Details for: ITGAL
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: retina horizontal cell (CL0000745)
Fold Change: 4.89
Marker Score: 4686 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.46
Marker Score: 29262 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.1
Marker Score: 905 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.08
Marker Score: 6573 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.01
Marker Score: 5628 - Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 1.82
Marker Score: 2683 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.7
Marker Score: 3319 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.64
Marker Score: 2267 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.57
Marker Score: 1141 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.49
Marker Score: 9540 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.47
Marker Score: 614 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168100 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.42
Marker Score: 3431 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.42
Marker Score: 79388 - Cell Name: blood cell (CL0000081)
Fold Change: 1.34
Marker Score: 15614 - Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 1.28
Marker Score: 3741 - Cell Name: mature T cell (CL0002419)
Fold Change: 1.25
Marker Score: 12335 - Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.21
Marker Score: 1022 - Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 1.2
Marker Score: 396 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.18
Marker Score: 323 - Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 1.18
Marker Score: 726 - Cell Name: thymocyte (CL0000893)
Fold Change: 1.17
Marker Score: 1228 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.17
Marker Score: 363 - Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.16
Marker Score: 263 - Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 1.15
Marker Score: 1115 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.13
Marker Score: 4759 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.12
Marker Score: 3087 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.11
Marker Score: 1337 - Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 1.06
Marker Score: 587 - Cell Name: early promyelocyte (CL0002154)
Fold Change: 1.06
Marker Score: 848 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.02
Marker Score: 53891 - Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.01
Marker Score: 581 - Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 1
Marker Score: 728 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71748 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47972 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30402 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.98
Marker Score: 660 - Cell Name: Unknown (CL0000548)
Fold Change: 0.97
Marker Score: 705 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 496 - Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.96
Marker Score: 750 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 450 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2408 - Cell Name: lymphocyte (CL0000542)
Fold Change: 0.95
Marker Score: 478 - Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.94
Marker Score: 1844 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.94
Marker Score: 2337.5 - Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.92
Marker Score: 857 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2733 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.91
Marker Score: 364 - Cell Name: ILC1, human (CL0001077)
Fold Change: 0.9
Marker Score: 229 - Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.9
Marker Score: 750 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.9
Marker Score: 450 - Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.9
Marker Score: 798 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.9
Marker Score: 412 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 318 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.88
Marker Score: 317 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4968 - Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 0.87
Marker Score: 303 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5264 - Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.84
Marker Score: 740 - Cell Name: natural killer cell (CL0000623)
Fold Change: 0.84
Marker Score: 1087 - Cell Name: naive T cell (CL0000898)
Fold Change: 0.84
Marker Score: 539 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.82
Marker Score: 478 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.81
Marker Score: 2408 - Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.81
Marker Score: 415 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 609 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.79
Marker Score: 20129 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.78
Marker Score: 3365 - Cell Name: myelocyte (CL0002193)
Fold Change: 0.78
Marker Score: 339 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.77
Marker Score: 657 - Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.77
Marker Score: 564 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.76
Marker Score: 1239 - Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.76
Marker Score: 773 - Cell Name: plasmablast (CL0000980)
Fold Change: 0.76
Marker Score: 1006 - Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.76
Marker Score: 816 - Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.76
Marker Score: 836 - Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 0.75
Marker Score: 833 - Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 683 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 386 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.74
Marker Score: 1751 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.74
Marker Score: 308 - Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.74
Marker Score: 225 - Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.73
Marker Score: 1248 - Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.72
Marker Score: 189 - Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 0.71
Marker Score: 232 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.71
Marker Score: 1004.5 - Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.71
Marker Score: 510.5 - Cell Name: centroblast (CL0009112)
Fold Change: 0.7
Marker Score: 346 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177 - Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.69
Marker Score: 1232 - Cell Name: memory T cell (CL0000813)
Fold Change: 0.69
Marker Score: 296 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.67
Marker Score: 1071 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.66
Marker Score: 166 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.66
Marker Score: 501 - Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.66
Marker Score: 182 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.64
Marker Score: 455 - Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.64
Marker Score: 1034 - Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 0.63
Marker Score: 287 - Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.62
Marker Score: 481 - Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.61
Marker Score: 423 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.61
Marker Score: 304
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Other Information
Genular Protein ID: 1964387034
Symbol: ITAL_HUMAN
Name: CD11 antigen-like family member A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2537322
Title: Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.
