Details for: KCNK2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 5.9124
Cell Significance Index: 126.3800 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 4.2097
Cell Significance Index: 65.1300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.6186
Cell Significance Index: 70.1700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.4050
Cell Significance Index: 106.3800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.0241
Cell Significance Index: -4.4300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.5562
Cell Significance Index: 58.9300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.7149
Cell Significance Index: 48.0700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4967
Cell Significance Index: 99.6300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3425
Cell Significance Index: 236.8600 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2379
Cell Significance Index: 30.5000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2377
Cell Significance Index: 14.6100 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.1951
Cell Significance Index: 4.6800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1950
Cell Significance Index: 4.2700 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.0512
Cell Significance Index: 1.4600 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.0174
Cell Significance Index: 0.3500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0090
Cell Significance Index: 3.9800 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.0071
Cell Significance Index: 0.1400 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0014
Cell Significance Index: 0.0200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0004
Cell Significance Index: -0.1300 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.0023
Cell Significance Index: -0.0300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0050
Cell Significance Index: -9.4300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0057
Cell Significance Index: -10.4600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0065
Cell Significance Index: -10.0300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0086
Cell Significance Index: -11.7600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0136
Cell Significance Index: -8.4700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0153
Cell Significance Index: -11.3400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0170
Cell Significance Index: -12.8600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0175
Cell Significance Index: -11.0900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0186
Cell Significance Index: -0.6100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0202
Cell Significance Index: -11.4000 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0210
Cell Significance Index: -11.4600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0243
Cell Significance Index: -11.0100 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.0347
Cell Significance Index: -0.3300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0376
Cell Significance Index: -10.8100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0455
Cell Significance Index: -0.7800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0521
Cell Significance Index: -6.7300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0533
Cell Significance Index: -10.5800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0561
Cell Significance Index: -10.1100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0566
Cell Significance Index: -11.9200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0577
Cell Significance Index: -9.8600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0729
Cell Significance Index: -10.6000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0762
Cell Significance Index: -10.4700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0816
Cell Significance Index: -2.6000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0868
Cell Significance Index: -10.6700 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0886
Cell Significance Index: -1.8800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0907
Cell Significance Index: -9.2600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0974
Cell Significance Index: -4.5800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1084
Cell Significance Index: -11.2900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1091
Cell Significance Index: -12.7100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1150
Cell Significance Index: -13.1700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1290
Cell Significance Index: -7.2400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.1381
Cell Significance Index: -3.3700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1427
Cell Significance Index: -10.9500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1528
Cell Significance Index: -11.3900 - Cell Name: neural cell (CL0002319)
Fold Change: -0.1851
Cell Significance Index: -2.1600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2114
Cell Significance Index: -11.1000 - Cell Name: neuron (CL0000540)
Fold Change: -0.2163
Cell Significance Index: -2.0500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2191
Cell Significance Index: -11.4100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2220
Cell Significance Index: -10.3500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2231
Cell Significance Index: -11.5900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2437
Cell Significance Index: -6.8100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2568
Cell Significance Index: -6.6000 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.2570
Cell Significance Index: -2.8000 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.2579
Cell Significance Index: -2.7400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2832
Cell Significance Index: -9.9200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2900
Cell Significance Index: -6.0700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2910
Cell Significance Index: -5.6800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3155
Cell Significance Index: -9.0500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3165
Cell Significance Index: -11.6200 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.3423
Cell Significance Index: -4.3200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3519
Cell Significance Index: -12.2300 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.3561
Cell Significance Index: -15.4800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.3603
Cell Significance Index: -12.6600 - Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: -0.3635
Cell Significance Index: -4.0100 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.3990
Cell Significance Index: -12.6200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4057
Cell Significance Index: -11.9500 - Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
Fold Change: -0.4071
Cell Significance Index: -4.1900 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.4225
Cell Significance Index: -10.5400 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.4231
Cell Significance Index: -5.0600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4277
Cell Significance Index: -11.4200 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.4327
Cell Significance Index: -10.4800 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.4403
Cell Significance Index: -10.9800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.4411
Cell Significance Index: -12.7100 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4464
Cell Significance Index: -11.1500 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.4475
Cell Significance Index: -9.3400 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.4551
Cell Significance Index: -7.2200 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.4557
Cell Significance Index: -11.6100 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4763
Cell Significance Index: -10.2900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4773
Cell Significance Index: -12.5500 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.4896
Cell Significance Index: -8.3700 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.4904
Cell Significance Index: -9.7800 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.4983
Cell Significance Index: -10.1400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5009
Cell Significance Index: -12.5200 - Cell Name: peg cell (CL4033014)
Fold Change: -0.5034
Cell Significance Index: -11.6300 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.5157
Cell Significance Index: -10.1500 - Cell Name: preosteoblast (CL0007010)
Fold Change: -0.5515
Cell Significance Index: -5.0100 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.5636
Cell Significance Index: -11.0200 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: -0.5641
Cell Significance Index: -8.4400 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.5687
Cell Significance Index: -9.8300 - Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.5692
Cell Significance Index: -8.5200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1042329577
Symbol: KCNK2_HUMAN
Name: Potassium channel subfamily K member 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10321245
Title: Inhalational anesthetics activate two-pore-domain background K+ channels.
