Details for: VCX3A

Gene ID: 51481

Symbol: VCX3A

Ensembl ID: ENSG00000169059

Description: variable charge X-linked 3A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.7401
    Cell Significance Index: 44.3800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.4235
    Cell Significance Index: 18.4200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.9899
    Cell Significance Index: 13.5800
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.5503
    Cell Significance Index: 4.1600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2606
    Cell Significance Index: 3.7100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.2585
    Cell Significance Index: 3.3400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1400
    Cell Significance Index: 1.1900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1371
    Cell Significance Index: 1.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0951
    Cell Significance Index: 2.8000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0909
    Cell Significance Index: 1.1500
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.0529
    Cell Significance Index: 0.6100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0437
    Cell Significance Index: 0.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0395
    Cell Significance Index: 2.4900
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.0183
    Cell Significance Index: 0.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0154
    Cell Significance Index: 2.6300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0125
    Cell Significance Index: 0.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0083
    Cell Significance Index: 0.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0053
    Cell Significance Index: 0.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0051
    Cell Significance Index: 0.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0025
    Cell Significance Index: 0.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0020
    Cell Significance Index: 0.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0008
    Cell Significance Index: 1.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0002
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0005
    Cell Significance Index: -0.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0006
    Cell Significance Index: -0.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0007
    Cell Significance Index: -0.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0007
    Cell Significance Index: -0.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0011
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0011
    Cell Significance Index: -0.1300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0013
    Cell Significance Index: -0.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0014
    Cell Significance Index: -0.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0017
    Cell Significance Index: -0.3100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0019
    Cell Significance Index: -0.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0023
    Cell Significance Index: -0.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0033
    Cell Significance Index: -0.4500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0036
    Cell Significance Index: -0.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0045
    Cell Significance Index: -0.2300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0046
    Cell Significance Index: -0.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0055
    Cell Significance Index: -0.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0069
    Cell Significance Index: -0.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0078
    Cell Significance Index: -0.4800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0078
    Cell Significance Index: -0.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0079
    Cell Significance Index: -0.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0081
    Cell Significance Index: -0.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0087
    Cell Significance Index: -0.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0092
    Cell Significance Index: -0.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0094
    Cell Significance Index: -0.5300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0099
    Cell Significance Index: -0.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0099
    Cell Significance Index: -0.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0099
    Cell Significance Index: -0.3300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0099
    Cell Significance Index: -0.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0100
    Cell Significance Index: -0.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0103
    Cell Significance Index: -0.3600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0105
    Cell Significance Index: -0.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0105
    Cell Significance Index: -0.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0108
    Cell Significance Index: -0.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0119
    Cell Significance Index: -0.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0119
    Cell Significance Index: -0.5600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0130
    Cell Significance Index: -0.1000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0131
    Cell Significance Index: -0.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0132
    Cell Significance Index: -0.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0139
    Cell Significance Index: -0.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0140
    Cell Significance Index: -0.3500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0145
    Cell Significance Index: -0.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0145
    Cell Significance Index: -0.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0150
    Cell Significance Index: -0.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0150
    Cell Significance Index: -0.5500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0154
    Cell Significance Index: -0.2600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0158
    Cell Significance Index: -0.2100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0159
    Cell Significance Index: -0.2200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0162
    Cell Significance Index: -0.3500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0165
    Cell Significance Index: -0.1800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0166
    Cell Significance Index: -0.2100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0168
    Cell Significance Index: -0.2200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0171
    Cell Significance Index: -0.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0172
    Cell Significance Index: -0.3400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0172
    Cell Significance Index: -0.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0179
    Cell Significance Index: -0.3600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0179
    Cell Significance Index: -0.3100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0179
    Cell Significance Index: -0.1900
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0179
    Cell Significance Index: -0.2000
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.0184
    Cell Significance Index: -0.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0186
    Cell Significance Index: -0.5300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0191
    Cell Significance Index: -0.3800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0194
    Cell Significance Index: -0.2300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0197
    Cell Significance Index: -0.2200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0200
    Cell Significance Index: -0.3000
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0203
    Cell Significance Index: -0.2100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0212
    Cell Significance Index: -0.2300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0216
    Cell Significance Index: -0.4500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0220
    Cell Significance Index: -0.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0223
    Cell Significance Index: -0.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0225
    Cell Significance Index: -0.5400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0225
    Cell Significance Index: -0.4400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0229
    Cell Significance Index: -0.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** VCX3A is a cytoplasmic protein, which suggests its involvement in intracellular signaling and regulation of cellular processes. Its expression is restricted to specific cell types, indicating a tissue-specific function. The gene's X-linked inheritance pattern implies that it is involved in sex-specific developmental processes. The variable charge nature of VCX3A may be essential for its interaction with other proteins and regulation of cellular activities. **Pathways and Functions** VCX3A's expression is significantly associated with brain development, suggesting its involvement in neural cell differentiation and maturation. The gene is also expressed in the nucleolus, a region of the nucleus responsible for ribosome biogenesis. This may imply that VCX3A plays a role in regulating protein synthesis or translation. Furthermore, VCX3A's expression in megakaryocytes and precursor B cells indicates its involvement in hematopoiesis, the process of blood cell development. **Clinical Significance** The clinical significance of VCX3A is still an emerging area of research. However, its expression in various cell types suggests that it may be involved in the pathogenesis of several diseases. For instance, alterations in VCX3A expression have been observed in certain types of cancer, such as leukemia and lymphoma. Additionally, VCX3A's role in brain development and function may be implicated in neurological disorders, such as autism and schizophrenia. Further studies are necessary to elucidate the functional significance of VCX3A and its potential as a therapeutic target. **Conclusion** In conclusion, VCX3A is a complex gene with multiple roles in cellular development and function. Its expression in various cell types and its involvement in brain development, hematopoiesis, and epithelial tissue homeostasis make it an essential gene to study. Further research is necessary to uncover the full range of VCX3A's functions and its potential involvement in disease pathology. As an immunologist, understanding VCX3A's role in immune cell development and function is crucial for developing novel therapeutic strategies for immune-related disorders.

Genular Protein ID: 1309483309

Symbol: VCX3_HUMAN

Name: Variable charge X-linked protein 3

UniProtKB Accession Codes:

Q9NNX9 Q9P0H4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10903929

Title: A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation.

PubMed ID: 10903929

DOI: 10.1086/303047

PubMed ID: 10607842

Title: A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.

PubMed ID: 10607842

DOI: 10.1093/hmg/9.2.311

Sequence Information:

  • Length: 186
  • Mass: 20020
  • Checksum: 8C9C5F66FB97EE9A
  • Sequence:
    • MSPKPRASGP PAKATEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR GKKGAATKMA 
AVTAPEAESG PAAPGPSDQP SQELPQHELP PEEPVSEGTQ HDPLSQESEL EEPLSQESEV 
EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEM 
EELPSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.