Details for: HTR1D

Gene ID: 3352

Symbol: HTR1D

Ensembl ID: ENSG00000179546

Description: 5-hydroxytryptamine receptor 1D

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.18
    Marker Score: 2196.5
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.73
    Marker Score: 1718
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.47
    Marker Score: 1462
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.28
    Marker Score: 1217
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7681
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 507
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.07
    Marker Score: 443.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.06
    Marker Score: 718
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5336
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.91
    Marker Score: 1484
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 489
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.82
    Marker Score: 1547
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1184
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2967
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 498
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.6
    Marker Score: 334
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1208
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.59
    Marker Score: 661
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.53
    Marker Score: 8315
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.45
    Marker Score: 2719
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 269
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.41
    Marker Score: 634.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.31
    Marker Score: 148
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 158
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.24
    Marker Score: 105
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.23
    Marker Score: 390
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.22
    Marker Score: 124
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.18
    Marker Score: 874
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 39
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.15
    Marker Score: 81
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.15
    Marker Score: 190
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.14
    Marker Score: 177
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.13
    Marker Score: 1129
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.13
    Marker Score: 88
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.11
    Marker Score: 105
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.1
    Marker Score: 137
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.09
    Marker Score: 228
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.09
    Marker Score: 54
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.09
    Marker Score: 93
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.07
    Marker Score: 86
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.07
    Marker Score: 112
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.06
    Marker Score: 44
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.05
    Marker Score: 93
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.05
    Marker Score: 214
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.05
    Marker Score: 104
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 42
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.05
    Marker Score: 909
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.04
    Marker Score: 43
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.04
    Marker Score: 596
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.04
    Marker Score: 105
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.04
    Marker Score: 53
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.04
    Marker Score: 176
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.04
    Marker Score: 129
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.04
    Marker Score: 217

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Other Information

**Key characteristics:** * HTR1D is a single-pass membrane protein with a molecular weight of approximately 140 kDa. * It is expressed in a variety of cell types, including blood vessel endothelial cells, type B pancreatic cells, colon goblet cells, enterocytes of the epithelium of large intestine, B cells, goblet cells, transit amplifying cells of colon, and transit amplifying cells of small intestine. * It is a ligand-gated ion channel, meaning that it opens or closes in response to the binding of a specific ligand. **Pathways and functions:** * HTR1D is a key regulator of the adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway, which is involved in a variety of cellular processes, including blood pressure regulation, heart rate regulation, and digestion. * It is also a key regulator of the Adenylate cyclase-inhibiting serotonin receptor signaling pathway, which is involved in regulating mood and behavior. * It is a ligand-gated ion channel that is expressed in the plasma membrane of blood vessel endothelial cells and can open in response to the binding of the neurotransmitter serotonin. This can lead to vasodilation and increased blood flow, which can be beneficial in conditions such as stroke and heart attack. **Clinical significance:** * Mutations in the HTR1D gene have been linked to a number of human diseases, including hypertension, heart failure, and depression. * HTR1D inhibitors are being developed as potential treatments for these diseases.

Genular Protein ID: 3571295775

Symbol: 5HT1D_HUMAN

Name: 5-hydroxytryptamine receptor 1D

UniProtKB Accession Codes:

P28221

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 3 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 40 DrugCentral 1 EMBL 6 Ensembl 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1652050

Title: Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.

PubMed ID: 1652050

PubMed ID: 1565658

Title: Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.

PubMed ID: 1565658

DOI: 10.1073/pnas.89.8.3630

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1828434

Title: Postsynaptic localization of 5-HT1D receptor binding sites in human caudate.

PubMed ID: 1828434

DOI: 10.1016/0014-4886(91)90142-y

PubMed ID: 10452531

Title: Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed.

PubMed ID: 10452531

DOI: 10.1016/s0014-5793(99)00918-7

PubMed ID: 18476671

Title: Serotonin receptors.

PubMed ID: 18476671

DOI: 10.1021/cr078224o

PubMed ID: 20945968

Title: Serotonin receptors - from molecular biology to clinical applications.

PubMed ID: 20945968

DOI: 10.33549/physiolres.931903

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 377
  • Mass: 41907
  • Checksum: 0A4FCF81FFE2322A
  • Sequence:
    • MSPLNQSAEG LPQEASNRSL NATETSEAWD PRTLQALKIS LAVVLSVITL ATVLSNAFVL 
TTILLTRKLH TPANYLIGSL ATTDLLVSIL VMPISIAYTI THTWNFGQIL CDIWLSSDIT 
CCTASILHLC VIALDRYWAI TDALEYSKRR TAGHAATMIA IVWAISICIS IPPLFWRQAK 
AQEEMSDCLV NTSQISYTIY STCGAFYIPS VLLIILYGRI YRAARNRILN PPSLYGKRFT 
TAHLITGSAG SSLCSLNSSL HEGHSHSAGS PLFFNHVKIK LADSALERKR ISAARERKAT 
KILGIILGAF IICWLPFFVV SLVLPICRDS CWIHPALFDF FTWLGYLNSL INPIIYTVFN 
EEFRQAFQKI VPFRKAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.