Details for: PHF1
Gene ID: 5252
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PHF1
Ensembl ID: ENSG00000112511
Description: PHD finger protein 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 12.05rCSI 9.48%PRS 68.31
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CSI 11.47rCSI 7.72%PRS 74.71
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CSI 9.07rCSI 17.18%PRS 89.08
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CSI 8.11rCSI 10.19%PRS 87.48
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CSI 7.45rCSI 26.98%PRS 80.95
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CSI 7.44rCSI 6.04%PRS 62.08
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CSI 6.85rCSI 7.15%PRS 83.57
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CSI 5.76rCSI 9.34%PRS 58.2
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CSI 5.48rCSI 6.55%PRS 43.13
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CSI 5.29rCSI 23.51%PRS 61.07
-
CSI 5.09rCSI 3.87%PRS 74.63
-
CSI 5.09rCSI 6.81%PRS 70.46
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CSI 4.94rCSI 6.37%PRS 44.63
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CSI 4.8rCSI 4.03%PRS 65.93
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CSI 4.67rCSI 3.93%PRS 78.54
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CSI 4.58rCSI 6.24%PRS 85.44
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CSI 4.47rCSI 22.44%PRS 74.07
-
CSI 4.36rCSI 3.94%PRS 58.45
-
CSI 3.98rCSI 5.41%PRS 73.38
-
CSI 3.93rCSI 3.05%PRS 63.43
-
CSI 3.81rCSI 6.73%PRS 69.73
-
CSI 3.7rCSI 23.11%PRS 53.45
-
CSI 3.58rCSI 3.3%PRS 62.98
-
CSI 3.49rCSI 2.45%PRS 79.81
-
CSI 3.34rCSI 4.73%PRS 57.89
-
CSI 3.24rCSI 2.43%PRS 76.68
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CSI 3.21rCSI 4.54%PRS 66.85
-
CSI 3.15rCSI 1.86%PRS 78.9
-
CSI 3.08rCSI 3.57%PRS 72.34
-
CSI 3.06rCSI 2.29%PRS 87.15
-
CSI 3.01rCSI 2.16%PRS 75.86
-
CSI 2.9rCSI 2.02%PRS 76.78
-
CSI 2.84rCSI 3.89%PRS 67.58
-
CSI 2.79rCSI 1.94%PRS 72.77
-
CSI 2.73rCSI 2.02%PRS 54.19
-
CSI 2.66rCSI 6.74%PRS 69.53
-
CSI 2.61rCSI 4%PRS 70.58
-
CSI 2.6rCSI 13.99%PRS 73.9
-
CSI 2.58rCSI 2.06%PRS 81.67
-
CSI 2.53rCSI 2.49%PRS 64.17
-
CSI 2.51rCSI 6.37%PRS 55.83
-
CSI 2.5rCSI 1.88%PRS 67.07
-
CSI 2.49rCSI 2.46%PRS 84.49
-
CSI 2.44rCSI 2.56%PRS 58.01
-
CSI 2.43rCSI 5.76%PRS 65.27
-
CSI 2.4rCSI 1.91%PRS 82.7
-
CSI 2.4rCSI 4.57%PRS 76.49
-
CSI 2.38rCSI 2.48%PRS 61.81
-
CSI 2.32rCSI 2.03%PRS 71.3
-
CSI 2.23rCSI 2.29%PRS 75.89
-
CSI 2.23rCSI 2.06%PRS 80.82
