Details for: ITGB6

Gene ID: 3694

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ITGB6

Ensembl ID: ENSG00000115221

Description: integrin subunit beta 6

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • colon epithelial cell CL0011108
    CSI 9.72
    rCSI 10.18%
    PRS 86.09
  • secretory cell CL0000151
    CSI 3.85
    rCSI 4.01%
    PRS 87.39
  • conjunctival epithelial cell CL1000432
    CSI 3.81
    rCSI 5.81%
    PRS 87.92
  • epithelial cell of lower respiratory tract CL0002632
    CSI 3.63
    rCSI 2.81%
    PRS 91.38
  • goblet cell CL0000160
    CSI 3.48
    rCSI 3.29%
    PRS 86.37
  • respiratory basal cell CL0002633
    CSI 3.44
    rCSI 3.56%
    PRS 90.48
  • intestine goblet cell CL0019031
    CSI 3.24
    rCSI 2.88%
    PRS 86.06
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 3.15
    rCSI 8.2%
    PRS 89.89
  • brush cell of tracheobronchial tree CL0002075
    CSI 2.92
    rCSI 8.67%
    PRS 94.48
  • epithelial cell of lung CL0000082
    CSI 2.84
    rCSI 2.35%
    PRS 89.51
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.66
    rCSI 3.78%
    PRS 85.97
  • M cell of gut CL0000682
    CSI 2.64
    rCSI 2.81%
    PRS 90.96
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 2.57
    rCSI 4.85%
    PRS 94.19
  • stem cell CL0000034
    CSI 2.42
    rCSI 2.33%
    PRS 84.01
  • respiratory hillock cell CL4030023
    CSI 2.39
    rCSI 4.25%
    PRS 92.97
  • BEST4+ enteroycte CL4030026
    CSI 2.28
    rCSI 2.83%
    PRS 88.46
  • luminal epithelial cell of mammary gland CL0002326
    CSI 2.26
    rCSI 4.1%
    PRS 94.11
  • respiratory suprabasal cell CL4033048
    CSI 2.25
    rCSI 2.88%
    PRS 90.52
  • mucous neck cell CL0000651
    CSI 2.23
    rCSI 3.22%
    PRS 91.82
  • fallopian tube secretory epithelial cell CL4030006
    CSI 2.2
    rCSI 2.11%
    PRS 87.3
  • pancreatic acinar cell CL0002064
    CSI 2.18
    rCSI 2.89%
    PRS 91.82
  • basal cell of prostate epithelium CL0002341
    CSI 2.09
    rCSI 6.06%
    PRS 91.72
  • pulmonary alveolar type 2 cell CL0002063
    CSI 2.09
    rCSI 3.24%
    PRS 90.09
  • lung ciliated cell CL1000271
    CSI 1.97
    rCSI 2.28%
    PRS 82.73
  • lung secretory cell CL1000272
    CSI 1.9
    rCSI 4.69%
    PRS 88.91
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.88
    rCSI 4.76%
    PRS 81.57
  • basal cell CL0000646
    CSI 1.87
    rCSI 2.5%
    PRS 85.92
  • epithelial cell of proximal tubule CL0002306
    CSI 1.83
    rCSI 4.48%
    PRS 81.55
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.62
    rCSI 4.19%
    PRS 85.18
  • renal principal cell CL0005009
    CSI 1.55
    rCSI 4.03%
    PRS 88.05
  • foveolar cell of stomach CL0002179
    CSI 1.54
    rCSI 3.28%
    PRS 91.29
  • placental villous trophoblast CL2000060
    CSI 1.32
    rCSI 2.04%
    PRS 87.07
  • pancreatic ductal cell CL0002079
    CSI 1.31
    rCSI 2.55%
    PRS 90.24
  • mammary gland epithelial cell CL0002327
    CSI 1.17
    rCSI 4.11%
    PRS 92.95
  • luminal cell of prostate epithelium CL0002340
    CSI 1.02
    rCSI 5.49%
    PRS 93.02
  • pulmonary alveolar type 1 cell CL0002062
    CSI 0.73
    rCSI 4.19%
    PRS 85.37
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 0.66
    rCSI 5.74%
    PRS 82.97
  • epithelial cell of urethra CL1000296
    CSI 0.45
    rCSI 11.28%
    PRS 91.84
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.33
    rCSI 3.44%
    PRS 84.54

