Details for: TUBD1

Gene ID: 51174

Symbol: TUBD1

Ensembl ID: ENSG00000108423

Description: tubulin delta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 108.5858
    Cell Significance Index: -16.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 66.8261
    Cell Significance Index: -16.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.3185
    Cell Significance Index: -15.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.7045
    Cell Significance Index: -18.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.1705
    Cell Significance Index: -16.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6730
    Cell Significance Index: -18.4400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0186
    Cell Significance Index: -8.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9216
    Cell Significance Index: 91.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8110
    Cell Significance Index: 160.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7643
    Cell Significance Index: 690.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5680
    Cell Significance Index: 7.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5421
    Cell Significance Index: 63.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5255
    Cell Significance Index: 57.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5172
    Cell Significance Index: 84.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5136
    Cell Significance Index: 103.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4544
    Cell Significance Index: 11.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4351
    Cell Significance Index: 26.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4169
    Cell Significance Index: 31.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3823
    Cell Significance Index: 72.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2854
    Cell Significance Index: 102.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2843
    Cell Significance Index: 196.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2691
    Cell Significance Index: 9.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2503
    Cell Significance Index: 17.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2481
    Cell Significance Index: 12.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2305
    Cell Significance Index: 101.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2268
    Cell Significance Index: 5.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2032
    Cell Significance Index: 5.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1602
    Cell Significance Index: 4.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1410
    Cell Significance Index: 18.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1345
    Cell Significance Index: 8.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1333
    Cell Significance Index: 24.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1206
    Cell Significance Index: 14.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1152
    Cell Significance Index: 62.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1086
    Cell Significance Index: 14.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1079
    Cell Significance Index: 5.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1069
    Cell Significance Index: 4.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0734
    Cell Significance Index: 4.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0584
    Cell Significance Index: 2.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0581
    Cell Significance Index: 2.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0571
    Cell Significance Index: 2.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0455
    Cell Significance Index: 1.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0324
    Cell Significance Index: 60.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0259
    Cell Significance Index: 1.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0230
    Cell Significance Index: 10.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0146
    Cell Significance Index: 9.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0112
    Cell Significance Index: 20.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0112
    Cell Significance Index: 17.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0069
    Cell Significance Index: 0.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0067
    Cell Significance Index: 0.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0025
    Cell Significance Index: -3.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0133
    Cell Significance Index: -9.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0137
    Cell Significance Index: -0.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0172
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0201
    Cell Significance Index: -3.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0206
    Cell Significance Index: -15.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0217
    Cell Significance Index: -16.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0219
    Cell Significance Index: -3.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0271
    Cell Significance Index: -15.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0333
    Cell Significance Index: -20.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0386
    Cell Significance Index: -4.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0475
    Cell Significance Index: -6.1400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0477
    Cell Significance Index: -1.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0500
    Cell Significance Index: -14.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0558
    Cell Significance Index: -3.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0730
    Cell Significance Index: -3.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0737
    Cell Significance Index: -4.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0741
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0816
    Cell Significance Index: -9.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0878
    Cell Significance Index: -1.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0891
    Cell Significance Index: -9.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0933
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0957
    Cell Significance Index: -20.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0986
    Cell Significance Index: -6.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0997
    Cell Significance Index: -7.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1328
    Cell Significance Index: -1.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1468
    Cell Significance Index: -15.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1582
    Cell Significance Index: -7.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1825
    Cell Significance Index: -3.8200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1938
    Cell Significance Index: -3.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1973
    Cell Significance Index: -6.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1979
    Cell Significance Index: -15.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2174
    Cell Significance Index: -13.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2210
    Cell Significance Index: -4.8400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2495
    Cell Significance Index: -4.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2644
    Cell Significance Index: -13.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2781
    Cell Significance Index: -7.1100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3205
    Cell Significance Index: -7.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3465
    Cell Significance Index: -9.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3523
    Cell Significance Index: -11.2200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3607
    Cell Significance Index: -5.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3809
    Cell Significance Index: -12.4700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3890
    Cell Significance Index: -14.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3926
    Cell Significance Index: -13.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3994
    Cell Significance Index: -11.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4100
    Cell Significance Index: -12.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4236
    Cell Significance Index: -4.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4236
    Cell Significance Index: -11.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4287
    Cell Significance Index: -5.1100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.4348
    Cell Significance Index: -4.6200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4368
    Cell Significance Index: -9.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Microtubule composition:** TUBD1 is a delta-1 tubulin subunit, which is one of the five types of tubulin subunits that make up microtubules. Microtubules are dynamic structures composed of tubulin dimers, and their stability and dynamics are crucial for maintaining cellular homeostasis. 2. **Cellular localization:** TUBD1 is expressed in various cell types, including hematopoietic cells, epithelial cells, and neural cells. Its expression is often associated with specific cellular functions, such as cell migration and differentiation. 3. **Post-translational modifications:** TUBD1 undergoes various post-translational modifications, including tyrosination, detyrosination, and acetylation, which regulate its microtubule-binding properties and cellular activity. **Pathways and Functions:** 1. **Microtubule organization:** TUBD1 plays a critical role in regulating microtubule dynamics and organization. Its interactions with other microtubule-associated proteins (MAPs) and the microtubule-associated protein 4 (MAP4) regulate microtubule stability and dynamics. 2. **Cell division:** TUBD1 is essential for maintaining microtubule stability during cell division, ensuring proper spindle formation and chromosome segregation. 3. **Cell migration:** TUBD1 is involved in regulating cell migration through the modulation of microtubule dynamics and the formation of filopodia and lamellipodia. 4. **Signaling pathways:** TUBD1 interacts with various signaling molecules, including Smoothened (SMO), and regulates the positive regulation of SMO signaling pathway, which is involved in cellular development and homeostasis. **Clinical Significance:** 1. **Cancer:** Abnormal expression of TUBD1 has been observed in various types of cancer, including leukemia, lymphoma, and colon cancer. Its dysregulation may contribute to cancer progression and metastasis. 2. **Neurological disorders:** TUBD1 mutations have been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, highlighting the importance of microtubule dynamics in maintaining neuronal health. 3. **Immune system:** TUBD1 is expressed in immune cells, including T cells and dendritic cells, and its dysregulation may contribute to immune dysfunction and autoimmune diseases. In conclusion, TUBD1 is a critical component of the microtubule cytoskeleton, playing a central role in regulating cellular structure and function. Its dysregulation has significant implications for various human diseases, highlighting the importance of further research into the molecular mechanisms underlying TUBD1 function.

