Details for: NOP2

Gene ID: 4839

Symbol: NOP2

Ensembl ID: ENSG00000111641

Description: NOP2 nucleolar protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 60.2076
    Cell Significance Index: -9.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.5474
    Cell Significance Index: -9.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.2931
    Cell Significance Index: -10.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5761
    Cell Significance Index: -9.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6381
    Cell Significance Index: -10.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.6307
    Cell Significance Index: -8.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2526
    Cell Significance Index: -4.9300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.6836
    Cell Significance Index: 27.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7001
    Cell Significance Index: 42.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6992
    Cell Significance Index: 19.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4861
    Cell Significance Index: 13.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3837
    Cell Significance Index: 11.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3802
    Cell Significance Index: 10.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3263
    Cell Significance Index: 32.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2991
    Cell Significance Index: 8.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2896
    Cell Significance Index: 7.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2859
    Cell Significance Index: 12.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2654
    Cell Significance Index: 53.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2566
    Cell Significance Index: 31.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2258
    Cell Significance Index: 26.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2175
    Cell Significance Index: 39.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2072
    Cell Significance Index: 24.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1868
    Cell Significance Index: 30.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1850
    Cell Significance Index: 127.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1636
    Cell Significance Index: 11.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1602
    Cell Significance Index: 144.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1346
    Cell Significance Index: 73.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1343
    Cell Significance Index: 17.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1193
    Cell Significance Index: 42.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1020
    Cell Significance Index: 2.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0977
    Cell Significance Index: 4.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0933
    Cell Significance Index: 12.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0792
    Cell Significance Index: 15.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0779
    Cell Significance Index: 5.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0749
    Cell Significance Index: 2.0400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0695
    Cell Significance Index: 0.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0595
    Cell Significance Index: 26.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0349
    Cell Significance Index: 1.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0263
    Cell Significance Index: 0.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0243
    Cell Significance Index: 0.8600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0226
    Cell Significance Index: 0.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0206
    Cell Significance Index: 0.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0185
    Cell Significance Index: 2.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0009
    Cell Significance Index: 0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0027
    Cell Significance Index: -2.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0054
    Cell Significance Index: -10.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0060
    Cell Significance Index: -11.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0071
    Cell Significance Index: -10.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0082
    Cell Significance Index: -11.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0120
    Cell Significance Index: -8.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0126
    Cell Significance Index: -1.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0147
    Cell Significance Index: -0.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0148
    Cell Significance Index: -10.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0161
    Cell Significance Index: -9.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0181
    Cell Significance Index: -11.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0185
    Cell Significance Index: -11.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0238
    Cell Significance Index: -1.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0242
    Cell Significance Index: -1.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0245
    Cell Significance Index: -11.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0263
    Cell Significance Index: -0.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0273
    Cell Significance Index: -7.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0291
    Cell Significance Index: -2.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0306
    Cell Significance Index: -0.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0313
    Cell Significance Index: -0.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0327
    Cell Significance Index: -1.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0342
    Cell Significance Index: -5.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0362
    Cell Significance Index: -1.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0401
    Cell Significance Index: -7.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0402
    Cell Significance Index: -2.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0411
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0533
    Cell Significance Index: -11.2300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0589
    Cell Significance Index: -1.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0701
    Cell Significance Index: -4.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0747
    Cell Significance Index: -8.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0764
    Cell Significance Index: -11.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0771
    Cell Significance Index: -4.7400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0811
    Cell Significance Index: -0.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0823
    Cell Significance Index: -2.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0880
    Cell Significance Index: -1.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0893
    Cell Significance Index: -1.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1010
    Cell Significance Index: -10.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1102
    Cell Significance Index: -2.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1122
    Cell Significance Index: -7.2400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1208
    Cell Significance Index: -1.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1253
    Cell Significance Index: -7.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1351
    Cell Significance Index: -3.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1470
    Cell Significance Index: -11.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1495
    Cell Significance Index: -3.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1602
    Cell Significance Index: -5.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1689
    Cell Significance Index: -11.3600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1692
    Cell Significance Index: -1.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1761
    Cell Significance Index: -5.6100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1946
    Cell Significance Index: -4.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1967
    Cell Significance Index: -4.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1979
    Cell Significance Index: -6.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2100
    Cell Significance Index: -7.3600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2259
    Cell Significance Index: -3.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2378
    Cell Significance Index: -4.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2382
    Cell Significance Index: -2.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2410
    Cell Significance Index: -5.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Nucleolar localization:** NOP2 is primarily localized in the nucleolus, where it participates in ribosomal RNA processing and assembly. 2. **RNA processing:** NOP2 is involved in the methylation and modification of ribosomal RNA, ensuring its proper processing and incorporation into ribosomes. 3. **Transcriptional regulation:** NOP2 acts as a transcriptional regulator, influencing the expression of various genes involved in cell proliferation, differentiation, and immune response. 4. **Immune cell specificity:** NOP2 is significantly expressed in immune cells, such as GABAergic interneurons, and plays a crucial role in regulating immune responses. **Pathways and Functions:** 1. **Ribosomal RNA maturation:** NOP2 is essential for the maturation of ribosomal RNA, ensuring proper ribosome assembly and function. 2. **Transcriptional regulation:** NOP2 regulates the expression of genes involved in cell proliferation, differentiation, and immune response, influencing the development and function of various cell types. 3. **Immune response:** NOP2 plays a crucial role in regulating immune responses, particularly in immune cells such as GABAergic interneurons and intestinal epithelial cells. 4. **Cell differentiation:** NOP2 is involved in the regulation of cell differentiation, influencing the development and function of various cell types, including mural cells and germ cells. **Clinical Significance:** Dysregulation of NOP2 has been implicated in various diseases, including cancer, neurodegenerative disorders, and immune-related disorders. For example: 1. **Cancer:** NOP2 has been identified as a tumor suppressor gene, with its dysregulation contributing to cancer development and progression. 2. **Neurodegenerative disorders:** NOP2 mutations have been linked to neurodegenerative disorders, such as frontotemporal dementia and Alzheimer's disease. 3. **Immune-related disorders:** NOP2 plays a crucial role in regulating immune responses, and its dysregulation has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. In conclusion, NOP2 is a critical gene involved in various cellular processes, including RNA processing, transcriptional regulation, and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of NOP2 in maintaining cellular homeostasis and immune function. Further research is necessary to fully elucidate the role of NOP2 in human health and disease.

