Details for: KLRC3

Gene ID: 3823

Symbol: KLRC3

Ensembl ID: ENSG00000205810

Description: killer cell lectin like receptor C3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8569
    Cell Significance Index: 59.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8075
    Cell Significance Index: 39.1600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 1.4122
    Cell Significance Index: 16.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0372
    Cell Significance Index: 47.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7927
    Cell Significance Index: 150.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.7711
    Cell Significance Index: 11.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5155
    Cell Significance Index: 50.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4647
    Cell Significance Index: 419.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4340
    Cell Significance Index: 11.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3294
    Cell Significance Index: 7.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2853
    Cell Significance Index: 46.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2606
    Cell Significance Index: 28.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1495
    Cell Significance Index: 10.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1281
    Cell Significance Index: 7.6900
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.1081
    Cell Significance Index: 1.1500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.0784
    Cell Significance Index: 0.2100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0198
    Cell Significance Index: 0.2500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0143
    Cell Significance Index: 0.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0108
    Cell Significance Index: 0.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0033
    Cell Significance Index: 0.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0014
    Cell Significance Index: -0.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0022
    Cell Significance Index: -0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0059
    Cell Significance Index: -4.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0085
    Cell Significance Index: -4.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0115
    Cell Significance Index: -4.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0146
    Cell Significance Index: -2.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0190
    Cell Significance Index: -3.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0213
    Cell Significance Index: -2.9300
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.0215
    Cell Significance Index: -0.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0219
    Cell Significance Index: -1.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0230
    Cell Significance Index: -2.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0235
    Cell Significance Index: -4.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0309
    Cell Significance Index: -3.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0323
    Cell Significance Index: -0.6700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0329
    Cell Significance Index: -0.4300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0334
    Cell Significance Index: -1.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0346
    Cell Significance Index: -4.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0381
    Cell Significance Index: -4.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0415
    Cell Significance Index: -2.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0514
    Cell Significance Index: -5.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0573
    Cell Significance Index: -4.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0574
    Cell Significance Index: -3.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0588
    Cell Significance Index: -2.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0631
    Cell Significance Index: -3.2800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0670
    Cell Significance Index: -0.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0901
    Cell Significance Index: -5.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0911
    Cell Significance Index: -3.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0920
    Cell Significance Index: -4.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0927
    Cell Significance Index: -4.3600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0960
    Cell Significance Index: -0.9500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0991
    Cell Significance Index: -1.0800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1003
    Cell Significance Index: -2.0400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1051
    Cell Significance Index: -0.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1070
    Cell Significance Index: -4.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1109
    Cell Significance Index: -3.6300
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1119
    Cell Significance Index: -1.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1131
    Cell Significance Index: -3.6000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1187
    Cell Significance Index: -2.8800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1257
    Cell Significance Index: -1.7100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1265
    Cell Significance Index: -3.1600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1407
    Cell Significance Index: -3.2500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1408
    Cell Significance Index: -1.5100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1413
    Cell Significance Index: -1.8100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1418
    Cell Significance Index: -3.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1487
    Cell Significance Index: -3.9100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1533
    Cell Significance Index: -2.1200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1539
    Cell Significance Index: -2.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1547
    Cell Significance Index: -3.8600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1611
    Cell Significance Index: -2.6100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1622
    Cell Significance Index: -3.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1631
    Cell Significance Index: -4.3600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1715
    Cell Significance Index: -4.3700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1738
    Cell Significance Index: -2.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1756
    Cell Significance Index: -4.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1758
    Cell Significance Index: -4.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1772
    Cell Significance Index: -3.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1778
    Cell Significance Index: -3.4700
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.1820
    Cell Significance Index: -1.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1821
    Cell Significance Index: -4.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1838
    Cell Significance Index: -3.6900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1861
    Cell Significance Index: -3.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1871
    Cell Significance Index: -3.7000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1876
    Cell Significance Index: -3.1600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1878
    Cell Significance Index: -2.0800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1880
    Cell Significance Index: -2.0600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1918
    Cell Significance Index: -2.8100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1964
    Cell Significance Index: -4.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1968
    Cell Significance Index: -5.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2006
    Cell Significance Index: -5.7500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2053
    Cell Significance Index: -4.0400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.2084
    Cell Significance Index: -2.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2109
    Cell Significance Index: -3.5300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2111
    Cell Significance Index: -4.2100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2157
    Cell Significance Index: -3.4600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2191
    Cell Significance Index: -3.3900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2202
    Cell Significance Index: -3.2500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2238
    Cell Significance Index: -3.8700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2247
    Cell Significance Index: -2.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** KLRC3 is a type II integral membrane protein, consisting of a single transmembrane domain and an extracellular domain with a lectin-like binding site. The protein is characterized by its ability to bind to specific carbohydrate ligands on the surface of target cells, which triggers a signaling cascade that enhances the cytotoxic activity of NK cells. KLRC3 is also known to be involved in the regulation of NK cell activation and the positive regulation of NK cell-mediated cytotoxicity. **Pathways and Functions** KLRC3 is involved in several signaling pathways, including: 1. **Stimulatory c-type lectin receptor signaling pathway**: KLRC3 binds to its specific carbohydrate ligands, triggering a signaling cascade that activates the NF-κB transcription factor, leading to the expression of genes involved in the regulation of NK cell-mediated cytotoxicity. 2. **Regulation of natural killer cell activation**: KLRC3 is involved in the regulation of NK cell activation, modulating the expression of activating and inhibitory receptors on NK cells. 3. **Positive regulation of natural killer cell-mediated cytotoxicity**: KLRC3 enhances the cytotoxic activity of NK cells by activating the signaling pathways that lead to the expression of genes involved in the production of cytotoxic granules and the activation of the NK cell cytotoxic function. **Clinical Significance** KLRC3 is involved in the defense against pathogens and tumor cells, and its dysregulation has been implicated in various diseases, including: 1. **Cancer**: KLRC3 is overexpressed on the surface of NK cells in certain types of cancer, such as melanoma and ovarian cancer, and is associated with the enhancement of tumor cell killing by NK cells. 2. **Autoimmune diseases**: KLRC3 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it is involved in the regulation of immune cell function and the production of autoantibodies. 3. **Infectious diseases**: KLRC3 is involved in the defense against certain infectious diseases, such as HIV and tuberculosis, where it plays a role in the regulation of immune cell function and the production of cytokines. In conclusion, KLRC3 is an important receptor that plays a crucial role in the regulation of NK cell-mediated cytotoxicity and the defense against pathogens and tumor cells. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of KLRC3 function and its role in human disease.

