Details for: NDP
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 20.8103
Cell Significance Index: -9.8300 - Cell Name: decidual cell (CL2000002)
Fold Change: 3.4799
Cell Significance Index: 55.8300 - Cell Name: Mueller cell (CL0000636)
Fold Change: 0.7162
Cell Significance Index: 5.5100 - Cell Name: peg cell (CL4033014)
Fold Change: 0.5835
Cell Significance Index: 13.4800 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.5196
Cell Significance Index: 13.6600 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.4646
Cell Significance Index: 11.2600 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.3258
Cell Significance Index: 5.0400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2473
Cell Significance Index: 33.9600 - Cell Name: theca cell (CL0000503)
Fold Change: 0.2417
Cell Significance Index: 1.4200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0607
Cell Significance Index: 33.1400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0549
Cell Significance Index: 11.0200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0193
Cell Significance Index: 0.3300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0015
Cell Significance Index: -1.0300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0047
Cell Significance Index: -8.8900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0082
Cell Significance Index: -15.1500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0088
Cell Significance Index: -3.1600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0097
Cell Significance Index: -7.1900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0099
Cell Significance Index: -15.2200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0112
Cell Significance Index: -15.2200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0131
Cell Significance Index: -9.9500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0144
Cell Significance Index: -0.9100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0151
Cell Significance Index: -9.5900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0154
Cell Significance Index: -6.8000 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0166
Cell Significance Index: -0.7200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0171
Cell Significance Index: -9.6500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0253
Cell Significance Index: -11.4900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0283
Cell Significance Index: -8.1500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0383
Cell Significance Index: -6.9000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0421
Cell Significance Index: -7.1900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0488
Cell Significance Index: -9.6900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0539
Cell Significance Index: -3.0300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0619
Cell Significance Index: -7.0900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0685
Cell Significance Index: -9.9600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0727
Cell Significance Index: -8.4700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0730
Cell Significance Index: -8.9700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0790
Cell Significance Index: -8.0700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0820
Cell Significance Index: -5.8000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0878
Cell Significance Index: -10.3500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0974
Cell Significance Index: -12.5800 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.1128
Cell Significance Index: -1.9500 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.1141
Cell Significance Index: -1.6000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1217
Cell Significance Index: -6.3200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1404
Cell Significance Index: -9.4400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1413
Cell Significance Index: -7.4200 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.1487
Cell Significance Index: -2.0800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1503
Cell Significance Index: -9.2400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1576
Cell Significance Index: -6.9700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1689
Cell Significance Index: -5.5300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1732
Cell Significance Index: -12.9100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1736
Cell Significance Index: -9.0400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1772
Cell Significance Index: -6.7100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2018
Cell Significance Index: -7.0700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2160
Cell Significance Index: -10.1500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2179
Cell Significance Index: -6.9400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2192
Cell Significance Index: -10.2200 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.2385
Cell Significance Index: -2.6700 - Cell Name: retinal astrocyte (CL4033015)
Fold Change: -0.2442
Cell Significance Index: -2.3900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2632
Cell Significance Index: -5.5100 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.2703
Cell Significance Index: -3.9300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2779
Cell Significance Index: -10.2000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2783
Cell Significance Index: -9.6700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2809
Cell Significance Index: -14.2000 - Cell Name: astrocyte (CL0000127)
Fold Change: -0.2905
Cell Significance Index: -3.3300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2905
Cell Significance Index: -8.2900 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2941
Cell Significance Index: -7.3400 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.3151
Cell Significance Index: -6.9000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3208
Cell Significance Index: -8.5800 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3212
Cell Significance Index: -9.4600 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3531
Cell Significance Index: -10.3700 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.3547
Cell Significance Index: -14.5300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.3577
Cell Significance Index: -10.3100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3586
Cell Significance Index: -9.6100 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3721
Cell Significance Index: -7.4700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3776
Cell Significance Index: -6.3200 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.3793
Cell Significance Index: -7.4700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3849
Cell Significance Index: -10.2800 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.3878
Cell Significance Index: -6.3900 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.3937
Cell Significance Index: -9.8200 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.3958
Cell Significance Index: -6.2800 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.4007
Cell Significance Index: -8.1500 - Cell Name: macroglial cell (CL0000126)
Fold Change: -0.4128
Cell Significance Index: -4.7800 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.4190
Cell Significance Index: -10.6800 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4226
Cell Significance Index: -10.5600 - Cell Name: osteoclast (CL0000092)
Fold Change: -0.4232
Cell Significance Index: -4.3200 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.4287
Cell Significance Index: -7.3900 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.4339
Cell Significance Index: -9.0600 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.4387
Cell Significance Index: -10.5200 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4411
Cell Significance Index: -9.5300 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.4468
Cell Significance Index: -9.5500 - Cell Name: granule cell (CL0000120)
Fold Change: -0.4515
Cell Significance Index: -5.1400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4518
Cell Significance Index: -12.9500 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.4533
Cell Significance Index: -11.0600 - Cell Name: neural cell (CL0002319)
Fold Change: -0.4552
Cell Significance Index: -5.3100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4599
Cell Significance Index: -9.7600 - Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.4795
Cell Significance Index: -6.8200 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.4811
Cell Significance Index: -6.8900 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: -0.4846
Cell Significance Index: -5.3800 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.4906
Cell Significance Index: -9.7000 - Cell Name: tendon cell (CL0000388)
Fold Change: -0.4942
Cell Significance Index: -6.7200 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.4960
Cell Significance Index: -9.8900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 729847528
Symbol: NDP_HUMAN
Name: Norrin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1303235
Title: Isolation of a candidate gene for Norrie disease by positional cloning.
