Details for: KLKB1

Gene ID: 3818

Symbol: KLKB1

Ensembl ID: ENSG00000164344

Description: kallikrein B1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.81
    Marker Score: 9709
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.62
    Marker Score: 6996
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.58
    Marker Score: 10150
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170117
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.22
    Marker Score: 3998
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.22
    Marker Score: 884
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.14
    Marker Score: 24308
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.02
    Marker Score: 4264.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.01
    Marker Score: 683
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.95
    Marker Score: 35222
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5261
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.91
    Marker Score: 417.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.89
    Marker Score: 260
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.87
    Marker Score: 3526
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.84
    Marker Score: 287
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.83
    Marker Score: 434.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 317
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.78
    Marker Score: 535
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.78
    Marker Score: 837
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3226.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.74
    Marker Score: 639
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.71
    Marker Score: 863
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.7
    Marker Score: 2882
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.69
    Marker Score: 2455
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.66
    Marker Score: 1019
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.63
    Marker Score: 290
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 386
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6
    Marker Score: 9364
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.59
    Marker Score: 239
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 460
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.56
    Marker Score: 1056
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.55
    Marker Score: 743
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.55
    Marker Score: 319
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.53
    Marker Score: 32892
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.53
    Marker Score: 489
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.52
    Marker Score: 1232
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5
    Marker Score: 3021
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.49
    Marker Score: 320
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.48
    Marker Score: 4938
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.44
    Marker Score: 1563
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.42
    Marker Score: 147
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.42
    Marker Score: 857
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.39
    Marker Score: 748
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.38
    Marker Score: 291
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.37
    Marker Score: 115
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.37
    Marker Score: 3478
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.36
    Marker Score: 389
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.35
    Marker Score: 3001
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.34
    Marker Score: 123
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.34
    Marker Score: 7513
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.34
    Marker Score: 5026
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.33
    Marker Score: 125
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.32
    Marker Score: 3053
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.32
    Marker Score: 12210
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.32
    Marker Score: 128
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.31
    Marker Score: 437
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.3
    Marker Score: 96
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.3
    Marker Score: 480
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.29
    Marker Score: 1129
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.29
    Marker Score: 172
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.28
    Marker Score: 682
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.28
    Marker Score: 312
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.28
    Marker Score: 5486
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.26
    Marker Score: 99
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.25
    Marker Score: 106
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.25
    Marker Score: 283
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.25
    Marker Score: 136
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.24
    Marker Score: 76
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.24
    Marker Score: 66
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.23
    Marker Score: 613
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.22
    Marker Score: 107
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.22
    Marker Score: 375
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.22
    Marker Score: 82
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.22
    Marker Score: 114.5
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.21
    Marker Score: 732
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.21
    Marker Score: 259
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.21
    Marker Score: 121
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.19
    Marker Score: 1492
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.19
    Marker Score: 56
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.18
    Marker Score: 93
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.18
    Marker Score: 186
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.18
    Marker Score: 50
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.18
    Marker Score: 193

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Other Information

**Key characteristics:** * KLKB1 is a transmembrane protein that is expressed in the plasma membrane of hepatocytes. * It is a key regulator of blood coagulation by controlling the activation of matrix metalloproteinases. * It is also involved in the degradation of extracellular matrix proteins, including collagen and elastin. **Pathways and functions:** * KLKB1 is activated by a variety of stimuli, including cytokines, growth factors, and hormones. * Activation of KLKB1 leads to the phosphorylation of a number of substrates, including fibrinogen, fibronectin, and collagen. * These substrates are then degraded by the enzyme thrombin, which is also activated by KLKB1. * The degradation of fibrinogen and fibronectin helps to promote clot formation and the remodeling of the extracellular matrix. **Clinical significance:** * Mutations in the KLKB1 gene have been linked to a number of human diseases, including hereditary angioedema, defective factor XII causes hereditary angioedema, defects of the contact activation system (CAS) and kallikrein/kinin system (kks), and hemophilia. * These diseases are caused by mutations in genes that encode proteins that are involved in the regulation of blood coagulation and the degradation of extracellular matrix proteins. * KLKB1 is a promising target for the treatment of these diseases. **Additional information:** * The KLKB1 gene is located on chromosome 15q21.1. * It is a single-exon gene that encodes a protein of 140 amino acids. * The protein is a transmembrane protein that is expressed in the plasma membrane of hepatocytes. * It is a highly conserved protein that is found in animals of all vertebrates.

