Details for: IGFBP3

Gene ID: 3486

Symbol: IGFBP3

Ensembl ID: ENSG00000146674

Description: insulin like growth factor binding protein 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.62
    Marker Score: 2464
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.55
    Marker Score: 11017
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 2.55
    Marker Score: 962
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.3
    Marker Score: 1983
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.18
    Marker Score: 3214
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.18
    Marker Score: 1716
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.17
    Marker Score: 1430
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.98
    Marker Score: 68628
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.8
    Marker Score: 611
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.75
    Marker Score: 990
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.68
    Marker Score: 18903
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.61
    Marker Score: 1699
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.58
    Marker Score: 21206
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.52
    Marker Score: 1614.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168704
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.46
    Marker Score: 722
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.3
    Marker Score: 1793
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.27
    Marker Score: 323
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.26
    Marker Score: 1473
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.25
    Marker Score: 1084
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.23
    Marker Score: 41877.5
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.19
    Marker Score: 266
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.15
    Marker Score: 1502
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.15
    Marker Score: 768
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.15
    Marker Score: 834
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.13
    Marker Score: 327
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.12
    Marker Score: 1583
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.09
    Marker Score: 8122
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.06
    Marker Score: 13999
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.03
    Marker Score: 1093
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.03
    Marker Score: 1876
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.03
    Marker Score: 651.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.02
    Marker Score: 779
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.01
    Marker Score: 1028
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.01
    Marker Score: 520
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71776
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1
    Marker Score: 3921
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47999.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.98
    Marker Score: 2484
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.98
    Marker Score: 457.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.93
    Marker Score: 795
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.93
    Marker Score: 647
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5212
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.91
    Marker Score: 184
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.88
    Marker Score: 5752
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.87
    Marker Score: 215
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5267
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.86
    Marker Score: 8604.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.85
    Marker Score: 469
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.83
    Marker Score: 267
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.83
    Marker Score: 802
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.82
    Marker Score: 587
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.81
    Marker Score: 348
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.81
    Marker Score: 12641
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8
    Marker Score: 1952.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.8
    Marker Score: 2092
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.79
    Marker Score: 920
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.78
    Marker Score: 765
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.76
    Marker Score: 316
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 683
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.75
    Marker Score: 965.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.74
    Marker Score: 162
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.73
    Marker Score: 599
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.73
    Marker Score: 895
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.72
    Marker Score: 1354
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.72
    Marker Score: 776
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.72
    Marker Score: 771
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.72
    Marker Score: 427
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.7
    Marker Score: 475
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7
    Marker Score: 4181
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2891.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.69
    Marker Score: 457
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.67
    Marker Score: 132
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.67
    Marker Score: 421
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.67
    Marker Score: 807
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.66
    Marker Score: 434.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.64
    Marker Score: 571
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.64
    Marker Score: 1706
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.63
    Marker Score: 563
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.63
    Marker Score: 1536
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.62
    Marker Score: 145
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.62
    Marker Score: 1192
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.62
    Marker Score: 239
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.62
    Marker Score: 1251
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.61
    Marker Score: 1212
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.6
    Marker Score: 568
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6
    Marker Score: 1137
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6
    Marker Score: 2319
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.57
    Marker Score: 325
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.55
    Marker Score: 132

