Details for: MYO5B

Gene ID: 4645

Symbol: MYO5B

Ensembl ID: ENSG00000167306

Description: myosin VB

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 28.6727
    Cell Significance Index: -19.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.4762
    Cell Significance Index: -17.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.7757
    Cell Significance Index: -20.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.8577
    Cell Significance Index: -12.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.2473
    Cell Significance Index: 494.9700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 3.1622
    Cell Significance Index: 31.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.1513
    Cell Significance Index: 142.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.5793
    Cell Significance Index: 74.3200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.4357
    Cell Significance Index: 14.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1431
    Cell Significance Index: 46.4300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.9782
    Cell Significance Index: 28.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9635
    Cell Significance Index: 319.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9205
    Cell Significance Index: 208.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5982
    Cell Significance Index: 83.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.4984
    Cell Significance Index: 100.7600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.4701
    Cell Significance Index: 9.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4231
    Cell Significance Index: 282.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2168
    Cell Significance Index: 11.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.2041
    Cell Significance Index: 175.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.2030
    Cell Significance Index: 25.6200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1793
    Cell Significance Index: 17.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1163
    Cell Significance Index: 77.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0186
    Cell Significance Index: 64.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9744
    Cell Significance Index: 21.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7827
    Cell Significance Index: 77.4300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7450
    Cell Significance Index: 12.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7366
    Cell Significance Index: 34.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6701
    Cell Significance Index: 120.8000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.6013
    Cell Significance Index: 8.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5581
    Cell Significance Index: 19.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4945
    Cell Significance Index: 60.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4899
    Cell Significance Index: 903.5200
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.4862
    Cell Significance Index: 4.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4521
    Cell Significance Index: 696.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4433
    Cell Significance Index: 84.3600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4404
    Cell Significance Index: 5.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4075
    Cell Significance Index: 767.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2966
    Cell Significance Index: 8.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2810
    Cell Significance Index: 13.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2493
    Cell Significance Index: 42.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2419
    Cell Significance Index: 328.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2187
    Cell Significance Index: 119.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1998
    Cell Significance Index: 12.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1787
    Cell Significance Index: 4.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1657
    Cell Significance Index: 12.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1542
    Cell Significance Index: 97.9100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1484
    Cell Significance Index: 3.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1436
    Cell Significance Index: 16.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1239
    Cell Significance Index: 111.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1213
    Cell Significance Index: 6.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1181
    Cell Significance Index: 23.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0974
    Cell Significance Index: 12.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0192
    Cell Significance Index: 5.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0160
    Cell Significance Index: 0.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0116
    Cell Significance Index: 4.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0031
    Cell Significance Index: -1.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0145
    Cell Significance Index: -10.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0174
    Cell Significance Index: -12.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0176
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0201
    Cell Significance Index: -11.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0247
    Cell Significance Index: -0.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0268
    Cell Significance Index: -0.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0272
    Cell Significance Index: -0.3900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0275
    Cell Significance Index: -0.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0324
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0354
    Cell Significance Index: -7.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0374
    Cell Significance Index: -16.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0463
    Cell Significance Index: -2.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0482
    Cell Significance Index: -21.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0573
    Cell Significance Index: -6.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0819
    Cell Significance Index: -8.3700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0860
    Cell Significance Index: -1.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0936
    Cell Significance Index: -7.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1214
    Cell Significance Index: -16.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1474
    Cell Significance Index: -4.7200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1649
    Cell Significance Index: -3.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1757
    Cell Significance Index: -18.2900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1840
    Cell Significance Index: -1.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1875
    Cell Significance Index: -22.1200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2155
    Cell Significance Index: -2.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2379
    Cell Significance Index: -18.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2429
    Cell Significance Index: -14.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2839
    Cell Significance Index: -5.8900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3092
    Cell Significance Index: -4.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3110
    Cell Significance Index: -16.2000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.3166
    Cell Significance Index: -2.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3173
    Cell Significance Index: -10.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3222
    Cell Significance Index: -14.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3392
    Cell Significance Index: -21.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3556
    Cell Significance Index: -6.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3586
    Cell Significance Index: -9.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3597
    Cell Significance Index: -13.6200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.3729
    Cell Significance Index: -4.3400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3743
    Cell Significance Index: -2.8800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3752
    Cell Significance Index: -8.0200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3765
    Cell Significance Index: -13.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3904
    Cell Significance Index: -20.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4061
    Cell Significance Index: -11.9600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.4088
    Cell Significance Index: -4.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Myosin-Vb structure:** Myosin-Vb is a member of the myosin superfamily, which consists of motor proteins that utilize ATP hydrolysis to generate force and move along actin filaments. Myosin-Vb has a unique structure, with two heads and a long tail domain that interacts with actin filaments. 2. **Cellular localization:** Myosin-Vb is primarily expressed in epithelial cells, which line the surfaces of organs and glands. It is also found in neural cells, particularly in GABAergic cortical interneurons. 3. **Functional roles:** Myosin-Vb is involved in various cellular processes, including actin filament organization, vesicle transport, and immune regulation. It plays a crucial role in maintaining tissue homeostasis and organ function. **Pathways and Functions:** 1. **Actin cytoskeleton organization:** Myosin-Vb interacts with actin filaments to regulate their organization and dynamics. This interaction is essential for maintaining cellular shape and structure. 2. **Vesicle transport:** Myosin-Vb is involved in the transport of vesicles along actin filaments, which is crucial for cellular communication and signaling. 3. **Immune regulation:** Myosin-Vb plays a role in immune responses, particularly in the regulation of immune cell migration and function. 4. **Renal water homeostasis:** Myosin-Vb is involved in the regulation of renal water homeostasis via aquaporin-mediated transport. **Clinical Significance:** 1. **Cancer research:** Myosin-Vb has been implicated in cancer progression and metastasis. Its expression is often upregulated in cancer cells, suggesting its role in tumor growth and invasion. 2. **Neurological disorders:** Myosin-Vb has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. Its dysregulation has been associated with impaired synaptic function and neuronal survival. 3. **Renal disease:** Myosin-Vb plays a crucial role in renal water homeostasis, and its dysregulation has been implicated in renal disease, such as nephrotic syndrome and diabetic nephropathy. 4. **Immunological disorders:** Myosin-Vb has been involved in immunological disorders, such as autoimmune diseases and inflammatory conditions. Its dysregulation has been associated with impaired immune function and tissue damage. In conclusion, the MYO5B gene encodes for myosin-Vb, a unique and versatile protein that plays a crucial role in various cellular processes, including actin filament organization, vesicle transport, and immune regulation. Its clinical significance is evident in its involvement in cancer, neurological disorders, renal disease, and immunological disorders. Further research is needed to elucidate the functional significance of myosin-Vb and its role in maintaining tissue homeostasis.

