Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: T cell (CL0000084)
Fold Change: 2.4
Marker Score: 4,138 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.36
Marker Score: 2,605 - Cell Name: basal cell (CL0000646)
Fold Change: 2.34
Marker Score: 3,025 - Cell Name: erythrocyte (CL0000232)
Fold Change: 2.17
Marker Score: 1,201 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 2.07
Marker Score: 2,862 - Cell Name: plasma cell (CL0000786)
Fold Change: 1.66
Marker Score: 1,850 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 857 - Cell Name: B cell (CL0000236)
Fold Change: 1.25
Marker Score: 1,195 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 490 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.17
Marker Score: 1,234 - Cell Name: goblet cell (CL0000160)
Fold Change: 1.12
Marker Score: 7,459 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.08
Marker Score: 629 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.03
Marker Score: 474 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 512 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 465 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,405 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,411 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,741 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 328 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.9
Marker Score: 5,157 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.89
Marker Score: 357 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,282 - Cell Name: mast cell (CL0000097)
Fold Change: 0.85
Marker Score: 491 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,268 - Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 707 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.74
Marker Score: 1,188 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 466 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.73
Marker Score: 382 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2,858 - Cell Name: fibroblast (CL0000057)
Fold Change: 0.64
Marker Score: 615 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.64
Marker Score: 507 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.61
Marker Score: 444 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.58
Marker Score: 327 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.57
Marker Score: 231 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.52
Marker Score: 217 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.5
Marker Score: 158 - Cell Name: radial glial cell (CL0000681)
Fold Change: 0.44
Marker Score: 163 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.38
Marker Score: 342 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.28
Marker Score: 188 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 66 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.23
Marker Score: 226 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 76 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42 - Cell Name: Schwann cell (CL0002573)
Fold Change: 0.16
Marker Score: 56 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.15
Marker Score: 37 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.15
Marker Score: 91 - Cell Name: precursor cell (CL0011115)
Fold Change: 0.14
Marker Score: 35 - Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.14
Marker Score: 39 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.14
Marker Score: 39 - Cell Name: M cell of gut (CL0000682)
Fold Change: 0.14
Marker Score: 37 - Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 0.14
Marker Score: 38 - Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.14
Marker Score: 210 - Cell Name: leukocyte (CL0000738)
Fold Change: 0.13
Marker Score: 75 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.12
Marker Score: 31 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.11
Marker Score: 247 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.11
Marker Score: 35 - Cell Name: male germ cell (CL0000015)
Fold Change: 0.11
Marker Score: 31 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.11
Marker Score: 37 - Cell Name: epithelial cell of lacrimal sac (CL1000436)
Fold Change: 0.1
Marker Score: 46 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.1
Marker Score: 35 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.1
Marker Score: 320 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1
Marker Score: 24 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.1
Marker Score: 204 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.09
Marker Score: 49 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.09
Marker Score: 25 - Cell Name: myelocyte (CL0002193)
Fold Change: 0.09
Marker Score: 37 - Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.08
Marker Score: 31 - Cell Name: lymphocyte (CL0000542)
Fold Change: 0.08
Marker Score: 41 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.08
Marker Score: 80 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.08
Marker Score: 58 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.07
Marker Score: 22 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.07
Marker Score: 31 - Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.07
Marker Score: 65 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.07
Marker Score: 25 - Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.07
Marker Score: 30 - Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.06
Marker Score: 34 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.06
Marker Score: 37 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.06
Marker Score: 30 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.06
Marker Score: 28 - Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.06
Marker Score: 33 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.06
Marker Score: 59 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.06
Marker Score: 37 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.05
Marker Score: 33 - Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.05
Marker Score: 37 - Cell Name: pericyte (CL0000669)
Fold Change: 0.05
Marker Score: 31 - Cell Name: paneth cell (CL0000510)
Fold Change: 0.05
Marker Score: 36 - Cell Name: macrophage (CL0000235)
Fold Change: 0.05
Marker Score: 55 - Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.05
Marker Score: 37 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.05
Marker Score: 31 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.04
Marker Score: 37 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.04
Marker Score: 36 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.04
Marker Score: 32 - Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.04
Marker Score: 34 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.04
Marker Score: 38 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.04
Marker Score: 36 - Cell Name: naive B cell (CL0000788)
Fold Change: 0.03
Marker Score: 31 - Cell Name: enterocyte (CL0000584)
Fold Change: 0.03
Marker Score: 165 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.03
Marker Score: 34 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.03
Marker Score: 38 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.03
Marker Score: 39
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2452957933
Symbol: K1C12_HUMAN
Name: Keratin, type I cytoskeletal 12
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8759347
Title: A gene expression profile of human corneal epithelium and the isolation of human keratin 12 cDNA.