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CSI 2.22rCSI 2.67%PRS 59.57
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CSI 2.21rCSI 3.04%PRS 80.94
-
CSI 2.14rCSI 2.73%PRS 68
-
CSI 2.13rCSI 1.59%PRS 78.13
-
CSI 2.09rCSI 2.05%PRS 77.22
-
CSI 2.07rCSI 2.76%PRS 82.05
-
CSI 2.05rCSI 2.04%PRS 54.84
-
CSI 2.04rCSI 2.82%PRS 62.67
-
CSI 2.04rCSI 2.48%PRS 69.07
-
CSI 2.03rCSI 1.54%PRS 75.37
-
CSI 2.02rCSI 1.88%PRS 62.21
-
CSI 2.02rCSI 1.94%PRS 52.2
-
CSI 2.01rCSI 1.34%PRS 64.68
-
CSI 2rCSI 4.01%PRS 50.62
-
CSI 1.98rCSI 2.12%PRS 60.95
-
CSI 1.96rCSI 1.72%PRS 67.12
-
CSI 1.95rCSI 1.71%PRS 49.42
-
CSI 1.89rCSI 2.42%PRS 66.29
-
CSI 1.82rCSI 2.78%PRS 57.84
-
CSI 1.81rCSI 1.5%PRS 60.78
-
CSI 1.8rCSI 2.11%PRS 78.04
-
CSI 1.78rCSI 2.01%PRS 77.74
-
CSI 1.78rCSI 3.14%PRS 42.41
-
CSI 1.77rCSI 1.62%PRS 76.12
-
CSI 1.76rCSI 2.69%PRS 77
-
CSI 1.75rCSI 3.15%PRS 54.65
-
CSI 1.75rCSI 1.78%PRS 74.43
-
CSI 1.74rCSI 5%PRS 81.24
-
CSI 1.73rCSI 2.37%PRS 68.51
-
CSI 1.73rCSI 4.48%PRS 65.11
-
CSI 1.72rCSI 3.57%PRS 58.78
-
CSI 1.69rCSI 2.3%PRS 53.37
-
CSI 1.68rCSI 1.25%PRS 74.9
-
CSI 1.62rCSI 2.41%PRS 63.17
-
CSI 1.62rCSI 1.77%PRS 65.33
-
CSI 1.6rCSI 2.55%PRS 53.94
-
CSI 1.6rCSI 2.8%PRS 53.52
-
CSI 1.58rCSI 3.59%PRS 65.55
-
CSI 1.58rCSI 1.25%PRS 48.39
-
CSI 1.58rCSI 3.6%PRS 53.4
-
CSI 1.57rCSI 1.82%PRS 51.62
-
CSI 1.56rCSI 2.38%PRS 62.23
-
CSI 1.53rCSI 2.2%PRS 65.36
-
CSI 1.53rCSI 2.89%PRS 79.82
-
CSI 1.51rCSI 2.07%PRS 63.29
-
CSI 1.5rCSI 2.3%PRS 70.93
-
CSI 1.49rCSI 3.46%PRS 79.37
-
CSI 1.47rCSI 1.3%PRS 59.56
-
CSI 1.44rCSI 1.92%PRS 61.86
-
CSI 0.2rCSI 1.0%PRS 71.0%
-
CSI 0.4rCSI 1.7%PRS 74.0%
-
CSI 0.5rCSI 1.6%PRS 70.4%
-
CSI 0.5rCSI 1.2%PRS 51.0%
-
CSI 0.5rCSI 1.7%PRS 47.5%
-
CSI 0.5rCSI 1.5%PRS 63.0%
-
CSI 0.6rCSI 3.2%PRS 46.7%
-
CSI 0.7rCSI 1.0%PRS 65.7%
-
CSI 0.7rCSI 0.9%PRS 48.8%
-
CSI 0.7rCSI 2.1%PRS 51.3%
-
CSI 0.7rCSI 1.2%PRS 51.1%
-
CSI 0.7rCSI 1.4%PRS 87.0%
-
CSI 0.7rCSI 2.4%PRS 86.4%
-
CSI 0.8rCSI 1.1%PRS 68.0%
-
CSI 0.8rCSI 2.0%PRS 85.0%
-
CSI 0.9rCSI 1.9%PRS 59.5%
-
CSI 0.9rCSI 2.3%PRS 79.8%
-
CSI 0.9rCSI 1.9%PRS 79.2%
-
CSI 1.0rCSI 2.9%PRS 74.0%
-
CSI 1.0rCSI 1.6%PRS 65.8%
-
CSI 1.1rCSI 2.8%PRS 70.4%
-
CSI 1.1rCSI 1.7%PRS 63.9%
-
CSI 1.1rCSI 1.9%PRS 58.5%
-
CSI 1.1rCSI 1.6%PRS 66.2%
-
CSI 1.1rCSI 2.1%PRS 83.3%
-
CSI 1.2rCSI 1.4%PRS 81.1%
-
CSI 1.2rCSI 2.5%PRS 79.7%
-
CSI 1.2rCSI 1.4%PRS 78.1%
-
CSI 1.2rCSI 1.3%PRS 67.2%
-
CSI 1.2rCSI 1.9%PRS 59.7%
-
CSI 1.2rCSI 2.7%PRS 65.8%
-
CSI 1.2rCSI 4.0%PRS 62.0%
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CSI 1.2rCSI 1.5%PRS 41.4%