PubMed ID: 2537322
PubMed ID: 10493829
Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.
PubMed ID: 10493829
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8099450
Title: Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene.
PubMed ID: 8099450
PubMed ID: 8103515
Title: Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter.
PubMed ID: 8103515
PubMed ID: 8097887
Title: Description of the leukocyte function-associated antigen 1 (LFA-1 or CD11a) promoter.
PubMed ID: 8097887
PubMed ID: 11812992
Title: JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes.
PubMed ID: 11812992
DOI: 10.1038/ni755
PubMed ID: 15356110
Title: LFA-1 contributes an early signal for NK cell cytotoxicity.
PubMed ID: 15356110
PubMed ID: 15528364
Title: The functional interaction of the beta 2 integrin lymphocyte function-associated antigen-1 with junctional adhesion molecule-A is mediated by the I domain.
PubMed ID: 15528364
PubMed ID: 16301335
Title: Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms.
PubMed ID: 16301335
PubMed ID: 18020948
Title: SARS-CoV accessory protein 7a directly interacts with human LFA-1.
PubMed ID: 18020948
DOI: 10.1515/bc.2007.157
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 23775590
Title: Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages.
PubMed ID: 23775590
PubMed ID: 27055590
Title: LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin.
PubMed ID: 27055590
PubMed ID: 29100055
Title: Extracellular ISG15 signals cytokine secretion through the LFA-1 integrin receptor.
PubMed ID: 29100055
PubMed ID: 7479767
Title: Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.
PubMed ID: 7479767
PubMed ID: 8805579
Title: The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin.
PubMed ID: 8805579
PubMed ID: 10493852
Title: Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain.
PubMed ID: 10493852
PubMed ID: 12526797
Title: Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.
PubMed ID: 12526797
Sequence Information:
- Length: 1170
- Mass: 128770
- Checksum: 22A7AF92EF286876
- Sequence:
MKDSCITVMA MALLSGFFFF APASSYNLDV RGARSFSPPR AGRHFGYRVL QVGNGVIVGA PGEGNSTGSL YQCQSGTGHC LPVTLRGSNY TSKYLGMTLA TDPTDGSILA CDPGLSRTCD QNTYLSGLCY LFRQNLQGPM LQGRPGFQEC IKGNVDLVFL FDGSMSLQPD EFQKILDFMK DVMKKLSNTS YQFAAVQFST SYKTEFDFSD YVKRKDPDAL LKHVKHMLLL TNTFGAINYV ATEVFREELG ARPDATKVLI IITDGEATDS GNIDAAKDII RYIIGIGKHF QTKESQETLH KFASKPASEF VKILDTFEKL KDLFTELQKK