Details for: KCNS2

Gene ID: 3788

Symbol: KCNS2

Ensembl ID: ENSG00000156486

Description: potassium voltage-gated channel modifier subfamily S member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.8772
    Cell Significance Index: 46.6000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.1026
    Cell Significance Index: 17.6900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.9869
    Cell Significance Index: 16.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9257
    Cell Significance Index: 20.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2453
    Cell Significance Index: 49.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0807
    Cell Significance Index: 1.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0459
    Cell Significance Index: 1.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0448
    Cell Significance Index: 1.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0286
    Cell Significance Index: 10.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0017
    Cell Significance Index: -0.2400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0019
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -3.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0022
    Cell Significance Index: -0.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0026
    Cell Significance Index: -3.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0045
    Cell Significance Index: -0.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0054
    Cell Significance Index: -4.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0063
    Cell Significance Index: -3.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0067
    Cell Significance Index: -0.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0074
    Cell Significance Index: -4.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0077
    Cell Significance Index: -0.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0086
    Cell Significance Index: -4.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0088
    Cell Significance Index: -3.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0112
    Cell Significance Index: -1.3100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0179
    Cell Significance Index: -0.5700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0189
    Cell Significance Index: -0.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0190
    Cell Significance Index: -3.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0270
    Cell Significance Index: -3.9200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0285
    Cell Significance Index: -0.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0288
    Cell Significance Index: -1.7700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0343
    Cell Significance Index: -0.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0360
    Cell Significance Index: -1.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0397
    Cell Significance Index: -4.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0415
    Cell Significance Index: -0.8200
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0510
    Cell Significance Index: -0.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0517
    Cell Significance Index: -3.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0542
    Cell Significance Index: -3.0400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0578
    Cell Significance Index: -0.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0588
    Cell Significance Index: -2.7400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0611
    Cell Significance Index: -0.6700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0687
    Cell Significance Index: -1.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0697
    Cell Significance Index: -2.4400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0701
    Cell Significance Index: -1.6800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0701
    Cell Significance Index: -0.9400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0734
    Cell Significance Index: -1.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0771
    Cell Significance Index: -2.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0781
    Cell Significance Index: -3.6700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0833
    Cell Significance Index: -1.8000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0838
    Cell Significance Index: -0.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0882
    Cell Significance Index: -3.1000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0890
    Cell Significance Index: -0.9700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0900
    Cell Significance Index: -0.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0915
    Cell Significance Index: -3.3600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0919
    Cell Significance Index: -1.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0924
    Cell Significance Index: -4.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1013
    Cell Significance Index: -2.9200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1054
    Cell Significance Index: -1.4800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1083
    Cell Significance Index: -1.3500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1097
    Cell Significance Index: -1.4200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1127
    Cell Significance Index: -1.0900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1137
    Cell Significance Index: -1.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1260
    Cell Significance Index: -3.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1267
    Cell Significance Index: -2.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1301
    Cell Significance Index: -3.7300
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.1306
    Cell Significance Index: -1.4500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1328
    Cell Significance Index: -3.2400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1352
    Cell Significance Index: -1.8700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1357
    Cell Significance Index: -1.9700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1367
    Cell Significance Index: -5.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1401
    Cell Significance Index: -3.7400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1402
    Cell Significance Index: -2.7600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1403
    Cell Significance Index: -1.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1415
    Cell Significance Index: -3.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1454
    Cell Significance Index: -3.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1457
    Cell Significance Index: -3.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1467
    Cell Significance Index: -4.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1478
    Cell Significance Index: -3.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1485
    Cell Significance Index: -3.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1495
    Cell Significance Index: -3.1300
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1537
    Cell Significance Index: -1.7500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1539
    Cell Significance Index: -3.2900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1544
    Cell Significance Index: -3.9700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1550
    Cell Significance Index: -3.0900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1556
    Cell Significance Index: -1.9300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1560
    Cell Significance Index: -3.1800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1595
    Cell Significance Index: -1.3400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1596
    Cell Significance Index: -3.3300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1670
    Cell Significance Index: -4.0500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1680
    Cell Significance Index: -1.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1784
    Cell Significance Index: -2.9900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1878
    Cell Significance Index: -2.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1901
    Cell Significance Index: -3.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2013
    Cell Significance Index: -3.4500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2041
    Cell Significance Index: -3.9900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2049
    Cell Significance Index: -2.4500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2050
    Cell Significance Index: -2.1400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2090
    Cell Significance Index: -2.7100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2094
    Cell Significance Index: -3.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Potassium Channel Modulator**: KCNS2 is a modifier of voltage-gated potassium channels, which are essential for regulating membrane excitability and maintaining cellular homeostasis. 2. **Neuronal and Immune Cell Specificity**: The gene is highly expressed in neurons, particularly GABAergic interneurons in the cerebral cortex, and in immune cells, such as T cells, plasma cells, and B cells. 3. **Regulation of Delayed Rectifier Potassium Channels**: KCNS2 modulates the activity of delayed rectifier potassium channels, which are involved in regulating the resting membrane potential and repolarization of action potentials. 4. **Protein Binding and Homooligomerization**: KCNS2 interacts with other proteins and forms homooligomers, which are essential for its function as a potassium channel modifier. **Pathways and Functions:** 1. **Voltage-Gated Potassium Channel Activity**: KCNS2 modulates the activity of voltage-gated potassium channels, which are involved in regulating membrane excitability and maintaining cellular homeostasis. 2. **Regulation of Delayed Rectifier Potassium Channels**: KCNS2 regulates the activity of delayed rectifier potassium channels, which are involved in regulating the resting membrane potential and repolarization of action potentials. 3. **Protein Binding and Homooligomerization**: KCNS2 interacts with other proteins and forms homooligomers, which are essential for its function as a potassium channel modifier. 4. **Cellular Homeostasis and Immune Function**: KCNS2 plays a critical role in maintaining cellular homeostasis and immune function, particularly in immune cells, such as T cells and plasma cells. **Clinical Significance:** 1. **Neurological Disorders**: Dysregulation of KCNS2 has been implicated in several neurological disorders, including epilepsy, migraines, and autism spectrum disorder. 2. **Autoimmune Disorders**: KCNS2 has been linked to autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis, where dysregulation of potassium channels contributes to disease pathogenesis. 3. **Cancer**: KCNS2 has been identified as a potential biomarker for cancer, particularly in hematological malignancies, where dysregulation of potassium channels contributes to tumorigenesis. 4. **Therapeutic Applications**: Targeting KCNS2 has been proposed as a potential therapeutic strategy for treating neurological and autoimmune disorders, where modulation of potassium channels can help restore cellular homeostasis and immune function. In conclusion, the KCNS2 gene plays a critical role in regulating potassium channels in the immune system and beyond. Dysregulation of KCNS2 has been implicated in several neurological and autoimmune disorders, highlighting its importance in human health. Further research is needed to fully elucidate the mechanisms by which KCNS2 regulates potassium channels and to explore its therapeutic potential.

