Details for: KCNC3

Gene ID: 3748

Symbol: KCNC3

Ensembl ID: ENSG00000131398

Description: potassium voltage-gated channel subfamily C member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 63.2613
    Cell Significance Index: -9.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.9808
    Cell Significance Index: -9.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1803
    Cell Significance Index: 27.2700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.0555
    Cell Significance Index: 12.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0404
    Cell Significance Index: 22.7800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.9571
    Cell Significance Index: 13.2800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.7996
    Cell Significance Index: -1.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6776
    Cell Significance Index: 135.9300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6393
    Cell Significance Index: 7.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6196
    Cell Significance Index: 117.9200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4827
    Cell Significance Index: 4.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4186
    Cell Significance Index: 28.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3796
    Cell Significance Index: 37.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3757
    Cell Significance Index: 10.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3554
    Cell Significance Index: 127.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3240
    Cell Significance Index: 292.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3186
    Cell Significance Index: 5.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2753
    Cell Significance Index: 14.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2088
    Cell Significance Index: 13.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1961
    Cell Significance Index: 31.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1899
    Cell Significance Index: 103.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1826
    Cell Significance Index: 19.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1767
    Cell Significance Index: 6.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1720
    Cell Significance Index: 7.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1705
    Cell Significance Index: 117.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1600
    Cell Significance Index: 4.6100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.1387
    Cell Significance Index: 1.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1309
    Cell Significance Index: 23.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1193
    Cell Significance Index: 7.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0933
    Cell Significance Index: 4.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0795
    Cell Significance Index: 15.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0664
    Cell Significance Index: 8.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0609
    Cell Significance Index: 4.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0468
    Cell Significance Index: 1.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0402
    Cell Significance Index: 0.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0346
    Cell Significance Index: 53.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0311
    Cell Significance Index: 57.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0291
    Cell Significance Index: 39.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0282
    Cell Significance Index: 1.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0154
    Cell Significance Index: 0.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0057
    Cell Significance Index: 0.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0009
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0077
    Cell Significance Index: -0.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0081
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0095
    Cell Significance Index: -7.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0100
    Cell Significance Index: -7.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0120
    Cell Significance Index: -3.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0122
    Cell Significance Index: -5.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0125
    Cell Significance Index: -7.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0127
    Cell Significance Index: -7.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0149
    Cell Significance Index: -6.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0150
    Cell Significance Index: -9.3600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0168
    Cell Significance Index: -0.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0279
    Cell Significance Index: -1.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0289
    Cell Significance Index: -3.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0330
    Cell Significance Index: -5.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0347
    Cell Significance Index: -1.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0358
    Cell Significance Index: -5.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0368
    Cell Significance Index: -3.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0413
    Cell Significance Index: -4.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0448
    Cell Significance Index: -0.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0462
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0463
    Cell Significance Index: -9.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0487
    Cell Significance Index: -6.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0545
    Cell Significance Index: -7.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0592
    Cell Significance Index: -1.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0623
    Cell Significance Index: -7.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0706
    Cell Significance Index: -5.4200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0773
    Cell Significance Index: -1.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0779
    Cell Significance Index: -1.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0784
    Cell Significance Index: -4.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0790
    Cell Significance Index: -5.8900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0849
    Cell Significance Index: -1.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0882
    Cell Significance Index: -1.8300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0917
    Cell Significance Index: -1.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0926
    Cell Significance Index: -9.6400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0941
    Cell Significance Index: -1.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0947
    Cell Significance Index: -4.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1049
    Cell Significance Index: -2.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1135
    Cell Significance Index: -3.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1157
    Cell Significance Index: -3.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1162
    Cell Significance Index: -9.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1193
    Cell Significance Index: -8.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1319
    Cell Significance Index: -4.3200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1350
    Cell Significance Index: -1.2800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1471
    Cell Significance Index: -3.0700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1480
    Cell Significance Index: -2.2900
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1511
    Cell Significance Index: -1.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1523
    Cell Significance Index: -4.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1528
    Cell Significance Index: -9.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1529
    Cell Significance Index: -4.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1579
    Cell Significance Index: -8.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1643
    Cell Significance Index: -5.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1750
    Cell Significance Index: -5.6100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2016
    Cell Significance Index: -5.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2056
    Cell Significance Index: -8.9400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2141
    Cell Significance Index: -1.8200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2244
    Cell Significance Index: -1.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Voltage-Gated Potassium Channel Function:** KCNC3 forms homooligomers to create tetrameric channels that are sensitive to voltage, allowing for the regulation of potassium ion flow across the plasma membrane. 2. **Delayed Rectifier Potassium Current:** KCNC3 channels contribute to the delayed rectifier potassium current, which helps to terminate neuronal action potentials and maintain the resting membrane potential. 3. **Ampullar and Chandelier Interneurons:** KCNC3 is specifically expressed in GABAergic cortical interneurons, including ampullar and chandelier cells, where it plays a crucial role in regulating synaptic transmission and network activity. 4. **Multi-Tissue Expression:** KCNC3 is widely expressed in various tissues, including the nervous system, kidney, colon, and immune cells, highlighting its diverse functional roles. **Pathways and Functions:** 1. **Voltage-Gated Potassium Channel Activity:** KCNC3 channels regulate potassium ion flow across the plasma membrane, influencing neuronal excitability, synaptic transmission, and cellular proliferation. 2. **Cellular Proliferation and Differentiation:** KCNC3 has been implicated in the regulation of cellular proliferation and differentiation in various tissues, including the nervous system and intestinal epithelium. 3. **Immune Cell Function:** KCNC3 is expressed in immune cells, including mononuclear cells and innate lymphoid cells, where it may contribute to the regulation of immune responses and inflammation. 4. **Renal Function:** KCNC3 has been shown to play a role in the regulation of renal function, particularly in the kidney proximal straight tubule epithelial cell. **Clinical Significance:** 1. **Neurological Disorders:** KCNC3 mutations have been associated with neurological disorders, including epilepsy, intellectual disability, and autism spectrum disorder, highlighting the gene's importance in neuronal function and development. 2. **Renal Disease:** KCNC3 dysfunction has been implicated in renal disease, including chronic kidney disease and acute kidney injury, underscoring the gene's role in maintaining renal function. 3. **Cancer:** KCNC3 expression has been observed in various types of cancer, including colorectal cancer, suggesting a potential role in tumorigenesis and cancer progression. 4. **Immune-Mediated Disorders:** KCNC3 has been implicated in immune-mediated disorders, including autoimmune diseases and inflammatory conditions, highlighting the gene's importance in regulating immune responses. In conclusion, KCNC3 is a critical regulator of voltage-gated potassium channels, with significant implications for neuronal function, cellular proliferation, and immune responses. Further research is necessary to fully elucidate the gene's functions and clinical significance, but its importance in multiple physiological and pathological contexts is clear.

