Gene KCNK3 - ENSG00000171303 | NCBI Gene ID: 3777

Details for: KCNK3

Gene ID: 3777

Symbol: KCNK3

Ensembl ID: ENSG00000171303

Description: potassium two pore domain channel subfamily K member 3

Associated with

Cardiac conduction
(R-HSA-5576891)
Muscle contraction
(R-HSA-397014)
Neuronal system
(R-HSA-112316)
Phase 4 - resting membrane potential
(R-HSA-5576886)
Potassium channels
(R-HSA-1296071)
Tandem pore domain potassium channels
(R-HSA-1296346)
Twik-releated acid-sensitive k+ channel (task)
(R-HSA-1299316)
Cellular response to hypoxia
(GO:0071456)
Cellular response to zinc ion
(GO:0071294)
Chemical synaptic transmission
(GO:0007268)
Cochlea development
(GO:0090102)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Negative regulation of cytosolic calcium ion concentration
(GO:0051481)
Open rectifier potassium channel activity
(GO:0005252)
Outward rectifier potassium channel activity
(GO:0015271)
Plasma membrane
(GO:0005886)
Potassium channel activity
(GO:0005267)
Potassium ion leak channel activity
(GO:0022841)
Potassium ion transmembrane transport
(GO:0071805)
Potassium ion transport
(GO:0006813)
Regulation of resting membrane potential
(GO:0060075)
Response to xenobiotic stimulus
(GO:0009410)
S100 protein binding
(GO:0044548)
Stabilization of membrane potential
(GO:0030322)
Synapse
(GO:0045202)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.84
Marker Score: 50474
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1165
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.46
Marker Score: 1100
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.36
Marker Score: 865
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 850
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.22
Marker Score: 640
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.19
Marker Score: 18628
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.16
Marker Score: 483
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4806
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.1
Marker Score: 4265
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.1
Marker Score: 442
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.08
Marker Score: 1526
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.08
Marker Score: 865
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.04
Marker Score: 38487
Cell Name: acinar cell (CL0000622)
Fold Change: 1.03
Marker Score: 728
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.02
Marker Score: 538
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71816
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48041
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 504
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 458
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.95
Marker Score: 1809
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5348
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.92
Marker Score: 13807
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 370
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.9
Marker Score: 286
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.88
Marker Score: 426
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.88
Marker Score: 403
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5284
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.82
Marker Score: 806
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.82
Marker Score: 390
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.81
Marker Score: 1707
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.79
Marker Score: 15713
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 595
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.78
Marker Score: 3590
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1258
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 705
Cell Name: neuron (CL0000540)
Fold Change: 0.77
Marker Score: 3116
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 392
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.73
Marker Score: 1486
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 458
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 0.7
Marker Score: 232
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.67
Marker Score: 349
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.67
Marker Score: 2767
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.66
Marker Score: 171
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.64
Marker Score: 1513
Cell Name: PP cell (CL0000696)
Fold Change: 0.63
Marker Score: 143
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.63
Marker Score: 368
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.63
Marker Score: 274
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.63
Marker Score: 217
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.63
Marker Score: 262.5
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.63
Marker Score: 233
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.57
Marker Score: 191
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 147
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 440
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.54
Marker Score: 587
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.54
Marker Score: 172
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.54
Marker Score: 281
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.51
Marker Score: 4778
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.5
Marker Score: 300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.47
Marker Score: 468
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 0.46
Marker Score: 174
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.46
Marker Score: 121
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.45
Marker Score: 300
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.44
Marker Score: 152
Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: 0.44
Marker Score: 123
Cell Name: pericyte (CL0000669)
Fold Change: 0.43
Marker Score: 249
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.43
Marker Score: 3660
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.41
Marker Score: 640
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.4
Marker Score: 265
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.4
Marker Score: 944
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.4
Marker Score: 3055
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.4
Marker Score: 764
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.37
Marker Score: 14219
Cell Name: neural cell (CL0002319)
Fold Change: 0.36
Marker Score: 172
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.35
Marker Score: 997
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.35
Marker Score: 389
Cell Name: fat cell (CL0000136)
Fold Change: 0.33
Marker Score: 182
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.32
Marker Score: 244
Cell Name: bipolar neuron (CL0000103)
Fold Change: 0.31
Marker Score: 105
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.31
Marker Score: 139
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.31
Marker Score: 107
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.31
Marker Score: 773
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.31
Marker Score: 308
Cell Name: goblet cell (CL0000160)
Fold Change: 0.3
Marker Score: 2016
Cell Name: muscle cell (CL0000187)
Fold Change: 0.3
Marker Score: 84
Cell Name: interneuron (CL0000099)
Fold Change: 0.29
Marker Score: 134
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.28
Marker Score: 161.5
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.28
Marker Score: 271
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.28
Marker Score: 72
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.28
Marker Score: 164
Cell Name: stellate neuron (CL0000122)
Fold Change: 0.28
Marker Score: 1491
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.28
Marker Score: 562
Cell Name: decidual cell (CL2000002)
Fold Change: 0.27
Marker Score: 1174
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.27
Marker Score: 98
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.27
Marker Score: 119