IYVIEGTSKQ DLTSFNMELS SSGISADLSR GHAVVGAVGA KDWAGGFLDL KADLQDDTFI GNEPLTPEVR AGYLGYTVTW LPSRQKTSLL ASGAPRYQHM GRVLLFQEPQ GGGHWSQVQT IHGTQIGSYF GGELCGVDVD QDGETELLLI GAPLFYGEQR GGRVFIYQRR QLGFEEVSEL QGDPGYPLGR FGEAITALTD INGDGLVDVA VGAPLEEQGA VYIFNGRHGG LSPQPSQRIE GTQVLSGIQW FGRSIHGVKD LEGDGLADVA VGAESQMIVL SSRPVVDMVT LMSFSPAEIP VHEVECSYST SNKMKEGVNI TICFQIKSLI PQFQGRLVAN LTYTLQLDGH RTRRRGLFPG GRHELRRNIA VTTSMSCTDF SFHFPVCVQD LISPINVSLN FSLWEEEGTP RDQRAQGKDI PPILRPSLHS ETWEIPFEKN CGEDKKCEAN LRVSFSPARS RALRLTAFAS LSVELSLSNL EEDAYWVQLD LHFPPGLSFR KVEMLKPHSQ IPVSCEELPE ESRLLSRALS CNVSSPIFKA GHSVALQMMF NTLVNSSWGD SVELHANVTC NNEDSDLLED NSATTIIPIL YPINILIQDQ EDSTLYVSFT PKGPKIHQVK HMYQVRIQPS IHDHNIPTLE AVVGVPQPPS EGPITHQWSV QMEPPVPCHY EDLERLPDAA EPCLPGALFR CPVVFRQEIL VQVIGTLELV GEIEASSMFS LCSSLSISFN SSKHFHLYGS NASLAQVVMK VDVVYEKQML YLYVLSGIGG LLLLLLIFIV LYKVGFFKRN LKEKMEAGRG VPNGIPAEDS EQLASGQEAG DPGCLKPLHE KDSESGGGKD
Genular Protein ID: 1979683276
Symbol: B2RAL6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 1170
- Mass: 128869
- Checksum: A67B480C96C9B2D7
- Sequence:
MKDSCITVMA MALLSGFFFF APASSYNLDV RGARSFSPPR AGRHFGYRVL QVGNGVIVGA PGEGNSTGSL YQCQSGTGHC LPVTLRGSNY TSKYLGMTLA TDPTDGSILA CDPGLSRTCD QNTYLSGLCY LFRQNLQGPM LQGRPGFQEC IKGNVDLVFL FDGSMSLQPD EFQKILDFMK DVMKKLSNTS YQFAAVQFST SYKTEFDFSD YVKRKDPDAL LKHVKHMLLL TNTFGAINYV ATEVFREELG ARPDATKVLI IITDGEATDS GNIDAAKDII RYIIGIGKHF QTKESQETLH KFASKPASEF VKILDTFEKL KDLFTELQKK IYVIEGTSKQ DLTSFNMELS SSGISADLSR GHAVVGAVGA KDWAGGFLDL KADLQDDTFI GNEPLTPEVR AGYLGYTVTW LPSRQKTSLL ASGAPRYQHM GRVLLFQEPQ GGGHWSQVQT IHGTQIGSYF GGELCGVDVD QDGETELLLI GAPLFYGEQR GGRVFIYQRR QLGFEEVSEL QGDPGYPLGR FGEAITALTD INGDGLVDVA VGAPLEEQGA VYIFNGRHGG LSPQPSQRIE RTQVLSGIQW FGRSIHGVKD LEGDGLADVA VGAESQMIVL SSRPVVDMVT LMSFSPAEIP VHEVECSYST SNKMKEGVNI TICFQIKSLI PQFQGRLVAN LTYTLQLDGH RTRRRGLFPG GRHELRRNIA VTTSMSCTDF SFHFPVCVQD LISPINVSLN FSLWEEEGTP RDQRAQGKDI PPILRPSLHS ETWEIPFEKN CGEDKKCEAN LRVSFSPARS RALRLTAFAS LSVELSLSNL EEDAYWVQLD LHFPPGLSFR KVEMLKPHSQ IPVSCEELPE ESRLLSRALS CNVSSPIFKA GHSVALQMMF NTLVNSSWGD SVELHANVTC NNEDSDLLED NSATTIIPIL YPINILIQDQ EDSTLYVSFT PKGPKIHQVK HMYQVRIQPS IHDHNIPTLE AVVGVPQPPS EGPITHQWSV QMEPPVPCHY EDLERLPDAA EPCLPGALFR CPVVFRQEIL VQVIGTLELV GEIEASSMFS LCSSLSISFN SSKHFHLYGS NASLAQVVMK VDVVYEKQML YLYVLSGIGG LLLLLLIFIV LYKVGFFKRN LKEKMEAGRG VPNGIPAEDS EQLASGQEAG DPGCLKPLHE KDSESGGGKD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.