Details for: MGAT5

Gene ID: 4249

Symbol: MGAT5

Ensembl ID: ENSG00000152127

Description: alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 368.3495
    Cell Significance Index: -57.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 225.4346
    Cell Significance Index: -57.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.4453
    Cell Significance Index: -57.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.2250
    Cell Significance Index: -54.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.2753
    Cell Significance Index: -35.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.6096
    Cell Significance Index: -57.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.9725
    Cell Significance Index: 304.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.4363
    Cell Significance Index: 1232.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.8973
    Cell Significance Index: 77.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3382
    Cell Significance Index: 469.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0094
    Cell Significance Index: 398.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.7620
    Cell Significance Index: 108.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.7100
    Cell Significance Index: 41.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.6698
    Cell Significance Index: 41.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4561
    Cell Significance Index: 55.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4559
    Cell Significance Index: 64.4000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.4215
    Cell Significance Index: 14.3400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2307
    Cell Significance Index: 17.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0963
    Cell Significance Index: 758.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9887
    Cell Significance Index: 160.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7289
    Cell Significance Index: 15.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6343
    Cell Significance Index: 38.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6228
    Cell Significance Index: 34.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5825
    Cell Significance Index: 16.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5788
    Cell Significance Index: 16.6800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.5693
    Cell Significance Index: 8.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4242
    Cell Significance Index: 76.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3807
    Cell Significance Index: 26.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3653
    Cell Significance Index: 199.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3453
    Cell Significance Index: 636.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3087
    Cell Significance Index: 5.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2873
    Cell Significance Index: 35.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1870
    Cell Significance Index: 287.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1850
    Cell Significance Index: 18.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1771
    Cell Significance Index: 333.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1565
    Cell Significance Index: 5.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1542
    Cell Significance Index: 97.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0816
    Cell Significance Index: 5.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0593
    Cell Significance Index: 26.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0509
    Cell Significance Index: 9.6900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0232
    Cell Significance Index: 0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0079
    Cell Significance Index: 10.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0280
    Cell Significance Index: -20.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0291
    Cell Significance Index: -12.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0340
    Cell Significance Index: -1.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0376
    Cell Significance Index: -5.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0423
    Cell Significance Index: -4.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0425
    Cell Significance Index: -31.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0479
    Cell Significance Index: -29.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0704
    Cell Significance Index: -39.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0793
    Cell Significance Index: -60.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0999
    Cell Significance Index: -17.0600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1275
    Cell Significance Index: -1.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1700
    Cell Significance Index: -48.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1884
    Cell Significance Index: -39.6900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1925
    Cell Significance Index: -4.1200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2342
    Cell Significance Index: -2.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2443
    Cell Significance Index: -33.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2819
    Cell Significance Index: -13.2500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3196
    Cell Significance Index: -36.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3258
    Cell Significance Index: -33.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3265
    Cell Significance Index: -41.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3372
    Cell Significance Index: -4.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3403
    Cell Significance Index: -39.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3606
    Cell Significance Index: -46.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3917
    Cell Significance Index: -40.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4000
    Cell Significance Index: -20.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4011
    Cell Significance Index: -45.9500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4033
    Cell Significance Index: -5.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4192
    Cell Significance Index: -19.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4633
    Cell Significance Index: -13.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4858
    Cell Significance Index: -10.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5230
    Cell Significance Index: -33.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5724
    Cell Significance Index: -12.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5838
    Cell Significance Index: -12.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5966
    Cell Significance Index: -15.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6240
    Cell Significance Index: -49.4200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.6391
    Cell Significance Index: -8.5300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6461
    Cell Significance Index: -5.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6677
    Cell Significance Index: -49.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7019
    Cell Significance Index: -22.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7155
    Cell Significance Index: -37.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7971
    Cell Significance Index: -17.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8190
    Cell Significance Index: -50.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8583
    Cell Significance Index: -60.7000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.8712
    Cell Significance Index: -12.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8958
    Cell Significance Index: -28.5300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.9238
    Cell Significance Index: -13.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9301
    Cell Significance Index: -30.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9883
    Cell Significance Index: -62.2900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.0486
    Cell Significance Index: -8.6600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.0719
    Cell Significance Index: -21.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1013
    Cell Significance Index: -38.5800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.1326
    Cell Significance Index: -24.4700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.1752
    Cell Significance Index: -15.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.2233
    Cell Significance Index: -24.5600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.2466
    Cell Significance Index: -18.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.3064
    Cell Significance Index: -33.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.3214
    Cell Significance Index: -25.7900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.3374
    Cell Significance Index: -8.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Glycosylation enzyme:** MGAT5 belongs to the glycosyltransferase family and catalyzes the addition of GlcNAc to Man5GlcNAc2, a key step in glycoprotein maturation. 2. **Cell surface glycoproteins:** MGAT5 is primarily involved in the modification of glycoproteins destined for the cell surface, where it plays a crucial role in cell signaling and immune function. 3. **Immune evasion:** MGAT5 has been implicated in the immune evasion strategies employed by pathogens, including SARS-CoV-2, where it contributes to the modulation of immune cell activity and the suppression of antiviral responses. 4. **Diverse tissue expression:** MGAT5 is expressed in various tissues, including the adrenal gland, cardiac myocytes, and immune cells, highlighting its broad functional significance. **Pathways and Functions:** 1. **Glycosylation pathways:** MGAT5 is involved in the elongation of N-glycan antennae, specifically in the medial/trans-Golgi compartment, where it contributes to the maturation of glycoproteins. 2. **Immune modulation:** MGAT5 modulates the activity of immune cells, including macrophages and T cells, influencing the immune response to pathogens and tumor cells. 3. **Cell signaling:** MGAT5 is involved in the regulation of cell signaling pathways, including those mediated by receptor tyrosine kinases and receptor tyrosine phosphatases. 4. **Protein stability:** MGAT5 contributes to the stability of glycoproteins by modifying their glycosylation patterns, which can affect their degradation and function. **Clinical Significance:** 1. **SARS-CoV-2 infection:** MGAT5 has been implicated in the immune evasion strategies employed by SARS-CoV-2, where it contributes to the suppression of antiviral responses and the modulation of immune cell activity. 2. **Cancer:** MGAT5 has been shown to be overexpressed in various types of cancer, where it may contribute to tumor progression and immune evasion. 3. **Neurological disorders:** MGAT5 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease, where it may contribute to the modulation of immune cell activity and the deposition of amyloid beta and alpha-synuclein. 4. **Immunotherapy:** MGAT5 may serve as a target for immunotherapeutic interventions, where its inhibition or modulation could enhance antiviral or anticancer responses. In conclusion, MGAT5 is a multifunctional enzyme that plays a critical role in the modification of glycoproteins and the regulation of immune cell activity. Its implications in immune evasion, cancer, and neurological disorders highlight the importance of further research into the mechanisms and functions of MGAT5.

