Details for: OPRM1

Gene ID: 4988

Symbol: OPRM1

Ensembl ID: ENSG00000112038

Description: opioid receptor mu 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.4435
    Cell Significance Index: -8.9900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 4.3204
    Cell Significance Index: 74.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.0708
    Cell Significance Index: 67.2400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.4750
    Cell Significance Index: 59.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.7110
    Cell Significance Index: 75.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2991
    Cell Significance Index: 260.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2931
    Cell Significance Index: -2.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7706
    Cell Significance Index: 29.1800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.7359
    Cell Significance Index: 18.3500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.6207
    Cell Significance Index: 8.2800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.5311
    Cell Significance Index: 5.8600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.5274
    Cell Significance Index: 6.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4633
    Cell Significance Index: 14.8400
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.4428
    Cell Significance Index: 2.3300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.3379
    Cell Significance Index: 3.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2454
    Cell Significance Index: 169.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0751
    Cell Significance Index: 26.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0587
    Cell Significance Index: 3.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0523
    Cell Significance Index: 1.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0431
    Cell Significance Index: 1.4100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0303
    Cell Significance Index: 0.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0289
    Cell Significance Index: 5.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0211
    Cell Significance Index: 3.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0171
    Cell Significance Index: 26.3600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0133
    Cell Significance Index: 0.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0130
    Cell Significance Index: 1.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0091
    Cell Significance Index: 12.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0082
    Cell Significance Index: 0.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0072
    Cell Significance Index: 0.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0067
    Cell Significance Index: 4.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0059
    Cell Significance Index: 11.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0033
    Cell Significance Index: 6.0600
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0047
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0105
    Cell Significance Index: -7.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0114
    Cell Significance Index: -8.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0127
    Cell Significance Index: -5.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0130
    Cell Significance Index: -9.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0156
    Cell Significance Index: -8.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0159
    Cell Significance Index: -9.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0164
    Cell Significance Index: -8.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0174
    Cell Significance Index: -2.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0175
    Cell Significance Index: -0.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0248
    Cell Significance Index: -7.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0258
    Cell Significance Index: -4.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0421
    Cell Significance Index: -6.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0448
    Cell Significance Index: -9.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0501
    Cell Significance Index: -3.8500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0545
    Cell Significance Index: -2.3700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0605
    Cell Significance Index: -0.4100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0642
    Cell Significance Index: -1.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0659
    Cell Significance Index: -9.0500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0690
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0776
    Cell Significance Index: -8.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0788
    Cell Significance Index: -2.2500
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0802
    Cell Significance Index: -0.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0824
    Cell Significance Index: -8.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0825
    Cell Significance Index: -9.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0832
    Cell Significance Index: -8.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0895
    Cell Significance Index: -5.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0998
    Cell Significance Index: -5.9900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1000
    Cell Significance Index: -2.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1041
    Cell Significance Index: -7.2000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1064
    Cell Significance Index: -1.5200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1073
    Cell Significance Index: -2.6800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1118
    Cell Significance Index: -1.0600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1282
    Cell Significance Index: -2.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1296
    Cell Significance Index: -6.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1335
    Cell Significance Index: -2.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1349
    Cell Significance Index: -8.2700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1371
    Cell Significance Index: -1.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1401
    Cell Significance Index: -7.8600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1420
    Cell Significance Index: -1.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1459
    Cell Significance Index: -5.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1510
    Cell Significance Index: -7.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1576
    Cell Significance Index: -7.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1635
    Cell Significance Index: -3.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1640
    Cell Significance Index: -8.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1662
    Cell Significance Index: -8.6600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1670
    Cell Significance Index: -2.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1711
    Cell Significance Index: -4.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1778
    Cell Significance Index: -8.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1824
    Cell Significance Index: -3.5600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1937
    Cell Significance Index: -2.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2165
    Cell Significance Index: -5.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2179
    Cell Significance Index: -5.6000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2276
    Cell Significance Index: -7.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2328
    Cell Significance Index: -8.1800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2371
    Cell Significance Index: -3.5000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2375
    Cell Significance Index: -2.2600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2512
    Cell Significance Index: -3.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2583
    Cell Significance Index: -5.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2706
    Cell Significance Index: -7.9700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2824
    Cell Significance Index: -6.8900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2835
    Cell Significance Index: -3.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2891
    Cell Significance Index: -7.8700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3076
    Cell Significance Index: -3.8200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3079
    Cell Significance Index: -3.6200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3112
    Cell Significance Index: -5.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3122
    Cell Significance Index: -8.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The OPRM1 gene exhibits several key characteristics that highlight its importance in the opioid system: 1. **High expression levels**: The OPRM1 gene is highly expressed in various tissues, including the brain, kidney, lung, and immune cells, indicating its widespread role in pain modulation and immune regulation. 2. **G-protein coupled receptor structure**: The OPRM1 gene encodes for a G-protein-coupled receptor, which is a large family of receptors that respond to a wide range of ligands, including hormones, neurotransmitters, and drugs. 3. **Mu-type opioid receptor specificity**: The OPRM1 gene is specific for the mu-type opioid receptor, which is the primary receptor subtype that binds to endogenous opioids and exogenous opioids. 4. **Multiple signaling pathways**: The OPRM1 gene is involved in multiple signaling pathways, including adenylate cyclase-inhibiting g protein-coupled acetylcholine receptor signaling pathway, calcium ion transmembrane transport, and cytokine signaling in immune system. **Pathways and Functions** The OPRM1 gene plays a critical role in various physiological processes, including: 1. **Pain modulation**: The OPRM1 gene is involved in pain modulation, and its dysregulation has been implicated in various pain-related disorders, such as chronic pain and opioid addiction. 2. **Stress response**: The OPRM1 gene is activated in response to stress, and its activation can lead to the release of endogenous opioids, which can help to reduce stress and anxiety. 3. **Immune regulation**: The OPRM1 gene is involved in immune regulation, and its dysregulation has been implicated in various immune-related disorders, such as inflammatory bowel disease and multiple sclerosis. 4. **Neuroprotection**: The OPRM1 gene has been shown to have neuroprotective effects, and its activation can help to protect against neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. **Clinical Significance** The OPRM1 gene has significant clinical implications for various disorders, including: 1. **Opioid addiction**: The OPRM1 gene has been implicated in opioid addiction, and its dysregulation can lead to the development of tolerance and dependence on opioids. 2. **Chronic pain**: The OPRM1 gene has been implicated in chronic pain, and its dysregulation can lead to the development of chronic pain syndromes. 3. **Inflammatory bowel disease**: The OPRM1 gene has been implicated in inflammatory bowel disease, and its dysregulation can lead to the development of inflammatory bowel disease. 4. **Neurodegenerative diseases**: The OPRM1 gene has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, and its dysregulation can lead to the development of these diseases. In conclusion, the OPRM1 gene plays a critical role in various physiological processes, including pain modulation, stress response, immune regulation, and neuroprotection. Its dysregulation has been implicated in various disorders, including opioid addiction, chronic pain, inflammatory bowel disease, and neurodegenerative diseases. Further research is needed to fully understand the mechanisms by which the OPRM1 gene regulates these processes and to develop effective therapeutic strategies for the treatment of these disorders.