Genular Protein ID: 1292832749

Symbol: MYO5B_HUMAN

Name: Unconventional myosin-Vb

UniProtKB Accession Codes:

Q9ULV0 B0I1R3 Q0P656 Q9H6Y6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10574461

Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.

PubMed ID: 10574461

DOI: 10.1093/dnares/6.5.329

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11495908

Title: Identification and characterization of a family of Rab11-interacting proteins.

PubMed ID: 11495908

DOI: 10.1074/jbc.m104831200

PubMed ID: 15772161

Title: CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling.

PubMed ID: 15772161

DOI: 10.1091/mbc.e04-11-1014

PubMed ID: 17462998

Title: Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells.

PubMed ID: 17462998

DOI: 10.1074/jbc.m608531200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19542231

Title: Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface.

PubMed ID: 19542231

DOI: 10.1074/jbc.m109.034355

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21206382

Title: Functional characterization of mutations in the myosin Vb gene associated with microvillus inclusion disease.

PubMed ID: 21206382

DOI: 10.1097/mpg.0b013e3181eea177

PubMed ID: 21282656

Title: Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization.

PubMed ID: 21282656

DOI: 10.1073/pnas.1010754108

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 29880681

Title: A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption.

PubMed ID: 29880681

DOI: 10.1126/science.aao6575

PubMed ID: 19006234

Title: Navajo microvillous inclusion disease is due to a mutation in MYO5B.

PubMed ID: 19006234

DOI: 10.1002/ajmg.a.32605

PubMed ID: 18724368

Title: MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity.

PubMed ID: 18724368

DOI: 10.1038/ng.225

PubMed ID: 20186687

Title: Loss-of-function of MYO5B is the main cause of microvillus inclusion disease: 15 novel mutations and a CaCo-2 RNAi cell model.

