Details for: HTR2A

Gene ID: 3356

Symbol: HTR2A

Ensembl ID: ENSG00000102468

Description: 5-hydroxytryptamine receptor 2A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.49
    Marker Score: 5148
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1512
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.71
    Marker Score: 105046
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.61
    Marker Score: 15182
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.43
    Marker Score: 14773
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.38
    Marker Score: 11833
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7471
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.03
    Marker Score: 302
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.83
    Marker Score: 3371
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.8
    Marker Score: 1230
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.76
    Marker Score: 1439
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 501
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.74
    Marker Score: 390
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.72
    Marker Score: 1696
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.71
    Marker Score: 325
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.69
    Marker Score: 1153
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.63
    Marker Score: 1276
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.61
    Marker Score: 563
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.6
    Marker Score: 2334
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.6
    Marker Score: 205
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 462
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.52
    Marker Score: 8121
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.49
    Marker Score: 2058
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.47
    Marker Score: 377
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.46
    Marker Score: 3558
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.45
    Marker Score: 253
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.44
    Marker Score: 151
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 112
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.41
    Marker Score: 249
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.41
    Marker Score: 460
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4
    Marker Score: 1563
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.4
    Marker Score: 14703
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.39
    Marker Score: 298
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.37
    Marker Score: 3542
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.36
    Marker Score: 346
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.36
    Marker Score: 367
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.35
    Marker Score: 203
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.34
    Marker Score: 12839
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.33
    Marker Score: 564.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.33
    Marker Score: 105
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.32
    Marker Score: 1326.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.31
    Marker Score: 887
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.31
    Marker Score: 306.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.3
    Marker Score: 261
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 142
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.3
    Marker Score: 5871
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.28
    Marker Score: 4248
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.24
    Marker Score: 88
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.24
    Marker Score: 82
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.23
    Marker Score: 226
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.23
    Marker Score: 72
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.23
    Marker Score: 84
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.22
    Marker Score: 272
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.22
    Marker Score: 49
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.21
    Marker Score: 53.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.2
    Marker Score: 89
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.2
    Marker Score: 247
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.19
    Marker Score: 79
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.19
    Marker Score: 233
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 110
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.18
    Marker Score: 71
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.18
    Marker Score: 1972
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.17
    Marker Score: 1031
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.17
    Marker Score: 75
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.17
    Marker Score: 715
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.16
    Marker Score: 290
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.16
    Marker Score: 480
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.15
    Marker Score: 1548
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.15
    Marker Score: 166
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.14
    Marker Score: 3072
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.14
    Marker Score: 164
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.14
    Marker Score: 372
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.14
    Marker Score: 70
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.14
    Marker Score: 193
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.13
    Marker Score: 154.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.13
    Marker Score: 77
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.13
    Marker Score: 29
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.12
    Marker Score: 253.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.11
    Marker Score: 260
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.11
    Marker Score: 115.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.11
    Marker Score: 1411
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.11
    Marker Score: 26

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Other Information

**Key characteristics:** * HTR2A is a 7-transmembrane protein. * It is a member of the G protein-coupled receptor (GPCR) family. * It is expressed in high levels in the brain and other tissues where serotonin and 5-hydroxytryptamine (5-HT) signaling are important. **Pathways and functions:** * HTR2A is a key regulator of serotonin signaling. * It is a ligand-gated channel that opens upon binding of 5-HT. * Activation of HTR2A by 5-HT allows it to interact with and activate downstream signaling pathways, including the G protein-coupled receptor (GPCR) pathway. * This pathway plays an important role in regulating mood, behavior, and other physiological processes. **Clinical significance:** * Mutations in HTR2A have been linked to a number of psychiatric disorders, including depression and schizophrenia. * Drugs that interact with HTR2A are used in the treatment of these disorders. * Understanding the role of HTR2A in serotonin signaling is important for the development of new treatments for psychiatric disorders.

Genular Protein ID: 1372994321

Symbol: 5HT2A_HUMAN

Name: 5-hydroxytryptamine receptor 2A

UniProtKB Accession Codes:

P28223 B2RAC5 B4DZ79 F5GWE8 Q5T8C0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EMBL 20 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 54 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 14 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1722404

Title: Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes.