Genular Protein ID: 3842293951

Symbol: OPRM_HUMAN

Name: Mu-type opioid receptor

UniProtKB Accession Codes:

P35372 B0FXJ1 B2R9S7 B8Q1L7 B8Q1L8 B8Q1L9 E7EWZ3 G8XRH6 G8XRH8 Q12930 Q4VWM1 Q4VWM2 Q4VWM3 Q4VWM4 Q4VWM6 Q4VWX6 Q5TDA1 Q6UPP1 Q6UQ80 Q7Z2D8 Q86V80 Q8IWW3 Q8IWW4 Q9UCZ4 Q9UN57

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 12 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 68 DrugCentral 1 EMBL 35 EMDB 10 Ensembl 17 ExpressionAtlas 1 GO 36 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 2 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 19 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7905839

Title: Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment.

PubMed ID: 7905839

DOI: 10.1016/0014-5793(94)80368-4

PubMed ID: 7957926

Title: Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain.

PubMed ID: 7957926

DOI: 10.1016/0014-5793(94)01129-x

PubMed ID: 7891175

Title: The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C.

PubMed ID: 7891175

DOI: 10.1523/jneurosci.15-03-02396.1995

PubMed ID: 12589820

Title: Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X.

PubMed ID: 12589820

DOI: 10.1016/s0006-291x(03)00089-5

PubMed ID: 12734358

Title: Molecular identification and functional expression of mu 3, a novel alternatively spliced variant of the human mu opiate receptor gene.

PubMed ID: 12734358

DOI: 10.4049/jimmunol.170.10.5118

PubMed ID: 15893644

Title: Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm.

PubMed ID: 15893644

DOI: 10.1016/j.neuroscience.2004.12.033

PubMed ID: 19077058

Title: Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene.

