Details for: KCNK3

Gene ID: 3777

Symbol: KCNK3

Ensembl ID: ENSG00000171303

Description: potassium two pore domain channel subfamily K member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.9811
    Cell Significance Index: -9.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 7.8206
    Cell Significance Index: 209.5600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 4.9767
    Cell Significance Index: 38.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.2456
    Cell Significance Index: 260.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.0074
    Cell Significance Index: 65.1600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.8708
    Cell Significance Index: 26.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.6560
    Cell Significance Index: 53.0400
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 1.1057
    Cell Significance Index: 9.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7305
    Cell Significance Index: 72.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6649
    Cell Significance Index: 600.4000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.6433
    Cell Significance Index: 3.9800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.6245
    Cell Significance Index: 7.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5609
    Cell Significance Index: 201.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5389
    Cell Significance Index: 102.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.5209
    Cell Significance Index: -1.1400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4898
    Cell Significance Index: 11.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4245
    Cell Significance Index: 46.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3960
    Cell Significance Index: 64.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3878
    Cell Significance Index: 66.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.3750
    Cell Significance Index: 234.1900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3452
    Cell Significance Index: 2.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3393
    Cell Significance Index: 20.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2163
    Cell Significance Index: 14.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1667
    Cell Significance Index: 33.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0914
    Cell Significance Index: 4.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0642
    Cell Significance Index: 44.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0631
    Cell Significance Index: 3.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0519
    Cell Significance Index: 0.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0514
    Cell Significance Index: 2.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0392
    Cell Significance Index: 5.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0117
    Cell Significance Index: 6.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0104
    Cell Significance Index: 0.2500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.0074
    Cell Significance Index: 0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0042
    Cell Significance Index: 3.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0028
    Cell Significance Index: 0.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0029
    Cell Significance Index: -0.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0038
    Cell Significance Index: -7.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0042
    Cell Significance Index: -0.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0045
    Cell Significance Index: -0.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0047
    Cell Significance Index: -7.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0048
    Cell Significance Index: -0.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0056
    Cell Significance Index: -7.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0066
    Cell Significance Index: -3.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0066
    Cell Significance Index: -0.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0099
    Cell Significance Index: -0.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0100
    Cell Significance Index: -5.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0116
    Cell Significance Index: -7.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0121
    Cell Significance Index: -9.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0123
    Cell Significance Index: -9.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0128
    Cell Significance Index: -0.5800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0140
    Cell Significance Index: -0.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0236
    Cell Significance Index: -6.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0249
    Cell Significance Index: -0.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0283
    Cell Significance Index: -0.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0312
    Cell Significance Index: -5.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0349
    Cell Significance Index: -3.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0379
    Cell Significance Index: -1.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0452
    Cell Significance Index: -6.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0490
    Cell Significance Index: -5.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0500
    Cell Significance Index: -5.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0540
    Cell Significance Index: -1.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0543
    Cell Significance Index: -1.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0636
    Cell Significance Index: -7.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0693
    Cell Significance Index: -4.3700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0705
    Cell Significance Index: -0.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0710
    Cell Significance Index: -9.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0727
    Cell Significance Index: -1.9800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0805
    Cell Significance Index: -3.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0831
    Cell Significance Index: -6.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0841
    Cell Significance Index: -8.7600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0902
    Cell Significance Index: -1.3600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0920
    Cell Significance Index: -1.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0968
    Cell Significance Index: -2.4200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0999
    Cell Significance Index: -1.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1132
    Cell Significance Index: -7.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1167
    Cell Significance Index: -5.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1237
    Cell Significance Index: -9.2200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1278
    Cell Significance Index: -1.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1321
    Cell Significance Index: -6.8600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1342
    Cell Significance Index: -1.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1370
    Cell Significance Index: -8.8400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1405
    Cell Significance Index: -1.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1467
    Cell Significance Index: -3.7700
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1501
    Cell Significance Index: -0.7900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1541
    Cell Significance Index: -1.6000
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1610
    Cell Significance Index: -0.7700
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.1617
    Cell Significance Index: -2.0100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1622
    Cell Significance Index: -4.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1640
    Cell Significance Index: -5.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1666
    Cell Significance Index: -7.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1681
    Cell Significance Index: -5.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1690
    Cell Significance Index: -5.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1806
    Cell Significance Index: -3.7800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1836
    Cell Significance Index: -1.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1842
    Cell Significance Index: -8.6600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1854
    Cell Significance Index: -3.8700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1863
    Cell Significance Index: -3.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1864
    Cell Significance Index: -7.0600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1980
    Cell Significance Index: -2.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KCNK3 is a member of the potassium two pore domain channel subfamily K, which is characterized by its unique two-pore structure. This channel allows for the passage of potassium ions, contributing to the regulation of membrane potential. The KCNK3 channel is also known for its ability to respond to various stimuli, including hypoxia, zinc ions, and xenobiotics. These responses are mediated by the channel's ability to modulate its activity in response to changes in the cellular environment. **Pathways and Functions:** KCNK3 plays a critical role in regulating membrane potential and cellular response to hypoxia through several key pathways: 1. **Cardiac Conduction:** KCNK3 channels are expressed in cardiac muscle myoblasts and contribute to the regulation of cardiac conduction. 2. **Cellular Response to Hypoxia:** KCNK3 channels respond to hypoxia by modulating their activity, which helps to regulate cellular response to low oxygen levels. 3. **Muscle Contraction:** KCNK3 channels are involved in the regulation of muscle contraction by modulating the resting membrane potential. 4. **Neuronal System:** KCNK3 channels are expressed in photoreceptor cells and contribute to the regulation of neuronal system function. 5. **Regulation of Resting Membrane Potential:** KCNK3 channels help to regulate the resting membrane potential by modulating the passage of potassium ions. **Clinical Significance:** KCNK3 has significant clinical implications, particularly in the context of cardiovascular and neurological disorders. Abnormalities in KCNK3 expression or function have been implicated in various diseases, including: 1. **Cardiac Arrhythmias:** KCNK3 channels contribute to the regulation of cardiac conduction, and abnormalities in KCNK3 expression or function can lead to cardiac arrhythmias. 2. **Neurological Disorders:** KCNK3 channels are expressed in photoreceptor cells and contribute to the regulation of neuronal system function. Abnormalities in KCNK3 expression or function have been implicated in neurological disorders, including retinitis pigmentosa. 3. **Hypoxia-Inducible Response:** KCNK3 channels respond to hypoxia by modulating their activity, which helps to regulate cellular response to low oxygen levels. Abnormalities in KCNK3 expression or function can lead to impaired hypoxia-inducible response, which can contribute to various diseases. In conclusion, KCNK3 is a critical potassium channel subfamily member that plays a significant role in regulating membrane potential and cellular response to hypoxia. Understanding the key characteristics, pathways, and functions of KCNK3 can provide valuable insights into its clinical significance and potential therapeutic applications.

