Details for: SLC22A18

Gene ID: 5002

Symbol: SLC22A18

Ensembl ID: ENSG00000110628

Description: solute carrier family 22 member 18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 77.3408
    Cell Significance Index: -12.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.6941
    Cell Significance Index: -11.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.0272
    Cell Significance Index: -10.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 24.1453
    Cell Significance Index: -12.4200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 18.1961
    Cell Significance Index: -12.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.5319
    Cell Significance Index: -11.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.7408
    Cell Significance Index: -12.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.7827
    Cell Significance Index: 56.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.5242
    Cell Significance Index: 76.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.1431
    Cell Significance Index: -8.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0866
    Cell Significance Index: -12.1800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.0800
    Cell Significance Index: -9.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.5162
    Cell Significance Index: 114.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.3398
    Cell Significance Index: 67.4200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.2397
    Cell Significance Index: 37.6700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.0034
    Cell Significance Index: 29.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4850
    Cell Significance Index: -3.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3876
    Cell Significance Index: 72.0800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.2212
    Cell Significance Index: 10.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9770
    Cell Significance Index: 13.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9302
    Cell Significance Index: 64.3300
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.8116
    Cell Significance Index: 1.0500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7771
    Cell Significance Index: 13.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7462
    Cell Significance Index: 20.3100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.7132
    Cell Significance Index: 4.6500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5929
    Cell Significance Index: 4.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5721
    Cell Significance Index: 516.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5565
    Cell Significance Index: 14.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4987
    Cell Significance Index: 10.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4333
    Cell Significance Index: 42.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4095
    Cell Significance Index: 9.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3798
    Cell Significance Index: 17.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3737
    Cell Significance Index: 40.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3711
    Cell Significance Index: 27.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3512
    Cell Significance Index: 8.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2959
    Cell Significance Index: 8.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2920
    Cell Significance Index: 10.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2672
    Cell Significance Index: 43.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2669
    Cell Significance Index: 52.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2457
    Cell Significance Index: 7.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2396
    Cell Significance Index: 43.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2217
    Cell Significance Index: 5.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2216
    Cell Significance Index: 42.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1900
    Cell Significance Index: 24.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1870
    Cell Significance Index: 102.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1748
    Cell Significance Index: 3.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1732
    Cell Significance Index: 1.6000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.1720
    Cell Significance Index: 1.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1716
    Cell Significance Index: 21.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1371
    Cell Significance Index: 18.8300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.1180
    Cell Significance Index: 1.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1066
    Cell Significance Index: 3.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1045
    Cell Significance Index: 13.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1026
    Cell Significance Index: 45.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0909
    Cell Significance Index: 6.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0701
    Cell Significance Index: 14.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0606
    Cell Significance Index: 3.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0266
    Cell Significance Index: 1.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0217
    Cell Significance Index: 0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0060
    Cell Significance Index: 11.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0058
    Cell Significance Index: 9.0000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0047
    Cell Significance Index: 0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0034
    Cell Significance Index: 6.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0006
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0051
    Cell Significance Index: -3.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0062
    Cell Significance Index: -8.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0081
    Cell Significance Index: -1.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0093
    Cell Significance Index: -6.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0095
    Cell Significance Index: -6.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0123
    Cell Significance Index: -5.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0141
    Cell Significance Index: -2.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0141
    Cell Significance Index: -1.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0148
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0156
    Cell Significance Index: -11.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0170
    Cell Significance Index: -6.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0194
    Cell Significance Index: -2.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0197
    Cell Significance Index: -11.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0239
    Cell Significance Index: -14.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0327
    Cell Significance Index: -3.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0348
    Cell Significance Index: -10.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0634
    Cell Significance Index: -13.3500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0639
    Cell Significance Index: -0.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0865
    Cell Significance Index: -10.2000
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0922
    Cell Significance Index: -0.5700
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -0.0986
    Cell Significance Index: -0.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1084
    Cell Significance Index: -2.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1088
    Cell Significance Index: -11.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1176
    Cell Significance Index: -4.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1263
    Cell Significance Index: -10.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1404
    Cell Significance Index: -8.6100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1451
    Cell Significance Index: -0.9000
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1725
    Cell Significance Index: -1.8700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1727
    Cell Significance Index: -2.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1770
    Cell Significance Index: -6.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1810
    Cell Significance Index: -4.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1901
    Cell Significance Index: -9.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1925
    Cell Significance Index: -10.8000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1952
    Cell Significance Index: -0.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1961
    Cell Significance Index: -12.3600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1990
    Cell Significance Index: -1.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SLC22A18 is a type II transmembrane protein with 12 transmembrane domains, which allows it to span the plasma membrane and interact with various ligands. Its structure and function are highly conserved across species, suggesting a critical role in maintaining cellular homeostasis. Notably, SLC22A18 exhibits a unique ability to transport a wide range of organic compounds, including monoatomic ions, metal ions, and small molecules, which can be either endogenously produced or exogenously derived. **Pathways and Functions:** SLC22A18 is involved in several key cellular pathways, including: 1. **Xenobiotic Detoxification**: SLC22A18 plays a crucial role in the export of xenobiotics, such as bile salts and organic acids, across the plasma membrane, thereby facilitating their removal from the body. 2. **Organic Cation Transport**: SLC22A18 is responsible for the transport of organic cations, including amino compounds and metal ions, across cell membranes, which is essential for maintaining cellular homeostasis. 3. **Slc-Mediated Transmembrane Transport**: SLC22A18 is a member of the solute carrier family 22, which is involved in the transport of various organic compounds across cell membranes, including small molecules and metal ions. **Clinical Significance:** SLC22A18 has been implicated in several diseases, including: 1. **Lung Cancer**: Mutations in SLC22A18 have been associated with lung cancer, highlighting its potential role as a tumor suppressor gene. 2. **Embryonal Rhabdomyosarcoma 1 (Rmse1)**: SLC22A18 has been linked to embryonal rhabdomyosarcoma 1, a rare type of cancer that affects the muscles. 3. **Disorders of Transmembrane Transporters**: SLC22A18 is involved in the transport of various organic compounds, and its dysfunction can lead to disorders of transmembrane transport, such as impaired xenobiotic detoxification and organic cation transport. In conclusion, SLC22A18 is a critical component of the immune system, involved in the transport of various organic compounds across cell membranes. Its dysfunction has been implicated in several diseases, highlighting the need for further research into its role in immune regulation and disease.

