Details for: KCNS2

Gene ID: 3788

Symbol: KCNS2

Ensembl ID: ENSG00000156486

Description: potassium voltage-gated channel modifier subfamily S member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 6.03
    Marker Score: 3340
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.45
    Marker Score: 4224
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2215
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.78
    Marker Score: 1012
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.49
    Marker Score: 782
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.25
    Marker Score: 1192
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.12
    Marker Score: 469
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.01
    Marker Score: 1908
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5346
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 489
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.74
    Marker Score: 11640
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1309
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 513
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.63
    Marker Score: 1063
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.59
    Marker Score: 945
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5
    Marker Score: 333
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.44
    Marker Score: 27346
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.42
    Marker Score: 4030
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.42
    Marker Score: 3581
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.41
    Marker Score: 197
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.41
    Marker Score: 246
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.39
    Marker Score: 1576
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.37
    Marker Score: 1416
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.36
    Marker Score: 737.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.36
    Marker Score: 212
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.33
    Marker Score: 350
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.27
    Marker Score: 10203
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.26
    Marker Score: 2436
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.24
    Marker Score: 370
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.22
    Marker Score: 930
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.2
    Marker Score: 827.5
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.2
    Marker Score: 245
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.19
    Marker Score: 305
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 84
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.17
    Marker Score: 101
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.17
    Marker Score: 91
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.17
    Marker Score: 1883
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.16
    Marker Score: 158
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.15
    Marker Score: 2972
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.14
    Marker Score: 62
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.13
    Marker Score: 1936
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.11
    Marker Score: 122
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 92
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.11
    Marker Score: 100
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.11
    Marker Score: 48
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.1
    Marker Score: 744
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1
    Marker Score: 3270
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.09
    Marker Score: 359
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.09
    Marker Score: 413
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.08
    Marker Score: 170
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.08
    Marker Score: 100
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.08
    Marker Score: 191
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 72
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.08
    Marker Score: 492
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.08
    Marker Score: 89
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 73
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.07
    Marker Score: 54
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.07
    Marker Score: 53
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.07
    Marker Score: 75.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.07
    Marker Score: 67
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.06
    Marker Score: 372
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.06
    Marker Score: 502
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.06
    Marker Score: 72
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.06
    Marker Score: 568
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.06
    Marker Score: 293
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.05
    Marker Score: 153.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 19

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Other Information

**Key characteristics:** * It is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is expressed in a variety of cell types, including erythrocyte, T cell, plasma cell, megakaryocyte, hematopoietic stem cell, B cell, goblet cell, megakaryocyte-erythroid progenitor cell, and cardiac endothelial cell. * It is a key regulator of delayed rectifier potassium channel activity. **Pathways and functions:** * It interacts with KCNQ1 and modulates its activity. * It is involved in the regulation of potassium ion transport in various cellular processes, including cardiac arrhythmias, neuronal signaling, and muscle contraction. * It is also involved in the regulation of blood pressure and fluid balance. **Clinical significance:** * Mutations in KCNS2 have been linked to a number of human diseases, including cardiac arrhythmias, epilepsy, and stroke. * Targeting KCNS2 has been explored as a therapeutic strategy for these diseases. **Additional information:** * It is a member of the potassium voltage-gated channel subfamily S, which is a large family of potassium channels that are involved in a variety of cellular processes. * It is a highly conserved protein, with a similar sequence found in organisms from yeast to humans.

Genular Protein ID: 3445030409

Symbol: KCNS2_HUMAN

Name: Potassium voltage-gated channel subfamily S member 2

UniProtKB Accession Codes:

Q9ULS6 A8KAN1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 5 Ensembl 2 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10574461

Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.

PubMed ID: 10574461

DOI: 10.1093/dnares/6.5.329

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 477
  • Mass: 54237
  • Checksum: F231AD99EC02EB46
  • Sequence:
    • MTGQSLWDVS EANVEDGEIR INVGGFKRRL RSHTLLRFPE TRLGRLLLCH SREAILELCD 
DYDDVQREFY FDRNPELFPY VLHFYHTGKL HVMAELCVFS FSQEIEYWGI NEFFIDSCCS 
YSYHGRKVEP EQEKWDEQSD QESTTSSFDE ILAFYNDASK FDGQPLGNFR RQLWLALDNP 
GYSVLSRVFS ILSILVVMGS IITMCLNSLP DFQIPDSQGN PGEDPRFEIV EHFGIAWFTF 
ELVARFAVAP DFLKFFKNAL NLIDLMSIVP FYITLVVNLV VESTPTLANL GRVAQVLRLM 
RIFRILKLAR HSTGLRSLGA TLKYSYKEVG LLLLYLSVGI SIFSVVAYTI EKEENEGLAT 
IPACWWWATV SMTTVGYGDV VPGTTAGKLT ASACILAGIL VVVLPITLIF NKFSHFYRRQ 
KQLESAMRSC DFGDGMKEVP SVNLRDYYAH KVKSLMASLT NMSRSSPSEL SLNDSLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.