Details for: ANOS1

Gene ID: 3730

Symbol: ANOS1

Ensembl ID: ENSG00000011201

Description: anosmin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.6
    Marker Score: 3138
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.45
    Marker Score: 1279
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.78
    Marker Score: 980
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.62
    Marker Score: 34589
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1158
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.47
    Marker Score: 1467.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168561
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 861
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.28
    Marker Score: 19068
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 846
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.25
    Marker Score: 820
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.23
    Marker Score: 444
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.17
    Marker Score: 768
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 480
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4794
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.11
    Marker Score: 7378
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.08
    Marker Score: 496
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.04
    Marker Score: 519
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 787
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.99
    Marker Score: 443
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.96
    Marker Score: 829
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.95
    Marker Score: 7045
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5309
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.91
    Marker Score: 3806.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.91
    Marker Score: 2130
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.86
    Marker Score: 1756
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.82
    Marker Score: 345
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.78
    Marker Score: 12201
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.75
    Marker Score: 27570
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 455
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.68
    Marker Score: 5871
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.68
    Marker Score: 410
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.68
    Marker Score: 4095
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.68
    Marker Score: 602
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.67
    Marker Score: 833
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.66
    Marker Score: 16877
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.63
    Marker Score: 200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.63
    Marker Score: 6349
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.63
    Marker Score: 171
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 407
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.58
    Marker Score: 186
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.57
    Marker Score: 1041
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.55
    Marker Score: 2535
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.55
    Marker Score: 7259
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 228
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.54
    Marker Score: 144
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.54
    Marker Score: 10698
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.53
    Marker Score: 179
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.52
    Marker Score: 910
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.52
    Marker Score: 2000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.51
    Marker Score: 566
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.5
    Marker Score: 193
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.49
    Marker Score: 1002
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.48
    Marker Score: 468
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.48
    Marker Score: 740
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.46
    Marker Score: 223
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.44
    Marker Score: 110
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.44
    Marker Score: 4209
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.44
    Marker Score: 246
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.44
    Marker Score: 607
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.44
    Marker Score: 539
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.43
    Marker Score: 2252
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.38
    Marker Score: 904
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.38
    Marker Score: 121
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.37
    Marker Score: 106
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 365
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.36
    Marker Score: 608
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 172
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.36
    Marker Score: 575
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.36
    Marker Score: 677.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.35
    Marker Score: 326
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.35
    Marker Score: 336
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.35
    Marker Score: 372
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.35
    Marker Score: 4660
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.34
    Marker Score: 2993.5
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.34
    Marker Score: 383
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.34
    Marker Score: 102
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.33
    Marker Score: 547
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.33
    Marker Score: 123
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.32
    Marker Score: 188
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.32
    Marker Score: 1386
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.32
    Marker Score: 150
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.32
    Marker Score: 144
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.31
    Marker Score: 218
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.31
    Marker Score: 1275
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.31
    Marker Score: 592.5

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Other Information

**Key characteristics:** - ANOS1 is a transmembrane protein that is expressed in a variety of cell types. - It is a key regulator of axon guidance and cell adhesion. - It interacts with the FGFR1 protein, which is a key regulator of axon guidance. - When ANOS1 is bound to FGFR1, it inhibits its activity and prevents the formation of a stable signaling complex. - This leads to the migration of neurons along the developing optic nerve in the early stages of development. **Pathways and functions:** - ANOS1 is involved in the regulation of axon guidance and cell adhesion. - It is a key regulator of the migration of neurons along the developing optic nerve in the early stages of development. - It also plays a role in the development of the cerebral cortex and the maintenance of neural connections. **Clinical significance:** - Mutations in the ANOS1 gene have been linked to a number of human diseases, including autism spectrum disorder, schizophrenia, and developmental disorders. - These mutations can lead to a loss of function of ANOS1, which can result in the migration of neurons along the developing optic nerve to incorrect destinations. - This can lead to a variety of developmental and neurological problems, including intellectual disability, behavioral problems, and seizures.

Genular Protein ID: 1875346552

Symbol: KALM_HUMAN

Name: Adhesion molecule-like X-linked

UniProtKB Accession Codes:

P23352 B2RPF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 12 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1913827

Title: The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules.

PubMed ID: 1913827

DOI: 10.1016/0092-8674(91)90193-3

PubMed ID: 1303284

Title: Structure of the X-linked Kallmann syndrome gene and its homologous pseudogene on the Y chromosome.

PubMed ID: 1303284

DOI: 10.1038/ng1292-305

PubMed ID: 1922361

Title: A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules.

PubMed ID: 1922361

DOI: 10.1038/353529a0

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7590336

Title: Characterization of the promoter of the human KAL gene, responsible for the X-chromosome-linked Kallmann syndrome.

PubMed ID: 7590336

DOI: 10.1016/0378-1119(95)00481-k

PubMed ID: 8842728

Title: The Kallmann syndrome gene product expressed in COS cells is cleaved on the cell surface to yield a diffusible component.

PubMed ID: 8842728

DOI: 10.1093/hmg/5.8.1109

PubMed ID: 8832397

Title: Initial characterization of anosmin-1, a putative extracellular matrix protein synthesized by definite neuronal cell populations in the central nervous system.

PubMed ID: 8832397

DOI: 10.1242/jcs.109.7.1749

PubMed ID: 12007408

Title: Anosmin-1, defective in the X-linked form of Kallmann syndrome, promotes axonal branch formation from olfactory bulb output neurons.

