Details for: KLKB1
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.81
Marker Score: 9709 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.62
Marker Score: 6996 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.58
Marker Score: 10150 - Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 170117 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.22
Marker Score: 3998 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.22
Marker Score: 884 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 488 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.14
Marker Score: 24308 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.02
Marker Score: 4264.5 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.01
Marker Score: 683 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71830 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48054.5 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 510 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.95
Marker Score: 35222 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5261 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 327 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.91
Marker Score: 417.5 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.89
Marker Score: 260 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5289 - Cell Name: neuron (CL0000540)
Fold Change: 0.87
Marker Score: 3526 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.84
Marker Score: 287 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.83
Marker Score: 434.5 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.79
Marker Score: 317 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.78
Marker Score: 535 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.78
Marker Score: 837 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1264 - Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.77
Marker Score: 3226.5 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 398 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.74
Marker Score: 639 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.71
Marker Score: 863 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.7
Marker Score: 2882 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.69
Marker Score: 2455 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.66
Marker Score: 1019 - Cell Name: interneuron (CL0000099)
Fold Change: 0.63
Marker Score: 290 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6
Marker Score: 386 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.6
Marker Score: 9364 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.59
Marker Score: 239 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.58
Marker Score: 460 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.56
Marker Score: 1056 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 232 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 175 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.55
Marker Score: 743 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.55
Marker Score: 319 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.53
Marker Score: 32892 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.53
Marker Score: 489 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.52
Marker Score: 1232 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.5
Marker Score: 3021 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.49
Marker Score: 320 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.48
Marker Score: 4938 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.44
Marker Score: 1563 - Cell Name: Schwann cell (CL0002573)
Fold Change: 0.42
Marker Score: 147 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.42
Marker Score: 857 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.39
Marker Score: 748 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.38
Marker Score: 291 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.37
Marker Score: 115 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.37
Marker Score: 3478 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.36
Marker Score: 389 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.35
Marker Score: 3001 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.34
Marker Score: 123 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.34
Marker Score: 7513 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.34
Marker Score: 5026 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.33
Marker Score: 125 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.32
Marker Score: 3053 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.32
Marker Score: 12210 - Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.32
Marker Score: 128 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.31
Marker Score: 437 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.3
Marker Score: 96 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.3
Marker Score: 480 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.29
Marker Score: 1129 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.29
Marker Score: 172 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.28
Marker Score: 682 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.28
Marker Score: 312 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.28
Marker Score: 5486 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.26
Marker Score: 99 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.25
Marker Score: 106 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.25
Marker Score: 283 - Cell Name: erythrocyte (CL0000232)
Fold Change: 0.25
Marker Score: 136 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.24
Marker Score: 76 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.24
Marker Score: 66 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.23
Marker Score: 613 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.22
Marker Score: 107 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.22
Marker Score: 375 - Cell Name: podocyte (CL0000653)
Fold Change: 0.22
Marker Score: 82 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.22
Marker Score: 114.5 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74 - Cell Name: ciliated cell (CL0000064)
Fold Change: 0.21
Marker Score: 732 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.21
Marker Score: 259 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.21
Marker Score: 121 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.19
Marker Score: 1492 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.19
Marker Score: 56 - Cell Name: lymphocyte (CL0000542)
Fold Change: 0.18
Marker Score: 93 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.18
Marker Score: 186 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.18
Marker Score: 50 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.18
Marker Score: 193
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Other Information
Genular Protein ID: 3284204931
Symbol: KLKB1_HUMAN
Name: Plasma kallikrein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3521732
Title: Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats.
PubMed ID: 3521732
DOI: 10.1021/bi00357a017
PubMed ID: 11031105
Title: Genomic structure of the human plasma prekallikrein gene, identification of allelic variants, and analysis in end-stage renal disease.
PubMed ID: 11031105
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1998666
Title: Location of the disulfide bonds in human plasma prekallikrein: the presence of four novel apple domains in the amino-terminal portion of the molecule.
PubMed ID: 1998666
DOI: 10.1021/bi00222a007
PubMed ID: 2844223
Title: Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor.
PubMed ID: 2844223
DOI: 10.1021/bi00412a005
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 14652634
Title: Severe prekallikrein (Fletcher factor) deficiency due to a compound heterozygosis (383Trp stop codon and Cys529Tyr).
PubMed ID: 14652634
DOI: 10.1160/th03-05-0275
PubMed ID: 17598838
Title: A new type of plasma prekallikrein deficiency associated with homozygosity for Gly104Arg and Asn124Ser in apple domain 2 of the heavy-chain region.
PubMed ID: 17598838
PubMed ID: 34847617
Title: Prekallikrein deficiency due to homozygous KLKB1(+) mutation c.444_445insT (p.Ser151PhefsTer34).
