Details for: NAGPA

Gene ID: 51172

Symbol: NAGPA

Ensembl ID: ENSG00000103174

Description: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 79.1410
    Cell Significance Index: -12.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.4288
    Cell Significance Index: -12.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.9810
    Cell Significance Index: -12.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 29.2932
    Cell Significance Index: -13.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 26.6921
    Cell Significance Index: -13.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.7574
    Cell Significance Index: -12.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.5762
    Cell Significance Index: -13.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.2779
    Cell Significance Index: -11.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3553
    Cell Significance Index: -13.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.9986
    Cell Significance Index: -9.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.4383
    Cell Significance Index: 464.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2084
    Cell Significance Index: 242.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1490
    Cell Significance Index: 113.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.0043
    Cell Significance Index: 28.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7764
    Cell Significance Index: 46.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6804
    Cell Significance Index: 14.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6412
    Cell Significance Index: 24.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6153
    Cell Significance Index: 100.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6010
    Cell Significance Index: 26.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4721
    Cell Significance Index: 31.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3949
    Cell Significance Index: 78.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3713
    Cell Significance Index: 25.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3553
    Cell Significance Index: 22.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2860
    Cell Significance Index: 7.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2540
    Cell Significance Index: 4.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2336
    Cell Significance Index: 10.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2293
    Cell Significance Index: 82.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2169
    Cell Significance Index: 6.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2090
    Cell Significance Index: 5.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1365
    Cell Significance Index: 7.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1009
    Cell Significance Index: 91.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0978
    Cell Significance Index: 67.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0921
    Cell Significance Index: 40.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0873
    Cell Significance Index: 15.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0800
    Cell Significance Index: 10.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0779
    Cell Significance Index: 42.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0632
    Cell Significance Index: 1.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0618
    Cell Significance Index: 7.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0594
    Cell Significance Index: 4.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0576
    Cell Significance Index: 1.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0555
    Cell Significance Index: 2.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0220
    Cell Significance Index: 2.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0077
    Cell Significance Index: 0.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0013
    Cell Significance Index: 2.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0021
    Cell Significance Index: -2.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0030
    Cell Significance Index: -0.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0038
    Cell Significance Index: -0.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0043
    Cell Significance Index: -6.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0095
    Cell Significance Index: -6.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0130
    Cell Significance Index: -1.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0132
    Cell Significance Index: -8.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0140
    Cell Significance Index: -10.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0156
    Cell Significance Index: -11.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0161
    Cell Significance Index: -0.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0175
    Cell Significance Index: -7.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0222
    Cell Significance Index: -12.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0239
    Cell Significance Index: -14.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0254
    Cell Significance Index: -0.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0303
    Cell Significance Index: -0.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0319
    Cell Significance Index: -2.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0376
    Cell Significance Index: -10.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0398
    Cell Significance Index: -6.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0428
    Cell Significance Index: -1.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0477
    Cell Significance Index: -5.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0493
    Cell Significance Index: -3.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0500
    Cell Significance Index: -7.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0526
    Cell Significance Index: -0.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0532
    Cell Significance Index: -6.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0538
    Cell Significance Index: -1.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0595
    Cell Significance Index: -1.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0618
    Cell Significance Index: -1.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0651
    Cell Significance Index: -1.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0693
    Cell Significance Index: -14.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0796
    Cell Significance Index: -9.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0937
    Cell Significance Index: -4.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0983
    Cell Significance Index: -2.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0994
    Cell Significance Index: -7.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1025
    Cell Significance Index: -3.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1210
    Cell Significance Index: -12.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1215
    Cell Significance Index: -3.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1305
    Cell Significance Index: -8.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1376
    Cell Significance Index: -8.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1452
    Cell Significance Index: -2.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1602
    Cell Significance Index: -12.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1658
    Cell Significance Index: -3.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1661
    Cell Significance Index: -9.3200
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.1773
    Cell Significance Index: -1.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1778
    Cell Significance Index: -5.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1976
    Cell Significance Index: -4.2700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2086
    Cell Significance Index: -1.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2192
    Cell Significance Index: -11.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2284
    Cell Significance Index: -8.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2346
    Cell Significance Index: -6.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2396
    Cell Significance Index: -4.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2483
    Cell Significance Index: -3.7200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2802
    Cell Significance Index: -5.5400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2821
    Cell Significance Index: -4.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2886
    Cell Significance Index: -7.2000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2942
    Cell Significance Index: -2.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NAGPA is a phosphodiesterase enzyme that specifically hydrolyzes the N-acetylglucosamine-1-phosphodiester bond in glycosaminoglycans and glycoproteins. This enzyme is characterized by its ability to regulate the levels of N-acetylglucosamine-1-phosphodiester, a key intermediate in the glycosylation process. NAGPA is also involved in the degradation of glycosaminoglycans and the regulation of protein targeting to lysosomes. The enzyme's activity is tightly regulated, and its dysregulation has been implicated in various diseases, including cancer and neurodegenerative disorders. **Pathways and Functions:** NAGPA is involved in several key pathways, including: 1. **Carbohydrate Metabolic Process:** NAGPA plays a crucial role in the regulation of glycosaminoglycan metabolism, which is essential for maintaining cellular homeostasis. 2. **Golgi Cisterna Membrane:** NAGPA is involved in the modification of glycoproteins and lipids within the Golgi apparatus, which is essential for protein targeting and secretion. 3. **Lysosome Organization:** NAGPA regulates the degradation of glycosaminoglycans and the targeting of proteins to lysosomes, which is essential for maintaining cellular homeostasis. 4. **Protein Modification Process:** NAGPA is involved in the modification of proteins through glycosylation, which is essential for protein function and stability. 5. **Protein Targeting to Lysosome:** NAGPA regulates the targeting of proteins to lysosomes, which is essential for maintaining cellular homeostasis and function. **Clinical Significance:** Dysregulation of NAGPA has been implicated in various diseases, including: 1. **Cancer:** NAGPA dysregulation has been implicated in the development and progression of various cancers, including colorectal and breast cancer. 2. **Neurodegenerative Disorders:** NAGPA dysregulation has been implicated in the development and progression of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. **Immunological Disorders:** NAGPA dysregulation has been implicated in the development and progression of immunological disorders, including autoimmune diseases and transplant rejection. In conclusion, NAGPA is a crucial enzyme involved in the regulation of glycosylation processes within cells. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the role of NAGPA in maintaining cellular homeostasis and function.

