Details for: SCARA3

Gene ID: 51435

Symbol: SCARA3

Ensembl ID: ENSG00000168077

Description: scavenger receptor class A member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 100.7714
    Cell Significance Index: -25.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.1191
    Cell Significance Index: -21.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.2624
    Cell Significance Index: -23.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 13.6708
    Cell Significance Index: 186.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4520
    Cell Significance Index: -25.4600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.7689
    Cell Significance Index: 63.9700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 2.5432
    Cell Significance Index: 29.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8882
    Cell Significance Index: 60.4800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.8426
    Cell Significance Index: 12.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7326
    Cell Significance Index: 93.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.7253
    Cell Significance Index: 105.4300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.6700
    Cell Significance Index: 10.6300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.6686
    Cell Significance Index: 9.3500
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.5460
    Cell Significance Index: 4.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5038
    Cell Significance Index: 14.0800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.3140
    Cell Significance Index: 5.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2668
    Cell Significance Index: 53.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2625
    Cell Significance Index: 52.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2607
    Cell Significance Index: 142.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2494
    Cell Significance Index: 5.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2180
    Cell Significance Index: 11.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1833
    Cell Significance Index: 4.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1778
    Cell Significance Index: 3.4700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1525
    Cell Significance Index: 2.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1191
    Cell Significance Index: 15.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1090
    Cell Significance Index: 20.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1038
    Cell Significance Index: 12.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1028
    Cell Significance Index: 4.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0782
    Cell Significance Index: 14.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0763
    Cell Significance Index: 10.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0567
    Cell Significance Index: 25.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0483
    Cell Significance Index: 5.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0481
    Cell Significance Index: 30.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0413
    Cell Significance Index: 6.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0275
    Cell Significance Index: 2.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0181
    Cell Significance Index: 6.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0170
    Cell Significance Index: 15.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0042
    Cell Significance Index: -7.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0139
    Cell Significance Index: -10.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0161
    Cell Significance Index: -10.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0169
    Cell Significance Index: -31.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0201
    Cell Significance Index: -1.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0208
    Cell Significance Index: -31.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0238
    Cell Significance Index: -32.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0328
    Cell Significance Index: -24.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0333
    Cell Significance Index: -24.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0341
    Cell Significance Index: -19.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0381
    Cell Significance Index: -1.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0434
    Cell Significance Index: -1.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0498
    Cell Significance Index: -10.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0505
    Cell Significance Index: -0.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0537
    Cell Significance Index: -24.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0543
    Cell Significance Index: -5.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0663
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0803
    Cell Significance Index: -13.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0859
    Cell Significance Index: -24.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0949
    Cell Significance Index: -4.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1297
    Cell Significance Index: -2.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1447
    Cell Significance Index: -8.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1491
    Cell Significance Index: -17.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2140
    Cell Significance Index: -21.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2216
    Cell Significance Index: -4.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2235
    Cell Significance Index: -26.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2313
    Cell Significance Index: -4.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2317
    Cell Significance Index: -26.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2418
    Cell Significance Index: -14.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2469
    Cell Significance Index: -25.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2470
    Cell Significance Index: -17.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2743
    Cell Significance Index: -20.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2878
    Cell Significance Index: -12.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3047
    Cell Significance Index: -15.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3251
    Cell Significance Index: -19.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3295
    Cell Significance Index: -17.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3592
    Cell Significance Index: -24.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3696
    Cell Significance Index: -28.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3740
    Cell Significance Index: -9.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3837
    Cell Significance Index: -12.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3940
    Cell Significance Index: -24.8300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4613
    Cell Significance Index: -9.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4804
    Cell Significance Index: -16.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4832
    Cell Significance Index: -25.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5016
    Cell Significance Index: -17.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5047
    Cell Significance Index: -19.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5338
    Cell Significance Index: -11.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5470
    Cell Significance Index: -17.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5552
    Cell Significance Index: -20.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5583
    Cell Significance Index: -14.3500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5800
    Cell Significance Index: -14.0500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.6136
    Cell Significance Index: -10.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6185
    Cell Significance Index: -17.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6628
    Cell Significance Index: -27.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6789
    Cell Significance Index: -13.6300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.6885
    Cell Significance Index: -7.8800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7208
    Cell Significance Index: -17.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7627
    Cell Significance Index: -22.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8054
    Cell Significance Index: -9.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8144
    Cell Significance Index: -23.2400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8246
    Cell Significance Index: -17.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8289
    Cell Significance Index: -22.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Scavenger Receptor Function:** SCARA3 is a member of the scavenger receptor family, which is characterized by its ability to bind and internalize various ligands, including proteins, lipids, and nanoparticles. 2. **Expression Pattern:** SCARA3 is expressed in a wide range of cell types, including hematopoietic oligopotent progenitor cells, mucosal type mast cells, smooth muscle fibers of the ileum, and stromal cells of bone marrow. 3. **Cellular Localization:** SCARA3 is primarily localized to the plasma membrane, but it can also be found in endosomal compartments and the Golgi apparatus. 4. **Signaling Pathways:** SCARA3 is involved in several signaling pathways, including the Toll-like receptor 3 signaling pathway, collagen trimer formation, and endoplasmic reticulum membrane dynamics. **Pathways and Functions:** 1. **Toll-like Receptor 3 Signaling Pathway:** SCARA3 is involved in the activation of the Toll-like receptor 3 signaling pathway, which plays a crucial role in the recognition of pathogens and the activation of innate immunity. 2. **Collagen Trimer Formation:** SCARA3 is involved in the formation of collagen trimer, a process that is essential for the structure and function of collagen-based tissues. 3. **Endoplasmic Reticulum Membrane Dynamics:** SCARA3 is involved in the regulation of endoplasmic reticulum membrane dynamics, including the sorting and trafficking of proteins. 4. **Vesicle-Mediated Transport:** SCARA3 is involved in the regulation of vesicle-mediated transport, including the sorting and trafficking of proteins and lipids. **Clinical Significance:** 1. **Innate Immunity:** SCARA3 plays a critical role in the recognition of pathogens and the activation of innate immunity, making it a potential target for the treatment of infectious diseases. 2. **Atherosclerosis:** SCARA3 has been implicated in the development of atherosclerosis, a condition characterized by the buildup of lipid-rich plaques in the arterial walls. 3. **Cancer:** SCARA3 has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role in tumor progression and metastasis. 4. **Neurodegenerative Diseases:** SCARA3 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, suggesting its potential role in the regulation of protein aggregation and clearance. In conclusion, SCARA3 is a multifaceted scavenger receptor that plays a critical role in various cellular processes, including protein binding, vesicle-mediated transport, and response to oxidative stress. Its expression is widespread across different cell types, and it has been implicated in several signaling pathways, including the Toll-like receptor 3 signaling pathway, collagen trimer formation, and endoplasmic reticulum membrane dynamics. Further research is needed to fully elucidate the functions and clinical significance of SCARA3.

