Cell Significance Index: 37.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9837
    Cell Significance Index: 44.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8005
    Cell Significance Index: 152.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4442
    Cell Significance Index: 26.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4329
    Cell Significance Index: 42.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3659
    Cell Significance Index: 330.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3620
    Cell Significance Index: 7.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3343
    Cell Significance Index: 36.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3086
    Cell Significance Index: 8.8900
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.2862
    Cell Significance Index: 2.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2264
    Cell Significance Index: 36.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1821
    Cell Significance Index: 12.6000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1784
    Cell Significance Index: 2.5400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.1430
    Cell Significance Index: 1.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1177
    Cell Significance Index: 2.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1032
    Cell Significance Index: 20.4800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1024
    Cell Significance Index: 1.7500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0844
    Cell Significance Index: 1.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0705
    Cell Significance Index: 1.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0629
    Cell Significance Index: 2.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0626
    Cell Significance Index: 3.2500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0541
    Cell Significance Index: 0.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0304
    Cell Significance Index: 0.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0099
    Cell Significance Index: 6.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0088
    Cell Significance Index: 0.2200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0083
    Cell Significance Index: 0.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0021
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0032
    Cell Significance Index: -2.4000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0033
    Cell Significance Index: -0.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0036
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0038
    Cell Significance Index: -0.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0039
    Cell Significance Index: -2.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0061
    Cell Significance Index: -1.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0063
    Cell Significance Index: -2.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0066
    Cell Significance Index: -1.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0074
    Cell Significance Index: -0.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0083
    Cell Significance Index: -1.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0094
    Cell Significance Index: -1.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0095
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0119
    Cell Significance Index: -2.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0125
    Cell Significance Index: -0.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0162
    Cell Significance Index: -2.2200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0171
    Cell Significance Index: -0.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0197
    Cell Significance Index: -0.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0208
    Cell Significance Index: -2.5600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0216
    Cell Significance Index: -0.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0330
    Cell Significance Index: -1.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0355
    Cell Significance Index: -2.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0376
    Cell Significance Index: -2.5300
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0382
    Cell Significance Index: -0.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0442
    Cell Significance Index: -2.4800
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0475
    Cell Significance Index: -0.5900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0500
    Cell Significance Index: -0.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0502
    Cell Significance Index: -1.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0522
    Cell Significance Index: -2.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0537
    Cell Significance Index: -1.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0585
    Cell Significance Index: -2.0500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0613
    Cell Significance Index: -1.5300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0632
    Cell Significance Index: -0.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0632
    Cell Significance Index: -1.2500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0673
    Cell Significance Index: -0.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0682
    Cell Significance Index: -0.9300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0703
    Cell Significance Index: -1.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0712
    Cell Significance Index: -1.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0741
    Cell Significance Index: -2.3600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0748
    Cell Significance Index: -1.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0753
    Cell Significance Index: -1.7400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0757
    Cell Significance Index: -0.9800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0760
    Cell Significance Index: -1.2200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0761
    Cell Significance Index: -0.9600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0779
    Cell Significance Index: -1.1200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0801
    Cell Significance Index: -2.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0811
    Cell Significance Index: -2.1700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0825
    Cell Significance Index: -0.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0870
    Cell Significance Index: -2.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0886
    Cell Significance Index: -2.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0887
    Cell Significance Index: -1.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0892
    Cell Significance Index: -2.5500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0894
    Cell Significance Index: -0.6500
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0894
    Cell Significance Index: -1.0800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0895
    Cell Significance Index: -1.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0913
    Cell Significance Index: -2.1900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0923
    Cell Significance Index: -1.3500
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0932
    Cell Significance Index: -1.1700
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0934
    Cell Significance Index: -1.0000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0945
    Cell Significance Index: -2.0100
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0957
    Cell Significance Index: -1.3100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0960
    Cell Significance Index: -1.2600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0977
    Cell Significance Index: -1.3400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0982
    Cell Significance Index: -1.5900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0992
    Cell Significance Index: -1.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0993
    Cell Significance Index: -2.6100
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1028
    Cell Significance Index: -1.3000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1048
    Cell Significance Index: -1.1100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1048
    Cell Significance Index: -1.3300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1049
    Cell Significance Index: -1.1500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1053
    Cell Significance Index: -1.6000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1055
    Cell Significance Index: -2.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor Structure:** HTR1D is a rhodopsin-like receptor, comprising seven transmembrane domains and an extracellular N-terminus with a highly conserved 5-HT binding site. 2. **Serotonin Ligand Binding:** HTR1D is a selective serotonin receptor, meaning it responds specifically to the neurotransmitter 5-hydroxytryptamine (5-HT or serotonin). 3. **G-Protein Coupling:** Upon serotonin binding, HTR1D activates Gαi proteins, leading to the inhibition of adenylate cyclase and subsequent reduction in cAMP levels. 4. **Signaling Pathways:** HTR1D's activation triggers a cascade of downstream signaling events, including the inhibition of adenylate cyclase, modulation of ion channels, and regulation of gene expression. **Pathways and Functions:** 1. **Neurotransmission and Behavior:** HTR1D plays a crucial role in modulating neurotransmission, particularly in the regulation of locomotion, anxiety, and fear responses. 2. **Immune Response:** HTR1D is expressed on immune cells, including B cells and GABAergic interneurons, and has been implicated in the regulation of immune cell function and cytokine production. 3. **Intestinal Function:** HTR1D is expressed in the gastrointestinal tract, where it regulates intestinal smooth muscle contraction, gut motility, and secretion. 4. **Cognitive Function:** HTR1D has been linked to cognitive processes, including attention, memory, and learning, suggesting a potential role in neurodegenerative diseases. **Clinical Significance:** 1. **Migraine Pathophysiology:** HTR1D has been implicated in the pathophysiology of migraines, with studies suggesting that its activation contributes to the development of migraine headaches. 2. **Neurodegenerative Diseases:** HTR1D's role in regulating neurotransmission and immune response has led to its investigation as a potential therapeutic target for neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Immune-Mediated Disorders:** HTR1D's expression on immune cells has raised interest in its potential role in immune-mediated disorders, including autoimmune diseases and inflammatory conditions. 4. **Psychiatric Disorders:** HTR1D's involvement in regulating behavior and neurotransmission has led to its investigation as a potential therapeutic target for psychiatric disorders, including depression, anxiety, and schizophrenia. In conclusion, HTR1D's complex structure, signaling pathways, and clinical implications make it an intriguing target for further research and potential therapeutic applications. As an expert immunologist, it is essential to continue exploring the multifaceted roles of HTR1D in human health and disease to unlock its full therapeutic potential.

