Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: epithelial cell of lacrimal sac (CL1000436)
Fold Change: 9.3952
Cell Significance Index: 67.6100 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 8.5731
Cell Significance Index: 122.0400 - Cell Name: erythrocyte (CL0000232)
Fold Change: 0.7711
Cell Significance Index: 19.6500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4471
Cell Significance Index: 85.0900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.3511
Cell Significance Index: 4.7900 - Cell Name: helper T cell (CL0000912)
Fold Change: 0.2885
Cell Significance Index: 4.1000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2643
Cell Significance Index: 238.6200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1011
Cell Significance Index: 10.0000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0248
Cell Significance Index: 4.0400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0212
Cell Significance Index: 0.6100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0211
Cell Significance Index: 0.7400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0161
Cell Significance Index: 2.0600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0124
Cell Significance Index: 8.5600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0004
Cell Significance Index: 0.0500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0006
Cell Significance Index: -0.4100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0007
Cell Significance Index: -0.4000 - Cell Name: thymocyte (CL0000893)
Fold Change: -0.0024
Cell Significance Index: -0.0300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0029
Cell Significance Index: -0.3400 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0070
Cell Significance Index: -0.1700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0132
Cell Significance Index: -0.3600 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.0138
Cell Significance Index: -0.0900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0156
Cell Significance Index: -29.2900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0191
Cell Significance Index: -35.2100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0212
Cell Significance Index: -0.9900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0229
Cell Significance Index: -35.2800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0239
Cell Significance Index: -0.5000 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0242
Cell Significance Index: -0.6000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0262
Cell Significance Index: -35.5800 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0270
Cell Significance Index: -0.5500 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0282
Cell Significance Index: -0.5500 - Cell Name: lung macrophage (CL1001603)
Fold Change: -0.0385
Cell Significance Index: -0.4200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0412
Cell Significance Index: -1.1000 - Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.0422
Cell Significance Index: -0.6000 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: -0.0442
Cell Significance Index: -0.4600 - Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.0461
Cell Significance Index: -0.4400 - Cell Name: immature NK T cell (CL0000914)
Fold Change: -0.0469
Cell Significance Index: -0.6000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0481
Cell Significance Index: -30.5300 - Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.0485
Cell Significance Index: -0.5900 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.0505
Cell Significance Index: -0.4800 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0523
Cell Significance Index: -28.5900 - Cell Name: muscle cell (CL0000187)
Fold Change: -0.0529
Cell Significance Index: -0.5100 - Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: -0.0530
Cell Significance Index: -0.5000 - Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: -0.0540
Cell Significance Index: -0.5400 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: -0.0542
Cell Significance Index: -0.5800 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: -0.0543
Cell Significance Index: -0.5200 - Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: -0.0572
Cell Significance Index: -0.5300 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.0580
Cell Significance Index: -0.4900 - Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: -0.0613
Cell Significance Index: -0.6000 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: -0.0647
Cell Significance Index: -0.6900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0660
Cell Significance Index: -29.9400 - Cell Name: peptic cell (CL0000155)
Fold Change: -0.0675
Cell Significance Index: -0.6000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0688
Cell Significance Index: -3.1200 - Cell Name: neural cell (CL0002319)
Fold Change: -0.0737
Cell Significance Index: -0.8600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0776
Cell Significance Index: -1.9400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0853
Cell Significance Index: -30.6000 - Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: -0.0873
Cell Significance Index: -0.7300 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.0889
Cell Significance Index: -0.5900 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.0927
Cell Significance Index: -0.6300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.1003
Cell Significance Index: -10.9100 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.1055
Cell Significance Index: -1.0700 - Cell Name: gut endothelial cell (CL0000131)
Fold Change: -0.1165
Cell Significance Index: -0.8000 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.1208
Cell Significance Index: -1.6700 - Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.1210
Cell Significance Index: -1.4300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1232
Cell Significance Index: -22.2100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1299
Cell Significance Index: -6.7500 - Cell Name: mucous neck cell (CL0000651)
Fold Change: -0.1365
Cell Significance Index: -0.6500 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1472
Cell Significance Index: -1.2000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1542
Cell Significance Index: -30.9400 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.1674
Cell Significance Index: -1.0400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1823
Cell Significance Index: -36.1800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1970
Cell Significance Index: -1.1900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2090
Cell Significance Index: -30.3900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.2111
Cell Significance Index: -28.9900 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.2279
Cell Significance Index: -2.9800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2375
Cell Significance Index: -16.4300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2390
Cell Significance Index: -14.6500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.2393
Cell Significance Index: -29.4200 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.2491
Cell Significance Index: -2.4100 - Cell Name: neutrophil (CL0000775)
Fold Change: -0.2810
Cell Significance Index: -3.5100 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2880
Cell Significance Index: -5.6300 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.3082
Cell Significance Index: -4.8900 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.3194
Cell Significance Index: -3.8600 - Cell Name: pro-B cell (CL0000826)
Fold Change: -0.3264
Cell Significance Index: -3.5100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.3483
Cell Significance Index: -20.9100 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.3741
Cell Significance Index: -3.8800 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.3812
Cell Significance Index: -4.8300 - Cell Name: immature B cell (CL0000816)
Fold Change: -0.3995
Cell Significance Index: -3.7800 - Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.4246
Cell Significance Index: -3.7800 - Cell Name: salivary gland cell (CL0009005)
Fold Change: -0.4300
Cell Significance Index: -5.3400 - Cell Name: naive B cell (CL0000788)
Fold Change: -0.4568
Cell Significance Index: -4.8100 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.4742
Cell Significance Index: -5.2500 - Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.4836
Cell Significance Index: -5.5700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.4870
Cell Significance Index: -22.8900 - Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.4879
Cell Significance Index: -5.6600 - Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: -0.4952
Cell Significance Index: -3.5600 - Cell Name: myelocyte (CL0002193)
Fold Change: -0.5068
Cell Significance Index: -5.4200 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.5244
Cell Significance Index: -5.0400 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.5267
Cell Significance Index: -5.4800 - Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -0.5322
Cell Significance Index: -5.5200 - Cell Name: osteoclast (CL0000092)
Fold Change: -0.5339
Cell Significance Index: -5.4500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2452957933
Symbol: K1C12_HUMAN
Name: Keratin, type I cytoskeletal 12
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8759347
Title: A gene expression profile of human corneal epithelium and the isolation of human keratin 12 cDNA.