Genular Protein ID: 1703274182

Symbol: NAGPA_HUMAN

Name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

UniProtKB Accession Codes:

Q9UK23 B2RAS1 Q96EJ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 6 Ensembl 4 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 1 Rhea 3 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10551838

Title: Molecular cloning and functional expression of two splice forms of human N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase.

PubMed ID: 10551838

DOI: 10.1074/jbc.274.46.32778

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12058031

Title: Human mannose 6-phosphate-uncovering enzyme is synthesized as a proenzyme that is activated by the endoprotease furin.

PubMed ID: 12058031

DOI: 10.1074/jbc.m202369200

PubMed ID: 20147709

Title: Mutations in the lysosomal enzyme-targeting pathway and persistent stuttering.

PubMed ID: 20147709

DOI: 10.1056/nejmoa0902630

PubMed ID: 23572527

Title: Structure and function of the DUF2233 domain in bacteria and in the human mannose 6-phosphate uncovering enzyme.

PubMed ID: 23572527

DOI: 10.1074/jbc.m112.434977

PubMed ID: 26544806

Title: Association between rare variants in AP4E1, a component of intracellular trafficking, and persistent stuttering.

PubMed ID: 26544806

DOI: 10.1016/j.ajhg.2015.10.007

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 515
  • Mass: 56073
  • Checksum: 9B80335E7F9DBAA9
  • Sequence:
    • MATSTGRWLL LRLALFGFLW EASGGLDSGA SRDDDLLLPY PRARARLPRD CTRVRAGNRE 
HESWPPPPAT PGAGGLAVRT FVSHFRDRAV AGHLTRAVEP LRTFSVLEPG GPGGCAARRR 
ATVEETARAA DCRVAQNGGF FRMNSGECLG NVVSDERRVS SSGGLQNAQF GIRRDGTLVT 
GYLSEEEVLD TENPFVQLLS GVVWLIRNGS IYINESQATE CDETQETGSF SKFVNVISAR 
TAIGHDRKGQ LVLFHADGQT EQRGINLWEM AEFLLKQDVV NAINLDGGGS ATFVLNGTLA 
SYPSDHCQDN MWRCPRQVST VVCVHEPRCQ PPDCHGHGTC VDGHCQCTGH FWRGPGCDEL 
DCGPSNCSQH GLCTETGCRC DAGWTGSNCS EECPLGWHGP GCQRPCKCEH HCPCDPKTGN 
CSVSRVKQCL QPPEATLRAG ELSFFTRTAW LALTLALAFL LLISTAANLS LLLSRAERNR 
RLHGDYAYHP LQEMNGEPLA AEKEQPGGAH NPFKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.