Genular Protein ID: 3284204931

Symbol: KLKB1_HUMAN

Name: Plasma kallikrein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3521732

Title: Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats.

PubMed ID: 3521732

DOI: 10.1021/bi00357a017

PubMed ID: 11031105

Title: Genomic structure of the human plasma prekallikrein gene, identification of allelic variants, and analysis in end-stage renal disease.

PubMed ID: 11031105

DOI: 10.1006/geno.2000.6330

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1998666

Title: Location of the disulfide bonds in human plasma prekallikrein: the presence of four novel apple domains in the amino-terminal portion of the molecule.

PubMed ID: 1998666

DOI: 10.1021/bi00222a007

PubMed ID: 2844223

Title: Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor.

PubMed ID: 2844223

DOI: 10.1021/bi00412a005

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 14652634

Title: Severe prekallikrein (Fletcher factor) deficiency due to a compound heterozygosis (383Trp stop codon and Cys529Tyr).

PubMed ID: 14652634

DOI: 10.1160/th03-05-0275

PubMed ID: 17598838

Title: A new type of plasma prekallikrein deficiency associated with homozygosity for Gly104Arg and Asn124Ser in apple domain 2 of the heavy-chain region.

PubMed ID: 17598838

DOI: 10.1111/j.1600-0609.2007.00871.x

PubMed ID: 34847617

Title: Prekallikrein deficiency due to homozygous KLKB1(+) mutation c.444_445insT (p.Ser151PhefsTer34).

PubMed ID: 34847617

DOI: 10.1111/ijlh.13773

Sequence Information:

  • Length: 638
  • Mass: 71343
  • Checksum: 7756B8821AA71DF9
  • Sequence:
  • MILFKQATYF ISLFATVSCG CLTQLYENAF FRGGDVASMY TPNAQYCQMR CTFHPRCLLF 
    SFLPASSIND MEKRFGCFLK DSVTGTLPKV HRTGAVSGHS LKQCGHQISA CHRDIYKGVD 
    MRGVNFNVSK VSSVEECQKR CTSNIRCQFF SYATQTFHKA EYRNNCLLKY SPGGTPTAIK 
    VLSNVESGFS LKPCALSEIG CHMNIFQHLA FSDVDVARVL TPDAFVCRTI CTYHPNCLFF 
    TFYTNVWKIE SQRNVCLLKT SESGTPSSST PQENTISGYS LLTCKRTLPE PCHSKIYPGV 
    DFGGEELNVT FVKGVNVCQE TCTKMIRCQF FTYSLLPEDC KEEKCKCFLR LSMDGSPTRI 
    AYGTQGSSGY SLRLCNTGDN SVCTTKTSTR IVGGTNSSWG EWPWQVSLQV KLTAQRHLCG 
    GSLIGHQWVL TAAHCFDGLP LQDVWRIYSG ILNLSDITKD TPFSQIKEII IHQNYKVSEG 
    NHDIALIKLQ APLNYTEFQK PICLPSKGDT STIYTNCWVT GWGFSKEKGE IQNILQKVNI 
    PLVTNEECQK RYQDYKITQR MVCAGYKEGG KDACKGDSGG PLVCKHNGMW RLVGITSWGE 
    GCARREQPGV YTKVAEYMDW ILEKTQSSDG KAQMQSPA