-
CSI 1.2rCSI 2.9%PRS 50.7%
-
CSI 1.2rCSI 1.1%PRS 72.4%
-
CSI 1.2rCSI 2.8%PRS 44.1%
-
CSI 1.3rCSI 3.6%PRS 74.3%
-
CSI 1.3rCSI 2.5%PRS 49.9%
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CSI 1.3rCSI 3.0%PRS 47.8%
-
CSI 1.3rCSI 1.0%PRS 62.1%
-
CSI 1.4rCSI 3.5%PRS 60.0%
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CSI 1.4rCSI 1.7%PRS 58.1%
-
CSI 1.4rCSI 2.9%PRS 63.4%
-
CSI 1.4rCSI 1.9%PRS 61.9%
-
CSI 1.5rCSI 1.3%PRS 59.6%
-
CSI 1.5rCSI 3.5%PRS 79.4%
-
CSI 1.5rCSI 2.3%PRS 70.9%
-
CSI 1.5rCSI 2.1%PRS 63.3%
-
CSI 1.5rCSI 2.9%PRS 79.8%
-
CSI 1.5rCSI 2.2%PRS 65.4%
-
CSI 1.6rCSI 2.4%PRS 62.2%
-
CSI 1.6rCSI 1.8%PRS 51.6%
-
CSI 1.6rCSI 3.6%PRS 53.4%
-
CSI 1.6rCSI 1.3%PRS 48.4%
-
CSI 1.6rCSI 3.6%PRS 65.6%
-
CSI 1.6rCSI 2.8%PRS 53.5%
-
CSI 1.6rCSI 2.6%PRS 53.9%
-
CSI 1.6rCSI 1.8%PRS 65.3%
-
CSI 1.6rCSI 2.4%PRS 63.2%
-
CSI 1.7rCSI 1.3%PRS 74.9%
-
CSI 1.7rCSI 2.3%PRS 53.4%
-
CSI 1.7rCSI 3.6%PRS 58.8%
-
CSI 1.7rCSI 4.5%PRS 65.1%
-
CSI 1.7rCSI 2.4%PRS 68.5%
-
CSI 1.7rCSI 5.0%PRS 81.2%
-
CSI 1.8rCSI 1.8%PRS 74.4%
-
CSI 1.8rCSI 3.2%PRS 54.7%
-
CSI 1.8rCSI 2.7%PRS 77.0%
-
CSI 1.8rCSI 1.6%PRS 76.1%
-
CSI 1.8rCSI 3.1%PRS 42.4%
-
CSI 1.8rCSI 2.0%PRS 77.7%
-
CSI 1.8rCSI 2.1%PRS 78.0%
-
CSI 1.8rCSI 1.5%PRS 60.8%
-
CSI 1.8rCSI 2.8%PRS 57.8%
-
CSI 1.9rCSI 2.4%PRS 66.3%
-
CSI 2.0rCSI 1.7%PRS 49.4%
-
CSI 2.0rCSI 1.7%PRS 67.1%
-
CSI 2.0rCSI 2.1%PRS 61.0%
-
CSI 2.0rCSI 4.0%PRS 50.6%
-
CSI 2.0rCSI 1.3%PRS 64.7%
-
CSI 2.0rCSI 1.9%PRS 52.2%
-
CSI 2.0rCSI 1.9%PRS 62.2%
-
CSI 2.0rCSI 1.5%PRS 75.4%
-
CSI 2.0rCSI 2.5%PRS 69.1%
-
CSI 2.0rCSI 2.8%PRS 62.7%
-
CSI 2.1rCSI 2.0%PRS 54.8%
-
CSI 2.1rCSI 2.8%PRS 82.1%
-
CSI 2.1rCSI 2.1%PRS 77.2%
-
CSI 2.1rCSI 1.6%PRS 78.1%
-
CSI 2.1rCSI 2.7%PRS 68.0%
-
CSI 2.2rCSI 3.0%PRS 80.9%
-
CSI 2.2rCSI 2.7%PRS 59.6%
-
CSI 2.2rCSI 2.1%PRS 80.8%
-
CSI 2.2rCSI 2.3%PRS 75.9%
-
CSI 2.3rCSI 2.0%PRS 71.3%
-
CSI 2.4rCSI 2.5%PRS 61.8%
-
CSI 2.4rCSI 4.6%PRS 76.5%
-
CSI 2.4rCSI 1.9%PRS 82.7%
-
CSI 2.4rCSI 5.8%PRS 65.3%
-
CSI 2.4rCSI 2.6%PRS 58.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3691491484
Symbol: PHF1_HUMAN
Name: PHD finger protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9545646
Title: The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster.
PubMed ID: 9545646
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16397222
Title: Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma.
PubMed ID: 16397222
PubMed ID: 18086877
Title: Role of hPHF1 in H3K27 methylation and Hox gene silencing.