Genular Protein ID: 2498171548

Symbol: KCNK3_HUMAN

Name: Potassium channel subfamily K member 3

UniProtKB Accession Codes:

O14649 Q53SU2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIRSF 1 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9312005

Title: TASK, a human background K+ channel to sense external pH variations near physiological pH.

PubMed ID: 9312005

DOI: 10.1093/emboj/16.17.5464

PubMed ID: 10748056

Title: Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3.

PubMed ID: 10748056

DOI: 10.1074/jbc.m001948200

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 10321245

Title: Inhalational anesthetics activate two-pore-domain background K+ channels.

PubMed ID: 10321245

DOI: 10.1038/8084

PubMed ID: 11680614

Title: TASK-5, a novel member of the tandem pore K+ channel family.

PubMed ID: 11680614

DOI: 10.1007/s004240100620

PubMed ID: 23169818

Title: SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.

PubMed ID: 23169818

DOI: 10.1126/scisignal.2003431

PubMed ID: 23883380

Title: A novel channelopathy in pulmonary arterial hypertension.

PubMed ID: 23883380

DOI: 10.1056/nejmoa1211097

Sequence Information:

  • Length: 394
  • Mass: 43518
  • Checksum: 9FF4C8266F615FB7
  • Sequence:
    • MKRQNVRTLA LIVCTFTYLL VGAAVFDALE SEPELIERQR LELRQQELRA RYNLSQGGYE 
ELERVVLRLK PHKAGVQWRF AGSFYFAITV ITTIGYGHAA PSTDGGKVFC MFYALLGIPL 
TLVMFQSLGE RINTLVRYLL HRAKKGLGMR RADVSMANMV LIGFFSCIST LCIGAAAFSH 
YEHWTFFQAY YYCFITLTTI GFGDYVALQK DQALQTQPQY VAFSFVYILT GLTVIGAFLN 
LVVLRFMTMN AEDEKRDAEH RALLTRNGQA GGGGGGGSAH TTDTASSTAA AGGGGFRNVY 
AEVLHFQSMC SCLWYKSREK LQYSIPMIIP RDLSTSDTCV EQSHSSPGGG GRYSDTPSRR 
CLCSGAPRSA ISSVSTGLHS LSTFRGLMKR RSSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.