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Other Information

**Key characteristics** * IGFBP3 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is a member of the IGFBP family of proteins, which are characterized by their ability to bind to IGFs and regulate their activity. * IGFBP3 is highly expressed in various cell types, including type EC enteroendocrine cells, decidual cells, hepatic stellate cells, pulmonary artery endothelial cells, bladder urothelial cells, epithelial cells of the urethra, skeletal muscle fibroblasts, and stem cells of the epidermis. **Pathways and functions** * IGFBP3 is a key regulator of IGF signaling through its interaction with IGFs. * It acts as a negative regulator of IGF signaling by binding to IGFs and blocking their interaction with their receptors. * In the absence of IGFs, IGFBP3 becomes phosphorylated by IGF-1 receptor, leading to its degradation by the proteasome. * This prevents the activation of downstream signaling pathways that are stimulated by IGFs, including the MAPK cascade and the transcription of cell death genes. * By controlling IGF signaling, IGFBP3 helps to maintain tissue homeostasis and prevent cancer. **Clinical significance** * Mutations in IGFBP3 have been linked to various human diseases, including cancer, cardiovascular disease, and diabetes. * In cancer, IGFBP3 mutations can lead to the survival of tumor cells, resistance to IGF-based therapies, and poor prognosis. * Therefore, targeting IGFBP3 signaling is an emerging therapeutic strategy for cancer treatment. **Additional notes** * IGFBP3 is a highly conserved protein with similar sequences in mammals. * It is a key regulator of the development and function of the pancreas. * It is also involved in the regulation of metabolism, cell growth, and differentiation.

Genular Protein ID: 946356234

Symbol: IBP3_HUMAN

Name: Insulin-like growth factor-binding protein 3

UniProtKB Accession Codes:

P17936 A4D2F5 D3DVM0 Q2V509 Q6P1M6 Q9UCL4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 11 EMDB 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 3 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2464130

Title: Cloning and expression of the growth hormone-dependent insulin-like growth factor-binding protein.

PubMed ID: 2464130

DOI: 10.1210/mend-2-12-1176

PubMed ID: 1695633

Title: Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity.

PubMed ID: 1695633

DOI: 10.1016/s0021-9258(19)38392-9

PubMed ID: 7508771

Title: Analysis of the primary structure of insulin-like growth factor binding protein-3 cDNA from Werner syndrome fibroblasts.

PubMed ID: 7508771

DOI: 10.3109/10425179309015621

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1697583

Title: Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia.

PubMed ID: 1697583

DOI: 10.1016/s0021-9258(18)77200-1

PubMed ID: 1726837

Title: Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species.

PubMed ID: 1726837

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 14561895

Title: Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis.

PubMed ID: 14561895

DOI: 10.1073/pnas.2135111100

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 20353938

Title: Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer.

PubMed ID: 20353938

DOI: 10.1074/jbc.m110.122226

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 19623253

Title: Humanin: a novel central regulator of peripheral insulin action.

PubMed ID: 19623253

DOI: 10.1371/journal.pone.0006334

PubMed ID: 19952275

Title: Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis.

PubMed ID: 19952275

DOI: 10.1210/en.2009-0577

PubMed ID: 26216267

Title: Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-beta.

PubMed ID: 26216267

DOI: 10.2174/0929866522666150728114955

Sequence Information:

  • Length: 291
  • Mass: 31674
  • Checksum: A9682065AB266586
  • Sequence:
    • MQRARPTLWA AALTLLVLLR GPPVARAGAS SAGLGPVVRC EPCDARALAQ CAPPPAVCAE 
LVREPGCGCC LTCALSEGQP CGIYTERCGS GLRCQPSPDE ARPLQALLDG RGLCVNASAV 
SRLRAYLLPA PPAPGNASES EEDRSAGSVE SPSVSSTHRV SDPKFHPLHS KIIIIKKGHA 
KDSQRYKVDY ESQSTDTQNF SSESKRETEY GPCRREMEDT LNHLKFLNVL SPRGVHIPNC 
DKKGFYKKKQ CRPSKGRKRG FCWCVDKYGQ PLPGYTTKGK EDVHCYSMQS K

Genular Protein ID: 2031344478

Symbol: B3KPF0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KPF0

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 8 Gene3D 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

Sequence Information:

  • Length: 75
  • Mass: 8708
  • Checksum: 8BBDFD878FFD01CF
  • Sequence:
    • MEDTLNHLKF LNVLSPRGVH IPNCDKKGFY KKKQCRPSKG RKRGFCWCVD KYGQPLPGYT 
TKGKEDVHCY SMQSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.