Details for: PHF1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 194.2200
Cell Significance Index: -30.2100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 117.2118
Cell Significance Index: -29.7300 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 72.8624
Cell Significance Index: -34.4000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 71.7280
Cell Significance Index: -29.1400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 65.9525
Cell Significance Index: -33.9300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 30.8355
Cell Significance Index: -29.4400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 24.8590
Cell Significance Index: -30.6500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.5231
Cell Significance Index: -28.1900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.8838
Cell Significance Index: -31.1100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 6.4172
Cell Significance Index: -19.7100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.6018
Cell Significance Index: -12.2600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.0970
Cell Significance Index: 57.0800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.3353
Cell Significance Index: 155.6200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.3134
Cell Significance Index: 17.9200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.0844
Cell Significance Index: 31.0900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.9872
Cell Significance Index: 51.8300 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.8809
Cell Significance Index: 6.7900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.8188
Cell Significance Index: 9.7600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6163
Cell Significance Index: 67.0400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.5910
Cell Significance Index: 37.2500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5564
Cell Significance Index: 90.4900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.5375
Cell Significance Index: 28.0000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.5285
Cell Significance Index: 67.7600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5144
Cell Significance Index: 103.1800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4876
Cell Significance Index: 36.3400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4444
Cell Significance Index: 20.7200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4321
Cell Significance Index: 20.3100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4005
Cell Significance Index: 55.0000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3958
Cell Significance Index: 20.5600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3931
Cell Significance Index: 48.3400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3806
Cell Significance Index: 22.8500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3334
Cell Significance Index: 119.5900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3280
Cell Significance Index: 22.6900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3234
Cell Significance Index: 58.3000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3135
Cell Significance Index: 14.2100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3046
Cell Significance Index: 210.6500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2705
Cell Significance Index: 7.8000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2287
Cell Significance Index: 39.0500 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.2230
Cell Significance Index: 28.8200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2092
Cell Significance Index: 41.5100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1631
Cell Significance Index: 72.1200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1288
Cell Significance Index: 70.3500 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.1261
Cell Significance Index: 1.9200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1198
Cell Significance Index: 6.0500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1006
Cell Significance Index: 19.1500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0963
Cell Significance Index: 2.6900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0714
Cell Significance Index: 2.5100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0604
Cell Significance Index: 7.1200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0540
Cell Significance Index: 3.4800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0527
Cell Significance Index: 99.2900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0478
Cell Significance Index: 3.6700 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.0370
Cell Significance Index: 1.1700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0272
Cell Significance Index: 17.2800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0239
Cell Significance Index: 2.3600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0208
Cell Significance Index: 32.0600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0172
Cell Significance Index: 31.7000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0034
Cell Significance Index: -4.6300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0088
Cell Significance Index: -0.2200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0143
Cell Significance Index: -0.3100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0174
Cell Significance Index: -7.9200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0174
Cell Significance Index: -12.8600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0186
Cell Significance Index: -13.6200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0206
Cell Significance Index: -15.5900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0255
Cell Significance Index: -15.9100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0284
Cell Significance Index: -16.0000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0440
Cell Significance Index: -4.4900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0719
Cell Significance Index: -8.2400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0776
Cell Significance Index: -11.2800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0814
Cell Significance Index: -17.1400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1046
Cell Significance Index: -1.7500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1132
Cell Significance Index: -32.5700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1178
Cell Significance Index: -8.3300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1277
Cell Significance Index: -3.4100 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1667
Cell Significance Index: -3.4900 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1857
Cell Significance Index: -21.2000 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.2465
Cell Significance Index: -2.8000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2604
Cell Significance Index: -27.1100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2701
Cell Significance Index: -11.0700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3014
Cell Significance Index: -6.4200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3046
Cell Significance Index: -17.0900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3099
Cell Significance Index: -8.1500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3103
Cell Significance Index: -8.3000 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.3160
Cell Significance Index: -4.4900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3622
Cell Significance Index: -28.6900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3660
Cell Significance Index: -12.7200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3823
Cell Significance Index: -12.2500 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.4026
Cell Significance Index: -6.9400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.4046
Cell Significance Index: -7.1500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4358
Cell Significance Index: -19.2800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4413
Cell Significance Index: -12.9600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4622
Cell Significance Index: -28.3400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4700
Cell Significance Index: -12.0800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.5296
Cell Significance Index: -11.2400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5459
Cell Significance Index: -20.6700 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.5845
Cell Significance Index: -8.3200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5875
Cell Significance Index: -20.5800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.6157
Cell Significance Index: -9.0900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6185
Cell Significance Index: -19.7000 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.6201
Cell Significance Index: -15.1300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6313
Cell Significance Index: -20.6700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3691491484
Symbol: PHF1_HUMAN
Name: PHD finger protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9545646
Title: The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster.