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ITGB6](/details-gene/3694) encodes the integrin beta-6 subunit, a transmembrane protein that exclusively pairs with the alpha-v (αv) subunit to form the αvβ6 integrin complex. This complex functions primarily as a cell surface receptor involved in cell-matrix adhesion, cell migration, and signal transduction. Expression of [ITGB6](/details-gene/3694) is highly restricted, with its most significant presence observed in various types of epithelial cells, particularly in the colon, respiratory tract, and glands. A key and defining function of the αvβ6 integrin is its ability to bind to and activate latent transforming growth factor-beta (TGF-β), a critical cytokine involved in wound healing, immune regulation, and fibrosis ([Link](https://doi.org/10.1083/jcb.200312172)). The gene has been associated with OMIM entry [147558](https://omim.org/entry/147558) and also serves as a receptor for certain viruses. ## Cellular Roles and Expression Landscape The expression profile of [ITGB6](/details-gene/3694) demonstrates a highly specialized role within epithelial tissues. **Overall**, the gene shows its most profound significance in the [colon epithelial cell](/details-cell/CL0011108), where it has a Cell Significance Index (CSI) of 9.72, marking it as a defining feature of this cell lineage. This strong epithelial signature is further supported by its high significance in various secretory and mucosal surface cells, including [secretory cell](/details-cell/CL0000151), [conjunctival epithelial cell](/details-cell/CL1000432), [epithelial cell of lower respiratory tract](/details-cell/CL0002632), and [goblet cell](/details-cell/CL0000160). This pattern suggests that [ITGB6](/details-gene/3694) is a key component of the cellular machinery responsible for maintaining barrier integrity, mediating cell-matrix interactions, and regulating tissue homeostasis in organs exposed to the external environment. Interestingly, the gene also shows significance in [kidney interstitial alternatively activated macrophage](/details-cell/CL1000695). This expression in a non-epithelial cell, specifically a macrophage subtype associated with tissue repair and resolution of inflammation, is consistent with the gene's primary function in activating TGF-β, a potent regulator of wound healing and fibrotic processes. The presence in cells such as [respiratory basal cell](/details-cell/CL0002633) and [stem cell](/details-cell/CL0000034) may indicate a role in epithelial repair and regeneration following injury. ## Pathways and Molecular Function The molecular functions and biological processes associated with [ITGB6](/details-gene/3694) are centered on its role within the αvβ6 integrin complex. Gene Ontology annotations confirm its involvement in '[Cell adhesion](/details-go/GO:0007155)', '[Cell-matrix adhesion](/details-go/GO:0007160)', and the '[Integrin-mediated signaling pathway](/details-go/GO:0007229)'. Its placement on the '[External side of plasma membrane](/details-go/GO:0009897)' as part of the '[Integrin alphav-beta6 complex](/details-go/GO:0034685)' is fundamental to these activities. The most critical function, reflected in the Reactome pathway '[Signaling by tgf-beta receptor complex](/details-reactome/R-HSA-170834)' and GO term '[Transforming growth factor beta receptor signaling pathway](/details-go/GO:0007179)', is the activation of latent TGF-β. Research has shown that mechanical force applied to the αvβ6-latent TGF-β complex is a key mechanism for releasing active TGF-β ([Link](https://doi.org/10.1038/nature21035)). This function directly links [ITGB6](/details-gene/3694) to processes like '[Wound healing](/details-go/GO:0042060)' and '[Inflammatory response](/details-go/GO:0006954)'. Furthermore, its annotated role in '[Virus receptor activity](/details-go/GO:0001618)' is supported by studies identifying αvβ6 as a receptor for coxsackieviruses and herpes simplex virus ([Link](https://doi.org/10.1128/jvi.78.13.6967-6973.2004), [Link](https://doi.org/10.1371/journal.ppat.1003806)). ## Research Directions The restricted expression of [ITGB6](/details-gene/3694) to epithelial surfaces and its unique ability to activate TGF-β make it a pivotal gene in tissue homeostasis and pathology, particularly in fibrosis and cancer. Its upregulation during injury and in certain diseases presents several avenues for future research. **Testable Hypotheses:** 1. Aberrant upregulation of [ITGB6](/details-gene/3694) on respiratory epithelial cells following viral infection or environmental insult is a primary driver of idiopathic pulmonary fibrosis (IPF) by creating a feed-forward loop of excessive TGF-β activation and extracellular matrix deposition. 2. The expression level of [ITGB6](/details-gene/3694) on [colon epithelial cells](/details-cell/CL0011108) dictates the efficiency of entry and subsequent lytic infection by enteric pathogens like Coxsackievirus B1, thereby serving as a key determinant of host susceptibility and disease severity ([Link](https://doi.org/10.1006/viro.1997.8831)). 3. In tumor microenvironments, the expression of [ITGB6](/details-gene/3694) on carcinoma cells promotes immune evasion by activating local TGF-β, which suppresses the function of cytotoxic T lymphocytes and natural killer cells. **Proposed Experiment:** To test the hypothesis regarding the role of [ITGB6](/details-gene/3694) in pulmonary fibrosis, a robust experimental approach would involve using a conditional knockout mouse model. *Itgb6* floxed mice could be crossed with mice expressing Cre recombinase under an epithelial-specific promoter (e.g., Sftpc-CreERT2 for alveolar type II cells). Following tamoxifen induction to delete *Itgb6* specifically in these cells, fibrosis would be induced using intratracheal bleomycin. The experimental and control groups would be compared by analyzing lung function (flexiVent), collagen deposition (histology and hydroxyproline assays), and levels of active TGF-β in bronchoalveolar lavage fluid. Single-cell RNA sequencing could further dissect the downstream effects of epithelial *Itgb6* deletion on fibroblast activation and immune cell infiltration. **Therapeutic Potential:** Due to its highly restricted expression in healthy adult tissues but significant upregulation in fibrosis and many carcinomas (e.g., pancreatic, oral, colon), the αvβ6 integrin is an outstanding therapeutic target. The strategy would focus on **inhibition**. Its cell-surface location makes it accessible to monoclonal antibodies or antibody-drug conjugates designed to either block ligand binding (and thus TGF-β activation) or to deliver cytotoxic agents directly to tumor cells. Small molecule inhibitors that disrupt the αvβ6-TGF-β interaction are also a viable strategy. Such therapies hold promise for treating aggressive cancers and debilitating fibrotic diseases with potentially high specificity and reduced off-target toxicity.