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**Key characteristics:** - KCNK3 is a pore-forming protein that belongs to the potassium channel superfamily. - It has two transmembrane domains: a pore domain and a regulatory domain. - The pore domain is responsible for the ion channel's gating, while the regulatory domain interacts with other proteins to modulate channel activity. - KCNK3 is a highly conserved protein with a wide expression in different tissues. **Pathways and functions:** - KCNK3 is involved in various cellular processes, including cardiac conduction, synaptic transmission, and muscle contraction. - In the heart, KCNK3 is expressed in cardiomyocytes and atrial and ventricular myocytes, where it contributes to the maintenance of normal heart rhythm and cardiac output. - In the central nervous system (CNS), KCNK3 is expressed in neurons, where it modulates synaptic transmission and neuronal excitability. - In the peripheral nervous system (PNS), KCNK3 is expressed in sensory neurons and autonomic neurons, where it contributes to the sensory function and the regulation of smooth muscle contractions. **Clinical significance:** - Mutations in KCNK3 have been linked to several human diseases, including hyperkalemia, heart failure, and epilepsy. - In these diseases, KCNK3 mutations can lead to abnormal potassium channel activity, resulting in cardiac arrhythmias, seizures, and other neurological symptoms. - Therefore, KCNK3 is a potential therapeutic target for treating these diseases. **Additional information:** - KCNK3 is a highly important ion channel in the human body. - It is a member of the potassium channel superfamily, which is the largest group of ion channels in the human body. - KCNK3 is a well-studied channel, with a wealth of literature describing its structure, function, and role in various physiological and pathological processes.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Potassium channel subfamily K member 3

Genular Protein ID: 2498171548

Symbol: KCNK3_HUMAN

Name: Potassium channel subfamily K member 3

UniProtKB Accession Codes:

O14649 Q53SU2

Database IDs:

Citations:

PubMed ID: 9312005

Title: TASK, a human background K+ channel to sense external pH variations near physiological pH.

PubMed ID: 9312005

DOI: 10.1093/emboj/16.17.5464

PubMed ID: 10748056

Title: Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3.

PubMed ID: 10748056

DOI: 10.1074/jbc.m001948200

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 10321245

Title: Inhalational anesthetics activate two-pore-domain background K+ channels.

PubMed ID: 10321245

DOI: 10.1038/8084

PubMed ID: 11680614

Title: TASK-5, a novel member of the tandem pore K+ channel family.

PubMed ID: 11680614

DOI: 10.1007/s004240100620

PubMed ID: 23169818

Title: SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.

PubMed ID: 23169818

DOI: 10.1126/scisignal.2003431

PubMed ID: 23883380

Title: A novel channelopathy in pulmonary arterial hypertension.

PubMed ID: 23883380

DOI: 10.1056/nejmoa1211097

Sequence Information:

Length: 394
Mass: 43518
Checksum: 9FF4C8266F615FB7
Sequence:

MKRQNVRTLA LIVCTFTYLL VGAAVFDALE SEPELIERQR LELRQQELRA RYNLSQGGYE 
ELERVVLRLK PHKAGVQWRF AGSFYFAITV ITTIGYGHAA PSTDGGKVFC MFYALLGIPL 
TLVMFQSLGE RINTLVRYLL HRAKKGLGMR RADVSMANMV LIGFFSCIST LCIGAAAFSH 
YEHWTFFQAY YYCFITLTTI GFGDYVALQK DQALQTQPQY VAFSFVYILT GLTVIGAFLN 
LVVLRFMTMN AEDEKRDAEH RALLTRNGQA GGGGGGGSAH TTDTASSTAA AGGGGFRNVY 
AEVLHFQSMC SCLWYKSREK LQYSIPMIIP RDLSTSDTCV EQSHSSPGGG GRYSDTPSRR 
CLCSGAPRSA ISSVSTGLHS LSTFRGLMKR RSSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: KCNK3

Associated with

Cells (max top 100)

Other Information

TASK, a human background K+ channel to sense external pH variations near physiological pH. PubMed ID: 9312005

Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3. PubMed ID: 10748056

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Inhalational anesthetics activate two-pore-domain background K+ channels. PubMed ID: 10321245

TASK-5, a novel member of the tandem pore K+ channel family. PubMed ID: 11680614

SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons. PubMed ID: 23169818

A novel channelopathy in pulmonary arterial hypertension. PubMed ID: 23883380