Details for: ITGAL

Gene ID: 3683

Symbol: ITGAL

Ensembl ID: ENSG00000005844

Description: integrin subunit alpha L

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.89
    Marker Score: 4686
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.46
    Marker Score: 29262
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.1
    Marker Score: 905
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.08
    Marker Score: 6573
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.01
    Marker Score: 5628
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.82
    Marker Score: 2683
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.7
    Marker Score: 3319
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.64
    Marker Score: 2267
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.57
    Marker Score: 1141
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.49
    Marker Score: 9540
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.47
    Marker Score: 614
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168100
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.42
    Marker Score: 3431
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.42
    Marker Score: 79388
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.34
    Marker Score: 15614
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.28
    Marker Score: 3741
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.25
    Marker Score: 12335
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.21
    Marker Score: 1022
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.2
    Marker Score: 396
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.18
    Marker Score: 323
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.18
    Marker Score: 726
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.17
    Marker Score: 1228
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.17
    Marker Score: 363
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.16
    Marker Score: 263
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.15
    Marker Score: 1115
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4759
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.12
    Marker Score: 3087
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.11
    Marker Score: 1337
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.06
    Marker Score: 587
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.06
    Marker Score: 848
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.02
    Marker Score: 53891
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.01
    Marker Score: 581
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1
    Marker Score: 728
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71748
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47972
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 660
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.97
    Marker Score: 705
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.96
    Marker Score: 750
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.95
    Marker Score: 478
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.94
    Marker Score: 1844
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.94
    Marker Score: 2337.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.92
    Marker Score: 857
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 364
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.9
    Marker Score: 229
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.9
    Marker Score: 750
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.9
    Marker Score: 450
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.9
    Marker Score: 798
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9
    Marker Score: 412
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4968
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.87
    Marker Score: 303
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5264
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.84
    Marker Score: 740
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.84
    Marker Score: 1087
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.84
    Marker Score: 539
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.82
    Marker Score: 478
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.81
    Marker Score: 2408
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.81
    Marker Score: 415
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 609
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.79
    Marker Score: 20129
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.78
    Marker Score: 3365
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.78
    Marker Score: 339
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.77
    Marker Score: 657
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.77
    Marker Score: 564
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1239
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.76
    Marker Score: 773
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.76
    Marker Score: 1006
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.76
    Marker Score: 816
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.76
    Marker Score: 836
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.75
    Marker Score: 833
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 683
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.74
    Marker Score: 1751
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.74
    Marker Score: 308
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.74
    Marker Score: 225
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.73
    Marker Score: 1248
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.72
    Marker Score: 189
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.71
    Marker Score: 232
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.71
    Marker Score: 1004.5
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.71
    Marker Score: 510.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.7
    Marker Score: 346
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.69
    Marker Score: 1232
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.69
    Marker Score: 296
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.67
    Marker Score: 1071
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.66
    Marker Score: 166
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.66
    Marker Score: 501
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.66
    Marker Score: 182
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.64
    Marker Score: 455
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.64
    Marker Score: 1034
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.63
    Marker Score: 287
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.62
    Marker Score: 481
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.61
    Marker Score: 423
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.61
    Marker Score: 304

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Other Information

**Key characteristics:** - ITGAL is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a member of the integrin superfamily, which includes other cell adhesion molecules such as VLA-4 and VLA-6. - ITGAL is expressed in high levels on the surface of endothelial cells, immune cells, and tumor cells. - It is involved in cell adhesion, migration, and signaling in various physiological and pathological processes, including angiogenesis, leukocyte trafficking, and tumor growth. **Pathways and functions:** - ITGAL is a key regulator of cell adhesion and migration. - It interacts with other integrins and cell adhesion molecules to form stable adhesion complexes, which are essential for cell migration and cell-cell interactions. - ITGAL also plays a role in leukocyte trafficking by interacting with integrins expressed on immune cells. - It is involved in the regulation of inflammation and tissue remodeling. - ITGAL is also a regulator of cell migration and invasion. **Clinical significance:** - Mutations in ITGAL have been linked to human diseases such as cancer, rheumatoid arthritis, and inflammatory bowel disease. - Targeting ITGAL has been explored as a therapeutic strategy for these diseases. - ITGAL is a promising target for the treatment of cancer and other diseases where cell adhesion and migration are critical. **Additional information:** - ITGAL is a highly conserved protein, with similar sequences found in mammals and humans. - It is expressed in high levels in the retina, where it is involved in the development and maintenance of blood-retina barrier. - ITGAL is also expressed in immune cells, where it plays a role in cell adhesion, migration, and immune responses.