PubMed ID: 19077058

DOI: 10.1111/j.1471-4159.2008.05833.x

PubMed ID: 19103668

Title: Expansion of the human mu-opioid receptor gene architecture: novel functional variants.

PubMed ID: 19103668

DOI: 10.1093/hmg/ddn439

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10393893

Title: The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses.

PubMed ID: 10393893

DOI: 10.1073/pnas.96.14.7752

PubMed ID: 7488213

Title: Mu opioid receptor gene expression in immune cells.

PubMed ID: 7488213

DOI: 10.1006/bbrc.1995.2709

PubMed ID: 12519790

Title: ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis.

PubMed ID: 12519790

DOI: 10.1074/jbc.m206709200

PubMed ID: 10529478

Title: Mutation of human mu opioid receptor extracellular 'disulfide cysteine' residues alters ligand binding but does not prevent receptor targeting to the cell plasma membrane.

PubMed ID: 10529478

DOI: 10.1016/s0169-328x(99)00241-7

PubMed ID: 10419536

Title: Calmodulin binding to G protein-coupling domain of opioid receptors.

PubMed ID: 10419536

DOI: 10.1074/jbc.274.31.22081

PubMed ID: 10836142

Title: Molecular mechanisms and regulation of opioid receptor signaling.

PubMed ID: 10836142

DOI: 10.1146/annurev.pharmtox.40.1.389

PubMed ID: 10899953

Title: Calmodulin regulation of basal and agonist-stimulated G protein coupling by the mu-opioid receptor (OP(3)) in morphine-pretreated cell.

PubMed ID: 10899953

DOI: 10.1046/j.1471-4159.2000.0750763.x

PubMed ID: 12413885

Title: Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells.

PubMed ID: 12413885

DOI: 10.1006/excr.2002.5638

PubMed ID: 12068084

Title: Agonists activate Gi1 alpha or Gi2 alpha fused to the human mu opioid receptor differently.

PubMed ID: 12068084

DOI: 10.1046/j.1471-4159.2002.00946.x

PubMed ID: 12810704

Title: Selective interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation.

PubMed ID: 12810704

DOI: 10.1074/jbc.m305866200

PubMed ID: 14573758

Title: Interaction between the mu opioid receptor and filamin A is involved in receptor regulation and trafficking.

PubMed ID: 14573758

DOI: 10.1124/mol.64.5.1092

PubMed ID: 15778451

Title: Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer.

PubMed ID: 15778451

DOI: 10.1124/mol.104.010272

PubMed ID: 15967873

Title: Functional complementation and the analysis of opioid receptor homodimerization.

PubMed ID: 15967873

DOI: 10.1124/mol.105.013847

PubMed ID: 16580639

Title: The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor.

PubMed ID: 16580639

DOI: 10.1016/j.bbrc.2006.03.084

PubMed ID: 16542645

Title: A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor.

PubMed ID: 16542645

DOI: 10.1016/j.brainres.2006.01.125

PubMed ID: 17224450

Title: Physical association between neuropeptide FF and micro-opioid receptors as a possible molecular basis for anti-opioid activity.

PubMed ID: 17224450

DOI: 10.1074/jbc.m606946200

PubMed ID: 19300905

Title: Membrane functional organisation and dynamic of mu-opioid receptors.

PubMed ID: 19300905

DOI: 10.1007/s00018-009-0008-4

PubMed ID: 19788913

Title: Regulation of mu opioid receptor internalization by the scaffold protein RanBPM.

PubMed ID: 19788913

DOI: 10.1016/j.neulet.2009.09.048

PubMed ID: 20214800

Title: Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence.

PubMed ID: 20214800

DOI: 10.1186/1471-2202-11-33

PubMed ID: 20525224

Title: A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism.

PubMed ID: 20525224

DOI: 10.1186/1744-8069-6-33

PubMed ID: 9399694

Title: Mu opioid receptor gene variants: lack of association with alcohol dependence.

PubMed ID: 9399694

DOI: 10.1038/sj.mp.4000331

PubMed ID: 9689128

Title: Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction.

