Details for: KLKB1

Gene ID: 3818

Symbol: KLKB1

Ensembl ID: ENSG00000164344

Description: kallikrein B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 53.2321
    Cell Significance Index: -8.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1186
    Cell Significance Index: -8.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.3535
    Cell Significance Index: 196.7500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.9124
    Cell Significance Index: 15.3700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.5020
    Cell Significance Index: 7.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3818
    Cell Significance Index: 76.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2727
    Cell Significance Index: 20.9300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2622
    Cell Significance Index: 3.8700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2381
    Cell Significance Index: 3.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1944
    Cell Significance Index: 37.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1927
    Cell Significance Index: 38.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1812
    Cell Significance Index: 6.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1581
    Cell Significance Index: 9.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1522
    Cell Significance Index: 6.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1077
    Cell Significance Index: 38.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1059
    Cell Significance Index: 3.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1010
    Cell Significance Index: 190.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0840
    Cell Significance Index: 53.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0631
    Cell Significance Index: 6.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0528
    Cell Significance Index: 2.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0525
    Cell Significance Index: 3.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0483
    Cell Significance Index: 74.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0452
    Cell Significance Index: 1.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0432
    Cell Significance Index: 7.0300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0422
    Cell Significance Index: 0.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0418
    Cell Significance Index: 28.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0328
    Cell Significance Index: 60.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0216
    Cell Significance Index: 0.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0214
    Cell Significance Index: 19.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0086
    Cell Significance Index: 0.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0010
    Cell Significance Index: 1.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0038
    Cell Significance Index: -1.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0073
    Cell Significance Index: -5.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0086
    Cell Significance Index: -6.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0127
    Cell Significance Index: -7.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0139
    Cell Significance Index: -7.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0164
    Cell Significance Index: -0.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0197
    Cell Significance Index: -5.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0237
    Cell Significance Index: -4.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0253
    Cell Significance Index: -4.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0308
    Cell Significance Index: -1.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0372
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0373
    Cell Significance Index: -4.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0388
    Cell Significance Index: -2.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0411
    Cell Significance Index: -8.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0437
    Cell Significance Index: -5.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0470
    Cell Significance Index: -5.1200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0504
    Cell Significance Index: -0.2900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0528
    Cell Significance Index: -0.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0540
    Cell Significance Index: -1.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0566
    Cell Significance Index: -6.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0569
    Cell Significance Index: -2.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0584
    Cell Significance Index: -6.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0589
    Cell Significance Index: -3.3100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0593
    Cell Significance Index: -2.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0597
    Cell Significance Index: -8.2000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0624
    Cell Significance Index: -1.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0651
    Cell Significance Index: -6.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0704
    Cell Significance Index: -8.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0711
    Cell Significance Index: -8.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1003
    Cell Significance Index: -7.9400
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1098
    Cell Significance Index: -0.9500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1105