Genular Protein ID: 585809239

Symbol: NOP2_HUMAN

Name: 28S rRNA (cytosine(4447)-C(5))-methyltransferase

UniProtKB Accession Codes:

P46087 A1A4Z3 B3KPD6 Q05BA7 Q0P5S5 Q3KQS4 Q58F30

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 EMDB 6 Ensembl 6 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 6 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2576976

Title: Cloning of the cDNA and sequence of the human proliferating-cell nucleolar protein P120.

PubMed ID: 2576976

PubMed ID: 2372471

Title: Genomic structure of the human proliferating cell nucleolar protein p120.

PubMed ID: 2372471

DOI: 10.3727/095535490820874704

PubMed ID: 1394192

Title: A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation.

PubMed ID: 1394192

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8089149

Title: Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein B23.

PubMed ID: 8089149

DOI: 10.1016/s0021-9258(17)31583-1

PubMed ID: 9654073

Title: The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120.

PubMed ID: 9654073

DOI: 10.1046/j.1432-1327.1998.2530734.x

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20926688

Title: RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits.

PubMed ID: 20926688

DOI: 10.1091/mbc.e10-04-0287

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24120868

Title: The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress.

PubMed ID: 24120868

DOI: 10.1016/j.celrep.2013.08.049

PubMed ID: 23848194

Title: Nucleolar scaffold protein, WDR46, determines the granular compartmental localization of nucleolin and DDX21.

PubMed ID: 23848194

DOI: 10.1111/gtc.12077

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 26196125

Title: Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120.

PubMed ID: 26196125

DOI: 10.1371/journal.pone.0133321

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 36161484

Title: Human NOP2/NSUN1 regulates ribosome biogenesis through non-catalytic complex formation with box C/D snoRNPs.

PubMed ID: 36161484

DOI: 10.1093/nar/gkac817

Sequence Information:

  • Length: 812
  • Mass: 89302
  • Checksum: 4C7A1BE79388F1C5
  • Sequence:
    • MGRKLDPTKE KRGPGRKARK QKGAETELVR FLPAVSDENS KRLSSRARKR AAKRRLGSVE 
APKTNKSPEA KPLPGKLPKG ISAGAVQTAG KKGPQSLFNA PRGKKRPAPG SDEEEEEEDS 
EEDGMVNHGD LWGSEDDADT VDDYGADSNS EDEEEGEALL PIERAARKQK AREAAAGIQW 
SEEETEDEEE EKEVTPESGP PKVEEADGGL QINVDEEPFV LPPAGEMEQD AQAPDLQRVH 
KRIQDIVGIL RDFGAQREEG RSRSEYLNRL KKDLAIYYSY GDFLLGKLMD LFPLSELVEF 
LEANEVPRPV TLRTNTLKTR RRDLAQALIN RGVNLDPLGK WSKTGLVVYD SSVPIGATPE 
YLAGHYMLQG ASSMLPVMAL APQEHERILD MCCAPGGKTS YMAQLMKNTG VILANDANAE 
RLKSVVGNLH RLGVTNTIIS HYDGRQFPKV VGGFDRVLLD APCSGTGVIS KDPAVKTNKD 
EKDILRCAHL QKELLLSAID SVNATSKTGG YLVYCTCSIT VEENEWVVDY ALKKRNVRLV 
PTGLDFGQEG FTRFRERRFH PSLRSTRRFY PHTHNMDGFF IAKFKKFSNS IPQSQTGNSE 
TATPTNVDLP QVIPKSENSS QPAKKAKGAA KTKQQLQKQQ HPKKASFQKL NGISKGADSE 
LSTVPSVTKT QASSSFQDSS QPAGKAEGIR EPKVTGKLKQ RSPKLQSSKK VAFLRQNAPP 
KGTDTQTPAV LSPSKTQATL KPKDHHQPLG RAKGVEKQQL PEQPFEKAAF QKQNDTPKGP 
QPPTVSPIRS SRPPPAKRKK SQSRGNSQLL LS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.