PubMed ID: 18086877
DOI: 10.1128/mcb.01589-07
PubMed ID: 18285464
Title: Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo.
PubMed ID: 18285464
DOI: 10.1128/mcb.02017-07
PubMed ID: 18385154
Title: A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell.
PubMed ID: 18385154
DOI: 10.1093/nar/gkn146
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20873783
Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.
PubMed ID: 20873783
DOI: 10.1021/pr100562w
PubMed ID: 22761769
Title: Novel fusion of MYST/Esa1-associated factor 6 and PHF1 in endometrial stromal sarcoma.
PubMed ID: 22761769
PubMed ID: 23228662
Title: Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3.
PubMed ID: 23228662
PubMed ID: 23150668
Title: Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis.
PubMed ID: 23150668
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 23273982
Title: An H3K36 methylation-engaging Tudor motif of Polycomb-like proteins mediates PRC2 complex targeting.
PubMed ID: 23273982
PubMed ID: 23142980
Title: Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1.
PubMed ID: 23142980
DOI: 10.1038/nsmb.2435
Sequence Information:
- Length: 567
- Mass: 62106
- Checksum: E81BA9475565957C
- Sequence:
MAQPPRLSRS GASSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT IKKVDSAREV CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP GNRLVSCEKC RHAYHQDCHV PRAPAPGEGE GTSWVCRQCV FAIATKRGGA LKKGPYARAM LGMKLSLPYG LKGLDWDAGH LSNRQQSYCY CGGPGEWNLK MLQCRSCLQW FHEACTQCLS KPLLYGDRFY EFECCVCRGG PEKVRRLQLR WVDVAHLVLY HLSVCCKKKY FDFDREILPF TSENWDSLLL GELSDTPKGE RSSRLLSALN SHKDRFISGR EIKKRKCLFG LHARMPPPVE PPTGDGALTS FPSGQGPGGG VSRPLGKRRR PEPEPLRRRQ KGKVEELGPP SAVRNQPEPQ EQRERAHLQR ALQASVSPPS PSPNQSYQGS SGYNFRPTDA RCLPSSPIRM FASFHPSAST AGTSGDSGPP DRSPLELHIG FPTDIPKSAP HSMTASSSSV SSPSPGLPRR SAPPSPLCRS LSPGTGGGVR GGVGYLSRGD PVRVLARRVR PDGSVQYLVE WGGGGIF
Genular Protein ID: 357863125
Symbol: A0A140VJR4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 457
- Mass: 49615
- Checksum: A3741140059F8404
- Sequence:
MAQPPRLSRS GASSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT IKKVDSAREV CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP GNRLVSCEKC RHAYHQDCHV PRAPAPGEGE GTSWVCRQCV FAIATKRGGA LKKGPYARAM LGMKLSLPYG LKGLDWDAGH LSNRQQSYCY CGGPGEWNLK MLQCRSCLQW FHEACTQCLS KPLLYGDRFY EFECCVCRGG PEKVRRLQLR WVDVAHLVLY HLSVCCKKKY FDFDREILPF TSENWDSLLL GELSDTPKGE RSSKLLSALN SHKDRFISGR EIKKRKCLFG LHARMPPPVE PPTGDGALTR AGPWGRGLTS PGEAPEAGAR APEEEAEGES GGAGATLSSA QSARAPGAEG AGSSAEGTAA APSGCLLPST LLPAPQGPLG TVDPQTGHPW NFTLVSPQTS LKVPPTR
Genular Protein ID: 4085261205
Symbol: A0A1U9X8A3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 457
- Mass: 49643
- Checksum: 611EF2B5A416841C
- Sequence:
MAQPPRLSRS GASSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT IKKVDSAREV CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP GNRLVSCEKC RHAYHQDCHV PRAPAPGEGE GTSWVCRQCV FAIATKRGGA LKKGPYARAM LGMKLSLPYG LKGLDWDAGH LSNRQQSYCY CGGPGEWNLK MLQCRSCLQW FHEACTQCLS KPLLYGDRFY EFECCVCRGG PEKVRRLQLR WVDVAHLVLY HLSVCCKKKY FDFDREILPF TSENWDSLLL GELSDTPKGE RSSRLLSALN SHKDRFISGR EIKKRKCLFG LHARMPPPVE PPTGDGALTR AGPWGRGLTS PGEAPEAGAR APEEEAEGES GGAGATLSSA QSARAPGAEG AGSSAEGTAA APSGCLLPST LLPAPQGPLG TVDPQTGHPW NFTLVSPQTS LKVPPTR