PubMed ID: 12007408

DOI: 10.1016/s0092-8674(02)00713-4

PubMed ID: 19696444

Title: Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1.

PubMed ID: 19696444

DOI: 10.1074/jbc.m109.049155

PubMed ID: 15949815

Title: Extended and flexible domain solution structure of the extracellular matrix protein anosmin-1 by X-ray scattering, analytical ultracentrifugation and constrained modelling.

PubMed ID: 15949815

DOI: 10.1016/j.jmb.2005.04.031

PubMed ID: 8504298

Title: Heterogeneity in the mutations responsible for X chromosome-linked Kallmann syndrome.

PubMed ID: 8504298

DOI: 10.1093/hmg/2.4.373

PubMed ID: 8989261

Title: Genetic heterogeneity evidenced by low incidence of KAL-1 gene mutations in sporadic cases of gonadotropin-releasing hormone deficiency.

PubMed ID: 8989261

DOI: 10.1210/jcem.82.1.3692

PubMed ID: 9589672

Title: A recurrent missense mutation in the KAL gene in patients with X-linked Kallmann's syndrome.

PubMed ID: 9589672

DOI: 10.1210/jcem.83.5.4817

PubMed ID: 11297579

Title: The importance of autosomal genes in Kallmann syndrome: genotype-phenotype correlations and neuroendocrine characteristics.

PubMed ID: 11297579

DOI: 10.1210/jcem.86.4.7420

PubMed ID: 15471890

Title: The product of X-linked Kallmann's syndrome gene (KAL1) affects the migratory activity of gonadotropin-releasing hormone (GnRH)-producing neurons.

PubMed ID: 15471890

DOI: 10.1093/hmg/ddh309

PubMed ID: 15001591

Title: Clinical assessment and mutation analysis of Kallmann syndrome 1 (KAL1) and fibroblast growth factor receptor 1 (FGFR1, or KAL2) in five families and 18 sporadic patients.

PubMed ID: 15001591

DOI: 10.1210/jc.2003-030476

PubMed ID: 15605412

Title: Kallmann syndrome: 14 novel mutations in KAL1 and FGFR1 (KAL2).

PubMed ID: 15605412

DOI: 10.1002/humu.9298

PubMed ID: 17054399

Title: Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2.

PubMed ID: 17054399

DOI: 10.1371/journal.pgen.0020175

PubMed ID: 17223984

Title: Clinical assessment and molecular analysis of GnRHR and KAL1 genes in males with idiopathic hypogonadotrophic hypogonadism.

PubMed ID: 17223984

DOI: 10.1111/j.1365-2265.2006.02702.x

PubMed ID: 17213338

Title: KAL1 mutations are not a common cause of idiopathic hypogonadotrophic hypogonadism in humans.

PubMed ID: 17213338

DOI: 10.1093/molehr/gal108

PubMed ID: 21168128

Title: A fertile male patient with Kallmann syndrome and two missense mutations in the KAL1 gene.

PubMed ID: 21168128

DOI: 10.1016/j.fertnstert.2010.11.045

PubMed ID: 20530987

Title: Identification of two novel missense mutations in the KAL1 gene in Han Chinese subjects with Kallmann Syndrome.

PubMed ID: 20530987

DOI: 10.1007/bf03346695

PubMed ID: 22927827

Title: SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.

PubMed ID: 22927827

DOI: 10.1371/journal.pgen.1002896

PubMed ID: 23643382

Title: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.

PubMed ID: 23643382

DOI: 10.1016/j.ajhg.2013.04.008

PubMed ID: 25077900

Title: The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients.

PubMed ID: 25077900

DOI: 10.1210/jc.2014-2110

Sequence Information:

  • Length: 680
  • Mass: 76112
  • Checksum: F491FE94FFD9250E
  • Sequence:
    • MVPGVPGAVL TLCLWLAASS GCLAAGPGAA AARRLDESLS AGSVQRARCA SRCLSLQITR 
ISAFFQHFQN NGSLVWCQNH KQCSKCLEPC KESGDLRKHQ CQSFCEPLFP KKSYECLTSC 
EFLKYILLVK QGDCPAPEKA SGFAAACVES CEVDNECSGV KKCCSNGCGH TCQVPKTLYK 
GVPLKPRKEL RFTELQSGQL EVKWSSKFNI SIEPVIYVVQ RRWNYGIHPS EDDATHWQTV 
AQTTDERVQL TDIRPSRWYQ FRVAAVNVHG TRGFTAPSKH FRSSKDPSAP PAPANLRLAN 
STVNSDGSVT VTIVWDLPEE PDIPVHHYKV FWSWMVSSKS LVPTKKKRRK TTDGFQNSVI 
LEKLQPDCDY VVELQAITYW GQTRLKSAKV SLHFTSTHAT NNKEQLVKTR KGGIQTQLPF 
QRRRPTRPLE VGAPFYQDGQ LQVKVYWKKT EDPTVNRYHV RWFPEACAHN RTTGSEASSG 
MTHENYIILQ DLSFSCKYKV TVQPIRPKSH SKAEAVFFTT PPCSALKGKS HKPVGCLGEA 
GHVLSKVLAK PENLSASFIV QDVNITGHFS WKMAKANLYQ PMTGFQVTWA EVTTESRQNS 
LPNSIISQSQ ILPSDHYVLT VPNLRPSTLY RLEVQVLTPG GEGPATIKTF RTPELPPSSA 
HRSHLKHRHP HHYKPSPERY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.