Details for: HTR2A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 46.1672
Cell Significance Index: -11.7100 - Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: 10.4046
Cell Significance Index: 167.3000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 9.7723
Cell Significance Index: -9.3300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.9146
Cell Significance Index: 384.0600 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.3300
Cell Significance Index: 20.2000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.1054
Cell Significance Index: 160.6800 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.8876
Cell Significance Index: 21.5000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.6949
Cell Significance Index: 19.8300 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.4700
Cell Significance Index: 6.2700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2579
Cell Significance Index: 92.5200 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.1982
Cell Significance Index: 3.1800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1947
Cell Significance Index: 134.6700 - Cell Name: myometrial cell (CL0002366)
Fold Change: 0.1928
Cell Significance Index: 2.2200 - Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
Fold Change: 0.1885
Cell Significance Index: 1.9100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1290
Cell Significance Index: 81.9600 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.1009
Cell Significance Index: 1.6000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0638
Cell Significance Index: 2.8200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0193
Cell Significance Index: 36.2500 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.0032
Cell Significance Index: 0.0300 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.0000
Cell Significance Index: 0.0000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0057
Cell Significance Index: -0.3800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0070
Cell Significance Index: -12.9100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0089
Cell Significance Index: -13.6300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0105
Cell Significance Index: -14.2700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0148
Cell Significance Index: -11.1700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0154
Cell Significance Index: -7.0000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0166
Cell Significance Index: -1.0200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0173
Cell Significance Index: -12.7900 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0213
Cell Significance Index: -0.9200 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0220
Cell Significance Index: -12.0300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0224
Cell Significance Index: -12.6200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0240
Cell Significance Index: -14.9800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0265
Cell Significance Index: -3.6400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0278
Cell Significance Index: -8.0000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0488
Cell Significance Index: -8.8000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0514
Cell Significance Index: -10.2000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0623
Cell Significance Index: -13.1300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0720
Cell Significance Index: -12.2900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0747
Cell Significance Index: -9.1800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0777
Cell Significance Index: -10.0400 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0797
Cell Significance Index: -10.2200 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0798
Cell Significance Index: -1.9900 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0894
Cell Significance Index: -1.2800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0932
Cell Significance Index: -3.0500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0987
Cell Significance Index: -11.5000 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1074
Cell Significance Index: -2.2800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1099
Cell Significance Index: -11.4400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1108
Cell Significance Index: -11.3200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1142
Cell Significance Index: -13.0800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1203
Cell Significance Index: -5.6100 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.1212
Cell Significance Index: -1.3200 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1347
Cell Significance Index: -3.2300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1361
Cell Significance Index: -10.7800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1395
Cell Significance Index: -10.4000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1475
Cell Significance Index: -11.3200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1561
Cell Significance Index: -9.8400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1646
Cell Significance Index: -8.6400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1700
Cell Significance Index: -4.7500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1701
Cell Significance Index: -8.8600 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1701
Cell Significance Index: -3.5600 - Cell Name: neural cell (CL0002319)
Fold Change: -0.1749
Cell Significance Index: -2.0400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1753
Cell Significance Index: -6.6400 - Cell Name: neuron (CL0000540)
Fold Change: -0.1931
Cell Significance Index: -1.8300 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1965
Cell Significance Index: -4.2000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1988
Cell Significance Index: -6.3300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2004
Cell Significance Index: -5.1500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2022
Cell Significance Index: -9.5100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2041
Cell Significance Index: -7.1500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2080
Cell Significance Index: -11.6700 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2303
Cell Significance Index: -4.9800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.2341
Cell Significance Index: -10.6100 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2431
Cell Significance Index: -4.8800 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2488
Cell Significance Index: -4.9200 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.2917
Cell Significance Index: -4.2400 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.2933
Cell Significance Index: -3.9100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3191
Cell Significance Index: -9.4000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3200
Cell Significance Index: -11.1200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3338
Cell Significance Index: -9.5700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3376
Cell Significance Index: -5.6500 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: -0.3377
Cell Significance Index: -2.5900 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.3465
Cell Significance Index: -6.8200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.3529
Cell Significance Index: -12.4000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3553
Cell Significance Index: -9.5200 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.3562
Cell Significance Index: -6.9700 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.3788
Cell Significance Index: -6.5500 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.3819
Cell Significance Index: -7.9700 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.3898
Cell Significance Index: -9.7200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3942
Cell Significance Index: -10.5500 - Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
Fold Change: -0.3993
Cell Significance Index: -4.3100 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.4040
Cell Significance Index: -8.2200 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4062
Cell Significance Index: -14.9100 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.4178
Cell Significance Index: -6.0900 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4180
Cell Significance Index: -10.4400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4217
Cell Significance Index: -11.2600 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4286
Cell Significance Index: -11.2700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.4288
Cell Significance Index: -12.3600 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.4491
Cell Significance Index: -5.5700 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.4493
Cell Significance Index: -5.6700 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.4600
Cell Significance Index: -11.7200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.4603
Cell Significance Index: -10.0800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1372994321
Symbol: 5HT2A_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1722404
Title: Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes.