PubMed ID: 1722404

DOI: 10.1016/0006-291x(91)92105-s

PubMed ID: 1323014

Title: The human 5-HT2 receptor is encoded by a multiple intron-exon gene.

PubMed ID: 1323014

DOI: 10.1016/0169-328x(92)90005-v

PubMed ID: 8035173

Title: Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor.

PubMed ID: 8035173

DOI: 10.1046/j.1471-4159.1994.63020465.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1330647

Title: Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes.

PubMed ID: 1330647

DOI: 10.1016/0922-4106(92)90123-d

PubMed ID: 11150294

Title: Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1.

PubMed ID: 11150294

DOI: 10.1074/jbc.m008089200

PubMed ID: 14988405

Title: The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins.

PubMed ID: 14988405

DOI: 10.1074/jbc.m312106200

PubMed ID: 18476671

Title: Serotonin receptors.

PubMed ID: 18476671

DOI: 10.1021/cr078224o

PubMed ID: 18703043

Title: Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells.

PubMed ID: 18703043

DOI: 10.1016/j.ejphar.2008.07.040

PubMed ID: 18297054

Title: Identification of a serotonin/glutamate receptor complex implicated in psychosis.

PubMed ID: 18297054

DOI: 10.1038/nature06612

PubMed ID: 19057895

Title: Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors.

PubMed ID: 19057895

DOI: 10.1007/s00210-008-0378-4

PubMed ID: 21645528

Title: Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors.

PubMed ID: 21645528

DOI: 10.1016/j.neuropharm.2011.05.023

PubMed ID: 20945968

Title: Serotonin receptors - from molecular biology to clinical applications.

PubMed ID: 20945968

DOI: 10.33549/physiolres.931903

PubMed ID: 22300836

Title: Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades.

PubMed ID: 22300836

DOI: 10.1016/j.neuropharm.2012.01.010

PubMed ID: 24637012

Title: Quantitative phosphoproteomics unravels biased phosphorylation of serotonin 2A receptor at Ser280 by hallucinogenic versus nonhallucinogenic agonists.

PubMed ID: 24637012

DOI: 10.1074/mcp.m113.036558

PubMed ID: 24089568

Title: 5-HT2 receptors facilitate JC polyomavirus entry.

PubMed ID: 24089568

DOI: 10.1128/jvi.02252-13

PubMed ID: 28129538

Title: Crystal structure of an LSD-bound human serotonin receptor.

PubMed ID: 28129538

DOI: 10.1016/j.cell.2016.12.033

PubMed ID: 36171289

Title: Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity.

PubMed ID: 36171289

DOI: 10.1038/s41586-022-05258-z

PubMed ID: 8655141

Title: Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia.

PubMed ID: 8655141

DOI: 10.1007/bf02281871

PubMed ID: 10581480

Title: Unified approach to the analysis of genetic variation in serotonergic pathways.

PubMed ID: 10581480

DOI: 10.1002/(sici)1096-8628(19991215)88:6<621::aid-ajmg9>3.0.co;2-h

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 471
  • Mass: 52603
  • Checksum: EF8AAC0BC5379DA2
  • Sequence:
    • MDILCEENTS LSSTTNSLMQ LNDDTRLYSN DFNSGEANTS DAFNWTVDSE NRTNLSCEGC 
LSPSCLSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS LEKKLQNATN YFLMSLAIAD 
MLLGFLVMPV SMLTILYGYR WPLPSKLCAV WIYLDVLFST ASIMHLCAIS LDRYVAIQNP 
IHHSRFNSRT KAFLKIIAVW TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF 
VSFFIPLTIM VITYFLTIKS LQKEATLCVS DLGTRAKLAS FSFLPQSSLS SEKLFQRSIH 
REPGSYTGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK ESCNEDVIGA 
LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK ENKKPLQLIL VNTIPALAYK 
SSQLQMGQKK NSKQDAKTTD NDCSMVALGK QHSEEASKDN SDGVNEKVSC V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.