Genular Protein ID: 3158654613

Symbol: TBD_HUMAN

Name: Tubulin delta chain

UniProtKB Accession Codes:

Q9UJT1 B4DPT8 B4DW01 D3DU02 E9PCA7 E9PCQ8 Q5KU36 Q9BWG9 Q9H7Z8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 10 Ensembl 8 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10620804

Title: Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function.

PubMed ID: 10620804

DOI: 10.1038/71350

PubMed ID: 15081367

Title: Delta-tubulin is a component of intercellular bridges and both the early and mature perinuclear rings during spermatogenesis.

PubMed ID: 15081367

DOI: 10.1016/j.ydbio.2004.01.026

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 453
  • Mass: 51034
  • Checksum: 2D78AB3D9EEB9158
  • Sequence:
    • MSIVTVQLGQ CGNQIGFEVF DALLSDSHSS QGLCSMRENE AYQASCKERF FSEEENGVPI 
ARAVLVDMEP KVINQMLSKA AQSGQWKYGQ HACFCQKQGS GNNWAYGYSV HGPRHEESIM 
NIIRKEVEKC DSFSGFFIIM SMAGGTGSGL GAFVTQNLED QYSNSLKMNQ IIWPYGTGEV 
IVQNYNSILT LSHLYRSSDA LLLHENDAIH KICAKLMNIK QISFSDINQV LAHQLGSVFQ 
PTYSAESSFH YRRNPLGDLM EHLVPHPEFK MLSVRNIPHM SENSLAYTTF TWAGLLKHLR 
QMLISNAKME EGIDRHVWPP LSGLPPLSKM SLNKDLHFNT SIANLVILRG KDVQSADVEG 
FKDPALYTSW LKPVNAFNVW KTQRAFSKYE KSAVLVSNSQ FLVKPLDMIV GKAWNMFASK 
AYIHQYTKFG IEEEDFLDSF TSLEQVVASY CNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.