Details for: SERPINA10

Gene ID: 51156

Symbol: SERPINA10

Ensembl ID: ENSG00000140093

Description: serpin family A member 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 8.2827
    Cell Significance Index: 139.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 5.3652
    Cell Significance Index: 188.5300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.8249
    Cell Significance Index: 56.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.6917
    Cell Significance Index: 58.3200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 2.1275
    Cell Significance Index: 32.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.0573
    Cell Significance Index: 126.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8205
    Cell Significance Index: 346.4500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.1072
    Cell Significance Index: 18.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8397
    Cell Significance Index: 38.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6376
    Cell Significance Index: 13.5800
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.5161
    Cell Significance Index: 4.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4969
    Cell Significance Index: 29.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4803
    Cell Significance Index: 95.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3932
    Cell Significance Index: 38.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3613
    Cell Significance Index: 39.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3129
    Cell Significance Index: 282.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2197
    Cell Significance Index: 35.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1789
    Cell Significance Index: 12.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1291
    Cell Significance Index: 80.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1180
    Cell Significance Index: 1.6900
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.1150
    Cell Significance Index: 1.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1011
    Cell Significance Index: 1.3800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1000
    Cell Significance Index: 1.2600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0773
    Cell Significance Index: 0.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0204
    Cell Significance Index: 0.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0181
    Cell Significance Index: 12.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0061
    Cell Significance Index: 0.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0045
    Cell Significance Index: 0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0036
    Cell Significance Index: 2.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0016
    Cell Significance Index: 2.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0007
    Cell Significance Index: 1.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0001
    Cell Significance Index: 0.0800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0017
    Cell Significance Index: -0.9400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0027
    Cell Significance Index: -0.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0027
    Cell Significance Index: -1.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0050
    Cell Significance Index: -1.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0052
    Cell Significance Index: -2.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0055
    Cell Significance Index: -1.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0057
    Cell Significance Index: -3.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0069
    Cell Significance Index: -1.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0074
    Cell Significance Index: -3.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0079
    Cell Significance Index: -0.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0094
    Cell Significance Index: -0.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0099
    Cell Significance Index: -2.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0100
    Cell Significance Index: -2.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0149
    Cell Significance Index: -0.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0158
    Cell Significance Index: -0.4300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0183
    Cell Significance Index: -0.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0203
    Cell Significance Index: -2.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0206
    Cell Significance Index: -3.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0210
    Cell Significance Index: -0.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0222
    Cell Significance Index: -3.0500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0236
    Cell Significance Index: -0.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0264
    Cell Significance Index: -3.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0294
    Cell Significance Index: -3.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0303
    Cell Significance Index: -3.1500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0316
    Cell Significance Index: -1.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0349
    Cell Significance Index: -2.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0454
    Cell Significance Index: -2.3600
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0461
    Cell Significance Index: -0.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0484
    Cell Significance Index: -2.1400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0504
    Cell Significance Index: -1.2600
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0506
    Cell Significance Index: -0.5100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0535
    Cell Significance Index: -0.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0549
    Cell Significance Index: -2.0800
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0572
    Cell Significance Index: -0.6800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0603
    Cell Significance Index: -0.5600
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0606
    Cell Significance Index: -0.6700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0610
    Cell Significance Index: -0.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0618
    Cell Significance Index: -0.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0621
    Cell Significance Index: -2.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0624
    Cell Significance Index: -3.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0661
    Cell Significance Index: -1.7700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0678
    Cell Significance Index: -0.9400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0728
    Cell Significance Index: -1.2000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0733
    Cell Significance Index: -0.6500
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0756
    Cell Significance Index: -0.8300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0783
    Cell Significance Index: -1.0400
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0822
    Cell Significance Index: -0.9200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0823
    Cell Significance Index: -1.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0833
    Cell Significance Index: -3.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0836
    Cell Significance Index: -2.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0869
    Cell Significance Index: -2.8500
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0921
    Cell Significance Index: -0.5700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0955
    Cell Significance Index: -0.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0958
    Cell Significance Index: -1.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0958
    Cell Significance Index: -3.0500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1046
    Cell Significance Index: -1.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1054
    Cell Significance Index: -3.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1055
    Cell Significance Index: -2.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1060
    Cell Significance Index: -2.7000
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1072
    Cell Significance Index: -0.9800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1105
    Cell Significance Index: -1.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1146
    Cell Significance Index: -3.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1186
    Cell Significance Index: -2.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1198
    Cell Significance Index: -3.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1213
    Cell Significance Index: -2.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serpin Family Member:** SERPINA10 belongs to the serpin family, which is characterized by its ability to inhibit serine proteases, thereby regulating proteolytic activity. 2. **Negative Regulation of Endopeptidase Activity:** SERPINA10 has been shown to negatively regulate endopeptidase activity, which is crucial in maintaining protein homeostasis and preventing excessive proteolysis. 3. **Heparin Binding:** The SERPINA10 protein exhibits heparin binding properties, which may contribute to its role in regulating proteolytic activity and protein metabolism. 4. **Significantly Expressed in Various Tissues:** SERPINA10 is significantly expressed in various tissues, including the liver, small intestine, and colon, where it influences the function of hepatoblasts, Paneth cells, and enteroendocrine cells. **Pathways and Functions:** 1. **Blood Coagulation:** SERPINA10 may play a role in regulating blood coagulation by inhibiting proteolytic activity. 2. **Endoplasmic Reticulum Lumen:** SERPINA10 is localized to the endoplasmic reticulum lumen, where it regulates protein metabolism and quality control. 3. **Extracellular Exosome:** SERPINA10 has been shown to be associated with extracellular exosomes, which are involved in intercellular communication and protein transport. 4. **Protein Binding:** SERPINA10 has been shown to bind to protein Z-dependent protease inhibitor, suggesting its involvement in the regulation of proteolytic activity. 5. **Regulation of Acrosome Reaction:** SERPINA10 may play a role in regulating the acrosome reaction, which is a crucial step in fertilization. **Clinical Significance:** 1. **Liver Disease:** SERPINA10 may play a role in liver disease, particularly in the regulation of protein metabolism and endoplasmic reticulum lumen. 2. **Gastrointestinal Disorders:** SERPINA10 may be involved in gastrointestinal disorders, such as inflammatory bowel disease and colorectal cancer, where its expression is altered. 3. **Endocrine Function:** SERPINA10 may play a role in regulating endocrine function, particularly in the regulation of insulin-like growth factor (IGF) transport and uptake by IGF binding proteins (IGFBPs). 4. **Protein Metabolism Disorders:** SERPINA10 may be involved in protein metabolism disorders, such as proteoporosis, where its expression is altered. In conclusion, SERPINA10 is a critical regulator of protein metabolism and endocrine function, and its dysregulation may contribute to various diseases, including liver disease, gastrointestinal disorders, and endocrine dysfunction. Further studies are required to fully elucidate the role of SERPINA10 in human health and disease.