Genular Protein ID: 2455945579

Symbol: NKG2E_HUMAN

Name: NKG2-E type II integral membrane protein

UniProtKB Accession Codes:

Q07444 Q8WXA4 Q96RL0 Q9UP04

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8276468

Title: Natural killer lectin-like receptors have divergent carboxy-termini, distinct from C-type lectins.

PubMed ID: 8276468

DOI: 10.1007/bf00241264

PubMed ID: 9683661

Title: The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex.

PubMed ID: 9683661

DOI: 10.1007/s002510050420

PubMed ID: 10201920

Title: Triggering of effector functions on a CD8+ T cell clone upon the aggregation of an activatory CD94/kp39 heterodimer.

PubMed ID: 10201920

PubMed ID: 11751968

Title: Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.

PubMed ID: 11751968

DOI: 10.4049/jimmunol.168.1.240

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 240
  • Mass: 27100
  • Checksum: 9F7056DD558A40C3
  • Sequence:
    • MSKQRGTFSE VSLAQDPKWQ QRKPKGNKSS ISGTEQEIFQ VELNLQNASL NHQGIDKIYD 
CQGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPFLEQN NSSPNARTQK ARHCGHCPEE 
WITYSNSCYY IGKERRTWEE SLQACASKNS SSLLCIDNEE EMKFLASILP SSWIGVFRNS 
SHHPWVTING LAFKHEIKDS DHAERNCAML HVRGLISDQC GSSRIIRRGF IMLTRLVLNS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.