Details for: HTR2A

Gene ID: 3356

Symbol: HTR2A

Ensembl ID: ENSG00000102468

Description: 5-hydroxytryptamine receptor 2A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.1672
    Cell Significance Index: -11.7100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 10.4046
    Cell Significance Index: 167.3000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.7723
    Cell Significance Index: -9.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9146
    Cell Significance Index: 384.0600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.3300
    Cell Significance Index: 20.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.1054
    Cell Significance Index: 160.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8876
    Cell Significance Index: 21.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6949
    Cell Significance Index: 19.8300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.4700
    Cell Significance Index: 6.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2579
    Cell Significance Index: 92.5200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1982
    Cell Significance Index: 3.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1947
    Cell Significance Index: 134.6700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.1928
    Cell Significance Index: 2.2200
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: 0.1885
    Cell Significance Index: 1.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1290
    Cell Significance Index: 81.9600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1009
    Cell Significance Index: 1.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0638
    Cell Significance Index: 2.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0193
    Cell Significance Index: 36.2500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0032
    Cell Significance Index: 0.0300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0057
    Cell Significance Index: -0.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0070
    Cell Significance Index: -12.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0089
    Cell Significance Index: -13.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0105
    Cell Significance Index: -14.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0148
    Cell Significance Index: -11.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0154
    Cell Significance Index: -7.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0166
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0173
    Cell Significance Index: -12.7900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0213
    Cell Significance Index: -0.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0220
    Cell Significance Index: -12.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0224
    Cell Significance Index: -12.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0240
    Cell Significance Index: -14.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0265
    Cell Significance Index: -3.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0278
    Cell Significance Index: -8.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0488
    Cell Significance Index: -8.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0514
    Cell Significance Index: -10.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0623
    Cell Significance Index: -13.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0720
    Cell Significance Index: -12.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0747
    Cell Significance Index: -9.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0777
    Cell Significance Index: -10.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0797
    Cell Significance Index: -10.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0798
    Cell Significance Index: -1.9900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0894
    Cell Significance Index: -1.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0932
    Cell Significance Index: -3.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0987
    Cell Significance Index: -11.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1074
    Cell Significance Index: -2.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1099
    Cell Significance Index: -11.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1108
    Cell Significance Index: -11.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1142
    Cell Significance Index: -13.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1203
    Cell Significance Index: -5.6100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1212
    Cell Significance Index: -1.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1347
    Cell Significance Index: -3.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1361
    Cell Significance Index: -10.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1395
    Cell Significance Index: -10.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1475
    Cell Significance Index: -11.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1561
    Cell Significance Index: -9.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1646
    Cell Significance Index: -8.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1700
    Cell Significance Index: -4.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1701
    Cell Significance Index: -8.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1701
    Cell Significance Index: -3.5600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1749
    Cell Significance Index: -2.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1753
    Cell Significance Index: -6.6400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1931
    Cell Significance Index: -1.8300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1965
    Cell Significance Index: -4.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1988
    Cell Significance Index: -6.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2004
    Cell Significance Index: -5.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2022
    Cell Significance Index: -9.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2041
    Cell Significance Index: -7.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2080
    Cell Significance Index: -11.6700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2303
    Cell Significance Index: -4.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2341
    Cell Significance Index: -10.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2431
    Cell Significance Index: -4.8800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2488
    Cell Significance Index: -4.9200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2917
    Cell Significance Index: -4.2400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2933
    Cell Significance Index: -3.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3191
    Cell Significance Index: -9.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3200
    Cell Significance Index: -11.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3338
    Cell Significance Index: -9.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3376
    Cell Significance Index: -5.6500
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.3377
    Cell Significance Index: -2.5900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3465
    Cell Significance Index: -6.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3529
    Cell Significance Index: -12.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3553
    Cell Significance Index: -9.5200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3562
    Cell Significance Index: -6.9700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3788
    Cell Significance Index: -6.5500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3819
    Cell Significance Index: -7.9700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3898
    Cell Significance Index: -9.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3942
    Cell Significance Index: -10.5500
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.3993
    Cell Significance Index: -4.3100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4040
    Cell Significance Index: -8.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4062
    Cell Significance Index: -14.9100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.4178
    Cell Significance Index: -6.0900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4180
    Cell Significance Index: -10.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4217
    Cell Significance Index: -11.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4286
    Cell Significance Index: -11.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4288
    Cell Significance Index: -12.3600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4491
    Cell Significance Index: -5.5700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4493
    Cell Significance Index: -5.6700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4600
    Cell Significance Index: -11.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4603
    Cell Significance Index: -10.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The HTR2A receptor is a type of G protein-coupled receptor that belongs to the class A/1 (rhodopsin-like receptors) family. It is characterized by its high affinity for serotonin (5-HT) and other ligands, such as 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine. The receptor is activated by serotonin binding, which triggers a cascade of intracellular signaling events that modulate various cellular processes. Some key characteristics of the HTR2A receptor include: * High affinity for serotonin and other ligands * Activation of phospholipase C activity and subsequent signaling events * Involvement in various physiological processes, including pain perception, temperature regulation, and vascular tone * Expression in the brain and other tissues, including the kidney, conventional dendritic cells, and granulocyte monocyte progenitor cells **Pathways and Functions** The HTR2A receptor is involved in various signaling pathways that regulate cellular processes. Some of the key pathways and functions of the HTR2A receptor include: * Phospholipase C-activating G protein-coupled receptor signaling pathway * Gq/11-coupled serotonin receptor activity * Phosphatidylinositol 3-kinase/protein kinase B signal transduction * Phospholipase C-activating serotonin receptor signaling pathway * Signaling by G protein-coupled receptors * Regulation of dopamine secretion * Release of sequestered calcium ion into the cytosol * Positive regulation of cytosolic calcium ion concentration * Positive regulation of Erk1 and Erk2 cascade * Positive regulation of fat cell differentiation * Positive regulation of glycolytic process **Clinical Significance** The HTR2A receptor has been implicated in various neuropsychiatric disorders, including schizophrenia, bipolar disorder, and depression. Dysregulation of the HTR2A receptor has been associated with altered serotonin signaling, which can lead to changes in mood, appetite, sleep, and pain perception. Some of the clinical significance of the HTR2A receptor includes: * Treatment of schizophrenia and bipolar disorder with serotonin receptor antagonists, such as risperidone and olanzapine * Use of antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), to regulate serotonin signaling * Investigation of the role of the HTR2A receptor in pain perception and temperature regulation * Development of novel therapeutic strategies to target the HTR2A receptor in the treatment of neuropsychiatric disorders In conclusion, the HTR2A gene encodes for a G protein-coupled receptor that plays a crucial role in various physiological and pathological processes. Its dysregulation has been implicated in several neuropsychiatric disorders, and its clinical significance is reflected in the development of various therapeutic strategies to target the HTR2A receptor.