Genular Protein ID: 1964387034

Symbol: ITAL_HUMAN

Name: CD11 antigen-like family member A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2537322

Title: Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.

PubMed ID: 2537322

DOI: 10.1083/jcb.108.2.703

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8099450

Title: Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene.

PubMed ID: 8099450

DOI: 10.1073/pnas.90.11.5364

PubMed ID: 8103515

Title: Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter.

PubMed ID: 8103515

DOI: 10.1016/s0021-9258(19)36514-7

PubMed ID: 8097887

Title: Description of the leukocyte function-associated antigen 1 (LFA-1 or CD11a) promoter.

PubMed ID: 8097887

DOI: 10.1073/pnas.90.9.4221

PubMed ID: 11812992

Title: JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes.

PubMed ID: 11812992

DOI: 10.1038/ni755

PubMed ID: 15356110

Title: LFA-1 contributes an early signal for NK cell cytotoxicity.

PubMed ID: 15356110

DOI: 10.4049/jimmunol.173.6.3653

PubMed ID: 15528364

Title: The functional interaction of the beta 2 integrin lymphocyte function-associated antigen-1 with junctional adhesion molecule-A is mediated by the I domain.

PubMed ID: 15528364

DOI: 10.4049/jimmunol.173.10.6259

PubMed ID: 16301335

Title: Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms.

PubMed ID: 16301335

DOI: 10.1083/jcb.200504016

PubMed ID: 18020948

Title: SARS-CoV accessory protein 7a directly interacts with human LFA-1.

PubMed ID: 18020948

DOI: 10.1515/bc.2007.157

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 23775590

Title: Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages.

PubMed ID: 23775590

DOI: 10.1007/s10495-013-0873-z

PubMed ID: 27055590

Title: LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin.

PubMed ID: 27055590

DOI: 10.1016/j.bbrc.2016.04.007

PubMed ID: 29100055

Title: Extracellular ISG15 signals cytokine secretion through the LFA-1 integrin receptor.

PubMed ID: 29100055

DOI: 10.1016/j.molcel.2017.10.003

PubMed ID: 7479767

Title: Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.

PubMed ID: 7479767

DOI: 10.1073/pnas.92.22.10277

PubMed ID: 8805579

Title: The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin.

PubMed ID: 8805579

DOI: 10.1016/s0969-2126(96)00100-1

PubMed ID: 10493852

Title: Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain.

PubMed ID: 10493852

DOI: 10.1006/jmbi.1999.3047

PubMed ID: 12526797

Title: Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.

PubMed ID: 12526797

DOI: 10.1016/s0092-8674(02)01257-6

Sequence Information:

  • Length: 1170
  • Mass: 128770
  • Checksum: 22A7AF92EF286876
  • Sequence:
  • MKDSCITVMA MALLSGFFFF APASSYNLDV RGARSFSPPR AGRHFGYRVL QVGNGVIVGA 
    PGEGNSTGSL YQCQSGTGHC LPVTLRGSNY TSKYLGMTLA TDPTDGSILA CDPGLSRTCD 
    QNTYLSGLCY LFRQNLQGPM LQGRPGFQEC IKGNVDLVFL FDGSMSLQPD EFQKILDFMK 
    DVMKKLSNTS YQFAAVQFST SYKTEFDFSD YVKRKDPDAL LKHVKHMLLL TNTFGAINYV 
    ATEVFREELG ARPDATKVLI IITDGEATDS GNIDAAKDII RYIIGIGKHF QTKESQETLH 
    KFASKPASEF VKILDTFEKL KDLFTELQKK IYVIEGTSKQ DLTSFNMELS SSGISADLSR 
    GHAVVGAVGA KDWAGGFLDL KADLQDDTFI GNEPLTPEVR AGYLGYTVTW LPSRQKTSLL 
    ASGAPRYQHM GRVLLFQEPQ GGGHWSQVQT IHGTQIGSYF GGELCGVDVD QDGETELLLI 
    GAPLFYGEQR GGRVFIYQRR QLGFEEVSEL QGDPGYPLGR FGEAITALTD INGDGLVDVA 
    VGAPLEEQGA VYIFNGRHGG LSPQPSQRIE GTQVLSGIQW FGRSIHGVKD LEGDGLADVA 
    VGAESQMIVL SSRPVVDMVT LMSFSPAEIP VHEVECSYST SNKMKEGVNI TICFQIKSLI 
    PQFQGRLVAN LTYTLQLDGH RTRRRGLFPG GRHELRRNIA VTTSMSCTDF SFHFPVCVQD 
    LISPINVSLN FSLWEEEGTP RDQRAQGKDI PPILRPSLHS ETWEIPFEKN CGEDKKCEAN 
    LRVSFSPARS RALRLTAFAS LSVELSLSNL EEDAYWVQLD LHFPPGLSFR KVEMLKPHSQ 
    IPVSCEELPE ESRLLSRALS CNVSSPIFKA GHSVALQMMF NTLVNSSWGD SVELHANVTC 
    NNEDSDLLED NSATTIIPIL YPINILIQDQ EDSTLYVSFT PKGPKIHQVK HMYQVRIQPS 
    IHDHNIPTLE AVVGVPQPPS EGPITHQWSV QMEPPVPCHY EDLERLPDAA EPCLPGALFR 
    CPVVFRQEIL VQVIGTLELV GEIEASSMFS LCSSLSISFN SSKHFHLYGS NASLAQVVMK 
    VDVVYEKQML YLYVLSGIGG LLLLLLIFIV LYKVGFFKRN LKEKMEAGRG VPNGIPAEDS 
    EQLASGQEAG DPGCLKPLHE KDSESGGGKD