Genular Protein ID: 2926514725

Symbol: ITB6_HUMAN

Name: Integrin beta-6

UniProtKB Accession Codes:

P18564 B2R9W5 C9JA97 Q0VA95 Q16500 Q53RG5 Q53RR6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 ELM 1 EMBL 7 EMDB 5 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 4 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2365683

Title: Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.

PubMed ID: 2365683

DOI: 10.1016/s0021-9258(19)38425-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1382574

Title: The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1.

PubMed ID: 1382574

DOI: 10.1093/intimm/4.9.1031

PubMed ID: 9426447

Title: Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells.

PubMed ID: 9426447

DOI: 10.1006/viro.1997.8831

PubMed ID: 11807098

Title: Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits.

PubMed ID: 11807098

DOI: 10.1083/jcb.200103037

PubMed ID: 15184403

Title: Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1.

PubMed ID: 15184403

DOI: 10.1083/jcb.200312172

PubMed ID: 15194773

Title: Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9.

PubMed ID: 15194773

DOI: 10.1128/jvi.78.13.6967-6973.2004

PubMed ID: 17545607

Title: HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6.

PubMed ID: 17545607

DOI: 10.1158/0008-5472.can-07-0318

PubMed ID: 17158881

Title: alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity.

PubMed ID: 17158881

DOI: 10.1074/jbc.m607008200

PubMed ID: 22278742

Title: GARP regulates the bioavailability and activation of TGFbeta.

PubMed ID: 22278742

DOI: 10.1091/mbc.e11-12-1018

PubMed ID: 24367260

Title: alphavbeta6- and alphavbeta8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion.

PubMed ID: 24367260

DOI: 10.1371/journal.ppat.1003806

PubMed ID: 25383667

Title: Structural determinants of integrin beta-subunit specificity for latent TGF-beta.

PubMed ID: 25383667

DOI: 10.1038/nsmb.2905

PubMed ID: 28117447

Title: Force interacts with macromolecular structure in activation of TGF-beta.

PubMed ID: 28117447

DOI: 10.1038/nature21035

PubMed ID: 24319098

Title: A missense mutation in ITGB6 causes pitted hypomineralized amelogenesis imperfecta.

PubMed ID: 24319098

DOI: 10.1093/hmg/ddt616

PubMed ID: 24305999

Title: ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta.