PubMed ID: 8759347
PubMed ID: 9399908
Title: Isolation and chromosomal localization of a cornea-specific human keratin 12 gene and detection of four mutations in Meesmann corneal epithelial dystrophy.
PubMed ID: 9399908
DOI: 10.1086/301650
PubMed ID: 10644419
Title: Molecular genetics of Meesmann's corneal dystrophy: ancestral and novel mutations in keratin 12 (K12) and complete sequence of the human KRT12 gene.
PubMed ID: 10644419
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 26758872
Title: Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy.
PubMed ID: 26758872
DOI: 10.1093/hmg/ddw001
PubMed ID: 9171831
Title: Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy.
PubMed ID: 9171831
DOI: 10.1038/ng0697-184
PubMed ID: 10612503
Title: A novel mutation in the helix termination motif of keratin K12 in a US family with Meesmann corneal dystrophy.
PubMed ID: 10612503
PubMed ID: 10781519
Title: A novel keratin 12 mutation in a German kindred with Meesmann's corneal dystrophy.
PubMed ID: 10781519
DOI: 10.1136/bjo.84.5.527
PubMed ID: 12543196
Title: Heterozygous Ala137Pro mutation in keratin 12 gene found in Japanese with Meesmann's corneal dystrophy.
PubMed ID: 12543196
PubMed ID: 15148206
Title: A novel arginine substitution mutation in 1A domain and a novel 27 bp insertion mutation in 2B domain of keratin 12 gene associated with Meesmann's corneal dystrophy.
PubMed ID: 15148206
PubMed ID: 16227835
Title: Novel mutations in the helix termination motif of keratin 3 and keratin 12 in 2 Taiwanese families with Meesmann corneal dystrophy.
PubMed ID: 16227835
PubMed ID: 16352477
Title: Meesmann corneal dystrophy (MECD): report of 2 families and a novel mutation in the cornea specific keratin 12 (KRT12) gene.
PubMed ID: 16352477
PubMed ID: 17653038
Title: A novel mutation of the Keratin 12 gene responsible for a severe phenotype of Meesmann's corneal dystrophy.
PubMed ID: 17653038
PubMed ID: 18245975
Title: A novel mutation as the basis for asymptomatic meesmann dystrophy in a Danish family.
PubMed ID: 18245975
PubMed ID: 18661274
Title: A novel mutation in the cornea-specific keratin 12 gene in Meesmann corneal dystrophy.
PubMed ID: 18661274
PubMed ID: 20577595
Title: Identification of a novel mutation in the cornea specific keratin 12 gene causing Meesmann's corneal dystrophy in a German family.
PubMed ID: 20577595
PubMed ID: 23222558
Title: Severe Meesmann's epithelial corneal dystrophy phenotype due to a missense mutation in the helix-initiation motif of keratin 12.
PubMed ID: 23222558
DOI: 10.1038/eye.2012.261
PubMed ID: 24099278
Title: KRT12 mutations and in vivo confocal microscopy in two Japanese families with Meesmann corneal dystrophy.
PubMed ID: 24099278
PubMed ID: 30535821
Title: In vivo histology and p.L132V mutation in KRT12 gene in Japanese patients with Meesmann corneal dystrophy.
PubMed ID: 30535821
Sequence Information:
- Length: 494
- Mass: 53511
- Checksum: 75C981380532B682
- Sequence:
MDLSNNTMSL SVRTPGLSRR LSSQSVIGRP RGMSASSVGS GYGGSAFGFG ASCGGGFSAA SMFGSSSGFG GGSGSSMAGG LGAGYGRALG GGSFGGLGMG FGGSPGGGSL GILSGNDGGL LSGSEKETMQ NLNDRLASYL DKVRALEEAN TELENKIREW YETRGTGTAD ASQSDYSKYY PLIEDLRNKI ISASIGNAQL LLQIDNARLA AEDFRMKYEN ELALRQGVEA DINGLRRVLD ELTLTRTDLE MQIESLNEEL AYMKKNHEDE LQSFRVGGPG EVSVEMDAAP GVDLTRLLND MRAQYETIAE QNRKDAEAWF IEKSGELRKE ISTNTEQLQS SKSEVTDLRR AFQNLEIELQ SQLAMKKSLE DSLAEAEGDY CAQLSQVQQL ISNLEAQLLQ VRADAERQNV DHQRLLNVKA RLELEIETYR RLLDGEAQGD GLEESLFVTD SKSQAQSTDS SKDPTKTRKI KTVVQEMVNG EVVSSQVQEI EELM
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.