Genular Protein ID: 3750399562

Symbol: S22AI_HUMAN

Name: Solute carrier family 22 member 18

UniProtKB Accession Codes:

Q96BI1 O14906 O43562 O60485 O60680 Q7LDS5 Q7LGF7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 6 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9751628

Title: Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5.

PubMed ID: 9751628

PubMed ID: 9802569

Title: A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice.

PubMed ID: 9802569

DOI: 10.1093/dnares/5.4.235

PubMed ID: 9570947

Title: Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain.

PubMed ID: 9570947

DOI: 10.1006/geno.1998.5221

PubMed ID: 9499412

Title: IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes.

PubMed ID: 9499412

DOI: 10.1093/hmg/7.4.597

PubMed ID: 9520460

Title: Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples.

PubMed ID: 9520460

DOI: 10.1073/pnas.95.7.3873

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9744804

Title: Functional characterization of ORCTL2 -- an organic cation transporter expressed in the renal proximal tubules.

PubMed ID: 9744804

DOI: 10.1016/s0014-5793(98)00907-7

PubMed ID: 16314844

Title: Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105.

PubMed ID: 16314844

DOI: 10.1038/sj.onc.1209167

Sequence Information:

  • Length: 424
  • Mass: 44846
  • Checksum: 9EFD5F902A77A6E8
  • Sequence:
    • MQGARAPRDQ GRSPGRMSAL GRSSVILLTY VLAATELTCL FMQFSIVPYL SRKLGLDSIA 
FGYLQTTFGV LQLLGGPVFG RFADQRGARA ALTLSFLAAL ALYLLLAAAS SPALPGVYLL 
FASRLPGALM HTLPAAQMVI TDLSAPEERP AALGRLGLCF GVGVILGSLL GGTLVSAYGI 
QCPAILAALA TLLGAVLSFT CIPASTKGAK TDAQAPLPGG PRASVFDLKA IASLLRLPDV 
PRIFLVKVAS NCPTGLFMVM FSIISMDFFQ LEAAQAGYLM SFFGLLQMVT QGLVIGQLSS 
HFSEEVLLRA SVLVFIVVGL AMAWMSSVFH FCLLVPGLVF SLCTLNVVTD SMLIKAVSTS 
DTGTMLGLCA SVQPLLRTLG PTVGGLLYRS FGVPVFGHVQ VAINTLVLLV LWRKPMPQRK 
DKVR

Genular Protein ID: 1516152992

Symbol: E9PRM7_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PRM7

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 326
  • Mass: 34953
  • Checksum: 1B23DCCB0BAE3FCA
  • Sequence:
    • MQGARAPRDQ GRSPGRMSAL GRSSVILLTY VLAATELTCL FMQFSIVPYL SRKLGLDSIA 
FGYLQTTFGV LQLLGGPVFG RIQCPAILAA LATLLGAVLS FTCIPASTKG AKTDAQAPLP 
GGPRASVFDL KAIASLLRLP DVPRIFLVKV ASNCPTGLFM VMFSIISMDF FQLEAAQAGY 
LMSFFGLLQM VTQGLVIGQL SSHFSEEVLL RASVLVFIVV GLAMAWMSSV FHFCLLVPGL 
VFSLCTLNVV TDSMLIKAVS TSDTGTMLGL CASVQPLLRT LGPTVGGLLY RSFGVPVFGH 
VQVAINTLVL LVLWRKPMPQ RKDKVR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.