Genular Protein ID: 1979683276

Symbol: B2RAL6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1170
  • Mass: 128869
  • Checksum: A67B480C96C9B2D7
  • Sequence:
  • MKDSCITVMA MALLSGFFFF APASSYNLDV RGARSFSPPR AGRHFGYRVL QVGNGVIVGA 
    PGEGNSTGSL YQCQSGTGHC LPVTLRGSNY TSKYLGMTLA TDPTDGSILA CDPGLSRTCD 
    QNTYLSGLCY LFRQNLQGPM LQGRPGFQEC IKGNVDLVFL FDGSMSLQPD EFQKILDFMK 
    DVMKKLSNTS YQFAAVQFST SYKTEFDFSD YVKRKDPDAL LKHVKHMLLL TNTFGAINYV 
    ATEVFREELG ARPDATKVLI IITDGEATDS GNIDAAKDII RYIIGIGKHF QTKESQETLH 
    KFASKPASEF VKILDTFEKL KDLFTELQKK IYVIEGTSKQ DLTSFNMELS SSGISADLSR 
    GHAVVGAVGA KDWAGGFLDL KADLQDDTFI GNEPLTPEVR AGYLGYTVTW LPSRQKTSLL 
    ASGAPRYQHM GRVLLFQEPQ GGGHWSQVQT IHGTQIGSYF GGELCGVDVD QDGETELLLI 
    GAPLFYGEQR GGRVFIYQRR QLGFEEVSEL QGDPGYPLGR FGEAITALTD INGDGLVDVA 
    VGAPLEEQGA VYIFNGRHGG LSPQPSQRIE RTQVLSGIQW FGRSIHGVKD LEGDGLADVA 
    VGAESQMIVL SSRPVVDMVT LMSFSPAEIP VHEVECSYST SNKMKEGVNI TICFQIKSLI 
    PQFQGRLVAN LTYTLQLDGH RTRRRGLFPG GRHELRRNIA VTTSMSCTDF SFHFPVCVQD 
    LISPINVSLN FSLWEEEGTP RDQRAQGKDI PPILRPSLHS ETWEIPFEKN CGEDKKCEAN 
    LRVSFSPARS RALRLTAFAS LSVELSLSNL EEDAYWVQLD LHFPPGLSFR KVEMLKPHSQ 
    IPVSCEELPE ESRLLSRALS CNVSSPIFKA GHSVALQMMF NTLVNSSWGD SVELHANVTC 
    NNEDSDLLED NSATTIIPIL YPINILIQDQ EDSTLYVSFT PKGPKIHQVK HMYQVRIQPS 
    IHDHNIPTLE AVVGVPQPPS EGPITHQWSV QMEPPVPCHY EDLERLPDAA EPCLPGALFR 
    CPVVFRQEIL VQVIGTLELV GEIEASSMFS LCSSLSISFN SSKHFHLYGS NASLAQVVMK 
    VDVVYEKQML YLYVLSGIGG LLLLLLIFIV LYKVGFFKRN LKEKMEAGRG VPNGIPAEDS 
    EQLASGQEAG DPGCLKPLHE KDSESGGGKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.