Details for: KCNK2

Gene ID: 3776

Symbol: KCNK2

Ensembl ID: ENSG00000082482

Description: potassium two pore domain channel subfamily K member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.36
    Marker Score: 4891
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.88
    Marker Score: 927
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.71
    Marker Score: 14724
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.55
    Marker Score: 95304
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.47
    Marker Score: 26173
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.37
    Marker Score: 13006
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.35
    Marker Score: 2750
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.33
    Marker Score: 26386
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.32
    Marker Score: 2497
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.28
    Marker Score: 2454
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.27
    Marker Score: 48258
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.13
    Marker Score: 681
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.12
    Marker Score: 3195
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.08
    Marker Score: 1156
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.04
    Marker Score: 1200
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1
    Marker Score: 945
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48039
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.89
    Marker Score: 3696
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.88
    Marker Score: 3575
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.87
    Marker Score: 978
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.77
    Marker Score: 12117
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.73
    Marker Score: 385
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.68
    Marker Score: 192
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.67
    Marker Score: 423
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.67
    Marker Score: 24819
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.63
    Marker Score: 5337
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.62
    Marker Score: 765
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.58
    Marker Score: 1376
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.58
    Marker Score: 258
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.56
    Marker Score: 3751
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.56
    Marker Score: 178.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.55
    Marker Score: 2549
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.53
    Marker Score: 170
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.51
    Marker Score: 243
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.48
    Marker Score: 185
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.46
    Marker Score: 15673
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.45
    Marker Score: 265
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.43
    Marker Score: 182
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.43
    Marker Score: 198
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.43
    Marker Score: 474
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.4
    Marker Score: 177
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.37
    Marker Score: 136
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.36
    Marker Score: 513
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.35
    Marker Score: 171
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.34
    Marker Score: 339
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.34
    Marker Score: 180
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.34
    Marker Score: 159
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.33
    Marker Score: 86
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.32
    Marker Score: 107
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.32
    Marker Score: 183
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.3
    Marker Score: 86
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.29
    Marker Score: 325
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.29
    Marker Score: 168
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.27
    Marker Score: 1447
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.27
    Marker Score: 139
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.25
    Marker Score: 74
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.25
    Marker Score: 253
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.25
    Marker Score: 422
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.25
    Marker Score: 62
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.25
    Marker Score: 133
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.24
    Marker Score: 368
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.23
    Marker Score: 81
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.23
    Marker Score: 132
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 137
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.23
    Marker Score: 84
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.21
    Marker Score: 183
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.21
    Marker Score: 702
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.2
    Marker Score: 487.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.2
    Marker Score: 79
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.19
    Marker Score: 65
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.18
    Marker Score: 172
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 159
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.17
    Marker Score: 97
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.17
    Marker Score: 76
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.16
    Marker Score: 126
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.16
    Marker Score: 452
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.16
    Marker Score: 35
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.16
    Marker Score: 185
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.14
    Marker Score: 141
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.14
    Marker Score: 28
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.14
    Marker Score: 68
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.13
    Marker Score: 35
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.13
    Marker Score: 796
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.13
    Marker Score: 36
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.13
    Marker Score: 140
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.13
    Marker Score: 979
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.13
    Marker Score: 34