PubMed ID: 1303235
DOI: 10.1038/ng0692-199
PubMed ID: 1303256
PubMed ID: 1303236
Title: Isolation and characterization of a candidate gene for Norrie disease.
PubMed ID: 1303236
DOI: 10.1038/ng0692-204
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9407136
Title: Norrie disease protein (norrin) forms disulfide-linked oligomers associated with the extracellular matrix.
PubMed ID: 9407136
PubMed ID: 10452356
Title: Localization of the Norrie disease gene mRNA by in situ hybridization.
PubMed ID: 10452356
PubMed ID: 8298646
Title: Molecular modelling of the Norrie disease protein predicts a cystine knot growth factor tertiary structure.
PubMed ID: 8298646
DOI: 10.1038/ng1293-376
PubMed ID: 24186977
Title: Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex.
PubMed ID: 24186977
PubMed ID: 8281159
Title: Identification of two new missense mutations (K58N and R121Q) in the Norrie disease (ND) gene in two Spanish families.
PubMed ID: 8281159
PubMed ID: 8069314
Title: A missense point mutation (Leu13Arg) of the Norrie disease gene in a large Cuban kindred with Norrie disease.
PubMed ID: 8069314
DOI: 10.1093/hmg/3.4.655
PubMed ID: 7993212
Title: Ocular findings associated with a Cys39Arg mutation in the Norrie disease gene.
PubMed ID: 7993212
PubMed ID: 1303264
Title: Norrie disease is caused by mutations in an extracellular protein resembling C-terminal globular domain of mucins.
PubMed ID: 1303264
DOI: 10.1038/ng1092-139
PubMed ID: 1307245
Title: Mutations in the candidate gene for Norrie disease.
PubMed ID: 1307245
DOI: 10.1093/hmg/1.7.461
PubMed ID: 8268931
Title: Characterization of a mutation within the NDP gene in a family with a manifesting female carrier.
PubMed ID: 8268931
PubMed ID: 8252044
Title: A mutation in the Norrie disease gene (NDP) associated with X-linked familial exudative vitreoretinopathy.
PubMed ID: 8252044
DOI: 10.1038/ng1093-180
PubMed ID: 7662640
Title: Mutations in the Norrie disease gene: a new mutation in a Japanese family.
PubMed ID: 7662640
DOI: 10.1136/bjo.79.7.703
PubMed ID: 7627181
PubMed ID: 7795608
Title: Missense mutations in the NDP gene in patients with a less severe course of Norrie disease.
PubMed ID: 7795608
DOI: 10.1093/hmg/4.3.489
PubMed ID: 8589700
Title: A novel mutation in the Norrie disease gene predicted to disrupt the cystine knot growth factor motif.
PubMed ID: 8589700
PubMed ID: 8741107
Title: Norrie-Warburg syndrome: two novel mutations in patients with classical clinical phenotype.
PubMed ID: 8741107
PubMed ID: 8946107
Title: X-linked exudative vitreoretinopathy caused by an arginine to leucine substitution (R121L) in the Norrie disease protein.
PubMed ID: 8946107
PubMed ID: 8807344
Title: Three novel and two recurrent mutations of the Norrie disease gene in patients with Norrie syndrome.
