Details for: NEU2

Gene ID: 4759

Symbol: NEU2

Ensembl ID: ENSG00000115488

Description: neuraminidase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 26.0526
    Cell Significance Index: 663.7700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 15.4141
    Cell Significance Index: 249.6500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 12.8359
    Cell Significance Index: 219.4200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 7.5736
    Cell Significance Index: 98.0000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 7.5420
    Cell Significance Index: 103.4300
  • Cell Name: mast cell (CL0000097)
    Fold Change: 7.4878
    Cell Significance Index: 98.5400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 5.0821
    Cell Significance Index: 53.9900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8747
    Cell Significance Index: 12.7000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.4302
    Cell Significance Index: 5.6500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1774
    Cell Significance Index: 2.0300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.1455
    Cell Significance Index: 0.8600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.1255
    Cell Significance Index: 1.5000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.0682
    Cell Significance Index: 0.8100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0197
    Cell Significance Index: 0.2400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0083
    Cell Significance Index: 0.0900
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0025
    Cell Significance Index: 0.0200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0013
    Cell Significance Index: -0.2700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0061
    Cell Significance Index: -0.0700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0082
    Cell Significance Index: -0.0800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0095
    Cell Significance Index: -0.1100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0111
    Cell Significance Index: -0.2700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0123
    Cell Significance Index: -0.1300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0124
    Cell Significance Index: -0.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0125
    Cell Significance Index: -0.3400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0130
    Cell Significance Index: -0.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0132
    Cell Significance Index: -0.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0140
    Cell Significance Index: -0.1300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0159
    Cell Significance Index: -0.2100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0164
    Cell Significance Index: -0.1400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0171
    Cell Significance Index: -0.2400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0180
    Cell Significance Index: -0.1900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0189
    Cell Significance Index: -0.1900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0190
    Cell Significance Index: -0.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0226
    Cell Significance Index: -0.7400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0230
    Cell Significance Index: -0.2700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0241
    Cell Significance Index: -0.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0249
    Cell Significance Index: -0.6200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0252
    Cell Significance Index: -0.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0257
    Cell Significance Index: -0.9000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0276
    Cell Significance Index: -0.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0307
    Cell Significance Index: -1.3600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0314
    Cell Significance Index: -0.6600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0338
    Cell Significance Index: -0.3400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0338
    Cell Significance Index: -0.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0357
    Cell Significance Index: -1.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0393
    Cell Significance Index: -0.8500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0411
    Cell Significance Index: -0.8200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0412
    Cell Significance Index: -0.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0415
    Cell Significance Index: -0.8800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0420
    Cell Significance Index: -0.8300
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0442
    Cell Significance Index: -0.3200
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0450
    Cell Significance Index: -0.4000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0482
    Cell Significance Index: -0.4500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0488
    Cell Significance Index: -0.9800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0492
    Cell Significance Index: -0.8500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0608
    Cell Significance Index: -0.8700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0616
    Cell Significance Index: -0.4100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0623
    Cell Significance Index: -0.4000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0633
    Cell Significance Index: -0.5900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0684
    Cell Significance Index: -0.5800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0692
    Cell Significance Index: -0.6100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0723
    Cell Significance Index: -0.8500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0793
    Cell Significance Index: -0.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0859
    Cell Significance Index: -1.8800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0919
    Cell Significance Index: -1.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0982
    Cell Significance Index: -1.0700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1076
    Cell Significance Index: -1.3800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1473
    Cell Significance Index: -1.8100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1726
    Cell Significance Index: -2.0700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1902
    Cell Significance Index: -2.0200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4901
    Cell Significance Index: -6.1900
  • Cell Name: neuron (CL0000540)
    Fold Change: -5.5070
    Cell Significance Index: -52.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme Activity:** NEU2 is a sialidase enzyme, specifically classified as an exo-alpha-(2->3)-sialidase, which cleaves sialic acid residues from glycoproteins and glycolipids. 2. **Cellular Expression:** NEU2 is expressed in a wide range of cell types, including erythrocytes, double negative thymocytes, megakaryocytes, and mast cells, highlighting its ubiquitous presence in the body. 3. **Signaling Pathways:** NEU2 is involved in various signaling pathways, including the regulation of cell migration, adhesion, and proliferation, which are crucial for immune responses and tissue development. **Pathways and Functions:** 1. **Sialic Acid Metabolism:** NEU2 plays a critical role in the catabolism of sialic acids, which are essential for maintaining cellular homeostasis and regulating immune responses. 2. **Glycosylation and Glycosphingolipid Metabolism:** NEU2 is involved in the regulation of glycosylation and glycosphingolipid metabolism, which are crucial for maintaining cellular function and integrity. 3. **Immune Response:** NEU2 is essential for the regulation of immune responses, including the activation of immune cells and the modulation of inflammation. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in NEU2 expression have been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer:** NEU2 is overexpressed in certain types of cancer, including breast cancer and colon cancer, suggesting its potential as a biomarker for cancer diagnosis and treatment. 3. **Immunodeficiency Disorders:** NEU2 deficiency has been linked to immunodeficiency disorders, highlighting its importance in maintaining immune function. In conclusion, NEU2 is a critical enzyme involved in sialic acid metabolism, glycosylation, and glycosphingolipid metabolism. Its significance extends to various cellular processes, including immune responses, and its dysregulation has been implicated in various diseases, including neurological disorders, cancer, and immunodeficiency disorders. Further research is necessary to fully elucidate the role of NEU2 in human health and disease.

Genular Protein ID: 2071885188

Symbol: NEUR2_HUMAN

Name: Sialidase-2

UniProtKB Accession Codes:

Q9Y3R4 Q3KNW4 Q6NTB4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChEBI 36 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 18 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10191093

Title: Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases.

PubMed ID: 10191093

DOI: 10.1006/geno.1999.5749

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10561456

Title: Expression of a novel human sialidase encoded by the NEU2 gene.

PubMed ID: 10561456

DOI: 10.1093/glycob/9.12.1313

PubMed ID: 14613940

Title: Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules.

PubMed ID: 14613940

DOI: 10.1074/jbc.m308381200

PubMed ID: 22228546

Title: Molecular insight into substrate recognition by human cytosolic sialidase NEU2.

PubMed ID: 22228546

DOI: 10.1002/prot.24013

PubMed ID: 15501818

Title: Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition.

PubMed ID: 15501818

DOI: 10.1074/jbc.m411506200

PubMed ID: 17426694

Title: A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir.

PubMed ID: 17426694

DOI: 10.1038/cr.2007.27

Sequence Information:

  • Length: 380
  • Mass: 42254
  • Checksum: AD7B08C478F4D0D9
  • Sequence:
    • MASLPVLQKE SVFQSGAHAY RIPALLYLPG QQSLLAFAEQ RASKKDEHAE LIVLRRGDYD 
APTHQVQWQA QEVVAQARLD GHRSMNPCPL YDAQTGTLFL FFIAIPGQVT EQQQLQTRAN 
VTRLCQVTST DHGRTWSSPR DLTDAAIGPA YREWSTFAVG PGHCLQLHDR ARSLVVPAYA 
YRKLHPIQRP IPSAFCFLSH DHGRTWARGH FVAQDTLECQ VAEVETGEQR VVTLNARSHL 
RARVQAQSTN DGLDFQESQL VKKLVEPPPQ GCQGSVISFP SPRSGPGSPA QWLLYTHPTH 
SWQRADLGAY LNPRPPAPEA WSEPVLLAKG SCAYSDLQSM GTGPDGSPLF GCLYEANDYE 
EIVFLMFTLK QAFPAEYLPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.