    Cell Significance Index: -1.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1121
    Cell Significance Index: -6.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1131
    Cell Significance Index: -5.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1313
    Cell Significance Index: -6.8400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1330
    Cell Significance Index: -1.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1486
    Cell Significance Index: -7.7200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1498
    Cell Significance Index: -1.1500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1509
    Cell Significance Index: -2.3000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1516
    Cell Significance Index: -1.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1531
    Cell Significance Index: -8.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1542
    Cell Significance Index: -7.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1567
    Cell Significance Index: -3.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1579
    Cell Significance Index: -5.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1579
    Cell Significance Index: -5.5300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1587
    Cell Significance Index: -2.1400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1592
    Cell Significance Index: -3.4400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1669
    Cell Significance Index: -1.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1701
    Cell Significance Index: -3.3200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1704
    Cell Significance Index: -5.3900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1734
    Cell Significance Index: -3.6200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1755
    Cell Significance Index: -3.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1758
    Cell Significance Index: -4.7100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1762
    Cell Significance Index: -2.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1766
    Cell Significance Index: -4.5400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1781
    Cell Significance Index: -1.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1815
    Cell Significance Index: -3.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1827
    Cell Significance Index: -5.9800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1850
    Cell Significance Index: -2.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1962
    Cell Significance Index: -2.8100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2030
    Cell Significance Index: -5.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2042
    Cell Significance Index: -4.1000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2149
    Cell Significance Index: -5.3600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2170
    Cell Significance Index: -3.2700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.2308
    Cell Significance Index: -2.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2416
    Cell Significance Index: -2.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2416
    Cell Significance Index: -8.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2425
    Cell Significance Index: -5.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLKB1 is a single-pass transmembrane glycoprotein, consisting of 268 amino acids, with a molecular weight of approximately 29 kDa. It is highly expressed in various tissues, including the liver, small intestine, colon, and brain, where it is involved in different cellular processes. KLKB1 is a zymogen that is activated by contact activation system (CAS) and kallikrein-kinin system (KKS) pathways, leading to the generation of bradykinin, a potent vasodilator and anti-inflammatory mediator. **Pathways and Functions:** KLKB1 is involved in multiple signaling pathways, including: 1. **Activation of matrix metalloproteinases (MMPs):** KLKB1 activates MMPs, which are crucial for tissue remodeling and degradation of the extracellular matrix. 2. **Blood coagulation:** KLKB1 is involved in the regulation of fibrinolysis and the intrinsic pathway of fibrin clot formation. 3. **Defective factor XII causes hereditary angioedema:** Mutations in KLKB1 have been linked to hereditary angioedema, a disorder characterized by recurrent episodes of severe edema. 4. **Defective serpin1 causes hereditary angioedema:** KLKB1 also interacts with serpin1, another enzyme involved in the regulation of the kallikrein-kinin system, leading to hereditary angioedema. 5. **Degradation of the extracellular matrix:** KLKB1 contributes to the degradation of the extracellular matrix, which is essential for tissue remodeling and repair. **Clinical Significance:** KLKB1 mutations are associated with several diseases, including: 1. **Hereditary angioedema:** Mutations in KLKB1 can lead to recurrent episodes of severe edema, which can be life-threatening if not properly managed. 2. **Hemostasis disorders:** KLKB1 plays a crucial role in regulating fibrinolysis and the intrinsic pathway of fibrin clot formation, making it a potential target for the treatment of bleeding disorders. 3. **Cancer:** KLKB1 has been implicated in the development and progression of various cancers, including liver, breast, and colon cancer. 4. **Neurological disorders:** KLKB1 has been linked to neurological disorders, such as Alzheimer's disease and stroke, where it is involved in the regulation of inflammation and tissue remodeling. In conclusion, KLKB1 is a multifunctional enzyme that plays a critical role in hemostasis, inflammation, and tissue remodeling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 3284204931