PubMed ID: 24305999

DOI: 10.1093/hmg/ddt611

Sequence Information:

  • Length: 788
  • Mass: 85936
  • Checksum: EDB7D533EC4C8C4D
  • Sequence:
    • MGIELLCLFF LFLGRNDHVQ GGCALGGAET CEDCLLIGPQ CAWCAQENFT HPSGVGERCD 
TPANLLAKGC QLNFIENPVS QVEILKNKPL SVGRQKNSSD IVQIAPQSLI LKLRPGGAQT 
LQVHVRQTED YPVDLYYLMD LSASMDDDLN TIKELGSRLS KEMSKLTSNF RLGFGSFVEK 
PVSPFVKTTP EEIANPCSSI PYFCLPTFGF KHILPLTNDA ERFNEIVKNQ KISANIDTPE 
GGFDAIMQAA VCKEKIGWRN DSLHLLVFVS DADSHFGMDS KLAGIVIPND GLCHLDSKNE 
YSMSTVLEYP TIGQLIDKLV QNNVLLIFAV TQEQVHLYEN YAKLIPGATV GLLQKDSGNI 
LQLIISAYEE LRSEVELEVL GDTEGLNLSF TAICNNGTLF QHQKKCSHMK VGDTASFSVT 
VNIPHCERRS RHIIIKPVGL GDALELLVSP ECNCDCQKEV EVNSSKCHHG NGSFQCGVCA 
CHPGHMGPRC ECGEDMLSTD SCKEAPDHPS CSGRGDCYCG QCICHLSPYG NIYGPYCQCD 
NFSCVRHKGL LCGGNGDCDC GECVCRSGWT GEYCNCTTST DSCVSEDGVL CSGRGDCVCG 
KCVCTNPGAS GPTCERCPTC GDPCNSKRSC IECHLSAAGQ AREECVDKCK LAGATISEEE 
DFSKDGSVSC SLQGENECLI TFLITTDNEG KTIIHSINEK DCPKPPNIPM IMLGVSLAIL 
LIGVVLLCIW KLLVSFHDRK EVAKFEAERS KAKWQTGTNP LYRGSTSTFK NVTYKHREKQ 
KVDLSTDC

Genular Protein ID: 3439987401

Symbol: B4E2B8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E2B8

Database IDs:

ARBA 16 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 5 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 5 RefSeq 1 RuleBase 1 SAM 1 SMART 6 SUPFAM 4

Sequence Information:

  • Length: 746
  • Mass: 81522
  • Checksum: E435089EF5DD0367
  • Sequence:
    • MITYKNFTHP SGVGERCDTP ANLLAKGCQL NFIENPVSQV EILKNKPLSV GRQKNSSDIV 
QIAPQSLILK LRPGGAQTLQ VHVRQTEDYP VDLYYLMDLS ASMDDDLNTI KELGSRLSKE 
MSKLTSNFRL GFGSFVEKPV SPFVKTTPEE IANPCSSIPY FCLPTFGFKH ILPLTNDAER 
FNEIVKNQKI SANIDTPEGG FDAIMQAAVC KEKIGWRNDS LHLLVFVSDA DSHFGMDSKL 
AGIVIPNDGL CHLDSKNEYS MSTVLEYPTI GQLIDKLVQN NVLLIFAVTQ EQVHLYENYA 
KLIPGATVGL LQKDSGNILQ LIISAYEELR SEVELEVLGD TEGLNLSFTA ICNNGTLFQH 
QKKCSHMKVG DTASFSVTVN IPHCERRSRH IIIKPVGLGD ALELLVSPEC NCDCQKEVEV 
NSSKCHHGNG SFQCGVCACH PGHMGPRCEC GEDMLSTDPC KEAPDHPSCS GRGDCYCGQC 
ICHLSPYGNI YGPYCQCDNF SCVRHKGLLC GGNGDCDCGE CVCRSGWTGE YCNCTTSTDS 
CVSEDGVLCS GRGDCVCGKC VCTNPGASGP TCERCPTCGD PCNSKRSCIE CHLSAAGQAR 
EECVDKCKLA GATISEEEDF SKDGSVSCSL QGENECLITF LITTDNEGKT IIHSINEKDC 
PKPPNIPVIM LGVSLAILLI GVVLLCIWKL LVSFHDRKEV AKFEAERSKA KWQTGTNPLY 
RGSTSTFKNV TYKHREKQKV DLSTDC