Genular Protein ID: 2749391498

Symbol: ZPI_HUMAN

Name: Protein Z-dependent protease inhibitor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10460162

Title: The protein Z-dependent protease inhibitor is a serpin.

PubMed ID: 10460162

DOI: 10.1021/bi990641a

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9689066

Title: Isolation of a protein Z-dependent plasma protease inhibitor.

PubMed ID: 9689066

DOI: 10.1073/pnas.95.16.9250

PubMed ID: 11049983

Title: Characterization of the protein Z-dependent protease inhibitor.

PubMed ID: 11049983

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22540147

Title: Characterization of the heparin-binding site of the protein z-dependent protease inhibitor.

PubMed ID: 22540147

DOI: 10.1021/bi300353c

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 19528533

Title: Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X.

PubMed ID: 19528533

DOI: 10.1182/blood-2009-04-210021

PubMed ID: 20427285

Title: Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa.

PubMed ID: 20427285

DOI: 10.1074/jbc.m110.112748

PubMed ID: 23375655

Title: Identification of mutations in SLC24A4, encoding a potassium-dependent sodium/calcium exchanger, as a cause of amelogenesis imperfecta.

PubMed ID: 23375655

DOI: 10.1016/j.ajhg.2013.01.003

Sequence Information:

  • Length: 444
  • Mass: 50707
  • Checksum: 06BD47C97BBDD700
  • Sequence:
  • MKVVPSLLLS VLLAQVWLVP GLAPSPQSPE TPAPQNQTSR VVQAPKEEEE DEQEASEEKA 
    SEEEKAWLMA SRQQLAKETS NFGFSLLRKI SMRHDGNMVF SPFGMSLAMT GLMLGATGPT 
    ETQIKRGLHL QALKPTKPGL LPSLFKGLRE TLSRNLELGL TQGSFAFIHK DFDVKETFFN 
    LSKRYFDTEC VPMNFRNASQ AKRLMNHYIN KETRGKIPKL FDEINPETKL ILVDYILFKG 
    KWLTPFDPVF TEVDTFHLDK YKTIKVPMMY GAGKFASTFD KNFRCHVLKL PYQGNATMLV 
    VLMEKMGDHL ALEDYLTTDL VETWLRNMKT RNMEVFFPKF KLDQKYEMHE LLRQMGIRRI 
    FSPFADLSEL SATGRNLQVS RVLQRTVIEV DERGTEAVAG ILSEITAYSM PPVIKVDRPF 
    HFMIYEETSG MLLFLGRVVN PTLL

Genular Protein ID: 1506186197

Symbol: G3V2W1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 484
  • Mass: 55114
  • Checksum: A635D581DA23E361
  • Sequence:
  • MSRSTQELLG YHCRLQDKLQ EQEGSLAAEG RHSLASAADH MKVVPSLLLS VLLAQVWLVP 
    GLAPSPQSPE TPAPQNQTSR VVQAPKEEEE DEQEASEEKA SEEEKAWLMA SRQQLAKETS 
    NFGFSLLRKI SMRHDGNMVF SPFGMSLAMT GLMLGATGPT ETQIKRGLHL QALKPTKPGL 
    LPSLFKGLRE TLSRNLELGL TQGSFAFIHK DFDVKETFFN LSKRYFDTEC VPMNFRNASQ 
    AKRLMNHYIN KETRGKIPKL FDEINPETKL ILVDYILFKG KWLTPFDPVF TEVDTFHLDK 
    YKTIKVPMMY GAGKFASTFD KNFRCHVLKL PYQGNATMLV VLMEKMGDHL ALEDYLTTDL 
    VETWLRNMKT RNMEVFFPKF KLDQKYEMHE LLRQMGIRRI FSPFADLSEL SATGRNLQVS 
    RVLQRTVIEV DERGTEAVAG ILSEITAYSM PPVIKVDRPF HFMIYEETSG MLLFLGRVVN 
    PTLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.