Genular Protein ID: 3445030409

Symbol: KCNS2_HUMAN

Name: Potassium voltage-gated channel subfamily S member 2

UniProtKB Accession Codes:

Q9ULS6 A8KAN1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 5 Ensembl 2 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10574461

Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.

PubMed ID: 10574461

DOI: 10.1093/dnares/6.5.329

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 477
  • Mass: 54237
  • Checksum: F231AD99EC02EB46
  • Sequence:
    • MTGQSLWDVS EANVEDGEIR INVGGFKRRL RSHTLLRFPE TRLGRLLLCH SREAILELCD 
DYDDVQREFY FDRNPELFPY VLHFYHTGKL HVMAELCVFS FSQEIEYWGI NEFFIDSCCS 
YSYHGRKVEP EQEKWDEQSD QESTTSSFDE ILAFYNDASK FDGQPLGNFR RQLWLALDNP 
GYSVLSRVFS ILSILVVMGS IITMCLNSLP DFQIPDSQGN PGEDPRFEIV EHFGIAWFTF 
ELVARFAVAP DFLKFFKNAL NLIDLMSIVP FYITLVVNLV VESTPTLANL GRVAQVLRLM 
RIFRILKLAR HSTGLRSLGA TLKYSYKEVG LLLLYLSVGI SIFSVVAYTI EKEENEGLAT 
IPACWWWATV SMTTVGYGDV VPGTTAGKLT ASACILAGIL VVVLPITLIF NKFSHFYRRQ 
KQLESAMRSC DFGDGMKEVP SVNLRDYYAH KVKSLMASLT NMSRSSPSEL SLNDSLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.