PubMed ID: 8759347
PubMed ID: 9399908
Title: Isolation and chromosomal localization of a cornea-specific human keratin 12 gene and detection of four mutations in Meesmann corneal epithelial dystrophy.
PubMed ID: 9399908
DOI: 10.1086/301650
PubMed ID: 10644419
Title: Molecular genetics of Meesmann's corneal dystrophy: ancestral and novel mutations in keratin 12 (K12) and complete sequence of the human KRT12 gene.
PubMed ID: 10644419
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 26758872
Title: Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy.
PubMed ID: 26758872
DOI: 10.1093/hmg/ddw001
PubMed ID: 9171831
Title: Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy.
PubMed ID: 9171831
DOI: 10.1038/ng0697-184
PubMed ID: 10612503
Title: A novel mutation in the helix termination motif of keratin K12 in a US family with Meesmann corneal dystrophy.
PubMed ID: 10612503
PubMed ID: 10781519
Title: A novel keratin 12 mutation in a German kindred with Meesmann's corneal dystrophy.
PubMed ID: 10781519
DOI: 10.1136/bjo.84.5.527
PubMed ID: 12543196
Title: Heterozygous Ala137Pro mutation in keratin 12 gene found in Japanese with Meesmann's corneal dystrophy.
PubMed ID: 12543196
PubMed ID: 15148206
Title: A novel arginine substitution mutation in 1A domain and a novel 27 bp insertion mutation in 2B domain of keratin 12 gene associated with Meesmann's corneal dystrophy.
PubMed ID: 15148206
PubMed ID: 16227835
Title: Novel mutations in the helix termination motif of keratin 3 and keratin 12 in 2 Taiwanese families with Meesmann corneal dystrophy.
PubMed ID: 16227835
PubMed ID: 16352477
Title: Meesmann corneal dystrophy (MECD): report of 2 families and a novel mutation in the cornea specific keratin 12 (KRT12) gene.
PubMed ID: 16352477
PubMed ID: 17653038
Title: A novel mutation of the Keratin 12 gene responsible for a severe phenotype of Meesmann's corneal dystrophy.
PubMed ID: 17653038
PubMed ID: 18245975
Title: A novel mutation as the basis for asymptomatic meesmann dystrophy in a Danish family.
PubMed ID: 18245975
PubMed ID: 18661274
Title: A novel mutation in the cornea-specific keratin 12 gene in Meesmann corneal dystrophy.
PubMed ID: 18661274
PubMed ID: 20577595
Title: Identification of a novel mutation in the cornea specific keratin 12 gene causing Meesmann's corneal dystrophy in a German family.
PubMed ID: 20577595
PubMed ID: 23222558
Title: Severe Meesmann's epithelial corneal dystrophy phenotype due to a missense mutation in the helix-initiation motif of keratin 12.
PubMed ID: 23222558
DOI: 10.1038/eye.2012.261
PubMed ID: 24099278
Title: KRT12 mutations and in vivo confocal microscopy in two Japanese families with Meesmann corneal dystrophy.
PubMed ID: 24099278
PubMed ID: 30535821
Title: In vivo histology and p.L132V mutation in KRT12 gene in Japanese patients with Meesmann corneal dystrophy.
PubMed ID: 30535821
Sequence Information:
- Length: 494
- Mass: 53511
- Checksum: 75C981380532B682
- Sequence:
MDLSNNTMSL SVRTPGLSRR LSSQSVIGRP RGMSASSVGS GYGGSAFGFG ASCGGGFSAA SMFGSSSGFG GGSGSSMAGG LGAGYGRALG GGSFGGLGMG FGGSPGGGSL GILSGNDGGL LSGSEKETMQ NLNDRLASYL DKVRALEEAN TELENKIREW YETRGTGTAD ASQSDYSKYY PLIEDLRNKI ISASIGNAQL LLQIDNARLA AEDFRMKYEN ELALRQGVEA DINGLRRVLD ELTLTRTDLE MQIESLNEEL AYMKKNHEDE LQSFRVGGPG EVSVEMDAAP GVDLTRLLND MRAQYETIAE QNRKDAEAWF IEKSGELRKE ISTNTEQLQS SKSEVTDLRR AFQNLEIELQ SQLAMKKSLE DSLAEAEGDY CAQLSQVQQL ISNLEAQLLQ VRADAERQNV DHQRLLNVKA RLELEIETYR RLLDGEAQGD GLEESLFVTD SKSQAQSTDS SKDPTKTRKI KTVVQEMVNG EVVSSQVQEI EELM
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.