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Other Information

## Summary The KCNK2 gene is a potassium channel subfamily K member 2, encoding a protein that is expressed in a variety of cell types. The protein is involved in a variety of cellular processes, including cardiac conduction, cardiac ventricle development, cellular response to hypoxia, cochlea development, G protein-coupled receptor signaling pathway, memory, muscle contraction, negative regulation of cardiac muscle cell proliferation, neuronal system, and outward rectifier potassium channel activity. ## Key characteristics * The KCNK2 gene is located on chromosome 19p13.2. * The protein is a transmembrane protein with a molecular weight of approximately 140 kDa. * The protein is expressed in a variety of cell types, including kidney proximal convoluted tubule epithelial cell, leptomeningeal cell, L6b glutamatergic cortical neuron, L2/3-6 intratelencephalic projecting glutamatergic neuron, cortical cell of adrenal gland, corticothalamic-projecting glutamatergic cortical neuron, immature innate lymphoid cell, sst GABAergic cortical interneuron, and cardiac endothelial cell. * The protein is a key regulator of cardiac muscle contraction. * Mutations in the KCNK2 gene have been linked to a variety of cardiac disorders, including heart failure, arrhythmias, and cardiomyopathy. ## Pathways and functions The KCNK2 gene is involved in a variety of cellular processes, including: * Cardiac conduction: The protein is expressed in the heart and is involved in the regulation of cardiac conduction. Mutations in the KCNK2 gene have been linked to a variety of cardiac disorders, including heart failure, arrhythmias, and cardiomyopathy. * Cardiac ventricle development: The protein is also expressed in the heart during embryonic development. Mutations in the KCNK2 gene have been linked to a variety of congenital heart defects. * Cellular response to hypoxia: The protein is expressed in a variety of cell types that are exposed to hypoxia, including cardiac endothelial cells, kidney proximal convoluted tubule epithelial cells, and L6b glutamatergic cortical neurons. Mutations in the KCNK2 gene have been linked to a variety of hypoxic-induced cardiac disorders, such as heart failure and stroke. * Cochlea development: The protein is expressed in the cells of the cochlea, which are responsible for hearing. Mutations in the KCNK2 gene have been linked to a variety of hearing disorders, including tinnitus and deafness. * G protein-coupled receptor signaling pathway: The protein is a key regulator of the G protein-coupled receptor signaling pathway. Mutations in the KCNK2 gene have been linked to a variety of G protein-coupled receptor signaling disorders, including hypertension and diabetes. * Memory: The protein is expressed in a variety of cell types that are involved in memory, including cortical cells and interneurons. Mutations in the KCNK2 gene have been linked to a variety of memory disorders, including Alzheimer's disease and autism. * Muscle contraction: The protein is expressed in skeletal muscle cells. Mutations in the KCNK2 gene have been linked to a variety of muscle disorders, including muscle weakness and cramps. ## Clinical significance Mutations in the KCNK2 gene have been linked to a variety of cardiac disorders, including heart failure, arrhythmias, and cardiomyopathy. The protein is a key regulator of cardiac muscle contraction, and mutations in the KCNK2 gene can lead to abnormal heart rhythms and heart failure. The protein is also involved in the regulation of cardiac ventricle development, and mutations in the KCNK2 gene can lead to congenital heart defects. In addition, mutations in the KCNK2 gene have been linked to a variety of hearing disorders, including tinnitus and deafness.

Genular Protein ID: 1042329577

Symbol: KCNK2_HUMAN

Name: Potassium channel subfamily K member 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10321245

Title: Inhalational anesthetics activate two-pore-domain background K+ channels.

PubMed ID: 10321245

DOI: 10.1038/8084

PubMed ID: 10784345

Title: Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel.

PubMed ID: 10784345

DOI: 10.1007/s004249900235

PubMed ID: 24196565

Title: A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels.

PubMed ID: 24196565

DOI: 10.1007/s00424-013-1384-z

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11319556

Title: KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel.

PubMed ID: 11319556

DOI: 10.1038/87434

PubMed ID: 23169818

Title: SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.

PubMed ID: 23169818

DOI: 10.1126/scisignal.2003431

PubMed ID: 26642364

Title: POPDC1S201F causes muscular dystrophy and arrhythmia by affecting protein trafficking.

