Details for: OR2T33

Gene ID: 391195

Symbol: OR2T33

Ensembl ID: ENSG00000177212

Description: olfactory receptor family 2 subfamily T member 33

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.2966
    Cell Significance Index: 2.9600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.1661
    Cell Significance Index: 1.9300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.0299
    Cell Significance Index: 0.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0021
    Cell Significance Index: 0.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0005
    Cell Significance Index: -0.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0007
    Cell Significance Index: -0.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0007
    Cell Significance Index: -0.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0013
    Cell Significance Index: -0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0016
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0030
    Cell Significance Index: -0.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0037
    Cell Significance Index: -0.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0057
    Cell Significance Index: -0.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0057
    Cell Significance Index: -0.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0057
    Cell Significance Index: -0.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0066
    Cell Significance Index: -0.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0097
    Cell Significance Index: -0.3100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0098
    Cell Significance Index: -0.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0098
    Cell Significance Index: -0.3200
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0099
    Cell Significance Index: -0.1000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0101
    Cell Significance Index: -0.1400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0103
    Cell Significance Index: -0.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0104
    Cell Significance Index: -0.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0118
    Cell Significance Index: -0.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0120
    Cell Significance Index: -0.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0121
    Cell Significance Index: -0.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0137
    Cell Significance Index: -0.5200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0142
    Cell Significance Index: -0.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0146
    Cell Significance Index: -0.8200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0164
    Cell Significance Index: -0.4100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0168
    Cell Significance Index: -0.7300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0176
    Cell Significance Index: -0.1700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0178
    Cell Significance Index: -0.2000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0198
    Cell Significance Index: -0.2600
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0208
    Cell Significance Index: -0.2200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0214
    Cell Significance Index: -0.2700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0217
    Cell Significance Index: -0.2700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0230
    Cell Significance Index: -0.2900
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0230
    Cell Significance Index: -0.2500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0231
    Cell Significance Index: -0.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0245
    Cell Significance Index: -0.5200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0245
    Cell Significance Index: -0.3200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0247
    Cell Significance Index: -0.6300
  • Cell Name: lung resident memory CD4-positive, alpha-beta T cell (CL4033038)
    Fold Change: -0.0251
    Cell Significance Index: -0.1900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0261
    Cell Significance Index: -0.2700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0271
    Cell Significance Index: -0.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0273
    Cell Significance Index: -0.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0289
    Cell Significance Index: -0.5800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0310
    Cell Significance Index: -0.6700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0316
    Cell Significance Index: -0.6600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0324
    Cell Significance Index: -0.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0330
    Cell Significance Index: -0.8800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0337
    Cell Significance Index: -0.4100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0355
    Cell Significance Index: -0.4400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0360
    Cell Significance Index: -0.3800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0361
    Cell Significance Index: -0.8800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0380
    Cell Significance Index: -0.3600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0386
    Cell Significance Index: -0.7600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0400
    Cell Significance Index: -0.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0400
    Cell Significance Index: -0.9600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0408
    Cell Significance Index: -0.4800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0420
    Cell Significance Index: -0.4200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0433
    Cell Significance Index: -0.7400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0438
    Cell Significance Index: -1.0600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0440
    Cell Significance Index: -0.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0448
    Cell Significance Index: -0.7500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0461
    Cell Significance Index: -0.3900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0466