PubMed ID: 20186687

DOI: 10.1002/humu.21224

PubMed ID: 24138727

Title: Microvillus inclusion disease: loss of Myosin vb disrupts intracellular traffic and cell polarity.

PubMed ID: 24138727

DOI: 10.1111/tra.12131

PubMed ID: 24892806

Title: Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.

PubMed ID: 24892806

DOI: 10.1172/jci71651

PubMed ID: 27532546

Title: MYO5B mutations cause cholestasis with normal serum gamma-glutamyl transferase activity in children without microvillous inclusion disease.

PubMed ID: 27532546

DOI: 10.1002/hep.28779

PubMed ID: 28027573

Title: Defects in myosin VB are associated with a spectrum of previously undiagnosed low gamma-glutamyltransferase cholestasis.

PubMed ID: 28027573

DOI: 10.1002/hep.29020

PubMed ID: 32304554

Title: Mutations in myosin 5B in children with early-onset cholestasis.

PubMed ID: 32304554

DOI: 10.1097/mpg.0000000000002740

PubMed ID: 33525641

Title: Congenital diarrhea and cholestatic liver disease: phenotypic spectrum associated with MYO5B mutations.

PubMed ID: 33525641

DOI: 10.3390/jcm10030481

PubMed ID: 35129155

Title: MYO5B gene mutations: a not negligible cause of intrahepatic cholestasis of infancy with normal gamma-glutamyl transferase phenotype.

PubMed ID: 35129155

DOI: 10.1097/mpg.0000000000003399

PubMed ID: 34816459

Title: Two cases of microvillus inclusion disease caused by MYO5B deficiency with prenatal abnormalities.

PubMed ID: 34816459

DOI: 10.1002/pd.6068

Sequence Information:

  • Length: 1848
  • Mass: 213672
  • Checksum: 4EB8FA02F6B38707
  • Sequence:
    • MSVGELYSQC TRVWIPDPDE VWRSAELTKD YKEGDKSLQL RLEDETILEY PIDVQRNQLP 
FLRNPDILVG ENDLTALSYL HEPAVLHNLK VRFLESNHIY TYCGIVLVAI NPYEQLPIYG 
QDVIYTYSGQ NMGDMDPHIF AVAEEAYKQM ARDEKNQSII VSGESGAGKT VSAKYAMRYF 
ATVGGSASET NIEEKVLASS PIMEAIGNAK TTRNDNSSRF GKYIQIGFDK RYHIIGANMR 
TYLLEKSRVV FQADDERNYH IFYQLCAAAG LPEFKELALT SAEDFFYTSQ GGDTSIEGVD 
DAEDFEKTRQ AFTLLGVKES HQMSIFKIIA SILHLGSVAI QAERDGDSCS ISPQDVYLSN 
FCRLLGVEHS QMEHWLCHRK LVTTSETYVK TMSLQQVINA RNALAKHIYA QLFGWIVEHI 
NKALHTSLKQ HSFIGVLDIY GFETFEVNSF EQFCINYANE KLQQQFNSHV FKLEQEEYMK 
EQIPWTLIDF YDNQPCIDLI EAKLGILDLL DEECKVPKGT DQNWAQKLYD RHSSSQHFQK 
PRMSNTAFII VHFADKVEYL SDGFLEKNRD TVYEEQINIL KASKFPLVAD LFHDDKDPVP 
ATTPGKGSSS KISVRSARPP MKVSNKEHKK TVGHQFRTSL HLLMETLNAT TPHYVRCIKP 
NDEKLPFHFD PKRAVQQLRA CGVLETIRIS AAGYPSRWAY HDFFNRYRVL VKKRELANTD 
KKAICRSVLE NLIKDPDKFQ FGRTKIFFRA GQVAYLEKLR ADKFRTATIM IQKTVRGWLQ 
KVKYHRLKGA TLTLQRYCRG HLARRLAEHL RRIRAAVVLQ KHYRMQRARQ AYQRVRRAAV 
VIQAFTRAMF VRRTYRQVLM EHKATTIQKH VRGWMARRHF QRLRDAAIVI QCAFRMLKAR 
RELKALRIEA RSAEHLKRLN VGMENKVVQL QRKIDEQNKE FKTLSEQLSV TTSTYTMEVE 
RLKKELVHYQ QSPGEDTSLR LQEEVESLRT ELQRAHSERK ILEDAHSREK DELRKRVADL 
EQENALLKDE KEQLNNQILC QSKDEFAQNS VKENLMKKEL EEERSRYQNL VKEYSQLEQR 
YDNLRDEMTI IKQTPGHRRN PSNQSSLESD SNYPSISTSE IGDTEDALQQ VEEIGLEKAA 
MDMTVFLKLQ KRVRELEQER KKLQVQLEKR EQQDSKKVQA EPPQTDIDLD PNADLAYNSL 
KRQELESENK KLKNDLNELR KAVADQATQN NSSHGSPDSY SLLLNQLKLA HEELEVRKEE 
VLILRTQIVS ADQRRLAGRN AEPNINARSS WPNSEKHVDQ EDAIEAYHGV CQTNSKTEDW 
GYLNEDGELG LAYQGLKQVA RLLEAQLQAQ SLEHEEEVEH LKAQLEALKE EMDKQQQTFC 
QTLLLSPEAQ VEFGVQQEIS RLTNENLDLK ELVEKLEKNE RKLKKQLKIY MKKAQDLEAA 
QALAQSERKR HELNRQVTVQ RKEKDFQGML EYHKEDEALL IRNLVTDLKP QMLSGTVPCL 
PAYILYMCIR HADYTNDDLK VHSLLTSTIN GIKKVLKKHN DDFEMTSFWL SNTCRLLHCL 
KQYSGDEGFM TQNTAKQNEH CLKNFDLTEY RQVLSDLSIQ IYQQLIKIAE GVLQPMIVSA 
MLENESIQGL SGVKPTGYRK RSSSMADGDN SYCLEAIIRQ MNAFHTVMCD QGLDPEIILQ 
VFKQLFYMIN AVTLNNLLLR KDVCSWSTGM QLRYNISQLE EWLRGRNLHQ SGAVQTMEPL 
IQAAQLLQLK KKTQEDAEAI CSLCTSLSTQ QIVKILNLYT PLNEFEERVT VAFIRTIQAQ 
LQERNDPQQL LLDAKHMFPV LFPFNPSSLT MDSIHIPACL NLEFLNEV