PubMed ID: 9545646
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16397222
Title: Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma.
PubMed ID: 16397222
PubMed ID: 18086877
Title: Role of hPHF1 in H3K27 methylation and Hox gene silencing.
PubMed ID: 18086877
DOI: 10.1128/mcb.01589-07
PubMed ID: 18285464
Title: Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo.
PubMed ID: 18285464
DOI: 10.1128/mcb.02017-07
PubMed ID: 18385154
Title: A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell.
PubMed ID: 18385154
DOI: 10.1093/nar/gkn146
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20873783
Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.
PubMed ID: 20873783
DOI: 10.1021/pr100562w
PubMed ID: 22761769
Title: Novel fusion of MYST/Esa1-associated factor 6 and PHF1 in endometrial stromal sarcoma.
PubMed ID: 22761769
PubMed ID: 23228662
Title: Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3.
PubMed ID: 23228662
PubMed ID: 23150668
Title: Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis.
PubMed ID: 23150668
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 23273982
Title: An H3K36 methylation-engaging Tudor motif of Polycomb-like proteins mediates PRC2 complex targeting.
PubMed ID: 23273982
PubMed ID: 23142980
Title: Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1.
PubMed ID: 23142980
DOI: 10.1038/nsmb.2435
Sequence Information:
- Length: 567
- Mass: 62106
- Checksum: E81BA9475565957C
- Sequence:
MAQPPRLSRS GASSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT IKKVDSAREV CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP GNRLVSCEKC RHAYHQDCHV PRAPAPGEGE GTSWVCRQCV FAIATKRGGA LKKGPYARAM LGMKLSLPYG LKGLDWDAGH LSNRQQSYCY CGGPGEWNLK MLQCRSCLQW FHEACTQCLS KPLLYGDRFY EFECCVCRGG PEKVRRLQLR WVDVAHLVLY HLSVCCKKKY FDFDREILPF TSENWDSLLL GELSDTPKGE RSSRLLSALN SHKDRFISGR EIKKRKCLFG LHARMPPPVE PPTGDGALTS FPSGQGPGGG VSRPLGKRRR PEPEPLRRRQ KGKVEELGPP SAVRNQPEPQ EQRERAHLQR ALQASVSPPS PSPNQSYQGS SGYNFRPTDA RCLPSSPIRM FASFHPSAST AGTSGDSGPP DRSPLELHIG FPTDIPKSAP HSMTASSSSV SSPSPGLPRR SAPPSPLCRS LSPGTGGGVR GGVGYLSRGD PVRVLARRVR PDGSVQYLVE WGGGGIF
Genular Protein ID: 357863125
Symbol: A0A140VJR4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 457
- Mass: 49615
- Checksum: A3741140059F8404
- Sequence:
MAQPPRLSRS GASSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT IKKVDSAREV CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP GNRLVSCEKC RHAYHQDCHV PRAPAPGEGE GTSWVCRQCV FAIATKRGGA LKKGPYARAM LGMKLSLPYG LKGLDWDAGH LSNRQQSYCY CGGPGEWNLK MLQCRSCLQW FHEACTQCLS KPLLYGDRFY EFECCVCRGG PEKVRRLQLR WVDVAHLVLY HLSVCCKKKY FDFDREILPF TSENWDSLLL GELSDTPKGE RSSKLLSALN SHKDRFISGR EIKKRKCLFG LHARMPPPVE PPTGDGALTR AGPWGRGLTS PGEAPEAGAR APEEEAEGES GGAGATLSSA QSARAPGAEG AGSSAEGTAA APSGCLLPST LLPAPQGPLG TVDPQTGHPW NFTLVSPQTS LKVPPTR
Genular Protein ID: 4085261205
Symbol: A0A1U9X8A3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 457
- Mass: 49643
- Checksum: 611EF2B5A416841C
- Sequence:
MAQPPRLSRS GASSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT IKKVDSAREV CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP GNRLVSCEKC RHAYHQDCHV PRAPAPGEGE GTSWVCRQCV FAIATKRGGA LKKGPYARAM LGMKLSLPYG LKGLDWDAGH LSNRQQSYCY CGGPGEWNLK MLQCRSCLQW FHEACTQCLS KPLLYGDRFY EFECCVCRGG PEKVRRLQLR WVDVAHLVLY HLSVCCKKKY FDFDREILPF TSENWDSLLL GELSDTPKGE RSSRLLSALN SHKDRFISGR EIKKRKCLFG LHARMPPPVE PPTGDGALTR AGPWGRGLTS PGEAPEAGAR APEEEAEGES GGAGATLSSA QSARAPGAEG AGSSAEGTAA APSGCLLPST LLPAPQGPLG TVDPQTGHPW NFTLVSPQTS LKVPPTR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.