Genular Protein ID: 108118108

Symbol: KCNC3_HUMAN

Name: Potassium voltage-gated channel subfamily C member 3

UniProtKB Accession Codes:

Q14003

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10712820

Title: Kv3.3 potassium channels in lens epithelium and corneal endothelium.

PubMed ID: 10712820

DOI: 10.1006/exer.1999.0796

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 26997484

Title: Kv3.3 channels bind Hax-1 and Arp2/3 to assemble a stable local actin network that regulates channel gating.

PubMed ID: 26997484

DOI: 10.1016/j.cell.2016.02.009

PubMed ID: 22289912

Title: Altered Kv3.3 channel gating in early-onset spinocerebellar ataxia type 13.

PubMed ID: 22289912

DOI: 10.1113/jphysiol.2012.228205

PubMed ID: 23734863

Title: Spinocerebellar ataxia-13 Kv3.3 potassium channels: arginine-to-histidine mutations affect both functional and protein expression on the cell surface.

PubMed ID: 23734863

DOI: 10.1042/bj20130034

PubMed ID: 25152487

Title: KCNC3(R420H), a K(+) channel mutation causative in spinocerebellar ataxia 13 displays aberrant intracellular trafficking.

PubMed ID: 25152487

DOI: 10.1016/j.nbd.2014.08.020

PubMed ID: 16501573

Title: Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental nervous system phenotypes.

PubMed ID: 16501573

DOI: 10.1038/ng1758

PubMed ID: 19953606

Title: KCNC3: phenotype, mutations, channel biophysics-a study of 260 familial ataxia patients.

PubMed ID: 19953606

DOI: 10.1002/humu.21165

PubMed ID: 21479265

Title: Frequency of KCNC3 DNA variants as causes of spinocerebellar ataxia 13 (SCA13).

PubMed ID: 21479265

DOI: 10.1371/journal.pone.0017811

PubMed ID: 25756792

Title: Functional analysis helps to define KCNC3 mutational spectrum in dutch ataxia cases.

PubMed ID: 25756792

DOI: 10.1371/journal.pone.0116599

Sequence Information:

  • Length: 757
  • Mass: 80578
  • Checksum: B44306B850DFD797
  • Sequence:
    • MLSSVCVSSF RGRQGASKQQ PAPPPQPPES PPPPPLPPQQ QQPAQPGPAA SPAGPPAPRG 
PGDRRAEPCP GLPAAAMGRH GGGGGDSGKI VINVGGVRHE TYRSTLRTLP GTRLAGLTEP 
EAAARFDYDP GADEFFFDRH PGVFAYVLNY YRTGKLHCPA DVCGPLFEEE LGFWGIDETD 
VEACCWMTYR QHRDAEEALD SFEAPDPAGA ANAANAAGAH DGGLDDEAGA GGGGLDGAGG 
ELKRLCFQDA GGGAGGPPGG AGGAGGTWWR RWQPRVWALF EDPYSSRAAR YVAFASLFFI 
LISITTFCLE THEGFIHISN KTVTQASPIP GAPPENITNV EVETEPFLTY VEGVCVVWFT 
FEFLMRITFC PDKVEFLKSS LNIIDCVAIL PFYLEVGLSG LSSKAAKDVL GFLRVVRFVR 
ILRIFKLTRH FVGLRVLGHT LRASTNEFLL LIIFLALGVL IFATMIYYAE RIGADPDDIL 
GSNHTYFKNI PIGFWWAVVT MTTLGYGDMY PKTWSGMLVG ALCALAGVLT IAMPVPVIVN 
NFGMYYSLAM AKQKLPKKKN KHIPRPPQPG SPNYCKPDPP PPPPPHPHHG SGGISPPPPI 
TPPSMGVTVA GAYPAGPHTH PGLLRGGAGG LGIMGLPPLP APGEPCPLAQ EEVIEINRAD 
PRPNGDPAAA ALAHEDCPAI DQPAMSPEDK SPITPGSRGR YSRDRACFLL TDYAPSPDGS 
IRKATGAPPL PPQDWRKPGP PSFLPDLNAN AAAWISP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.