PubMed ID: 9689128

DOI: 10.1073/pnas.95.16.9608

Sequence Information:

  • Length: 400
  • Mass: 44779
  • Checksum: 1DABEBEC9AFF6F66
  • Sequence:
    • MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP 
PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALADALAT 
STLPFQSVNY LMGTWPFGTI LCKIVISIDY YNMFTSIFTL CTMSVDRYIA VCHPVKALDF 
RTPRNAKIIN VCNWILSSAI GLPVMFMATT KYRQGSIDCT LTFSHPTWYW ENLLKICVFI 
FAFIMPVLII TVCYGLMILR LKSVRMLSGS KEKDRNLRRI TRMVLVVVAV FIVCWTPIHI 
YVIIKALVTI PETTFQTVSW HFCIALGYTN SCLNPVLYAF LDENFKRCFR EFCIPTSSNI 
EQQNSTRIRQ NTRDHPSTAN TVDRTNHQLE NLEAETAPLP

Genular Protein ID: 2497788599

Symbol: L0E130_HUMAN

Name: N/A

UniProtKB Accession Codes:

L0E130

Database IDs:

ARBA 14 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 GO 6 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 476
  • Mass: 53317
  • Checksum: 2278F4BD57576580
  • Sequence:
    • MSDAQLGPLR LTLLSVSART GFCKKQQELW QRRKEAAEAL GTRKVSVLLA TSHSGARPAV 
STMDSSAAPT NASNCTDALA YSSCSPAPSP GSWVNLSHLD GNLSDPCGPN RTDLGGRDSL 
CPPTGSPSMI TAITIMALYS IVCVVGLFGN FLVMYVIVRY TKMKTATNIY IFNLALADAL 
ATSTLPFQSV NYLMGTWPFG TILCKIVISI DYYNMFTSIF TLCTMSVDRY IAVCHPVKAL 
DFRTPRNAKI INVCNWILSS AIGLPVMFMA TTKYRQGSID CTLTFSHPTW YWENLLKICV 
FIFAFIMPVL IITVCYGLMI LRLKSVRMLS GSKEKDRNLR RITRMVLVVV AVFIVCWTPI 
HIYVIIKALV TIPETTFQTV SWHFCIALGY TNSCLNPVLY AFLDENFKRC FREFCIPTSS 
NIEQQNSTRI RQNTRDHPST ANTVDRTNHQ NYYIIHRCCC NTPLISQKPV LLWFCD

Genular Protein ID: 3069528402

Symbol: G8XRH5_HUMAN

Name: N/A

UniProtKB Accession Codes:

G8XRH5

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 11 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 11 RuleBase 1 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 462
  • Mass: 51470
  • Checksum: 0F2F037805EF2097
  • Sequence:
    • MSDAQLGPLR LTLLSVSART GFCKKQQELW QRRKEAAEAL GTRKVSVLLA TSHSGARPAV 
STMDSSAAPT NASNCTDALA YSSCSPAPSP GSWVNLSHLD GNLSDPCGPN RTDLGGRDSL 
CPPTGSPSMI TAITIMALYS IVCVVGLFGN FLVMYVIVRY TKMKTATNIY IFNLALADAL 
ATSTLPFQSV NYLMGTWPFG TILCKIVISI DYYNMFTSIF TLCTMSVDRY IAVCHPVKAL 
DFRTPRNAKI INVCNWILSS AIGLPVMFMA TTKYRQGSID CTLTFSHPTW YWENLLKICV 
FIFAFIMPVL IITVCYGLMI LRLKSVRMLS GSKEKDRNLR RITRMVLVVV AVFIVCWTPI 
HIYVIIKALV TIPETTFQTV SWHFCIALGY TNSCLNPVLY AFLDENFKRC FREFCIPTSS 
NIEQQNSTRI RQNTRDHPST ANTVDRTNHQ LENLEAETAP LP

Genular Protein ID: 822125328

Symbol: B8K2Q5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B8K2Q5

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 RefSeq 3 SAM 1 SUPFAM 1

Citations:

PubMed ID: 19077058

Title: Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene.

PubMed ID: 19077058

DOI: 10.1111/j.1471-4159.2008.05833.x

Sequence Information:

  • Length: 115
  • Mass: 12071
  • Checksum: 6D2E8AE9EF7C1C6C
  • Sequence:
    • MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP 
PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALA

Genular Protein ID: 599313361

Symbol: G8XRH4_HUMAN

Name: N/A

UniProtKB Accession Codes:

G8XRH4

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PRINTS 1 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 159
  • Mass: 16634
  • Checksum: 9A03528CCB58F0F9
  • Sequence:
    • MSDAQLGPLR LTLLSVSART GFCKKQQELW QRRKEAAEAL GTRKVSVLLA TSHSGARPAV 
STMDSSAAPT NASNCTDALA YSSCSPAPSP GSWVNLSHLD GNLSDPCGPN RTDLGGRDSL 
CPPTGSPSMI TAITIMALYS IVCVVGLFGN FLVMYVIVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.