Details for: ITGAM

Gene ID: 3684

Symbol: ITGAM

Ensembl ID: ENSG00000169896

Description: integrin subunit alpha M

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.76
    Marker Score: 1191
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.19
    Marker Score: 122715
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.96
    Marker Score: 2246
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.9
    Marker Score: 4738.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.73
    Marker Score: 859
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1152
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.54
    Marker Score: 663
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.39
    Marker Score: 503
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.34
    Marker Score: 5550
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 839.5
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.18
    Marker Score: 387
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.16
    Marker Score: 7045
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.15
    Marker Score: 478
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.13
    Marker Score: 13146
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.13
    Marker Score: 283
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.07
    Marker Score: 493
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 1.06
    Marker Score: 686
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.06
    Marker Score: 1283
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.05
    Marker Score: 3311
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251778
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71797
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48022
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.94
    Marker Score: 518
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5288
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 365
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.88
    Marker Score: 2582
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.88
    Marker Score: 1789
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.82
    Marker Score: 2263
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.81
    Marker Score: 1579
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 611
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3272
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1254
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.76
    Marker Score: 309.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.75
    Marker Score: 464
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1189
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.73
    Marker Score: 584
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.73
    Marker Score: 18608
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.71
    Marker Score: 1045
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 453
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.69
    Marker Score: 348
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.67
    Marker Score: 1730
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.63
    Marker Score: 644
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.63
    Marker Score: 872
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.62
    Marker Score: 616.5
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.62
    Marker Score: 801
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.61
    Marker Score: 1164.5
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.61
    Marker Score: 794
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.61
    Marker Score: 154
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.58
    Marker Score: 1065
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.58
    Marker Score: 352
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.58
    Marker Score: 240
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.57
    Marker Score: 184
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.56
    Marker Score: 622
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.5
    Marker Score: 171
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.48
    Marker Score: 7574
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.47
    Marker Score: 245
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.46
    Marker Score: 2945
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.44
    Marker Score: 211
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.44
    Marker Score: 340
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.43
    Marker Score: 1046
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.42
    Marker Score: 395
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.4
    Marker Score: 1177.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 388
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.4
    Marker Score: 275
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.39
    Marker Score: 229
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.39
    Marker Score: 195
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.38
    Marker Score: 274.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.37
    Marker Score: 168
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.37
    Marker Score: 225
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.37
    Marker Score: 901
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.37
    Marker Score: 301
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.36
    Marker Score: 235.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 93
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.34
    Marker Score: 222
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.33
    Marker Score: 207
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.32
    Marker Score: 154
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.31
    Marker Score: 189
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.31
    Marker Score: 71
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.3
    Marker Score: 92
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.29
    Marker Score: 206
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.29
    Marker Score: 290.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 139
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.29
    Marker Score: 145
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.29
    Marker Score: 198
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.29
    Marker Score: 169
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.28
    Marker Score: 54
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.27
    Marker Score: 97
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.27
    Marker Score: 113

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Other Information

**Key characteristics:** * ITGAM is a type I transmembrane protein with a molecular weight of approximately 120 kDa. * It is a glycoprotein that is expressed on the cell surface of immune cells. * ITGAM is a member of the integrin family of cell adhesion molecules, which are expressed on various cell types, including endothelial cells, fibroblasts, and leukocytes. * ITGAM is a key component of the integrin-mediated adhesion complex, which is responsible for the adhesion of immune cells to the extracellular matrix. * ITGAM is also involved in the regulation of inflammation and immune responses. **Pathways and functions:** * ITGAM is involved in the regulation of inflammation and immune responses. * It is expressed on macrophages and dendritic cells, which are important immune cells involved in the inflammatory response. * ITGAM binds to ligands expressed on activated endothelial cells and promotes the adhesion of immune cells to the blood vessel wall. * This interaction is important for the recruitment of immune cells to sites of inflammation. * ITGAM also plays a role in the regulation of angiogenesis, the formation of new blood vessels. * In addition, ITGAM is involved in the regulation of cell migration and adhesion. **Clinical significance:** * Mutations in ITGAM have been linked to several autoimmune diseases, including rheumatoid arthritis, Crohn's disease, and psoriasis. * ITGAM is a potential target for therapeutic interventions in inflammatory diseases. * Inhibition of ITGAM has been shown to inhibit inflammation and improve disease activity in animal models of autoimmune diseases. **Conclusion:** ITGAM is a key cell surface protein that plays a critical role in the regulation of inflammation and immune responses. It is expressed on various immune cells and is involved in the adhesion and migration of immune cells to the extracellular matrix. Mutations in ITGAM have been linked to several autoimmune diseases, highlighting its importance in maintaining immune homeostasis.

Genular Protein ID: 286483829

Symbol: ITAM_HUMAN

Name: Integrin alpha-M

UniProtKB Accession Codes:

P11215 Q4VAK0 Q4VAK1 Q4VAK2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTC 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 39 EMDB 2 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 27 PDBsum 22 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2457584

Title: The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B.

PubMed ID: 2457584

DOI: 10.1016/s0021-9258(18)37770-6

PubMed ID: 2833753

Title: Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins.

PubMed ID: 2833753

DOI: 10.1073/pnas.85.8.2776

PubMed ID: 2454931

Title: Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3).

PubMed ID: 2454931

DOI: 10.1083/jcb.106.6.2153

PubMed ID: 8419480

Title: Structural analysis of the CD11b gene and phylogenetic analysis of the alpha-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution.

PubMed ID: 8419480

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2563162

Title: cDNA sequence for the alpha M subunit of the human neutrophil adherence receptor indicates homology to integrin alpha subunits.