    Cell Significance Index: -0.9300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0474
    Cell Significance Index: -0.6500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0501
    Cell Significance Index: -0.9800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0503
    Cell Significance Index: -0.8600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0512
    Cell Significance Index: -0.8300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0521
    Cell Significance Index: -0.5900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0522
    Cell Significance Index: -0.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0537
    Cell Significance Index: -0.6400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0544
    Cell Significance Index: -0.6600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0559
    Cell Significance Index: -0.7600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0563
    Cell Significance Index: -0.6800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0571
    Cell Significance Index: -0.7400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0571
    Cell Significance Index: -0.7700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0576
    Cell Significance Index: -0.8500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0579
    Cell Significance Index: -0.8100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0581
    Cell Significance Index: -0.8200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0587
    Cell Significance Index: -0.7600
  • Cell Name: OFF parasol ganglion cell (CL4033051)
    Fold Change: -0.0593
    Cell Significance Index: -0.7500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0603
    Cell Significance Index: -0.4400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0605
    Cell Significance Index: -0.7900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0606
    Cell Significance Index: -0.5000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0608
    Cell Significance Index: -0.8000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0615
    Cell Significance Index: -0.7700
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.0616
    Cell Significance Index: -0.7600
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0621
    Cell Significance Index: -0.7800
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.0622
    Cell Significance Index: -0.7800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0629
    Cell Significance Index: -0.7400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0630
    Cell Significance Index: -0.7500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0633
    Cell Significance Index: -0.7900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0634
    Cell Significance Index: -0.7400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0644
    Cell Significance Index: -0.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR2T33 is a G protein-coupled receptor (GPCR) that belongs to the olfactory receptor family 2 subfamily T. This gene is characterized by its ability to detect chemical stimuli, which triggers a signaling cascade that ultimately leads to the perception of smell. The OR2T33 receptor is expressed in various cell types, including those in the olfactory system, the central nervous system, and the gastrointestinal tract. Its expression in progenitor cells and intestinal crypt stem cells suggests a role in tissue regeneration and homeostasis. **Pathways and Functions:** The OR2T33 gene is involved in several key pathways, including: 1. **Detection of chemical stimulus involved in sensory perception of smell**: OR2T33 receptors are responsible for detecting odorant molecules, which binds to the receptor and triggers a signaling cascade that ultimately leads to the perception of smell. 2. **Expression and translocation of olfactory receptors**: OR2T33 receptors are expressed in the olfactory epithelium and play a crucial role in the translocation of olfactory receptors to the plasma membrane, where they can interact with odorant molecules. 3. **G protein-coupled receptor activity**: OR2T33 receptors are GPCRs, which means they are coupled to G proteins that transmit signals downstream of the receptor. 4. **G protein-coupled receptor signaling pathway**: The OR2T33 receptor is part of the G protein-coupled receptor signaling pathway, which involves a complex interplay between receptors, G proteins, and downstream effectors. **Clinical Significance:** The OR2T33 gene has significant clinical implications, particularly in the context of olfactory disorders. Mutations in the OR2T33 gene have been associated with: 1. **Olfactory disorders**: OR2T33 mutations can lead to impaired olfactory perception, which can affect an individual's quality of life and cognitive function. 2. **Neurodegenerative diseases**: OR2T33 receptors have been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, which are characterized by impaired olfactory perception. 3. **Cancer**: OR2T33 receptors have been shown to play a role in cancer progression and metastasis, particularly in the context of gastrointestinal cancers. In conclusion, the OR2T33 gene is a complex and multifunctional gene that plays a crucial role in the detection of chemical stimuli involved in sensory perception of smell. Its diverse expression patterns and functional roles highlight its importance in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the clinical significance of OR2T33 and its potential applications in the diagnosis and treatment of olfactory disorders and neurodegenerative diseases.

Genular Protein ID: 44348268

Symbol: O2T33_HUMAN

Name: Olfactory receptor 2T33

UniProtKB Accession Codes:

Q8NG76 B2RNN0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 320
  • Mass: 35876
  • Checksum: FB63E5CC900E99DC
  • Sequence:
    • MEMRNTTPDF ILLGLFNHTR AHQVLFMMVL SIVLTSLFGN SLMILLIHWD HRLHTPMYFL 
LSQLSLMDMM LVSTTVPKMA ADYLTGSKAI SRAGCGVQIF FLPTLGGGEC FLLAAMAYDR 
YAAVCHPLRY PTLMSWQLCL RMTMSCWLLG AADGLLQAVV TLSFPYCGAH EIDHFFCETP 
VLVRLACADT SVFENAMYIC CVLMLLVPFS LILSSYGLIL AAVLHMRSTE ARKKAFATCS 
SHVAVVGLFY GAAIFTYMRP KSHRSTNHDK VVSAFYTMFT PLLNPLIYSV KNSEVKGALK 
RWLGTCVNIK HQQNEAHRSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.