Symbol: KLKB1_HUMAN

Name: Plasma kallikrein

UniProtKB Accession Codes:

P03952 A6NH96 B2R8H9 Q17RE8 Q17RE9 Q4W5C3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 DrugCentral 1 EC 2 EMBL 16 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PIR 1 PRINTS 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3521732

Title: Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats.

PubMed ID: 3521732

DOI: 10.1021/bi00357a017

PubMed ID: 11031105

Title: Genomic structure of the human plasma prekallikrein gene, identification of allelic variants, and analysis in end-stage renal disease.

PubMed ID: 11031105

DOI: 10.1006/geno.2000.6330

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1998666

Title: Location of the disulfide bonds in human plasma prekallikrein: the presence of four novel apple domains in the amino-terminal portion of the molecule.

PubMed ID: 1998666

DOI: 10.1021/bi00222a007

PubMed ID: 2844223

Title: Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor.

PubMed ID: 2844223

DOI: 10.1021/bi00412a005

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 33732248

Title: Iripin-3, a New Salivary Protein Isolated From Ixodes ricinus Ticks, Displays Immunomodulatory and Anti-Hemostatic Properties In Vitro.

PubMed ID: 33732248

DOI: 10.3389/fimmu.2021.626200

PubMed ID: 36756125

Title: Iripin-1, a new anti-inflammatory tick serpin, inhibits leukocyte recruitment <i>in vivo</i> while altering the levels of chemokines and adhesion molecules.

PubMed ID: 36756125

DOI: 10.3389/fimmu.2023.1116324

PubMed ID: 14652634

Title: Severe prekallikrein (Fletcher factor) deficiency due to a compound heterozygosis (383Trp stop codon and Cys529Tyr).

PubMed ID: 14652634

DOI: 10.1160/th03-05-0275

PubMed ID: 17598838

Title: A new type of plasma prekallikrein deficiency associated with homozygosity for Gly104Arg and Asn124Ser in apple domain 2 of the heavy-chain region.

PubMed ID: 17598838

DOI: 10.1111/j.1600-0609.2007.00871.x

PubMed ID: 34847617

Title: Prekallikrein deficiency due to homozygous KLKB1(+) mutation c.444_445insT (p.Ser151PhefsTer34).

PubMed ID: 34847617

DOI: 10.1111/ijlh.13773

Sequence Information:

  • Length: 638
  • Mass: 71343
  • Checksum: 7756B8821AA71DF9
  • Sequence:
    • MILFKQATYF ISLFATVSCG CLTQLYENAF FRGGDVASMY TPNAQYCQMR CTFHPRCLLF 
SFLPASSIND MEKRFGCFLK DSVTGTLPKV HRTGAVSGHS LKQCGHQISA CHRDIYKGVD 
MRGVNFNVSK VSSVEECQKR CTSNIRCQFF SYATQTFHKA EYRNNCLLKY SPGGTPTAIK 
VLSNVESGFS LKPCALSEIG CHMNIFQHLA FSDVDVARVL TPDAFVCRTI CTYHPNCLFF 
TFYTNVWKIE SQRNVCLLKT SESGTPSSST PQENTISGYS LLTCKRTLPE PCHSKIYPGV 
DFGGEELNVT FVKGVNVCQE TCTKMIRCQF FTYSLLPEDC KEEKCKCFLR LSMDGSPTRI 
AYGTQGSSGY SLRLCNTGDN SVCTTKTSTR IVGGTNSSWG EWPWQVSLQV KLTAQRHLCG 
GSLIGHQWVL TAAHCFDGLP LQDVWRIYSG ILNLSDITKD TPFSQIKEII IHQNYKVSEG 
NHDIALIKLQ APLNYTEFQK PICLPSKGDT STIYTNCWVT GWGFSKEKGE IQNILQKVNI 
PLVTNEECQK RYQDYKITQR MVCAGYKEGG KDACKGDSGG PLVCKHNGMW RLVGITSWGE 
GCARREQPGV YTKVAEYMDW ILEKTQSSDG KAQMQSPA

Genular Protein ID: 1907117497

Symbol: A8K9A9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K9A9

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 8 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 8 PeptideAtlas 1 Pfam 2 RefSeq 3 RuleBase 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 638
  • Mass: 71354
  • Checksum: 4A6E2E777F838FB3
  • Sequence:
    • MILFKQATYF ISLFATVSCG CLTQLYENAF FRGGDVASMY TPNAQYCQMR CTFHPRCLLF 
SFLPASSIND MEKRFGCFLK DSVTGTPPKV HRTGAVSGHS LKQCGHQISA CHRDIYKGVD 
MRGVNFNVSK VSSVEECQKR CTNNIRCQFF SYATQTFHKA EYRNNCLLKY SPGGTPTAIK 
VLSNVESGFS LKPCALSEIG CHMNIFQHLA FSDVDVARVL TPDAFVCRTI CTYHPNCLFF 
TFYTNVWKIE SQRNVCLLKT SESGTPSSST PQENTISGYS LLTCKRTLPE PCHSKIYPGV 
DFGGEELNVT FVKGVNVCQE TCTKMIRCQF FTYSLLPEDC KEEKCKCFLR LSMDGSPTRI 
AYGTQGSSGY SLRLCNTGDN SVCTTKTSTR IVGGTNSSWG EWPWQVSLQV KLTAQRHLCG 
GSLIGHQWVL TAAHCFDGLP LQDVWRIYSG ILNLSDITKD TPFSQIKEII IHQNYKVSEG 
NHDIALIKLQ APLNYTEFQK PICLPSKGDT STIYTNCWVT GWGFSKEKGE IQNILQKVNI 
PLVTNEECQK RYQDYKITQR MVCAGYKEGG KDACKGDSGG PLVCKHNGMW RLVGITSWGE 
GCARREQPGV YTKVAEYMDW ILEKTQSSDG KAQMQSPA