Genular Protein ID: 1372994321

Symbol: 5HT2A_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1722404

Title: Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes.

PubMed ID: 1722404

DOI: 10.1016/0006-291x(91)92105-s

PubMed ID: 1323014

Title: The human 5-HT2 receptor is encoded by a multiple intron-exon gene.

PubMed ID: 1323014

DOI: 10.1016/0169-328x(92)90005-v

PubMed ID: 8035173

Title: Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor.

PubMed ID: 8035173

DOI: 10.1046/j.1471-4159.1994.63020465.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1330647

Title: Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes.

PubMed ID: 1330647

DOI: 10.1016/0922-4106(92)90123-d

PubMed ID: 11150294

Title: Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1.

PubMed ID: 11150294

DOI: 10.1074/jbc.m008089200

PubMed ID: 14988405

Title: The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins.

PubMed ID: 14988405

DOI: 10.1074/jbc.m312106200

PubMed ID: 18476671

Title: Serotonin receptors.

PubMed ID: 18476671

DOI: 10.1021/cr078224o

PubMed ID: 18703043

Title: Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells.

PubMed ID: 18703043

DOI: 10.1016/j.ejphar.2008.07.040

PubMed ID: 18297054

Title: Identification of a serotonin/glutamate receptor complex implicated in psychosis.

PubMed ID: 18297054

DOI: 10.1038/nature06612

PubMed ID: 19057895

Title: Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors.

PubMed ID: 19057895

DOI: 10.1007/s00210-008-0378-4

PubMed ID: 21645528

Title: Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors.

PubMed ID: 21645528

DOI: 10.1016/j.neuropharm.2011.05.023

PubMed ID: 20945968

Title: Serotonin receptors - from molecular biology to clinical applications.

PubMed ID: 20945968

DOI: 10.33549/physiolres.931903

PubMed ID: 22300836

Title: Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades.

PubMed ID: 22300836

DOI: 10.1016/j.neuropharm.2012.01.010

PubMed ID: 24637012

Title: Quantitative phosphoproteomics unravels biased phosphorylation of serotonin 2A receptor at Ser280 by hallucinogenic versus nonhallucinogenic agonists.

PubMed ID: 24637012

DOI: 10.1074/mcp.m113.036558

PubMed ID: 24089568

Title: 5-HT2 receptors facilitate JC polyomavirus entry.

PubMed ID: 24089568

DOI: 10.1128/jvi.02252-13

PubMed ID: 28129538

Title: Crystal structure of an LSD-bound human serotonin receptor.

PubMed ID: 28129538

DOI: 10.1016/j.cell.2016.12.033

PubMed ID: 36171289

Title: Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity.

PubMed ID: 36171289

DOI: 10.1038/s41586-022-05258-z

PubMed ID: 35084960

Title: Structure-based discovery of nonhallucinogenic psychedelic analogs.

PubMed ID: 35084960

DOI: 10.1126/science.abl8615

PubMed ID: 38552625

Title: Flexible scaffold-based cheminformatics approach for polypharmacological drug design.

PubMed ID: 38552625

DOI: 10.1016/j.cell.2024.02.034

PubMed ID: 8655141

Title: Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia.

PubMed ID: 8655141

DOI: 10.1007/bf02281871

PubMed ID: 10581480

Title: Unified approach to the analysis of genetic variation in serotonergic pathways.

PubMed ID: 10581480

DOI: 10.1002/(sici)1096-8628(19991215)88:6<621::aid-ajmg9>3.0.co;2-h

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 471
  • Mass: 52603
  • Checksum: EF8AAC0BC5379DA2
  • Sequence:
  • MDILCEENTS LSSTTNSLMQ LNDDTRLYSN DFNSGEANTS DAFNWTVDSE NRTNLSCEGC 
    LSPSCLSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS LEKKLQNATN YFLMSLAIAD 
    MLLGFLVMPV SMLTILYGYR WPLPSKLCAV WIYLDVLFST ASIMHLCAIS LDRYVAIQNP 
    IHHSRFNSRT KAFLKIIAVW TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF 
    VSFFIPLTIM VITYFLTIKS LQKEATLCVS DLGTRAKLAS FSFLPQSSLS SEKLFQRSIH 
    REPGSYTGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK ESCNEDVIGA 
    LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK ENKKPLQLIL VNTIPALAYK 
    SSQLQMGQKK NSKQDAKTTD NDCSMVALGK QHSEEASKDN SDGVNEKVSC V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.