Genular Protein ID: 3571295775

Symbol: 5HT1D_HUMAN

Name: N/A

UniProtKB Accession Codes:

P28221

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 3 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 40 DrugCentral 1 EMBL 6 Ensembl 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1652050

Title: Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.

PubMed ID: 1652050

PubMed ID: 1565658

Title: Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.

PubMed ID: 1565658

DOI: 10.1073/pnas.89.8.3630

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1828434

Title: Postsynaptic localization of 5-HT1D receptor binding sites in human caudate.

PubMed ID: 1828434

DOI: 10.1016/0014-4886(91)90142-y

PubMed ID: 10452531

Title: Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed.

PubMed ID: 10452531

DOI: 10.1016/s0014-5793(99)00918-7

PubMed ID: 18476671

Title: Serotonin receptors.

PubMed ID: 18476671

DOI: 10.1021/cr078224o

PubMed ID: 20945968

Title: Serotonin receptors - from molecular biology to clinical applications.

PubMed ID: 20945968

DOI: 10.33549/physiolres.931903

PubMed ID: 33762731

Title: Structural insights into the lipid and ligand regulation of serotonin receptors.

PubMed ID: 33762731

DOI: 10.1038/s41586-021-03376-8

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 377
  • Mass: 41907
  • Checksum: 0A4FCF81FFE2322A
  • Sequence:
    • MSPLNQSAEG LPQEASNRSL NATETSEAWD PRTLQALKIS LAVVLSVITL ATVLSNAFVL 
TTILLTRKLH TPANYLIGSL ATTDLLVSIL VMPISIAYTI THTWNFGQIL CDIWLSSDIT 
CCTASILHLC VIALDRYWAI TDALEYSKRR TAGHAATMIA IVWAISICIS IPPLFWRQAK 
AQEEMSDCLV NTSQISYTIY STCGAFYIPS VLLIILYGRI YRAARNRILN PPSLYGKRFT 
TAHLITGSAG SSLCSLNSSL HEGHSHSAGS PLFFNHVKIK LADSALERKR ISAARERKAT 
KILGIILGAF IICWLPFFVV SLVLPICRDS CWIHPALFDF FTWLGYLNSL INPIIYTVFN 
EEFRQAFQKI VPFRKAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.