PubMed ID: 1722404
PubMed ID: 1323014
Title: The human 5-HT2 receptor is encoded by a multiple intron-exon gene.
PubMed ID: 1323014
PubMed ID: 8035173
Title: Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor.
PubMed ID: 8035173
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1330647
Title: Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes.
PubMed ID: 1330647
PubMed ID: 11150294
Title: Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1.
PubMed ID: 11150294
PubMed ID: 14988405
Title: The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins.
PubMed ID: 14988405
PubMed ID: 18476671
PubMed ID: 18703043
Title: Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells.
PubMed ID: 18703043
PubMed ID: 18297054
Title: Identification of a serotonin/glutamate receptor complex implicated in psychosis.
PubMed ID: 18297054
DOI: 10.1038/nature06612
PubMed ID: 19057895
Title: Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors.
PubMed ID: 19057895
PubMed ID: 21645528
Title: Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors.
PubMed ID: 21645528
PubMed ID: 20945968
Title: Serotonin receptors - from molecular biology to clinical applications.
PubMed ID: 20945968
PubMed ID: 22300836
Title: Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades.
PubMed ID: 22300836
PubMed ID: 24637012
Title: Quantitative phosphoproteomics unravels biased phosphorylation of serotonin 2A receptor at Ser280 by hallucinogenic versus nonhallucinogenic agonists.
PubMed ID: 24637012
PubMed ID: 24089568
Title: 5-HT2 receptors facilitate JC polyomavirus entry.
PubMed ID: 24089568
DOI: 10.1128/jvi.02252-13
PubMed ID: 28129538
Title: Crystal structure of an LSD-bound human serotonin receptor.
PubMed ID: 28129538
PubMed ID: 36171289
Title: Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity.
PubMed ID: 36171289
PubMed ID: 35084960
Title: Structure-based discovery of nonhallucinogenic psychedelic analogs.
PubMed ID: 35084960
PubMed ID: 38552625
Title: Flexible scaffold-based cheminformatics approach for polypharmacological drug design.
PubMed ID: 38552625
PubMed ID: 8655141
Title: Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia.
PubMed ID: 8655141
DOI: 10.1007/bf02281871
PubMed ID: 10581480
Title: Unified approach to the analysis of genetic variation in serotonergic pathways.
PubMed ID: 10581480
DOI: 10.1002/(sici)1096-8628(19991215)88:6<621::aid-ajmg9>3.0.co;2-h
PubMed ID: 10391209
Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.
PubMed ID: 10391209
DOI: 10.1038/10290
Sequence Information:
- Length: 471
- Mass: 52603
- Checksum: EF8AAC0BC5379DA2
- Sequence:
MDILCEENTS LSSTTNSLMQ LNDDTRLYSN DFNSGEANTS DAFNWTVDSE NRTNLSCEGC LSPSCLSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAV WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF VSFFIPLTIM VITYFLTIKS LQKEATLCVS DLGTRAKLAS FSFLPQSSLS SEKLFQRSIH REPGSYTGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK ESCNEDVIGA LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK ENKKPLQLIL VNTIPALAYK SSQLQMGQKK NSKQDAKTTD NDCSMVALGK QHSEEASKDN SDGVNEKVSC V
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.