Details for: CD207

Gene ID: 50489

Symbol: CD207

Ensembl ID: ENSG00000116031

Description: CD207 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.0466
    Cell Significance Index: 34.9900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.2010
    Cell Significance Index: 15.5400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.6384
    Cell Significance Index: 8.7600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0013
    Cell Significance Index: 0.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0002
    Cell Significance Index: -0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0046
    Cell Significance Index: -8.6600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0058
    Cell Significance Index: -0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0068
    Cell Significance Index: -4.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0078
    Cell Significance Index: -14.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0091
    Cell Significance Index: -13.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0113
    Cell Significance Index: -5.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0118
    Cell Significance Index: -8.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0150
    Cell Significance Index: -0.7000
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0169
    Cell Significance Index: -0.2900
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0186
    Cell Significance Index: -0.1700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0190
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0258
    Cell Significance Index: -4.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0287
    Cell Significance Index: -1.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0342
    Cell Significance Index: -4.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0353
    Cell Significance Index: -5.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0355
    Cell Significance Index: -0.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0410
    Cell Significance Index: -0.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0421
    Cell Significance Index: -8.4500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0435
    Cell Significance Index: -0.4300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0435
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0455
    Cell Significance Index: -5.2100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0491
    Cell Significance Index: -0.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0515
    Cell Significance Index: -5.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0556
    Cell Significance Index: -11.0300
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0589
    Cell Significance Index: -0.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0644
    Cell Significance Index: -4.0600
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0731
    Cell Significance Index: -0.7000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0928
    Cell Significance Index: -1.1300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0964
    Cell Significance Index: -0.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1212
    Cell Significance Index: -8.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1486
    Cell Significance Index: -8.3400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1587
    Cell Significance Index: -2.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1602
    Cell Significance Index: -7.5300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1716
    Cell Significance Index: -1.7800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1911
    Cell Significance Index: -4.6300
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.1914
    Cell Significance Index: -1.4600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1963
    Cell Significance Index: -3.1800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1990
    Cell Significance Index: -3.3800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.2025
    Cell Significance Index: -2.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2034
    Cell Significance Index: -2.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2063
    Cell Significance Index: -10.8300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2163
    Cell Significance Index: -5.5100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2204
    Cell Significance Index: -4.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2383
    Cell Significance Index: -10.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2421
    Cell Significance Index: -8.4800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2489
    Cell Significance Index: -3.6400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2668
    Cell Significance Index: -3.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2721
    Cell Significance Index: -8.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2747
    Cell Significance Index: -8.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2789
    Cell Significance Index: -10.5600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2979
    Cell Significance Index: -5.9400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.3176
    Cell Significance Index: -3.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3329
    Cell Significance Index: -9.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3356
    Cell Significance Index: -12.3200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3431
    Cell Significance Index: -3.9800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3556
    Cell Significance Index: -8.8700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3647
    Cell Significance Index: -9.1100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3674
    Cell Significance Index: -4.7200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3896
    Cell Significance Index: -4.6000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3951
    Cell Significance Index: -8.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4020
    Cell Significance Index: -7.4300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4064
    Cell Significance Index: -8.7800
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.4079
    Cell Significance Index: -4.2200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4125
    Cell Significance Index: -8.6100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4243
    Cell Significance Index: -9.0100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.4330
    Cell Significance Index: -0.9800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4359
    Cell Significance Index: -8.5800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.4390
    Cell Significance Index: -5.9200
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.4417
    Cell Significance Index: -4.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4483
    Cell Significance Index: -9.0000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4494
    Cell Significance Index: -7.2100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.4548
    Cell Significance Index: -4.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4552
    Cell Significance Index: -9.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4681
    Cell Significance Index: -5.5800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.4776
    Cell Significance Index: -3.8000
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.4850
    Cell Significance Index: -5.3000
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.4915
    Cell Significance Index: -5.3000
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.4930
    Cell Significance Index: -5.7300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4964
    Cell Significance Index: -4.6600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.4981
    Cell Significance Index: -7.2600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.5056
    Cell Significance Index: -6.0100
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.5150
    Cell Significance Index: -4.9600
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.5172
    Cell Significance Index: -5.4400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5228
    Cell Significance Index: -9.0400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.5239
    Cell Significance Index: -6.1600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.5277
    Cell Significance Index: -4.4600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.5289
    Cell Significance Index: -6.2500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.5342
    Cell Significance Index: -7.0100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.5342
    Cell Significance Index: -6.7100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.5381
    Cell Significance Index: -5.9600
  • Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
    Fold Change: -0.5390
    Cell Significance Index: -5.5100
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.5405
    Cell Significance Index: -6.2000
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.5406
    Cell Significance Index: -5.6800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5573
    Cell Significance Index: -12.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5593
    Cell Significance Index: -8.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular expression:** CD207 is expressed in a wide range of cell types, including hematopoietic stem cells, precursor B cells, and epithelial cells from various tissues, such as the fallopian tube, hair follicle, and anterior lens. 2. **Antigen processing and presentation:** CD207 is involved in the process of antigen processing and presentation, particularly in the context of Class I MHC-mediated antigen presentation. 3. **D-mannose binding:** The protein exhibits D-mannose binding properties, which enable it to recognize and bind to carbohydrate-based antigens. 4. **Cross-presentation:** CD207 facilitates the cross-presentation of soluble exogenous antigens, which is a crucial process for initiating an immune response against viral infections and other pathogens. **Pathways and Functions:** 1. **Adaptive immune system:** CD207 plays a crucial role in the adaptive immune system, particularly in the context of antigen processing and presentation. 2. **Antigen processing-cross presentation:** The protein is involved in the process of antigen processing and cross-presentation, which is essential for initiating an immune response against viral infections and other pathogens. 3. **Carbohydrate binding:** CD207 exhibits D-mannose binding properties, which enable it to recognize and bind to carbohydrate-based antigens. 4. **Immune response:** The protein plays a crucial role in the immune response, particularly in the context of antigen processing and presentation. **Clinical Significance:** 1. **Viral infections:** CD207 is involved in the process of cross-presentation of soluble exogenous antigens, which is essential for initiating an immune response against viral infections. 2. **Cancer immunotherapy:** The protein may play a role in cancer immunotherapy, particularly in the context of antigen processing and presentation. 3. **Autoimmune diseases:** CD207 may also play a role in autoimmune diseases, particularly in the context of antigen processing and presentation. 4. **Infectious diseases:** The protein may be involved in the immune response against infectious diseases, particularly in the context of antigen processing and presentation. In conclusion, CD207 is a crucial gene in the immune system, involved in antigen processing and presentation, particularly in the context of Class I MHC-mediated antigen presentation. The protein exhibits D-mannose binding properties, which enable it to recognize and bind to carbohydrate-based antigens, facilitating the cross-presentation of soluble exogenous antigens. The clinical significance of CD207 lies in its involvement in the immune response against viral infections, cancer immunotherapy, autoimmune diseases, and infectious diseases. Further research is needed to fully understand the role of CD207 in the immune system and its potential applications in immunotherapy.

