Details for: KLRC3

Gene ID: 3823

Symbol: KLRC3

Ensembl ID: ENSG00000205810

Description: killer cell lectin like receptor C3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1997
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.82
    Marker Score: 7064
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.75
    Marker Score: 2582
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1171
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.22
    Marker Score: 809
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4819
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.84
    Marker Score: 2056
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 581.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.7
    Marker Score: 178
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.7
    Marker Score: 865
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.63
    Marker Score: 386
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.61
    Marker Score: 446
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.5
    Marker Score: 487
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.5
    Marker Score: 890
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.46
    Marker Score: 634
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.45
    Marker Score: 367
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 178
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.38
    Marker Score: 405
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.37
    Marker Score: 359.5
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.33
    Marker Score: 952
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.31
    Marker Score: 109
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.3
    Marker Score: 173
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.29
    Marker Score: 287
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.27
    Marker Score: 733
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.23
    Marker Score: 140
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.23
    Marker Score: 555
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.23
    Marker Score: 650
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.22
    Marker Score: 400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.21
    Marker Score: 64
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.19
    Marker Score: 84
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 107
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.19
    Marker Score: 159
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.19
    Marker Score: 42
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.18
    Marker Score: 126
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.18
    Marker Score: 122
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.17
    Marker Score: 102
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.16
    Marker Score: 213
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.16
    Marker Score: 1881
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.16
    Marker Score: 228
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.16
    Marker Score: 57
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.16
    Marker Score: 120
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.15
    Marker Score: 370
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.13
    Marker Score: 211
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.13
    Marker Score: 263
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.12
    Marker Score: 233
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.12
    Marker Score: 64
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.12
    Marker Score: 260
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.11
    Marker Score: 91
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 58
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.11
    Marker Score: 56
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.11
    Marker Score: 61
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.11
    Marker Score: 124
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.1
    Marker Score: 110
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1
    Marker Score: 630
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.09
    Marker Score: 123
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.09
    Marker Score: 375.5
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.09
    Marker Score: 176
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.09
    Marker Score: 76
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.08
    Marker Score: 92
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.08
    Marker Score: 66
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.08
    Marker Score: 139
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.08
    Marker Score: 72
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.08
    Marker Score: 60
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.08
    Marker Score: 1210
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.08
    Marker Score: 137
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.07
    Marker Score: 430
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.07
    Marker Score: 119
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 65
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.07
    Marker Score: 656

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Other Information

**Key characteristics:** * The KLRC3 gene is located on chromosome 19q21.1. * It is a member of the killer cell lectin-like receptor family. * It is a type I transmembrane receptor with a single extracellular domain and a cytoplasmic domain. * The extracellular domain is responsible for binding to ligands such as HLA-E and activating NK cells. **Pathways and functions:** * KLRC3 is expressed in high levels in enterocytes of the large intestine, neural progenitor cells, effector memory CD8-positive T cells, and terminally differentiated cells. * It is involved in the regulation of NK cell activation through the Stimulatory c-type lectin receptor signaling pathway. * It also plays a role in the regulation of NK cell activation through the Transmembrane signaling receptor activity pathway. **Clinical significance:** * Mutations in the KLRC3 gene have been linked to several human cancers, including lung cancer, colon cancer, and breast cancer. * Targeting KLRC3 has been investigated as a potential therapeutic strategy for these cancers. * Studies have shown that blocking the activity of KLRC3 can inhibit NK cell activation and tumor growth. **Additional points:** * The KLRC3 gene product is a glycoprotein with a molecular weight of approximately 120 kDa. * It is a transmembrane protein that is expressed on the surface of NK cells and tumor cells. * It is a key regulator of NK cell activation.

Genular Protein ID: 2455945579

Symbol: NKG2E_HUMAN

Name: NKG2-E type II integral membrane protein

UniProtKB Accession Codes:

Q07444 Q8WXA4 Q96RL0 Q9UP04

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8276468

Title: Natural killer lectin-like receptors have divergent carboxy-termini, distinct from C-type lectins.

PubMed ID: 8276468

DOI: 10.1007/bf00241264

PubMed ID: 9683661

Title: The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex.

PubMed ID: 9683661

DOI: 10.1007/s002510050420

PubMed ID: 10201920

Title: Triggering of effector functions on a CD8+ T cell clone upon the aggregation of an activatory CD94/kp39 heterodimer.

PubMed ID: 10201920

PubMed ID: 11751968

Title: Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.

PubMed ID: 11751968

DOI: 10.4049/jimmunol.168.1.240

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 240
  • Mass: 27100
  • Checksum: 9F7056DD558A40C3
  • Sequence:
    • MSKQRGTFSE VSLAQDPKWQ QRKPKGNKSS ISGTEQEIFQ VELNLQNASL NHQGIDKIYD 
CQGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPFLEQN NSSPNARTQK ARHCGHCPEE 
WITYSNSCYY IGKERRTWEE SLQACASKNS SSLLCIDNEE EMKFLASILP SSWIGVFRNS 
SHHPWVTING LAFKHEIKDS DHAERNCAML HVRGLISDQC GSSRIIRRGF IMLTRLVLNS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.