Genular Protein ID: 4137635402

Symbol: Q7Z7A5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z7A5

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 4 HOGENOM 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1

Sequence Information:

  • Length: 720
  • Mass: 82405
  • Checksum: 029C482A99C68E73
  • Sequence:
    • MHWPVTRECT RVWIPDPDEV WRSAELTKDY KEGDKSLQLR LEDETILEYP IDVQRNQLPF 
LRNPDILVGE NDLTALSYLH EPAVLHNLKV RFLESNHIYT YCGIVLVAIN PYEQLPIYGQ 
DVIYTYSGQN MGDMDPHIFA VAEEAYKQMA RDEKNQSIIV SGESGAGKTV SAKYAMRYFA 
TVGGSASETN IEEKVLASSP IMEAIGNAKT TRNDNSSRFG KYIQIGFDKR YHIIGANMRT 
YLLEKSRVVF QADDERNYHI FYQLCAAAGL PEFKELALTS AEDFFYTSQG GDTSIEGVDD 
AEDFEKTRQA FTLLGVKESH QMSIFKIIAS ILHLGSVAIQ AERDGDSCSI SPQDVYLSNF 
CRLLGVEHSQ MEHWLCHRKL VTTSETYVKT MSLQQVINAR NALAKHIYAQ LFGWIVEHIN 
KALHTSLKQH SFIGVLDIYG FETFEVNSFE QFCINYANEK LQQQFNSHVF KLEQEEYMKE 
QIPWTLIDFY DNQPCIDLIE AKLGILDLLD EECKVPKGTD QNWAQKLYDR HSSSQHFQKP 
RMSNTAFIIV HFADKVEYLS DGFLEKNRDT VYEEQINILK ASKFPLVADL FHDDKDPVPA 
TTPGKGSSSK ISVRSARPPM KVSNKEHKKT VGHQFRTSLS TQQIVKILNL YTPLNEFEER 
VTVAFIRTIQ AQLQERNDPQ QLLLDAKHMF PVLFPFNPSS LTMDSIHIPA CLNLEFLNEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.