Genular Protein ID: 1086790385

Symbol: CLC4K_HUMAN

Name: C-type lectin domain family 4 member K

UniProtKB Accession Codes:

Q9UJ71

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 1 Ensembl 1 EvolutionaryTrace 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 22 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10661407

Title: Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules.

PubMed ID: 10661407

DOI: 10.1016/s1074-7613(00)80160-0

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12626394

Title: Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cells.

PubMed ID: 12626394

DOI: 10.1093/glycob/cwg045

PubMed ID: 14610287

Title: Langerin/CD207 sheds light on formation of Birbeck granules and their possible function in Langerhans cells.

PubMed ID: 14610287

DOI: 10.1385/ir:28:2:93

PubMed ID: 17334373

Title: Langerin is a natural barrier to HIV-1 transmission by Langerhans cells.

PubMed ID: 17334373

DOI: 10.1038/nm1541

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20026605

Title: Dual specificity of langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain.

PubMed ID: 20026605

DOI: 10.1074/jbc.m109.041863

PubMed ID: 20097424

Title: C-type lectin Langerin is a beta-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi.

PubMed ID: 20097424

DOI: 10.1016/j.molimm.2009.12.016

PubMed ID: 19175323

Title: Structural studies of langerin and Birbeck granule: a macromolecular organization model.

PubMed ID: 19175323

DOI: 10.1021/bi802151w

PubMed ID: 15816828

Title: A lack of Birbeck granules in Langerhans cells is associated with a naturally occurring point mutation in the human Langerin gene.

PubMed ID: 15816828

DOI: 10.1111/j.0022-202x.2005.23645.x

PubMed ID: 16567809

Title: Polymorphisms in human langerin affect stability and sugar binding activity.

PubMed ID: 16567809

DOI: 10.1074/jbc.m511502200

Sequence Information:

  • Length: 328
  • Mass: 36725
  • Checksum: 83DF432682BF4B62
  • Sequence:
    • MTVEKEAPDA HFTVDKQNIS LWPREPPPKS GPSLVPGKTP TVRAALICLT LVLVASVLLQ 
AVLYPRFMGT ISDVKTNVQL LKGRVDNIST LDSEIKKNSD GMEAAGVQIQ MVNESLGYVR 
SQFLKLKTSV EKANAQIQIL TRSWEEVSTL NAQIPELKSD LEKASALNTK IRALQGSLEN 
MSKLLKRQND ILQVVSQGWK YFKGNFYYFS LIPKTWYSAE QFCVSRNSHL TSVTSESEQE 
FLYKTAGGLI YWIGLTKAGM EGDWSWVDDT PFNKVQSVRF WIPGEPNNAG NNEHCGNIKA 
PSLQAWNDAP CDKTFLFICK RPYVPSEP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.