Genular Protein ID: 3391266592

Symbol: SCAR3_HUMAN

Name: Scavenger receptor class A member 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9580669

Title: CSR, a scavenger receptor-like protein with a protective role against cellular damage caused by UV irradiation and oxidative stress.

PubMed ID: 9580669

DOI: 10.1093/hmg/7.6.1039

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 606
  • Mass: 65137
  • Checksum: 15EEC028AAF7762E
  • Sequence:
  • MKVRSAGGDG DALCVTEEDL AGDDEDMPTF PCTQKGRPGP RCSRCQKNLS LHTSVRILYL 
    FLALLLVAVA VLASLVFRKV DSLSEDISLT QSIYDKKLVL MQKNLQGLDP KALNNCSFCH 
    EAGQLGPEIR KLQEELEGIQ KLLLAQEVQL DQTLQAQEVL STTSRQISQE MGSCSFSIHQ 
    VNQSLGLFLA QVRGWQATTA GLDLSLKDLT QECYDVKAAV HQINFTVGQT SEWIHGIQRK 
    TDEETLTLQK IVTDWQNYTR LFSGLRTTST KTGEAVKNIQ ATLGASSQRI SQNSESMHDL 
    VLQVMGLQLQ LDNISSFLDD HEENMHDLQY HTHYAQNRTV ERFESLEGRM ASHEIEIGTI 
    FTNINATDNH VHSMLKYLDD VRLSCTLGFH THAEELYYLN KSVSIMLGTT DLLRERFSLL 
    SARLDLNVRN LSMIVEEMKA VDTQHGEILR NVTILRGAPG PPGPRGFKGD MGVKGPVGGR 
    GPKGDPGSLG PLGPQGPQGQ PGEAGPVGER GPVGPRGFPG LKGSKGSFGT GGPRGQPGPK 
    GDIGPPGPEG PPGSPGPSGP QGKPGIAGKT GSPGQRGAMG PKGEPGIQGP PGLPGPPGPP 
    GSQSFY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.