Genular Protein ID: 2098844688

Symbol: A0A087WXP3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WXP3

Database IDs:

ARBA 16 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 5 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 9 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 2 Pfam 5 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 6 SMR 1 SUPFAM 4 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 693
  • Mass: 75849
  • Checksum: F04FC7553E9228C7
  • Sequence:
    • MGIELLCLFF LFLGRNDHVQ GGAQTLQVHV RQTEDYPVDL YYLMDLSASM DDDLNTIKEL 
GSRLSKEMSK LTSNFRLGFG SFVEKPVSPF VKTTPEEIAN PCSSIPYFCL PTFGFKHILP 
LTNDAERFNE IVKNQKISAN IDTPEGGFDA IMQAAVCKEK IGWRNDSLHL LVFVSDADSH 
FGMDSKLAGI VIPNDGLCHL DSKNEYSMST VLEYPTIGQL IDKLVQNNVL LIFAVTQEQV 
HLYENYAKLI PGATVGLLQK DSGNILQLII SAYEELRSEV ELEVLGDTEG LNLSFTAICN 
NGTLFQHQKK CSHMKVGDTA SFSVTVNIPH CERRSRHIII KPVGLGDALE LLVSPECNCD 
CQKEVEVNSS KCHHGNGSFQ CGVCACHPGH MGPRCECGED MLSTDSCKEA PDHPSCSGRG 
DCYCGQCICH LSPYGNIYGP YCQCDNFSCV RHKGLLCGGN GDCDCGECVC RSGWTGEYCN 
CTTSTDSCVS EDGVLCSGRG DCVCGKCVCT NPGASGPTCE RCPTCGDPCN SKRSCIECHL 
SAAGQAREEC VDKCKLAGAT ISEEEDFSKD GSVSCSLQGE NECLITFLIT TDNEGKTIIH 
SINEKDCPKP PNIPMIMLGV SLAILLIGVV LLCIWKLLVS FHDRKEVAKF EAERSKAKWQ 
TGTNPLYRGS TSTFKNVTYK HREKQKVDLS TDC

Genular Protein ID: 857721210

Symbol: E9PEE8_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PEE8

Database IDs:

ARBA 16 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 5 GeneTree 1 HGNC 1 InterPro 9 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 1 PROSITE 1 PeptideAtlas 2 Pfam 5 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMART 6 SMR 1 SUPFAM 4 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 746
  • Mass: 81544
  • Checksum: A3767C1EEB3DF1CD
  • Sequence:
    • MITYKNFTHP SGVGERCDTP ANLLAKGCQL NFIENPVSQV EILKNKPLSV GRQKNSSDIV 
QIAPQSLILK LRPGGAQTLQ VHVRQTEDYP VDLYYLMDLS ASMDDDLNTI KELGSRLSKE 
MSKLTSNFRL GFGSFVEKPV SPFVKTTPEE IANPCSSIPY FCLPTFGFKH ILPLTNDAER 
FNEIVKNQKI SANIDTPEGG FDAIMQAAVC KEKIGWRNDS LHLLVFVSDA DSHFGMDSKL 
AGIVIPNDGL CHLDSKNEYS MSTVLEYPTI GQLIDKLVQN NVLLIFAVTQ EQVHLYENYA 
KLIPGATVGL LQKDSGNILQ LIISAYEELR SEVELEVLGD TEGLNLSFTA ICNNGTLFQH 
QKKCSHMKVG DTASFSVTVN IPHCERRSRH IIIKPVGLGD ALELLVSPEC NCDCQKEVEV 
NSSKCHHGNG SFQCGVCACH PGHMGPRCEC GEDMLSTDSC KEAPDHPSCS GRGDCYCGQC 
ICHLSPYGNI YGPYCQCDNF SCVRHKGLLC GGNGDCDCGE CVCRSGWTGE YCNCTTSTDS 
CVSEDGVLCS GRGDCVCGKC VCTNPGASGP TCERCPTCGD PCNSKRSCIE CHLSAAGQAR 
EECVDKCKLA GATISEEEDF SKDGSVSCSL QGENECLITF LITTDNEGKT IIHSINEKDC 
PKPPNIPMIM LGVSLAILLI GVVLLCIWKL LVSFHDRKEV AKFEAERSKA KWQTGTNPLY 
RGSTSTFKNV TYKHREKQKV DLSTDC