Details for: NPTX2

Gene ID: 4885

Symbol: NPTX2

Ensembl ID: ENSG00000106236

Description: neuronal pentraxin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.4789
    Cell Significance Index: -12.5500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 18.2110
    Cell Significance Index: -12.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9999
    Cell Significance Index: 98.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9158
    Cell Significance Index: 61.5800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7010
    Cell Significance Index: 8.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6794
    Cell Significance Index: 129.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6735
    Cell Significance Index: 19.2200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5643
    Cell Significance Index: 13.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5265
    Cell Significance Index: 33.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5127
    Cell Significance Index: 83.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4745
    Cell Significance Index: 16.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4441
    Cell Significance Index: 20.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4199
    Cell Significance Index: 45.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3579
    Cell Significance Index: 71.8000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.2926
    Cell Significance Index: 3.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2123
    Cell Significance Index: 14.6800
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.1721
    Cell Significance Index: 1.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1558
    Cell Significance Index: 4.4900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1408
    Cell Significance Index: 1.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1351
    Cell Significance Index: 8.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1079
    Cell Significance Index: 38.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0962
    Cell Significance Index: 3.3800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0854
    Cell Significance Index: 1.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0791
    Cell Significance Index: 2.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0692
    Cell Significance Index: 1.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0654
    Cell Significance Index: 45.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0387
    Cell Significance Index: 17.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0320
    Cell Significance Index: 3.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0096
    Cell Significance Index: 5.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0054
    Cell Significance Index: 0.9200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0030
    Cell Significance Index: 0.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0007
    Cell Significance Index: 0.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0007
    Cell Significance Index: 0.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0004
    Cell Significance Index: 0.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0033
    Cell Significance Index: -2.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0044
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0063
    Cell Significance Index: -11.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0098
    Cell Significance Index: -18.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0100
    Cell Significance Index: -1.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0103
    Cell Significance Index: -15.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0126
    Cell Significance Index: -0.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0132
    Cell Significance Index: -17.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0148
    Cell Significance Index: -3.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0164
    Cell Significance Index: -12.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0187
    Cell Significance Index: -0.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0199
    Cell Significance Index: -12.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0274
    Cell Significance Index: -1.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0275
    Cell Significance Index: -7.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0301
    Cell Significance Index: -0.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0308
    Cell Significance Index: -14.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0318
    Cell Significance Index: -5.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0382
    Cell Significance Index: -0.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0621
    Cell Significance Index: -12.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0638
    Cell Significance Index: -6.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0642
    Cell Significance Index: -8.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0748
    Cell Significance Index: -1.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0749
    Cell Significance Index: -2.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0763
    Cell Significance Index: -8.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0813
    Cell Significance Index: -10.0000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0816
    Cell Significance Index: -1.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0920
    Cell Significance Index: -13.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1059
    Cell Significance Index: -2.2600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1064
    Cell Significance Index: -0.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1068
    Cell Significance Index: -12.5900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1083
    Cell Significance Index: -1.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1099
    Cell Significance Index: -3.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1280
    Cell Significance Index: -16.5400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1326
    Cell Significance Index: -2.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1331
    Cell Significance Index: -8.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1344
    Cell Significance Index: -10.3100
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.1473
    Cell Significance Index: -1.5900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1537
    Cell Significance Index: -1.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1690
    Cell Significance Index: -7.4800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1748
    Cell Significance Index: -1.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1777
    Cell Significance Index: -5.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1905
    Cell Significance Index: -8.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1908
    Cell Significance Index: -9.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1945
    Cell Significance Index: -12.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2200
    Cell Significance Index: -16.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2229
    Cell Significance Index: -8.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2330
    Cell Significance Index: -7.6300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2401
    Cell Significance Index: -1.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2419
    Cell Significance Index: -6.3600
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.2721
    Cell Significance Index: -3.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2783
    Cell Significance Index: -9.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3065
    Cell Significance Index: -4.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3173
    Cell Significance Index: -6.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3177
    Cell Significance Index: -6.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3252
    Cell Significance Index: -7.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3281
    Cell Significance Index: -12.0500
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.3304
    Cell Significance Index: -2.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3409
    Cell Significance Index: -16.0200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3437
    Cell Significance Index: -4.0100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3437
    Cell Significance Index: -4.9900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.3479
    Cell Significance Index: -3.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3892
    Cell Significance Index: -6.6700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4018
    Cell Significance Index: -10.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4169
    Cell Significance Index: -12.2800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4188
    Cell Significance Index: -3.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4209
    Cell Significance Index: -11.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NPTX2 is a member of the pentraxin family of proteins, characterized by the presence of a pentraxin domain. This domain is responsible for the protein's ability to bind to carbohydrates, lipids, and other molecules, facilitating its role in synaptic transmission and immune responses. NPTX2 is primarily expressed in the nervous system, with high levels found in neurons, glial cells, and immune cells. Its expression is also detected in various other cell types, including skeletal muscle satellite stem cells, germ cells, and intestinal crypt stem cells. **Pathways and Functions:** NPTX2 is involved in several key biological pathways, including: 1. **Synaptic Transmission:** NPTX2 plays a crucial role in synaptic transmission, particularly in the glutamatergic synapse. It binds to synaptic vesicles and modulates the release of neurotransmitters, such as glutamate. 2. **Neuronal Development:** NPTX2 is involved in neuronal development, particularly in the formation of synaptic connections between neurons. 3. **Immune Responses:** NPTX2 is expressed in immune cells, including macrophages and dendritic cells, and plays a role in the regulation of immune responses. 4. **Chemical Synaptic Transmission:** NPTX2 is also involved in chemical synaptic transmission, where it binds to neurotransmitters and modulates their release. **Clinical Significance:** NPTX2 has been implicated in various neurological and immunological disorders, including: 1. **Neurodegenerative Diseases:** NPTX2 has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Immune-Mediated Disorders:** NPTX2 has been implicated in immune-mediated disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Neuroinflammatory Disorders:** NPTX2 has been linked to neuroinflammatory disorders, such as multiple sclerosis and Guillain-Barré syndrome. In conclusion, NPTX2 is a multifunctional protein that plays a crucial role in various biological processes, including synaptic transmission, neuronal development, and immune responses. Its dysregulation has been implicated in various neurological and immunological disorders, highlighting the importance of further research into the functions and clinical significance of NPTX2.