PubMed ID: 34847617
DOI: 10.1111/ijlh.13773
Sequence Information:
- Length: 638
- Mass: 71343
- Checksum: 7756B8821AA71DF9
- Sequence:
MILFKQATYF ISLFATVSCG CLTQLYENAF FRGGDVASMY TPNAQYCQMR CTFHPRCLLF SFLPASSIND MEKRFGCFLK DSVTGTLPKV HRTGAVSGHS LKQCGHQISA CHRDIYKGVD MRGVNFNVSK VSSVEECQKR CTSNIRCQFF SYATQTFHKA EYRNNCLLKY SPGGTPTAIK VLSNVESGFS LKPCALSEIG CHMNIFQHLA FSDVDVARVL TPDAFVCRTI CTYHPNCLFF TFYTNVWKIE SQRNVCLLKT SESGTPSSST PQENTISGYS LLTCKRTLPE PCHSKIYPGV DFGGEELNVT FVKGVNVCQE TCTKMIRCQF FTYSLLPEDC KEEKCKCFLR LSMDGSPTRI AYGTQGSSGY SLRLCNTGDN SVCTTKTSTR IVGGTNSSWG EWPWQVSLQV KLTAQRHLCG GSLIGHQWVL TAAHCFDGLP LQDVWRIYSG ILNLSDITKD TPFSQIKEII IHQNYKVSEG NHDIALIKLQ APLNYTEFQK PICLPSKGDT STIYTNCWVT GWGFSKEKGE IQNILQKVNI PLVTNEECQK RYQDYKITQR MVCAGYKEGG KDACKGDSGG PLVCKHNGMW RLVGITSWGE GCARREQPGV YTKVAEYMDW ILEKTQSSDG KAQMQSPA
Genular Protein ID: 1907117497
Symbol: A8K9A9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 638
- Mass: 71354
- Checksum: 4A6E2E777F838FB3
- Sequence:
MILFKQATYF ISLFATVSCG CLTQLYENAF FRGGDVASMY TPNAQYCQMR CTFHPRCLLF SFLPASSIND MEKRFGCFLK DSVTGTPPKV HRTGAVSGHS LKQCGHQISA CHRDIYKGVD MRGVNFNVSK VSSVEECQKR CTNNIRCQFF SYATQTFHKA EYRNNCLLKY SPGGTPTAIK VLSNVESGFS LKPCALSEIG CHMNIFQHLA FSDVDVARVL TPDAFVCRTI CTYHPNCLFF TFYTNVWKIE SQRNVCLLKT SESGTPSSST PQENTISGYS LLTCKRTLPE PCHSKIYPGV DFGGEELNVT FVKGVNVCQE TCTKMIRCQF FTYSLLPEDC KEEKCKCFLR LSMDGSPTRI AYGTQGSSGY SLRLCNTGDN SVCTTKTSTR IVGGTNSSWG EWPWQVSLQV KLTAQRHLCG GSLIGHQWVL TAAHCFDGLP LQDVWRIYSG ILNLSDITKD TPFSQIKEII IHQNYKVSEG NHDIALIKLQ APLNYTEFQK PICLPSKGDT STIYTNCWVT GWGFSKEKGE IQNILQKVNI PLVTNEECQK RYQDYKITQR MVCAGYKEGG KDACKGDSGG PLVCKHNGMW RLVGITSWGE GCARREQPGV YTKVAEYMDW ILEKTQSSDG KAQMQSPA
Genular Protein ID: 741038964
Symbol: E9PBC5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
Sequence Information:
- Length: 514
- Mass: 57643
- Checksum: 087E8B4DD706F3DA
- Sequence:
MYTPNAQYCQ MRCTFHPRCL LFSFLPASSI NDMEKRFGCF LKDSVTGTLP KVHRTGAVSG HSLKQCGHQI SACHRDIYKG VDMRGVNFNV SKVSSVEECQ KRCTSNIRCQ FFSYATQTFH KAEYRNNCLL KYSPGGTPTA IKVLSNVESG FSLKPCALSE IGCHMNIFQH LAFSDVDVAR VLTPDAFVCR TICTYHPNCL FFTFYTNVWK IESQRNVCLL KTSESGTPSS STPQENTISG YSLLTCKRTL PEPCHSKIYP GVDFGGEELN VTFVKGVNVC QETCTKMIRC QFFTYSLLPE DCKEEKCKCF LRLSMDGSPT RIAYGTQGSS GYSLRLCNTG DNSVCTTKTS TRIVGGTNSS WGEWPWQVSL QVKLTAQRHL CGGSLIGHQW VLTAAHCFDG LPLQDVWRIY SGILNLSDIT KDTPFSQIKE IIIHQNYKVS EGNHDIALIK LQAPLNYTEF QKPICLPSKG DTSTIYTNCW VTGWGFSKEK GRFRWSLSLQ TQWNVAFGGH HQLG
Genular Protein ID: 2783124790
Symbol: B4DMX2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 514
- Mass: 57648
- Checksum: 64BAE34E4B5EA816
- Sequence:
MYTPNAQYCQ MRCTFHPRCL LFSFLPASSI NDMEKRFGCF LKDSVTGTLP KVHRTGAVSG HSLKQCGHQI SACHRDIYKG VDMRGVNFNV SKVSSVEECQ KRCTNDIRCQ FFSYATQTFH KAEYRNNCLL KYSPGGTPTA IKVLSNVESG FSLKPCALSE IGCQMNIFQH LAFSDVDVAR VLTPDAFVCR TICTYHPNCL FFTFYTNVWK IESQRNVCLL KTSESGTPSS CTPQENTISG YSLLTCKRTL PEPCHSKIYP GVDFGGEELN VTFVKGVNVC QETCTKMIRC QFFTYSLLPE DCKEEKCKCF LRLSMDGSPT RIAYGTQGSS GYSLRLCNTG DNSVCTTKTS TRIVGGTNSS WGEWPWQVSL QVKLTAQRHL CGGSLIGHQW VLTAAHCFDG LPLQDVWRIY SGILNLSDIT KDTPFSQIKE IIIHQNYKVS EGNHDIALIK LQAPLNYTEF QKPICLPSKG DTSTIYTNCW VTGWGFSKEK GRFRWSLSLQ TQRNVAFGGH HQLG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.