PubMed ID: 2563162

DOI: 10.1073/pnas.86.1.257

PubMed ID: 1683702

Title: The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression.

PubMed ID: 1683702

DOI: 10.1073/pnas.88.23.10525

PubMed ID: 1346576

Title: Characterization of the myeloid-specific CD11b promoter.

PubMed ID: 1346576

PubMed ID: 3539202

Title: N-terminal sequence of human leukocyte glycoprotein Mo1: conservation across species and homology to platelet IIb/IIIa.

PubMed ID: 3539202

DOI: 10.1016/0167-4838(86)90037-3

PubMed ID: 9558116

Title: Human polymorphonuclear leukocytes adhere to complement factor H through an interaction that involves alphaMbeta2 (CD11b/CD18).

PubMed ID: 9558116

PubMed ID: 12208882

Title: The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1.

PubMed ID: 12208882

DOI: 10.1084/jem.20020267

PubMed ID: 15194813

Title: JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration.

PubMed ID: 15194813

DOI: 10.1091/mbc.e04-04-0317

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20008295

Title: Factor H and factor H-related protein 1 bind to human neutrophils via complement receptor 3, mediate attachment to Candida albicans, and enhance neutrophil antimicrobial activity.

PubMed ID: 20008295

DOI: 10.4049/jimmunol.0901702

PubMed ID: 21193407

Title: Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation.

PubMed ID: 21193407

DOI: 10.1074/jbc.m110.171256

PubMed ID: 27055590

Title: LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin.

PubMed ID: 27055590

DOI: 10.1016/j.bbrc.2016.04.007

PubMed ID: 28807980

Title: CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation.

PubMed ID: 28807980

DOI: 10.1182/blood-2017-03-768507

PubMed ID: 7867070

Title: Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18).

PubMed ID: 7867070

DOI: 10.1016/0092-8674(95)90517-0

PubMed ID: 8747460

Title: Two conformations of the integrin A-domain (I-domain): a pathway for activation?

PubMed ID: 8747460

DOI: 10.1016/s0969-2126(01)00271-4

PubMed ID: 9687375

Title: Cation binding to the integrin CD11b I domain and activation model assessment.

PubMed ID: 9687375

DOI: 10.1016/s0969-2126(98)00093-8

PubMed ID: 9560195

Title: Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface.

PubMed ID: 9560195

DOI: 10.1073/pnas.95.9.4870

PubMed ID: 18204448

Title: A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.

PubMed ID: 18204448

DOI: 10.1038/ng.71

PubMed ID: 18204446

Title: Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.

PubMed ID: 18204446

DOI: 10.1038/ng.81

Sequence Information:

  • Length: 1152
  • Mass: 127179
  • Checksum: DF77408ED5EE25F9
  • Sequence:
    • MALRVLLLTA LTLCHGFNLD TENAMTFQEN ARGFGQSVVQ LQGSRVVVGA PQEIVAANQR 
GSLYQCDYST GSCEPIRLQV PVEAVNMSLG LSLAATTSPP QLLACGPTVH QTCSENTYVK 
GLCFLFGSNL RQQPQKFPEA LRGCPQEDSD IAFLIDGSGS IIPHDFRRMK EFVSTVMEQL 
KKSKTLFSLM QYSEEFRIHF TFKEFQNNPN PRSLVKPITQ LLGRTHTATG IRKVVRELFN 
ITNGARKNAF KILVVITDGE KFGDPLGYED VIPEADREGV IRYVIGVGDA FRSEKSRQEL 
NTIASKPPRD HVFQVNNFEA LKTIQNQLRE KIFAIEGTQT GSSSSFEHEM SQEGFSAAIT 
SNGPLLSTVG SYDWAGGVFL YTSKEKSTFI NMTRVDSDMN DAYLGYAAAI ILRNRVQSLV 
LGAPRYQHIG LVAMFRQNTG MWESNANVKG TQIGAYFGAS LCSVDVDSNG STDLVLIGAP 
HYYEQTRGGQ VSVCPLPRGR ARWQCDAVLY GEQGQPWGRF GAALTVLGDV NGDKLTDVAI 
GAPGEEDNRG AVYLFHGTSG SGISPSHSQR IAGSKLSPRL QYFGQSLSGG QDLTMDGLVD 
LTVGAQGHVL LLRSQPVLRV KAIMEFNPRE VARNVFECND QVVKGKEAGE VRVCLHVQKS 
TRDRLREGQI QSVVTYDLAL DSGRPHSRAV FNETKNSTRR QTQVLGLTQT CETLKLQLPN 
CIEDPVSPIV LRLNFSLVGT PLSAFGNLRP VLAEDAQRLF TALFPFEKNC GNDNICQDDL 
SITFSFMSLD CLVVGGPREF NVTVTVRNDG EDSYRTQVTF FFPLDLSYRK VSTLQNQRSQ 
RSWRLACESA SSTEVSGALK STSCSINHPI FPENSEVTFN ITFDVDSKAS LGNKLLLKAN 
VTSENNMPRT NKTEFQLELP VKYAVYMVVT SHGVSTKYLN FTASENTSRV MQHQYQVSNL 
GQRSLPISLV FLVPVRLNQT VIWDRPQVTF SENLSSTCHT KERLPSHSDF LAELRKAPVV 
NCSIAVCQRI QCDIPFFGIQ EEFNATLKGN LSFDWYIKTS HNHLLIVSTA EILFNDSVFT 
LLPGQGAFVR SQTETKVEPF EVPNPLPLIV GSSVGGLLLL ALITAALYKL GFFKRQYKDM 
MSEGGPPGAE PQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.