Genular Protein ID: 3621435437

Symbol: NPTX2_HUMAN

Name: Neuronal pentraxin-2

UniProtKB Accession Codes:

P47972 A4D267 Q86XV7 Q96G70

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 8 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8530029

Title: Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization.

PubMed ID: 8530029

DOI: 10.1006/geno.1995.1134

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10748068

Title: Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2.

PubMed ID: 10748068

DOI: 10.1074/jbc.m002254200

Sequence Information:

  • Length: 431
  • Mass: 47042
  • Checksum: 87B7BF9BA1049AC5
  • Sequence:
    • MLALLAASVA LAVAAGAQDS PAPGSRFVCT ALPPEAVHAG CPLPAMPMQG GAQSPEEELR 
AAVLQLRETV VQQKETLGAQ REAIRELTGK LARCEGLAGG KARGAGATGK DTMGDLPRDP 
GHVVEQLSRS LQTLKDRLES LEHQLRANVS NAGLPGDFRE VLQQRLGELE RQLLRKVAEL 
EDEKSLLHNE TSAHRQKTES TLNALLQRVT ELERGNSAFK SPDAFKVSLP LRTNYLYGKI 
KKTLPELYAF TICLWLRSSA SPGIGTPFSY AVPGQANEIV LIEWGNNPIE LLINDKVAQL 
PLFVSDGKWH HICVTWTTRD GMWEAFQDGE KLGTGENLAP WHPIKPGGVL ILGQEQDTVG 
GRFDATQAFV GELSQFNIWD RVLRAQEIVN IANCSTNMPG NIIPWVDNNV DVFGGASKWP 
VETCEERLLD L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.