PubMed ID: 8807344
DOI: 10.1002/(sici)1098-1004(1996)8:1<85::aid-humu15>3.0.co;2-n
PubMed ID: 9382152
Title: Two new missense mutations (A105T and C110G) in the norrin gene in two Italian families with Norrie disease and familial exudative vitreoretinopathy.
PubMed ID: 9382152
DOI: 10.1002/(sici)1096-8628(19971017)72:2<242::aid-ajmg23>3.0.co;2-m
PubMed ID: 8990009
Title: Two new mutations in exon 3 of the NDP gene: S73X and S101F associated with severe and less severe ocular phenotype, respectively.
PubMed ID: 8990009
DOI: 10.1002/(sici)1098-1004(1997)9:1<53::aid-humu9>3.0.co;2-q
PubMed ID: 9143917
Title: Identification of novel missense mutations in the Norrie disease gene associated with one X-linked and four sporadic cases of familial exudative vitreoretinopathy.
PubMed ID: 9143917
DOI: 10.1002/(sici)1098-1004(1997)9:5<396::aid-humu3>3.0.co;2-2
PubMed ID: 9143918
Title: Norrie disease gene mutation in a large Costa Rican kindred with a novel phenotype including venous insufficiency.
PubMed ID: 9143918
DOI: 10.1002/(sici)1098-1004(1997)9:5<402::aid-humu4>3.0.co;2-5
PubMed ID: 10544980
Title: Norrie disease and exudative vitreoretinopathy in families with affected female carriers.
PubMed ID: 10544980
PubMed ID: 10484772
Title: Coats' disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis.
PubMed ID: 10484772
PubMed ID: 11337749
Title: Two Thai families with Norrie disease (ND): association of two novel missense mutations with severe ND phenotype, seizures, and a manifesting carrier.
PubMed ID: 11337749
DOI: 10.1002/1096-8628(20010415)100:1<52::aid-ajmg1214>3.0.co;2-b
PubMed ID: 14635119
Title: NDP gene mutations in 14 French families with Norrie disease.
PubMed ID: 14635119
DOI: 10.1002/humu.9204
PubMed ID: 15609522
Title: A novel missense Norrie disease mutation associated with a severe ocular phenotype.
PubMed ID: 15609522
PubMed ID: 16163268
Title: Genotype-phenotype variations in five Spanish families with Norrie disease or X-linked FEVR.
PubMed ID: 16163268
PubMed ID: 16970763
Title: Mutations in the NDP gene: contribution to Norrie disease, familial exudative vitreoretinopathy and retinopathy of prematurity.
PubMed ID: 16970763
PubMed ID: 15776010
Title: Phenotypic heterogeneity associated with a novel mutation (Gly112Glu) in the Norrie disease protein.
PubMed ID: 15776010
PubMed ID: 17128466
Title: Gene symbol: NDP. Disease: Norrie disease.
PubMed ID: 17128466
PubMed ID: 17334993
Title: A novel missense mutation in the NDP gene in a child with Norrie disease and severe neurological involvement including infantile spasms.
PubMed ID: 17334993
DOI: 10.1002/ajmg.a.31531
PubMed ID: 17296899
Title: Retinal phenotype-genotype correlation of pediatric patients expressing mutations in the Norrie disease gene.
PubMed ID: 17296899
PubMed ID: 17325173
Title: Novel mutations in Norrie disease gene in Japanese patients with Norrie disease and familial exudative vitreoretinopathy.
PubMed ID: 17325173
DOI: 10.1167/iovs.06-1042
PubMed ID: 20340138
Title: Overview of the mutation spectrum in familial exudative vitreoretinopathy and Norrie disease with identification of 21 novel variants in FZD4, LRP5, and NDP.
PubMed ID: 20340138
DOI: 10.1002/humu.21250
PubMed ID: 28192794
Title: The Genetic Causes of Nonsyndromic Congenital Retinal Detachment: A Genetic and Phenotypic Study of Pakistani Families.
PubMed ID: 28192794
Sequence Information:
- Length: 133
- Mass: 15044
- Checksum: D219E8B7F957286A
- Sequence:
MRKHVLAASF SMLSLLVIMG DTDSKTDSSF IMDSDPRRCM RHHYVDSISH PLYKCSSKMV LLARCEGHCS QASRSEPLVS FSTVLKQPFR SSCHCCRPQT SKLKALRLRC SGGMRLTATY RYILSCHCEE CNS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.