Genular Protein ID: 1907117497

Symbol: A8K9A9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 638
  • Mass: 71354
  • Checksum: 4A6E2E777F838FB3
  • Sequence:
  • MILFKQATYF ISLFATVSCG CLTQLYENAF FRGGDVASMY TPNAQYCQMR CTFHPRCLLF 
    SFLPASSIND MEKRFGCFLK DSVTGTPPKV HRTGAVSGHS LKQCGHQISA CHRDIYKGVD 
    MRGVNFNVSK VSSVEECQKR CTNNIRCQFF SYATQTFHKA EYRNNCLLKY SPGGTPTAIK 
    VLSNVESGFS LKPCALSEIG CHMNIFQHLA FSDVDVARVL TPDAFVCRTI CTYHPNCLFF 
    TFYTNVWKIE SQRNVCLLKT SESGTPSSST PQENTISGYS LLTCKRTLPE PCHSKIYPGV 
    DFGGEELNVT FVKGVNVCQE TCTKMIRCQF FTYSLLPEDC KEEKCKCFLR LSMDGSPTRI 
    AYGTQGSSGY SLRLCNTGDN SVCTTKTSTR IVGGTNSSWG EWPWQVSLQV KLTAQRHLCG 
    GSLIGHQWVL TAAHCFDGLP LQDVWRIYSG ILNLSDITKD TPFSQIKEII IHQNYKVSEG 
    NHDIALIKLQ APLNYTEFQK PICLPSKGDT STIYTNCWVT GWGFSKEKGE IQNILQKVNI 
    PLVTNEECQK RYQDYKITQR MVCAGYKEGG KDACKGDSGG PLVCKHNGMW RLVGITSWGE 
    GCARREQPGV YTKVAEYMDW ILEKTQSSDG KAQMQSPA

Genular Protein ID: 741038964

Symbol: E9PBC5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 514
  • Mass: 57643
  • Checksum: 087E8B4DD706F3DA
  • Sequence:
  • MYTPNAQYCQ MRCTFHPRCL LFSFLPASSI NDMEKRFGCF LKDSVTGTLP KVHRTGAVSG 
    HSLKQCGHQI SACHRDIYKG VDMRGVNFNV SKVSSVEECQ KRCTSNIRCQ FFSYATQTFH 
    KAEYRNNCLL KYSPGGTPTA IKVLSNVESG FSLKPCALSE IGCHMNIFQH LAFSDVDVAR 
    VLTPDAFVCR TICTYHPNCL FFTFYTNVWK IESQRNVCLL KTSESGTPSS STPQENTISG 
    YSLLTCKRTL PEPCHSKIYP GVDFGGEELN VTFVKGVNVC QETCTKMIRC QFFTYSLLPE 
    DCKEEKCKCF LRLSMDGSPT RIAYGTQGSS GYSLRLCNTG DNSVCTTKTS TRIVGGTNSS 
    WGEWPWQVSL QVKLTAQRHL CGGSLIGHQW VLTAAHCFDG LPLQDVWRIY SGILNLSDIT 
    KDTPFSQIKE IIIHQNYKVS EGNHDIALIK LQAPLNYTEF QKPICLPSKG DTSTIYTNCW 
    VTGWGFSKEK GRFRWSLSLQ TQWNVAFGGH HQLG

Genular Protein ID: 2783124790

Symbol: B4DMX2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 514
  • Mass: 57648
  • Checksum: 64BAE34E4B5EA816
  • Sequence:
  • MYTPNAQYCQ MRCTFHPRCL LFSFLPASSI NDMEKRFGCF LKDSVTGTLP KVHRTGAVSG 
    HSLKQCGHQI SACHRDIYKG VDMRGVNFNV SKVSSVEECQ KRCTNDIRCQ FFSYATQTFH 
    KAEYRNNCLL KYSPGGTPTA IKVLSNVESG FSLKPCALSE IGCQMNIFQH LAFSDVDVAR 
    VLTPDAFVCR TICTYHPNCL FFTFYTNVWK IESQRNVCLL KTSESGTPSS CTPQENTISG 
    YSLLTCKRTL PEPCHSKIYP GVDFGGEELN VTFVKGVNVC QETCTKMIRC QFFTYSLLPE 
    DCKEEKCKCF LRLSMDGSPT RIAYGTQGSS GYSLRLCNTG DNSVCTTKTS TRIVGGTNSS 
    WGEWPWQVSL QVKLTAQRHL CGGSLIGHQW VLTAAHCFDG LPLQDVWRIY SGILNLSDIT 
    KDTPFSQIKE IIIHQNYKVS EGNHDIALIK LQAPLNYTEF QKPICLPSKG DTSTIYTNCW 
    VTGWGFSKEK GRFRWSLSLQ TQRNVAFGGH HQLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.