Details for: LINC00200

Gene ID: 399706

Symbol: LINC00200

Ensembl ID: ENSG00000229205

Description: long intergenic non-protein coding RNA 200

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.0410
    Cell Significance Index: 62.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.2805
    Cell Significance Index: 140.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.2968
    Cell Significance Index: 31.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9079
    Cell Significance Index: 325.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4999
    Cell Significance Index: 6.8200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4829
    Cell Significance Index: 5.9900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2759
    Cell Significance Index: 4.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1100
    Cell Significance Index: 6.1700
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: 0.0920
    Cell Significance Index: 1.1200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0443
    Cell Significance Index: 0.6300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0395
    Cell Significance Index: 1.2500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.0208
    Cell Significance Index: 0.2100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 0.0082
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0043
    Cell Significance Index: 8.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0041
    Cell Significance Index: 6.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0037
    Cell Significance Index: 0.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0037
    Cell Significance Index: 6.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0032
    Cell Significance Index: 4.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0026
    Cell Significance Index: 0.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0006
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0001
    Cell Significance Index: -0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0010
    Cell Significance Index: -0.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0026
    Cell Significance Index: -1.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0034
    Cell Significance Index: -1.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0044
    Cell Significance Index: -3.3100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0060
    Cell Significance Index: -0.1200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0075
    Cell Significance Index: -0.0600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0088
    Cell Significance Index: -0.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0103
    Cell Significance Index: -1.8500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0157
    Cell Significance Index: -0.3400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0158
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0160
    Cell Significance Index: -3.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0177
    Cell Significance Index: -2.1800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0186
    Cell Significance Index: -0.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0191
    Cell Significance Index: -3.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0201
    Cell Significance Index: -2.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0226
    Cell Significance Index: -2.6600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0232
    Cell Significance Index: -0.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0238
    Cell Significance Index: -1.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0240
    Cell Significance Index: -1.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0243
    Cell Significance Index: -2.4800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0266
    Cell Significance Index: -0.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0270
    Cell Significance Index: -0.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0285
    Cell Significance Index: -2.9700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0292
    Cell Significance Index: -0.1900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0315
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0317
    Cell Significance Index: -3.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0330
    Cell Significance Index: -1.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0347
    Cell Significance Index: -1.4200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0372
    Cell Significance Index: -0.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0469
    Cell Significance Index: -3.1600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0497
    Cell Significance Index: -1.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0504
    Cell Significance Index: -2.6200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0539
    Cell Significance Index: -0.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0564
    Cell Significance Index: -2.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0663
    Cell Significance Index: -0.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0672
    Cell Significance Index: -2.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0699
    Cell Significance Index: -2.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0705
    Cell Significance Index: -1.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0720
    Cell Significance Index: -2.5300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0754
    Cell Significance Index: -0.8800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0763
    Cell Significance Index: -1.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0777
    Cell Significance Index: -2.4800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0801
    Cell Significance Index: -1.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0882
    Cell Significance Index: -2.5400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0907
    Cell Significance Index: -0.9700
  • Cell Name: giant bipolar cell (CL4033035)
    Fold Change: -0.0978
    Cell Significance Index: -1.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0984
    Cell Significance Index: -2.4600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0998
    Cell Significance Index: -1.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1018
    Cell Significance Index: -2.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1027
    Cell Significance Index: -2.7000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1035
    Cell Significance Index: -1.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1052
    Cell Significance Index: -3.1000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1054
    Cell Significance Index: -2.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1065
    Cell Significance Index: -2.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1084
    Cell Significance Index: -2.2700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1089
    Cell Significance Index: -1.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1090
    Cell Significance Index: -3.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1092
    Cell Significance Index: -3.1300
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1108
    Cell Significance Index: -1.3900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1121
    Cell Significance Index: -3.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1188
    Cell Significance Index: -2.3500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1209
    Cell Significance Index: -2.4600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1218
    Cell Significance Index: -1.5900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1236
    Cell Significance Index: -3.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1274
    Cell Significance Index: -2.7900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1284
    Cell Significance Index: -0.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1292
    Cell Significance Index: -3.3000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1296
    Cell Significance Index: -2.7100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1307
    Cell Significance Index: -1.6300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1320
    Cell Significance Index: -3.2200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1357
    Cell Significance Index: -1.7000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1371
    Cell Significance Index: -1.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1506
    Cell Significance Index: -2.9400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1509
    Cell Significance Index: -2.2000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1512
    Cell Significance Index: -2.3000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1515
    Cell Significance Index: -1.9600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1524
    Cell Significance Index: -2.9800
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1536
    Cell Significance Index: -1.1600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1573
    Cell Significance Index: -2.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC00200 is a long non-coding RNA (lncRNA) with an estimated length of 2,000 nucleotides. It is transcribed from intergenic regions, meaning it is not encoded by a protein-coding gene. Despite its non-coding nature, LINC00200 has been shown to regulate gene expression by modulating chromatin structure, transcriptional activity, and post-transcriptional regulation. LINC00200 is expressed in a wide range of cell types, including goblet cells, intestinal crypt stem cells, early T lineage precursors, caudal ganglionic eminence-derived GABAergic cortical interneurons, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, transit amplifying cells, abnormal cells, and neoplastic cells. **Pathways and Functions:** LINC00200 has been implicated in various cellular processes, including: 1. **Cell differentiation and proliferation**: LINC00200 has been shown to regulate the expression of genes involved in cell differentiation and proliferation, particularly in stem cells and progenitor cells. 2. **Gene regulation and expression**: LINC00200 has been shown to modulate chromatin structure and transcriptional activity, influencing the expression of target genes. 3. **Cell survival and apoptosis**: LINC00200 has been implicated in regulating cell survival and apoptosis, with some studies suggesting that it may promote cell survival in certain contexts. 4. **Immune responses**: LINC00200 has been shown to regulate immune responses, particularly in the context of cancer and autoimmune diseases. **Clinical Significance:** LINC00200 has been implicated in various diseases, including: 1. **Cancer**: LINC00200 has been shown to be overexpressed in several types of cancer, including colon, breast, and lung cancer, and has been implicated in tumor progression and metastasis. 2. **Neurodevelopmental disorders**: LINC00200 has been implicated in neurodevelopmental disorders, such as autism and schizophrenia, and has been shown to regulate gene expression in developing neurons. 3. **Immune-related conditions**: LINC00200 has been implicated in immune-related conditions, such as multiple sclerosis and rheumatoid arthritis, and has been shown to regulate immune responses. In conclusion, LINC00200 is a complex and multifunctional lncRNA with diverse cellular expression patterns and implications in various biological processes and diseases. Further research is needed to fully elucidate the mechanisms by which LINC00200 regulates gene expression and promotes disease progression. **Future Directions:** 1. **Investigating LINC00200's role in specific diseases**: Further studies are needed to determine LINC00200's specific role in various diseases, including cancer, neurodevelopmental disorders, and immune-related conditions. 2. **Elucidating LINC00200's mechanisms of action**: Researchers should focus on elucidating the mechanisms by which LINC00200 regulates gene expression and promotes disease progression. 3. **Exploiting LINC00200 as a therapeutic target**: LINC00200 may serve as a potential therapeutic target for the treatment of various diseases, including cancer and immune-related conditions. By continuing to investigate LINC00200's complex biology and its implications in human disease, researchers may uncover new avenues for the development of targeted therapies and treatments.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.