Genular Protein ID: 741038964

Symbol: E9PBC5_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PBC5

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 HGNC 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 6 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 514
  • Mass: 57643
  • Checksum: 087E8B4DD706F3DA
  • Sequence:
    • MYTPNAQYCQ MRCTFHPRCL LFSFLPASSI NDMEKRFGCF LKDSVTGTLP KVHRTGAVSG 
HSLKQCGHQI SACHRDIYKG VDMRGVNFNV SKVSSVEECQ KRCTSNIRCQ FFSYATQTFH 
KAEYRNNCLL KYSPGGTPTA IKVLSNVESG FSLKPCALSE IGCHMNIFQH LAFSDVDVAR 
VLTPDAFVCR TICTYHPNCL FFTFYTNVWK IESQRNVCLL KTSESGTPSS STPQENTISG 
YSLLTCKRTL PEPCHSKIYP GVDFGGEELN VTFVKGVNVC QETCTKMIRC QFFTYSLLPE 
DCKEEKCKCF LRLSMDGSPT RIAYGTQGSS GYSLRLCNTG DNSVCTTKTS TRIVGGTNSS 
WGEWPWQVSL QVKLTAQRHL CGGSLIGHQW VLTAAHCFDG LPLQDVWRIY SGILNLSDIT 
KDTPFSQIKE IIIHQNYKVS EGNHDIALIK LQAPLNYTEF QKPICLPSKG DTSTIYTNCW 
VTGWGFSKEK GRFRWSLSLQ TQWNVAFGGH HQLG

Genular Protein ID: 2783124790

Symbol: B4DMX2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DMX2

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 7 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 6 PeptideAtlas 1 Pfam 2 RefSeq 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 514
  • Mass: 57648
  • Checksum: 64BAE34E4B5EA816
  • Sequence:
    • MYTPNAQYCQ MRCTFHPRCL LFSFLPASSI NDMEKRFGCF LKDSVTGTLP KVHRTGAVSG 
HSLKQCGHQI SACHRDIYKG VDMRGVNFNV SKVSSVEECQ KRCTNDIRCQ FFSYATQTFH 
KAEYRNNCLL KYSPGGTPTA IKVLSNVESG FSLKPCALSE IGCQMNIFQH LAFSDVDVAR 
VLTPDAFVCR TICTYHPNCL FFTFYTNVWK IESQRNVCLL KTSESGTPSS CTPQENTISG 
YSLLTCKRTL PEPCHSKIYP GVDFGGEELN VTFVKGVNVC QETCTKMIRC QFFTYSLLPE 
DCKEEKCKCF LRLSMDGSPT RIAYGTQGSS GYSLRLCNTG DNSVCTTKTS TRIVGGTNSS 
WGEWPWQVSL QVKLTAQRHL CGGSLIGHQW VLTAAHCFDG LPLQDVWRIY SGILNLSDIT 
KDTPFSQIKE IIIHQNYKVS EGNHDIALIK LQAPLNYTEF QKPICLPSKG DTSTIYTNCW 
VTGWGFSKEK GRFRWSLSLQ TQRNVAFGGH HQLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.