PubMed ID: 26642364

DOI: 10.1172/jci79562

Sequence Information:

  • Length: 426
  • Mass: 47093
  • Checksum: DB10382B1803DA13
  • Sequence:
  • MLPSASRERP GYRAGVAAPD LLDPKSAAQN SKPRLSFSTK PTVLASRVES DTTINVMKWK 
    TVSTIFLVVV LYLIIGATVF KALEQPHEIS QRTTIVIQKQ TFISQHSCVN STELDELIQQ 
    IVAAINAGII PLGNTSNQIS HWDLGSSFFF AGTVITTIGF GNISPRTEGG KIFCIIYALL 
    GIPLFGFLLA GVGDQLGTIF GKGIAKVEDT FIKWNVSQTK IRIISTIIFI LFGCVLFVAL 
    PAIIFKHIEG WSALDAIYFV VITLTTIGFG DYVAGGSDIE YLDFYKPVVW FWILVGLAYF 
    AAVLSMIGDW LRVISKKTKE EVGEFRAHAA EWTANVTAEF KETRRRLSVE IYDKFQRATS 
    IKRKLSAELA GNHNQELTPC RRTLSVNHLT SERDVLPPLL KTESIYLNGL TPHCAGEEIA 
    VIENIK

Genular Protein ID: 782303559

Symbol: U3N6F0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 411
  • Mass: 45495
  • Checksum: FDE40CAB21B42A1C
  • Sequence:
  • MAAPDLLDPK SAAQNSKPRL SFSTKPTVLA SRVESDTTIN VMKWKTVSTI FLVVVLYLII 
    GATVFKALEQ PHEISQRTTI VIQKQTFISQ HSCVNSTELD ELIQQIVAAI NAGIIPLGNT 
    SNQISHWDLG SSFFFAGTVI TTIGFGNISP RTEGGKIFCI IYALLGIPLF GFLLAGVGDQ 
    LGTIFGKGIA KVEDTFIKWN VSQTKIRIIS TIIFILFGCV LFVALPAIIF KHIEGWSALD 
    AIYFVVITLT TIGFGDYVAG GSDIEYLDFY KPVVWFWILV GLAYFAAVLS MIGDWLRVIS 
    KKTKEEVGEF RAHAAEWTAN VTAEFKETRR RLSVEIYDKF QRATSIKRKL SAELAGNHNQ 
    ELTPCRRTLS VNHLTSERDV LPPLLKTESI YLNGLTPHCA GEEIAVIENI K

Genular Protein ID: 3940273243

Symbol: Q6ZW95_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 152
  • Mass: 17248
  • Checksum: DC9BF5C52AC672AB
  • Sequence:
  • MMNPRAKRDF YLAAPDLLDP KSAAQNSKPR LSFSTKPTVL ASRVESDTTI NVMKWKTVST 
    IFLVVVLYLI IGATVFKALE QPHEISQRTT IVIQKQTFIS QHSCVNSTEL DELIQDLETS 
    HHAQKAAKYS VSSMPYWEFP SLVFSWLELE IS

Genular Protein ID: 2967993962

Symbol: U3N834_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 422
  • Mass: 46888
  • Checksum: 1AD4E0B5C1B6CBE7
  • Sequence:
  • MMNPRAKRDF YLAAPDLLDP KSAAQNSKPR LSFSTKPTVL ASRVESDTTI NVMKWKTVST 
    IFLVVVLYLI IGATVFKALE QPHEISQRTT IVIQKQTFIS QHSCVNSTEL DELIQQIVAA 
    INAGIIPLGN TSNQISHWDL GSSFFFAGTV ITTIGFGNIS PRTEGGKIFC IIYALLGIPL 
    FGFLLAGVGD QLGTIFGKGI AKVEDTFIKW NVSQTKIRII STIIFILFGC VLFVALPAII 
    FKHIEGWSAL DAIYFVVITL TTIGFGDYVA GGSDIEYLDF YKPVVWFWIL VGLAYFAAVL 
    SMIGDWLRVI SKKTKEEVGE FRAHAAEWTA NVTAEFKETR RRLSVEIYDK FQRATSIKRK 
    LSAELAGNHN QELTPCRRTL SVNHLTSERD VLPPLLKTES IYLNGLTPHC AGEEIAVIEN 
    IK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.