PubMed ID: 10321245
DOI: 10.1038/8084
PubMed ID: 10784345
Title: Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel.
PubMed ID: 10784345
PubMed ID: 24196565
Title: A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels.
PubMed ID: 24196565
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11319556
Title: KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel.
PubMed ID: 11319556
DOI: 10.1038/87434
PubMed ID: 23169818
Title: SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.
PubMed ID: 23169818
PubMed ID: 26642364
Title: POPDC1S201F causes muscular dystrophy and arrhythmia by affecting protein trafficking.
PubMed ID: 26642364
DOI: 10.1172/jci79562
PubMed ID: 30573346
Title: Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK.
PubMed ID: 30573346
PubMed ID: 38605031
Title: Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2.
PubMed ID: 38605031
Sequence Information:
- Length: 426
- Mass: 47093
- Checksum: DB10382B1803DA13
- Sequence:
MLPSASRERP GYRAGVAAPD LLDPKSAAQN SKPRLSFSTK PTVLASRVES DTTINVMKWK TVSTIFLVVV LYLIIGATVF KALEQPHEIS QRTTIVIQKQ TFISQHSCVN STELDELIQQ IVAAINAGII PLGNTSNQIS HWDLGSSFFF AGTVITTIGF GNISPRTEGG KIFCIIYALL GIPLFGFLLA GVGDQLGTIF GKGIAKVEDT FIKWNVSQTK IRIISTIIFI LFGCVLFVAL PAIIFKHIEG WSALDAIYFV VITLTTIGFG DYVAGGSDIE YLDFYKPVVW FWILVGLAYF AAVLSMIGDW LRVISKKTKE EVGEFRAHAA EWTANVTAEF KETRRRLSVE IYDKFQRATS IKRKLSAELA GNHNQELTPC RRTLSVNHLT SERDVLPPLL KTESIYLNGL TPHCAGEEIA VIENIK
Genular Protein ID: 782303559
Symbol: U3N6F0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 411
- Mass: 45495
- Checksum: FDE40CAB21B42A1C
- Sequence:
MAAPDLLDPK SAAQNSKPRL SFSTKPTVLA SRVESDTTIN VMKWKTVSTI FLVVVLYLII GATVFKALEQ PHEISQRTTI VIQKQTFISQ HSCVNSTELD ELIQQIVAAI NAGIIPLGNT SNQISHWDLG SSFFFAGTVI TTIGFGNISP RTEGGKIFCI IYALLGIPLF GFLLAGVGDQ LGTIFGKGIA KVEDTFIKWN VSQTKIRIIS TIIFILFGCV LFVALPAIIF KHIEGWSALD AIYFVVITLT TIGFGDYVAG GSDIEYLDFY KPVVWFWILV GLAYFAAVLS MIGDWLRVIS KKTKEEVGEF RAHAAEWTAN VTAEFKETRR RLSVEIYDKF QRATSIKRKL SAELAGNHNQ ELTPCRRTLS VNHLTSERDV LPPLLKTESI YLNGLTPHCA GEEIAVIENI K
Genular Protein ID: 2967993962
Symbol: U3N834_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 422
- Mass: 46888
- Checksum: 1AD4E0B5C1B6CBE7
- Sequence:
MMNPRAKRDF YLAAPDLLDP KSAAQNSKPR LSFSTKPTVL ASRVESDTTI NVMKWKTVST IFLVVVLYLI IGATVFKALE QPHEISQRTT IVIQKQTFIS QHSCVNSTEL DELIQQIVAA INAGIIPLGN TSNQISHWDL GSSFFFAGTV ITTIGFGNIS PRTEGGKIFC IIYALLGIPL FGFLLAGVGD QLGTIFGKGI AKVEDTFIKW NVSQTKIRII STIIFILFGC VLFVALPAII FKHIEGWSAL DAIYFVVITL TTIGFGDYVA GGSDIEYLDF YKPVVWFWIL VGLAYFAAVL SMIGDWLRVI SKKTKEEVGE FRAHAAEWTA NVTAEFKETR RRLSVEIYDK FQRATSIKRK LSAELAGNHN QELTPCRRTL SVNHLTSERD VLPPLLKTES IYLNGLTPHC AGEEIAVIEN IK
Genular Protein ID: 3940273243
Symbol: Q6ZW95_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
Sequence Information:
- Length: 152
- Mass: 17248
- Checksum: DC9BF5C52AC672AB
- Sequence:
MMNPRAKRDF YLAAPDLLDP KSAAQNSKPR LSFSTKPTVL ASRVESDTTI NVMKWKTVST IFLVVVLYLI IGATVFKALE QPHEISQRTT IVIQKQTFIS QHSCVNSTEL DELIQDLETS HHAQKAAKYS VSSMPYWEFP SLVFSWLELE IS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.