Genular Protein ID: 3384716413

Symbol: MGT5A_HUMAN

Name: Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

UniProtKB Accession Codes:

Q09328 D3DP70

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 Ensembl 2 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 11 Rhea 3 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8292036

Title: cDNA cloning and chromosomal mapping of human N-acetylglucosaminyltransferase V+.

PubMed ID: 8292036

DOI: 10.1006/bbrc.1994.1045

PubMed ID: 10395745

Title: Characterization of UDP-N-acetylglucosamine: alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V from a human hepatoma cell line Hep3B.

PubMed ID: 10395745

DOI: 10.1006/abbi.1999.1252

PubMed ID: 11872751

Title: A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activity.

PubMed ID: 11872751

DOI: 10.1074/jbc.m200521200

PubMed ID: 17142794

Title: A secreted type of beta1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase.

PubMed ID: 17142794

DOI: 10.1096/fj.05-5066com

PubMed ID: 22614033

Title: N-acetylglucosaminyltransferase V negatively regulates integrin alpha5beta1-mediated monocyte adhesion and transmigration through vascular endothelium.

PubMed ID: 22614033

DOI: 10.3892/ijo.2012.1484

PubMed ID: 30140003

Title: Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V.

PubMed ID: 30140003

DOI: 10.1038/s41467-018-05931-w

Sequence Information:

  • Length: 741
  • Mass: 84543
  • Checksum: 1073F8E67AD0E23B
  • Sequence:
    • MALFTPWKLS SQKLGFFLVT FGFIWGMMLL HFTIQQRTQP ESSSMLREQI LDLSKRYIKA 
LAEENRNVVD GPYAGVMTAY DLKKTLAVLL DNILQRIGKL ESKVDNLVVN GTGTNSTNST 
TAVPSLVALE KINVADIING AQEKCVLPPM DGYPHCEGKI KWMKDMWRSD PCYADYGVDG 
STCSFFIYLS EVENWCPHLP WRAKNPYEEA DHNSLAEIRT DFNILYSMMK KHEEFRWMRL 
RIRRMADAWI QAIKSLAEKQ NLEKRKRKKV LVHLGLLTKE SGFKIAETAF SGGPLGELVQ 
WSDLITSLYL LGHDIRISAS LAELKEIMKK VVGNRSGCPT VGDRIVELIY IDIVGLAQFK 
KTLGPSWVHY QCMLRVLDSF GTEPEFNHAN YAQSKGHKTP WGKWNLNPQQ FYTMFPHTPD 
NSFLGFVVEQ HLNSSDIHHI NEIKRQNQSL VYGKVDSFWK NKKIYLDIIH TYMEVHATVY 
GSSTKNIPSY VKNHGILSGR DLQFLLRETK LFVGLGFPYE GPAPLEAIAN GCAFLNPKFN 
PPKSSKNTDF FIGKPTLREL TSQHPYAEVF IGRPHVWTVD LNNQEEVEDA VKAILNQKIE 
PYMPYEFTCE GMLQRINAFI EKQDFCHGQV MWPPLSALQV KLAEPGQSCK QVCQESQLIC 
EPSFFQHLNK DKDMLKYKVT CQSSELAKDI LVPSFDPKNK HCVFQGDLLL FSCAGAHPRH 
QRVCPCRDFI KGQVALCKDC L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.