Details for: NSG2

Gene ID: 51617

Symbol: NSG2

Ensembl ID: ENSG00000170091

Description: neuronal vesicle trafficking associated 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.9854
    Cell Significance Index: 261.7500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 4.0571
    Cell Significance Index: 97.3000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 4.0570
    Cell Significance Index: 50.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.7979
    Cell Significance Index: 167.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.5120
    Cell Significance Index: 132.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.8512
    Cell Significance Index: 175.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.5329
    Cell Significance Index: 155.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.0340
    Cell Significance Index: 729.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.9866
    Cell Significance Index: 56.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8378
    Cell Significance Index: 368.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.7820
    Cell Significance Index: 119.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3827
    Cell Significance Index: 956.3300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.2338
    Cell Significance Index: 16.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.1968
    Cell Significance Index: 20.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0808
    Cell Significance Index: 23.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8964
    Cell Significance Index: 19.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6748
    Cell Significance Index: 128.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3851
    Cell Significance Index: 347.7400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2656
    Cell Significance Index: 6.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2612
    Cell Significance Index: 25.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1377
    Cell Significance Index: 22.4000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0284
    Cell Significance Index: 0.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0124
    Cell Significance Index: 1.3500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0010
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0129
    Cell Significance Index: -24.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0138
    Cell Significance Index: -25.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0142
    Cell Significance Index: -0.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0189
    Cell Significance Index: -29.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0190
    Cell Significance Index: -0.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0224
    Cell Significance Index: -30.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0237
    Cell Significance Index: -1.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0270
    Cell Significance Index: -1.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0396
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0411
    Cell Significance Index: -30.4800
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.0446
    Cell Significance Index: -0.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0455
    Cell Significance Index: -33.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0502
    Cell Significance Index: -31.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0547
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0584
    Cell Significance Index: -36.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0601
    Cell Significance Index: -33.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0613
    Cell Significance Index: -33.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0691
    Cell Significance Index: -31.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0807
    Cell Significance Index: -1.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0905
    Cell Significance Index: -26.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1313
    Cell Significance Index: -4.2100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1485
    Cell Significance Index: -3.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1489
    Cell Significance Index: -4.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1531
    Cell Significance Index: -30.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1604
    Cell Significance Index: -7.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1701
    Cell Significance Index: -5.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1707
    Cell Significance Index: -24.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1720
    Cell Significance Index: -36.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1742
    Cell Significance Index: -2.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1803
    Cell Significance Index: -32.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1878
    Cell Significance Index: -32.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1912
    Cell Significance Index: -13.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2445
    Cell Significance Index: -33.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2577
    Cell Significance Index: -15.4700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2616
    Cell Significance Index: -2.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2650
    Cell Significance Index: -32.5900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2659
    Cell Significance Index: -1.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2720
    Cell Significance Index: -31.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3006
    Cell Significance Index: -34.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3013
    Cell Significance Index: -30.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3118
    Cell Significance Index: -32.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3316
    Cell Significance Index: -10.5600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3448
    Cell Significance Index: -7.4500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3818
    Cell Significance Index: -4.1600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3898
    Cell Significance Index: -2.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4239
    Cell Significance Index: -32.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4254
    Cell Significance Index: -33.6900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4457
    Cell Significance Index: -5.2000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.5243
    Cell Significance Index: -6.2700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5260
    Cell Significance Index: -13.1200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5340
    Cell Significance Index: -11.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5544
    Cell Significance Index: -19.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5574
    Cell Significance Index: -35.1300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.6040
    Cell Significance Index: -14.6300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.6065
    Cell Significance Index: -8.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6587
    Cell Significance Index: -30.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6898
    Cell Significance Index: -32.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7213
    Cell Significance Index: -18.0300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.7374
    Cell Significance Index: -9.8300
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.7434
    Cell Significance Index: -5.8300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.8012
    Cell Significance Index: -10.1100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.8622
    Cell Significance Index: -16.9700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.8811
    Cell Significance Index: -17.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8862
    Cell Significance Index: -22.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9029
    Cell Significance Index: -19.2300
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.9294
    Cell Significance Index: -9.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.0521
    Cell Significance Index: -21.8300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.0698
    Cell Significance Index: -8.8300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.0943
    Cell Significance Index: -34.6100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.1036
    Cell Significance Index: -16.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1038
    Cell Significance Index: -31.6400
  • Cell Name: granule cell (CL0000120)
    Fold Change: -1.1059
    Cell Significance Index: -12.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.1314
    Cell Significance Index: -30.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1740
    Cell Significance Index: -34.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.2660
    Cell Significance Index: -34.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.2813
    Cell Significance Index: -26.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NSG2 is a protein-coding gene that is primarily expressed in neurons, with notable expression in glycinergic, GABAergic, and glutamatergic neurons. The protein p19, encoded by NSG2, is a small, soluble protein that interacts with clathrin, a key component of clathrin-coated vesicles. This interaction is thought to regulate the formation and trafficking of clathrin-coated vesicles, which are essential for the transport of neurotransmitter receptors to the postsynaptic density. **Pathways and Functions:** NSG2 is involved in several key cellular pathways, including: 1. **Clathrin coat assembly:** NSG2 interacts with clathrin to regulate the formation of clathrin-coated vesicles, which are essential for the transport of neurotransmitter receptors to the postsynaptic density. 2. **Endosomal transport:** NSG2 is also involved in the transport of vesicles within the endosomal system, which is critical for the regulation of synaptic homeostasis. 3. **Regulation of postsynaptic membrane neurotransmitter receptor levels:** NSG2 plays a key role in regulating the levels of neurotransmitter receptors at the postsynaptic density, which is essential for maintaining synaptic function and plasticity. **Clinical Significance:** Dysregulation of NSG2 has been implicated in several neurological disorders, including: 1. **Neurodegenerative diseases:** Mutations in NSG2 have been associated with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, which are characterized by impaired synaptic function and plasticity. 2. **Neuropsychiatric disorders:** NSG2 has also been implicated in neuropsychiatric disorders such as schizophrenia and bipolar disorder, which are characterized by impaired synaptic function and neurotransmitter regulation. 3. **Developmental disorders:** NSG2 has been implicated in developmental disorders such as autism spectrum disorder, which is characterized by impaired synaptic function and neurotransmitter regulation. In conclusion, NSG2 plays a critical role in regulating the trafficking of vesicles within neurons, particularly in the context of neurotransmitter receptors at the postsynaptic density. Dysregulation of NSG2 has been implicated in several neurological disorders, highlighting the importance of further research into the molecular mechanisms underlying synaptic function and plasticity.

Genular Protein ID: 4124452100

Symbol: NSG2_HUMAN

Name: Protein p19

UniProtKB Accession Codes:

Q9Y328 B2R5Y0 D3DQN0 Q9UHX8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 16 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 171
  • Mass: 19085
  • Checksum: F5E69DEA61D0FFEC
  • Sequence:
    • MVKLNSNPSE KGTKPPSVED GFQTVPLITP LEVNHLQLPA PEKVIVKTRT EYQPEQKNKG 
KFRVPKIAEF TVTILVSLAL AFLACIVFLV VYKAFTYDHS CPEGFVYKHK RCIPASLDAY 
YSSQDPNSRS RFYTVISHYS VAKQSTARAI GPWLSAAAVI HEPKPPKTQG H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.